Research Topics
Genomes and Genes
| Dean SheppardSummaryAffiliation: University of California Country: USA Publications
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Publications
Killed by leukocytes that don't know when to leaveDean Sheppard
Nat Immunol 3:337-8. 2002
Enteric expression of the integrin alpha(v)beta(6) is essential for nematode-induced mucosal mast cell hyperplasia and expression of the granule chymase, mouse mast cell protease-1Pamela A Knight
Department of Veterinary Clinical Studies, University of Edinburgh, Midlothian, Scotland
Am J Pathol 161:771-9. 2002....- Integrin-mediated activation of latent transforming growth factor betaDean Sheppard
Lung Biology Center, University of California San Francisco, 2922, San Francisco, CA, 94143 2922, USA
Cancer Metastasis Rev 24:395-402. 2005.... - Partial inhibition of integrin alpha(v)beta6 prevents pulmonary fibrosis without exacerbating inflammationGerald S Horan
Department of Exploratory Biology, Biogen Idec, 12 Cambridge Center, Cambridge, MA 02142, USA
Am J Respir Crit Care Med 177:56-65. 2008.... - ROCKing pulmonary fibrosisDean Sheppard
Lung Biology Center, Department of Medicine, UCSF, San Francisco, California 94143 2922, USA
J Clin Invest 123:1005-6. 2013..Because of his advanced age, he is not considered a candidate for lung transplantation. What treatment should you recommend?.. 
Modulation of acute lung injury by integrinsDean Sheppard
University of California San Francisco, CA 94143 2922, USA
Proc Am Thorac Soc 9:126-9. 2012..These results identify αvβ6 and αvβ5 as promising therapeutic targets for the treatment of acute lung injury and septic shock...- Transforming growth factor beta: a central modulator of pulmonary and airway inflammation and fibrosisDean Sheppard
Lung Biology Center and Department of Medicine, University of California San Francisco, Box 2922, San Francisco, CA 94143 2922, USA
Proc Am Thorac Soc 3:413-7. 2006.... - Aspen Lung Conference 2010: systems biology of lung diseases--progress in the omics eraDean Sheppard
Lung Biology Center, University of California, San Francisco, San Francisco, CA 94143 2922, USA
Proc Am Thorac Soc 8:199-202. 2011.... - Interleukin-1beta causes acute lung injury via alphavbeta5 and alphavbeta6 integrin-dependent mechanismsMichael T Ganter
Laboratory of Surgical Research, Department of Anesthesia, University of California, San Francisco 94110, USA
Circ Res 102:804-12. 2008..In summary, these results demonstrate a critical role for the alphavbeta5/beta6 integrins in mediating the IL-1beta-induced ALI and indicate that these integrins could be a potentially attractive therapeutic target in ALI... - The lymphangiogenic vascular endothelial growth factors VEGF-C and -D are ligands for the integrin alpha9beta1Nicholas E Vlahakis
Lung Biology Center, University of California San Francisco, San Francisco, California, 94143 2922, USA
J Biol Chem 280:4544-52. 2005..The interaction between alpha9beta1 and VEGF-C and/or -D may begin to explain the abnormal lymphatic phenotype of the alpha9 knock-out mice... - Population stratification confounds genetic association studies among LatinosShweta Choudhry
University of California, San Francisco, 94143-0833, USA
Hum Genet 118:652-64. 2006..Our findings suggest that empirical assessment of the effects of stratification is critical to appropriately interpret the results of case-control studies in admixed populations... - Interleukin-1beta decreases expression of the epithelial sodium channel alpha-subunit in alveolar epithelial cells via a p38 MAPK-dependent signaling pathwayJeremie Roux
Laboratory of Surgical Research, Cardiovascular Research Institute, Department of Anesthesia, University of California, San Francisco 94110, USA
J Biol Chem 280:18579-89. 2005.... - Genetic admixture and asthma-related phenotypes in Mexican American and Puerto Rican asthmaticsKeyan Salari
Department of Medicine, University of California, San Francisco, California 94143-1732, USA
Genet Epidemiol 29:76-86. 2005..These results suggest that asthma severity may be influenced by genetic factors differentiating Europeans and Native Americans in Mexican Americans, although differing results for Puerto Ricans require further investigation... - Mfge8 diminishes the severity of tissue fibrosis in mice by binding and targeting collagen for uptake by macrophagesKamran Atabai
Lung Biology Center, Cardiovascular Research Institute, UCSF, San Francisco, California, USA
J Clin Invest 119:3713-22. 2009..These data demonstrate a critical role for Mfge8 in decreasing the severity of murine tissue fibrosis by facilitating the removal of accumulated collagen... - The αvβ6 integrin modulates airway hyperresponsiveness in mice by regulating intraepithelial mast cellsKotaro Sugimoto
