Fred Sherman

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. pmc The diversity of acetylated proteins
    Bogdan Polevoda
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Genome Biol 3:reviews0006. 2002
  2. ncbi request reprint The importance of mutation, then and now: studies with yeast cytochrome c
    Fred Sherman
    Department of Biochemistry and Biophysics, University of Rochester Medical School, Box 712, Rochester, NY 14642, USA
    Mutat Res 589:1-16. 2005
  3. pmc Properties of Nat4, an N(alpha)-acetyltransferase of Saccharomyces cerevisiae that modifies N termini of histones H2A and H4
    Bogdan Polevoda
    Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY 14642, USA
    Mol Cell Biol 29:2913-24. 2009
  4. pmc Mutant LYS2 mRNAs retained and degraded in the nucleus of Saccharomyces cerevisiae
    Biswadip Das
    Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 103:10871-6. 2006
  5. ncbi request reprint Yeast N(alpha)-terminal acetyltransferases are associated with ribosomes
    Bogdan Polevoda
    Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Cell Biochem 103:492-508. 2008
  6. ncbi request reprint Phenotypes of yeast mutants lacking the mitochondrial protein Pet20p
    Bogdan Polevoda
    Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, New York 14642, USA
    Yeast 23:127-39. 2006
  7. pmc A nuclear degradation pathway controls the abundance of normal mRNAs in Saccharomyces cerevisiae
    Letian Kuai
    Department of Biochemistry and Biophysics, Box 712, University of Rochester Medical Center, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 102:13962-7. 2005
  8. pmc Cap-binding protein 1-mediated and eukaryotic translation initiation factor 4E-mediated pioneer rounds of translation in yeast
    Qinshan Gao
    Department of Biochemistry and Biophysics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 712, University of Rochester, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 102:4258-63. 2005
  9. ncbi request reprint Sue1p is required for degradation of labile forms of altered cytochromes C in yeast mitochondria
    Jun Wei
    Department of Biochemistry and Biophysics, University of Rochester, School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 279:30449-58. 2004
  10. pmc Polyadenylation of rRNA in Saccharomyces cerevisiae
    Letian Kuai
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 101:8581-6. 2004

