Research Topics
Genomes and Genes | Fred ShermanSummaryAffiliation: University of Rochester Country: USA Publications
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Publications
The diversity of acetylated proteinsBogdan Polevoda
Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
Genome Biol 3:reviews0006. 2002....
The importance of mutation, then and now: studies with yeast cytochrome cFred Sherman
Department of Biochemistry and Biophysics, University of Rochester Medical School, Box 712, Rochester, NY 14642, USA
Mutat Res 589:1-16. 2005..Current work on degradation of proteins in mitochondria, on degradation of mRNA in the nucleus, and on N-terminal acetylation stems from properties of CYC1 mutants isolated in early screens more than a decade ago...
Properties of Nat4, an N(alpha)-acetyltransferase of Saccharomyces cerevisiae that modifies N termini of histones H2A and H4Bogdan Polevoda
Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY 14642, USA
Mol Cell Biol 29:2913-24. 2009..Thus, N-terminal serine acetylation of histone H4 may be a part of an essential charge patch first described for the histone H2A.Z variant in Tetrahymena species...- Mutant LYS2 mRNAs retained and degraded in the nucleus of Saccharomyces cerevisiaeBiswadip Das
Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY 14642, USA
Proc Natl Acad Sci U S A 103:10871-6. 2006.... - Yeast N(alpha)-terminal acetyltransferases are associated with ribosomesBogdan Polevoda
Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, New York 14642, USA
J Cell Biochem 103:492-508. 2008..Moreover, Ard1p copurifies with Rpl35p-TAP. We suggest that these two ribosomal proteins, which are in close proximity to the ribosomal exit tunnel, may play a role in NatA attachment to the ribosome... - Phenotypes of yeast mutants lacking the mitochondrial protein Pet20pBogdan Polevoda
Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, New York 14642, USA
Yeast 23:127-39. 2006..It is also possible that Pet20p may constitute a non-catalytic subunit of an uncharacterized mitochondrial complex or serve as a transporter or a coupling factor... - Cap-binding protein 1-mediated and eukaryotic translation initiation factor 4E-mediated pioneer rounds of translation in yeastQinshan Gao
Department of Biochemistry and Biophysics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 712, University of Rochester, Rochester, NY 14642, USA
Proc Natl Acad Sci U S A 102:4258-63. 2005..These results suggest that both Cbc1p- and eIF4E-mediated pioneer rounds of translation occur in yeast... - A nuclear degradation pathway controls the abundance of normal mRNAs in Saccharomyces cerevisiaeLetian Kuai
Department of Biochemistry and Biophysics, Box 712, University of Rochester Medical Center, Rochester, NY 14642, USA
Proc Natl Acad Sci U S A 102:13962-7. 2005..This conclusion was corroborated by finding an inverse relationship of the CBC1 and SKS1 mRNA levels in normal strains grown under different conditions... - Polyadenylation of rRNA in Saccharomyces cerevisiaeLetian Kuai
Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Proc Natl Acad Sci U S A 101:8581-6. 2004..For at least one rRNA type, the polyadenylation preferentially occurs on the precursor rather than the mature product. The existence of polyadenylated rRNAs may reflect a quality-control mechanism of rRNA biogenesis... - Sue1p is required for degradation of labile forms of altered cytochromes C in yeast mitochondriaJun Wei
Department of Biochemistry and Biophysics, University of Rochester, School of Medicine and Dentistry, Rochester, New York 14642, USA
J Biol Chem 279:30449-58. 2004..These results indicate that Sue1p may play an important role in the degradation of abnormal holo-iso-1-cytochrome c in the mitochondria... - Nat3p and Mdm20p are required for function of yeast NatB Nalpha-terminal acetyltransferase and of actin and tropomyosinBogdan Polevoda
Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
J Biol Chem 278:30686-97. 2003..Furthermore, unacetylated actin and certain N-terminally altered actins have comparable defective properties in vitro, particularly actin-activated ATPase activity and sliding velocity... - Methylation of proteins involved in translationBogdan Polevoda
Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, New York 14642, USA
Mol Microbiol 65:590-606. 2007..Differential methylation of specific RPs and TFs in a number of organisms at different physiological states indicates that this modification may play a regulatory role... 