Lung Biology Center, Department of Medicine, UCSF, San Francisco, California, USA
J Clin Invest 122:748-58. 2012.... - IL-17A produced by αβ T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contractionMakoto Kudo
Lung Biology Center, Department of Medicine, University of California, San Francisco, California, USA
Nat Med 18:547-54. 2012..These data indicate that the IL-17A produced by T(H)17 cells contributes to allergen-induced airway hyper-responsiveness through direct effects on airway smooth muscle... - Integrin alphavbeta5 regulates lung vascular permeability and pulmonary endothelial barrier functionGeorge Su
Lung Biology Center, Division of Pulmonary and Critical Care Medicine, Laboratory of Surgical Research, Department of Anesthesia, and Cardiovascular Research Institute, University of California, San Francisco, California 94158, USA
Am J Respir Cell Mol Biol 36:377-86. 2007..These results identify integrin alphavbeta5 as a central regulator of increased pulmonary vascular permeability and a potentially attractive therapeutic target in ALI... - Squamous metaplasia amplifies pathologic epithelial-mesenchymal interactions in COPD patientsJun Araya
Department of Pathology, Lung Biology Center, UCSF, San Francisco, California 94110, USA
J Clin Invest 117:3551-62. 2007..Our findings have identified TGF-beta as a potential therapeutic target for COPD... - Pharmacogenetic differences in response to albuterol between Puerto Ricans and Mexicans with asthmaShweta Choudhry
University of California San Francisco, San Francisco, CA 94143 0833, USA
Am J Respir Crit Care Med 171:563-70. 2005..We tested the association of beta(2)AR genotypes with asthma severity and bronchodilator response to albuterol in Puerto Ricans and Mexicans with asthma... - Integrin alpha9beta1 directly binds to vascular endothelial growth factor (VEGF)-A and contributes to VEGF-A-induced angiogenesisNicholas E Vlahakis
Lung Biology Center, University of California, San Francisco, California 94143 2922, USA
J Biol Chem 282:15187-96. 2007.... - Induction of an epithelial integrin alphavbeta6 in human cytomegalovirus-infected endothelial cells leads to activation of transforming growth factor-beta1 and increased collagen productionTakako Tabata
Department of Cell and Tissue Biology, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0640, USA
Am J Pathol 172:1127-40. 2008..Our results suggest that activation of TGF-beta1 by integrin alphavbeta6 contributes to pathological changes and may impair endothelial cell functions in tissues that are chronically infected with CMV... - Effective treatment of mouse sepsis with an inhibitory antibody targeting integrin αvβ5George Su
Lung Biology Center, University of California, San Francisco, CA, USA
Crit Care Med 41:546-53. 2013..Integrin αvβ5 has been identified as a regulator of vascular leak and endothelial permeability. We hypothesized that targeting αvβ5 could represent a viable treatment strategy for sepsis... - Integrin α9β1 in airway smooth muscle suppresses exaggerated airway narrowingChun Chen
Lung Biology Center, Department of Medicine, UCSF, San Francisco, CA 94143 2922, USA
J Clin Invest 122:2916-27. 2012..Targeting key components of this pathway could thus lead to new treatment strategies for asthma... - Differential enzymatic activity of common haplotypic versions of the human acidic Mammalian chitinase proteinMax A Seibold
Department of Medicine, Howard Hughes Medical Institute, University of California, San Francisco, California 94143, USA
J Biol Chem 284:19650-8. 2009..The structural, kinetic, and genetic data regarding the AMCase isoforms are consistent with the Th2-priming effects of environmental chitin and a role for AMCase in negatively regulating this stimulus... - Integrin beta6 mediates phospholipid and collectin homeostasis by activation of latent TGF-beta1Laura L Koth
Lung Biology Center, Department of Medicine, San Francisco General Hospital, California, USA
Am J Respir Cell Mol Biol 37:651-9. 2007..These findings show that alphavbeta6 and TGF-beta1 regulate homeostasis of phospholipids and collectins in adult mouse lungs and may have implications for anti-fibrotic therapeutics that inhibit active TGF-beta in the lung... - ADAM33 is not essential for growth and development and does not modulate allergic asthma in miceChun Chen
Lung Biology Center, University of California San Francisco, Box 2922, San Francisco, CA 94143 2922, USA
Mol Cell Biol 26:6950-6. 2006..Our results demonstrate that ADAM33 is not essential for growth or reproduction in the mouse and does not modulate baseline or allergen-induced airway responsiveness... - The Integrin alpha9beta1 contributes to granulopoiesis by enhancing granulocyte colony-stimulating factor receptor signalingChun Chen