Collaborators

Detail Information

Publications28

  1. pmc The diversity of acetylated proteins
    Bogdan Polevoda
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Genome Biol 3:reviews0006. 2002
    ....
  2. ncbi request reprint The importance of mutation, then and now: studies with yeast cytochrome c
    Fred Sherman
    Department of Biochemistry and Biophysics, University of Rochester Medical School, Box 712, Rochester, NY 14642, USA
    Mutat Res 589:1-16. 2005
    ..Current work on degradation of proteins in mitochondria, on degradation of mRNA in the nucleus, and on N-terminal acetylation stems from properties of CYC1 mutants isolated in early screens more than a decade ago...
  3. pmc Properties of Nat4, an N(alpha)-acetyltransferase of Saccharomyces cerevisiae that modifies N termini of histones H2A and H4
    Bogdan Polevoda
    Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY 14642, USA
    Mol Cell Biol 29:2913-24. 2009
    ..Thus, N-terminal serine acetylation of histone H4 may be a part of an essential charge patch first described for the histone H2A.Z variant in Tetrahymena species...
  4. pmc Mutant LYS2 mRNAs retained and degraded in the nucleus of Saccharomyces cerevisiae
    Biswadip Das
    Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 103:10871-6. 2006
    ..Furthermore, this "retention signal" causing susceptibility to DRN is lost by altering one of the base pairs, establishing that mRNAs susceptible and unsusceptible to DRN can be attributed to a single nucleotide in the proper context...
  5. ncbi request reprint Yeast N(alpha)-terminal acetyltransferases are associated with ribosomes
    Bogdan Polevoda
    Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Cell Biochem 103:492-508. 2008
    ..Moreover, Ard1p copurifies with Rpl35p-TAP. We suggest that these two ribosomal proteins, which are in close proximity to the ribosomal exit tunnel, may play a role in NatA attachment to the ribosome...
  6. ncbi request reprint Phenotypes of yeast mutants lacking the mitochondrial protein Pet20p
    Bogdan Polevoda
    Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, New York 14642, USA
    Yeast 23:127-39. 2006
    ..It is also possible that Pet20p may constitute a non-catalytic subunit of an uncharacterized mitochondrial complex or serve as a transporter or a coupling factor...
  7. pmc A nuclear degradation pathway controls the abundance of normal mRNAs in Saccharomyces cerevisiae
    Letian Kuai
    Department of Biochemistry and Biophysics, Box 712, University of Rochester Medical Center, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 102:13962-7. 2005
    ..This conclusion was corroborated by finding an inverse relationship of the CBC1 and SKS1 mRNA levels in normal strains grown under different conditions...
  8. pmc Cap-binding protein 1-mediated and eukaryotic translation initiation factor 4E-mediated pioneer rounds of translation in yeast
    Qinshan Gao
    Department of Biochemistry and Biophysics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 712, University of Rochester, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 102:4258-63. 2005
    ..These results suggest that both Cbc1p- and eIF4E-mediated pioneer rounds of translation occur in yeast...
  9. ncbi request reprint Sue1p is required for degradation of labile forms of altered cytochromes C in yeast mitochondria
    Jun Wei
    Department of Biochemistry and Biophysics, University of Rochester, School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 279:30449-58. 2004
    ..These results indicate that Sue1p may play an important role in the degradation of abnormal holo-iso-1-cytochrome c in the mitochondria...
  10. pmc Polyadenylation of rRNA in Saccharomyces cerevisiae
    Letian Kuai
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 101:8581-6. 2004
    ..For at least one rRNA type, the polyadenylation preferentially occurs on the precursor rather than the mature product. The existence of polyadenylated rRNAs may reflect a quality-control mechanism of rRNA biogenesis...
  11. ncbi request reprint Overexpressed ribosomal proteins suppress defective chaperonins in Saccharomyces cerevisiae
    M Anaul Kabir
    Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY 14642, USA
    FEMS Yeast Res 8:1236-44. 2008
    ..We suggest that certain overexpressed ribosomal and other proteins can act as weak chaperones, phenotypically alleviating the partial defects of mutationally altered Cct subunits...
  12. ncbi request reprint Methylation of proteins involved in translation
    Bogdan Polevoda
    Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, New York 14642, USA
    Mol Microbiol 65:590-606. 2007
    ..Differential methylation of specific RPs and TFs in a number of organisms at different physiological states indicates that this modification may play a regulatory role...
  13. ncbi request reprint Nat3p and Mdm20p are required for function of yeast NatB Nalpha-terminal acetyltransferase and of actin and tropomyosin
    Bogdan Polevoda
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 278:30686-97. 2003
    ..Furthermore, unacetylated actin and certain N-terminally altered actins have comparable defective properties in vitro, particularly actin-activated ATPase activity and sliding velocity...
  14. ncbi request reprint N-terminal acetyltransferases and sequence requirements for N-terminal acetylation of eukaryotic proteins
    Bogdan Polevoda
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Mol Biol 325:595-622. 2003
    ..Overall patterns of N-terminal acetylated proteins and the orthologous genes possibly encoding NATs suggest that yeast and higher eukaryotes have the same systems for N-terminal acetylation...