Overexpressed ribosomal proteins suppress defective chaperonins in Saccharomyces cerevisiaeM Anaul Kabir
Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY 14642, USA
FEMS Yeast Res 8:1236-44. 2008..We suggest that certain overexpressed ribosomal and other proteins can act as weak chaperones, phenotypically alleviating the partial defects of mutationally altered Cct subunits...- N-terminal acetyltransferases and sequence requirements for N-terminal acetylation of eukaryotic proteinsBogdan Polevoda
Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
J Mol Biol 325:595-622. 2003..Overall patterns of N-terminal acetylated proteins and the orthologous genes possibly encoding NATs suggest that yeast and higher eukaryotes have the same systems for N-terminal acetylation... - Candida albicans SOU1 encodes a sorbose reductase required for L-sorbose utilizationJay R Greenberg
Department of Biochemistry and Biophysics, University of Rochester Medical Center, Box 712, Rochester, NY 14642, USA
Yeast 22:957-69. 2005..This activity has not been described previously in yeasts and may be involved in the conversion of phosphorylated D-sorbitol to fructose-6-phosphate or glucose-6-phosphate... - The yeast translation release factors Mrf1p and Sup45p (eRF1) are methylated, respectively, by the methyltransferases Mtq1p and Mtq2pBogdan Polevoda
Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, New York 14642, USA
J Biol Chem 281:2562-71. 2006..Most interestingly, the mtq2-Delta was significantly more resistant to the anti-microtubule drugs thiabendazole and benomyl, suggesting that Mtq2p may also methylate certain microtubule-related proteins... - Degradation of normal mRNA in the nucleus of Saccharomyces cerevisiaeBiswadip Das
Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
Mol Cell Biol 23:5502-15. 2003..We propose that certain normal mRNAs retained in the nucleus are degraded by the DRN system, similar to degradation of transcripts with 3' end formation defects in certain mutants... - Physiological effects of unassembled chaperonin Cct subunits in the yeast Saccharomyces cerevisiaeM Anaul Kabir
Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY 14642, USA
Yeast 22:219-39. 2005..Furthermore, we also suggest that the Cct subunits can act as suppressors only in certain states, such as when associated with ATP... - Composition and function of the eukaryotic N-terminal acetyltransferase subunitsBogdan Polevoda
Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Biochem Biophys Res Commun 308:1-11. 2003..Thus, the vertebrate NATs remain to be definitively identified, and, furthermore, it remains to be seen if any of the yeast NATs contribute to other functions... - Enhanced mitochondrial degradation of yeast cytochrome c with amphipathic structuresXi Chen
Department of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA
Curr Genet 47:67-83. 2005..The use of ADD assisted in the differentiation of substrates of different mitochondrial degradation pathways... - A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substratesBogdan Polevoda
Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY 14642, USA
BMC Proc 3:S2. 2009..ABSTRACT : We have introduced a consistent nomenclature for the various subunits of the NatA-NatE N-terminal acetyltransferases from yeast, humans and other eukaryotes... - Role of the 14-3-3 protein in carbon metabolism of the pathogenic yeast Candida albicansYing-Kai Wang
Department of Biochemistry and Biophysics, University of Rochester Medical School, Rochester, NY 14642, USA
Yeast 21:685-702. 2004..albicans essential gene BMH1 as a negative regulator of the utilization of secondary carbon source in yeast, which further substantiates the involvement of 14-3-3 proteins in diverse functions... - Getting started with yeastFred Sherman
Department of Biochemistry and Biophysics, University of Rochester Medical School, Rochester, New York 14642, USA
Methods Enzymol 350:3-41. 2002 - N-Terminal modifications of the 19S regulatory particle subunits of the yeast proteasomeYayoi Kimura
Kihara Institute for Biological Research Graduate School of Integrated Science, Yokohama City University, Maioka 641 12, Totsuka, Yokohama, Japan
Arch Biochem Biophys 409:341-8. 2003..These characteristics were different from those of the 20S proteasome: the chymotrypsin-like activity and accumulation level of 20S proteasome were appreciably higher from the nat1 deletion mutant than from the normal strain... - SHAM-sensitive alternative respiration in the xylose-metabolizing yeast Pichia stipitisNian-Qing Shi
The Microbiology Doctoral Training Program, Department of Bacteriology, University of Wisconsin, 1550 Linden Drive, Madison, WI 53706, USA
Yeast 19:1203-20. 2002..We propose that the non-proton-translocating NAD(P)H dehydrogenases are linked to PsSto1p in xylose-metabolizing cells and that this non-ATP-generating route serves a regulatory function in the complex redox network of P. stipitis... - The 2006 George W. Beadle Medal. Fred ShermanAnita Hopper
Genetics 172:723-4. 2006 - The concomitant expression and availability of conventional and alternative, cyanide-insensitive, respiratory pathways in Candida albicansEva J Helmerhorst
Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, 700 Albany Street W201, Boston, MA 02118, USA
Mitochondrion 5:200-11. 2005..The availability of two electron pathways in C. albicans and the potential use of either pathway endows this pleomorphic fungus with another level at which it can rapidly adjust to altered environmental conditions...
Research Grants
- Regulation and Gene Expression of Yeast Cytochrome cFred Sherman; Fiscal Year: 2009..Human NAT subunits are essential for development and are over-expressed in thyroid and hepatocellular carcinomas. ..
- REGULATION AND GENE EXPRESSION OF CYTOCHROME CFred Sherman; Fiscal Year: 2001..The proteins that exhibit altered mobilities on 2-D gels will be identified and sequenced by mass spectrometry. ..
- Regulation and Gene Expression of Yeast Cytochrome cFred Sherman; Fiscal Year: 2010..Human NAT subunits are essential for development and are over-expressed in thyroid and hepatocellular carcinomas. ..
- Regulation and Gene Expression of Yeast Cytochrome cFred Sherman; Fiscal Year: 2009..Human NAT subunits are essential for development and are over-expressed in thyroid and hepatocellular carcinomas. ..
- Regulation and Gene Expression of Yeast Cytochrome cFred Sherman; Fiscal Year: 2005..The latter study would provide the first evidence that apo-cytochrome c and heme interact in vivo in the absence of heme lyase. ..
- GENETIC VARIABILITY OF THE YEAST CANDIDA ALBICANSFred Sherman; Fiscal Year: 2004..This work establishes for the first time a negative regulatory network for a secondary carbon source in an important pathogen. ..
- GENETIC CONTROL OF CYTOCHROME C IN YEASTFred Sherman; Fiscal Year: 1980....
- REGULATION AND GENE EXPRESSION OF CYTOCHROME C.Fred Sherman; Fiscal Year: 1993..Also, we are developing a set of mapping strains that can be used to conveniently assign and recessive mutation to its chromosome...
- INSTABILITIES OF THE PATHOGENIC YEAST CANDIDA ALBICANSFred Sherman; Fiscal Year: 1993..albicans to adapt to new conditions of their host. The patterns and types of chromosomal aberrations in the stable and unstable mutants my shed light on mechanisms by which they arise...