  15. ncbi request reprint Candida albicans SOU1 encodes a sorbose reductase required for L-sorbose utilization
    Jay R Greenberg
    Department of Biochemistry and Biophysics, University of Rochester Medical Center, Box 712, Rochester, NY 14642, USA
    Yeast 22:957-69. 2005
    ..This activity has not been described previously in yeasts and may be involved in the conversion of phosphorylated D-sorbitol to fructose-6-phosphate or glucose-6-phosphate...
  16. ncbi request reprint The yeast translation release factors Mrf1p and Sup45p (eRF1) are methylated, respectively, by the methyltransferases Mtq1p and Mtq2p
    Bogdan Polevoda
    Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 281:2562-71. 2006
    ..Most interestingly, the mtq2-Delta was significantly more resistant to the anti-microtubule drugs thiabendazole and benomyl, suggesting that Mtq2p may also methylate certain microtubule-related proteins...
  17. ncbi request reprint Physiological effects of unassembled chaperonin Cct subunits in the yeast Saccharomyces cerevisiae
    M Anaul Kabir
    Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY 14642, USA
    Yeast 22:219-39. 2005
    ..Furthermore, we also suggest that the Cct subunits can act as suppressors only in certain states, such as when associated with ATP...
  18. pmc Degradation of normal mRNA in the nucleus of Saccharomyces cerevisiae
    Biswadip Das
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Mol Cell Biol 23:5502-15. 2003
    ..We propose that certain normal mRNAs retained in the nucleus are degraded by the DRN system, similar to degradation of transcripts with 3' end formation defects in certain mutants...
  19. ncbi request reprint Composition and function of the eukaryotic N-terminal acetyltransferase subunits
    Bogdan Polevoda
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Biochem Biophys Res Commun 308:1-11. 2003
    ..Thus, the vertebrate NATs remain to be definitively identified, and, furthermore, it remains to be seen if any of the yeast NATs contribute to other functions...
  20. ncbi request reprint Enhanced mitochondrial degradation of yeast cytochrome c with amphipathic structures
    Xi Chen
    Department of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA
    Curr Genet 47:67-83. 2005
    ..The use of ADD assisted in the differentiation of substrates of different mitochondrial degradation pathways...
  21. pmc Adaptation of Candida albicans to growth on sorbose via monosomy of chromosome 5 accompanied by duplication of another chromosome carrying a gene responsible for sorbose utilization
    Anatoliy Kravets
    Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY, USA
    FEMS Yeast Res 14:708-13. 2014
    ..This shows that control of expression of SOU1 can involve multiple mechanisms; in this case, negative regulation and increase in gene copy number operating simultaneously in cell. ..
  22. pmc A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates
    Bogdan Polevoda
    Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY 14642, USA
    BMC Proc 3:S2. 2009
    ..ABSTRACT : We have introduced a consistent nomenclature for the various subunits of the NatA-NatE N-terminal acetyltransferases from yeast, humans and other eukaryotes...
  23. ncbi request reprint Role of the 14-3-3 protein in carbon metabolism of the pathogenic yeast Candida albicans
    Ying Kai Wang
    Department of Biochemistry and Biophysics, University of Rochester Medical School, Rochester, NY 14642, USA
    Yeast 21:685-702. 2004
    ..albicans essential gene BMH1 as a negative regulator of the utilization of secondary carbon source in yeast, which further substantiates the involvement of 14-3-3 proteins in diverse functions...
  24. ncbi request reprint Getting started with yeast
    Fred Sherman
    Department of Biochemistry and Biophysics, University of Rochester Medical School, Rochester, New York 14642, USA
    Methods Enzymol 350:3-41. 2002
  25. ncbi request reprint SHAM-sensitive alternative respiration in the xylose-metabolizing yeast Pichia stipitis
    Nian Qing Shi
    The Microbiology Doctoral Training Program, Department of Bacteriology, University of Wisconsin, 1550 Linden Drive, Madison, WI 53706, USA
    Yeast 19:1203-20. 2002
    ..We propose that the non-proton-translocating NAD(P)H dehydrogenases are linked to PsSto1p in xylose-metabolizing cells and that this non-ATP-generating route serves a regulatory function in the complex redox network of P. stipitis...
  26. ncbi request reprint N-Terminal modifications of the 19S regulatory particle subunits of the yeast proteasome
    Yayoi Kimura
    Kihara Institute for Biological Research Graduate School of Integrated Science, Yokohama City University, Maioka 641 12, Totsuka, Yokohama, Japan
    Arch Biochem Biophys 409:341-8. 2003
    ..These characteristics were different from those of the 20S proteasome: the chymotrypsin-like activity and accumulation level of 20S proteasome were appreciably higher from the nat1 deletion mutant than from the normal strain...
  27. pmc The 2006 George W. Beadle Medal. Fred Sherman
    Anita Hopper
    Genetics 172:723-4. 2006
  28. ncbi request reprint The concomitant expression and availability of conventional and alternative, cyanide-insensitive, respiratory pathways in Candida albicans
    Eva J Helmerhorst
    Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, 700 Albany Street W201, Boston, MA 02118, USA
    Mitochondrion 5:200-11. 2005
    ..The availability of two electron pathways in C. albicans and the potential use of either pathway endows this pleomorphic fungus with another level at which it can rapidly adjust to altered environmental conditions...

Research Grants45

  1. GENETIC VARIABILITY OF THE YEAST CANDIDA ALBICANS
    Fred Sherman; Fiscal Year: 2002
    ..This work establishes for the first time a negative regulatory network for a secondary carbon source in an important pathogen. ..
  2. INSTABILITIES OF THE PATHOGENIC YEAST CANDIDA ALBICANS
    Fred Sherman; Fiscal Year: 1992
    ..albicans to adapt to new conditions of their host. The patterns and types of chromosomal aberrations in the stable and unstable mutants my shed light on mechanisms by which they arise...
  3. Regulation and Gene Expression of Yeast Cytochrome c
    Fred Sherman; Fiscal Year: 2007
    ..Human NAT subunits are essential for development and are over-expressed in thyroid and hepatocellular carcinomas. ..
  4. Regulation and Gene Expression of Yeast Cytochrome c
    Fred Sherman; Fiscal Year: 2010
    ..Human NAT subunits are essential for development and are over-expressed in thyroid and hepatocellular carcinomas. ..
  5. REGULATION AND GENE EXPRESSION OF CYTOCHROME C
    Fred Sherman; Fiscal Year: 1999
    ..The proteins that exhibit altered mobilities on 2-D gels will be identified and sequenced by mass spectrometry. ..
  6. Regulation and Gene Expression of Yeast Cytochrome c
    Fred Sherman; Fiscal Year: 2005
    ..The latter study would provide the first evidence that apo-cytochrome c and heme interact in vivo in the absence of heme lyase. ..
  7. Regulation and Gene Expression of Yeast Cytochrome c
    Fred Sherman; Fiscal Year: 2004
    ..The latter study would provide the first evidence that apo-cytochrome c and heme interact in vivo in the absence of heme lyase. ..
  8. REGULATION AND GENE EXPRESSION OF CYTOCHROME C
    Fred Sherman; Fiscal Year: 2000
    ..The proteins that exhibit altered mobilities on 2-D gels will be identified and sequenced by mass spectrometry. ..
  9. REGULATION AND GENE EXPRESSION OF CYTOCHROME C
    Fred Sherman; Fiscal Year: 2001
    ..The proteins that exhibit altered mobilities on 2-D gels will be identified and sequenced by mass spectrometry. ..
  10. REGULATION AND GENE EXPRESSION OF CYTOCHROME C.
    Fred Sherman; Fiscal Year: 1993
    ..Also, we are developing a set of mapping strains that can be used to conveniently assign and recessive mutation to its chromosome...
  11. Regulation and Gene Expression of Yeast Cytochrome c
    Fred Sherman; Fiscal Year: 2009
    ..Human NAT subunits are essential for development and are over-expressed in thyroid and hepatocellular carcinomas. ..
  12. Regulation and Gene Expression of Yeast Cytochrome c
    Fred Sherman; Fiscal Year: 2003
    ..The latter study would provide the first evidence that apo-cytochrome c and heme interact in vivo in the absence of heme lyase. ..
  13. GENETIC VARIABILITY OF THE YEAST CANDIDA ALBICANS
    Fred Sherman; Fiscal Year: 2001
    ..This work establishes for the first time a negative regulatory network for a secondary carbon source in an important pathogen. ..
  14. INSTABILITIES OF THE PATHOGENIC YEAST CANDIDA ALBICANS
    Fred Sherman; Fiscal Year: 1993
    ..albicans to adapt to new conditions of their host. The patterns and types of chromosomal aberrations in the stable and unstable mutants my shed light on mechanisms by which they arise...
  15. GENETIC CONTROL OF CYTOCHROME C IN YEAST
    Fred Sherman; Fiscal Year: 1980
    ....
  16. REGULATION AND GENE EXPRESSION OF CYTOCHROME C.
    Fred Sherman; Fiscal Year: 1992
    ..Also, we are developing a set of mapping strains that can be used to conveniently assign and recessive mutation to its chromosome...
  17. REGULATION AND GENE EXPRESSION OF CYTOCHROME C.
    Fred Sherman; Fiscal Year: 1991
    ..Also, we are developing a set of mapping strains that can be used to conveniently assign and recessive mutation to its chromosome...
  18. Regulation and Gene Expression of Yeast Cytochrome c
    Fred Sherman; Fiscal Year: 2009
    ..Human NAT subunits are essential for development and are over-expressed in thyroid and hepatocellular carcinomas. ..
  19. GENETIC VARIABILITY OF THE YEAST CANDIDA ALBICANS
    Fred Sherman; Fiscal Year: 2004
    ..This work establishes for the first time a negative regulatory network for a secondary carbon source in an important pathogen. ..
  20. GENETIC VARIABILITY OF THE YEAST CANDIDA ALBICANS
    Fred Sherman; Fiscal Year: 2003
    ..This work establishes for the first time a negative regulatory network for a secondary carbon source in an important pathogen. ..
  21. Regulation and Gene Expression of Yeast Cytochrome c
    Fred Sherman; Fiscal Year: 2002
    ..The latter study would provide the first evidence that apo-cytochrome c and heme interact in vivo in the absence of heme lyase. ..
  22. INSTABILITIES OF THE PATHOGENIC YEAST CANDIDA ALBICANS
    Fred Sherman; Fiscal Year: 1991
    ..albicans to adapt to new conditions of their host. The patterns and types of chromosomal aberrations in the stable and unstable mutants my shed light on mechanisms by which they arise...
  23. REGULATION AND GENE EXPRESSION OF CYTOCHROME C
    Fred Sherman; Fiscal Year: 1990
    ..Also, we are developing a set of mapping strains that can be used to conveniently assign and recessive mutation to its chromosome...