Lung Biology Center, Department of Medicine, University of California, San Francisco, San Francisco, California 94158, USA
Immunity 25:895-906. 2006.... - The alpha9beta1 integrin enhances cell migration by polyamine-mediated modulation of an inward-rectifier potassium channelGregory W DeHart
Lung Biology Center, Department of Medicine, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 105:7188-93. 2008..These results identify a pathway through which the alpha9 integrin subunit stimulates cell migration by localized polyamine catabolism and modulation of Kir channel function... - Short form of α9 promotes α9β1 integrin-dependent cell adhesion by modulating the function of the full-length α9 subunitShigeyuki Kon
Lung Biology Center, Department of Medicine, University of California, San Francisco, CA 94143, USA
Exp Cell Res 317:1774-84. 2011..This promoting effect of SFα9 requires the authentic cytoplasmic domain of the co-expressed full-length α9 subunit. Thus, SFα9 is a novel functional modulator of α9β1 integrin by inside-out signaling... - Expression of αvβ8 integrin on dendritic cells regulates Th17 cell development and experimental autoimmune encephalomyelitis in miceAndrew C Melton
Lung Biology Center, Department of Medicine, University of California, San Francisco, California, USA
J Clin Invest 120:4436-44. 2010..Our results therefore suggest that the integrin αvβ8 pathway is biologically important and that αvβ8 expression on DCs could be a therapeutic target for the treatment of Th17-driven autoimmune disease... - Induction of a homeostatic circuit in lung tissue by microbial compoundsKenji Takabayshi
Department of Medicine, University of California, San Diego, La Jolla, 92093, USA
Immunity 24:475-87. 2006.... - Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injuryR Gisli Jenkins
Lung Biology Center, UCSF, San Francisco, California 94158, USA
J Clin Invest 116:1606-14. 2006.... - Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysemaDavid G Morris
Lung Biology Center, Department of Medicine, San Francisco General Hospital, San Francisco, California 94143, USA
Nature 422:169-73. 2003..Furthermore, we show that a functional alteration in the TGF-beta activation pathway affects susceptibility to this disease... - Spatiotemporally separated antigen uptake by alveolar dendritic cells and airway presentation to T cells in the lungEmily E Thornton
Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA
J Exp Med 209:1183-99. 2012.... - Epithelial cells utilize cortical actin/myosin to activate latent TGF-β through integrin α(v)β(6)-dependent physical forceMarilyn M Giacomini
Lung Biology Center, Department of Medicine, University of California, San Francisco, CA, USA
Exp Cell Res 318:716-22. 2012.... - Loss of integrin alpha(v)beta8 on dendritic cells causes autoimmunity and colitis in miceMark A Travis
Lung Biology Center, Department of Medicine, University of California San Francisco, 1550 4th Street, Room 545, San Francisco, California 94158, USA
Nature 449:361-5. 2007.... - Transforming growth factor-beta1 decreases expression of the epithelial sodium channel alphaENaC and alveolar epithelial vectorial sodium and fluid transport via an ERK1/2-dependent mechanismJames Frank
Laboratory of Surgical Research, Cardiovascular Research Institute, Lung Biology Center, Departments of Anesthesia, Surgery, and Medicine, University of California, San Francisco, California 94110, USA
J Biol Chem 278:43939-50. 2003..This reduction in sodium and fluid transport is attributable in large part to a reduction in apical membrane alphaENaC expression mediated through an ERK1/2-dependent inhibition of the alphaENaC promoter activity... - Activation of transforming growth factor-beta by the integrin alphavbeta8 delays epithelial wound closureClaus Neurohr
Department of Medicine, Lung Biology Center, University of California, San Francisco, 94143 2922, USA
Am J Respir Cell Mol Biol 35:252-9. 2006..Wounding induced activation of TGF-beta through effects of both integrins, but antibodies against alphavbeta8 enhanced the degree of wound closure, whereas antibodies against alphavbeta6 did not... - Epistatic interactions between Tgfb1 and genetic loci, Tgfbm2 and Tgfbm3, determine susceptibility to an asthmatic stimulusJulia Freimuth
Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94158, USA
Proc Natl Acad Sci U S A 109:18042-7. 2012..TGFβ antagonists for treatment of lung diseases might therefore give diverse outcomes, dependent on genetic variation... - Alternaria induces STAT6-dependent acute airway eosinophilia and epithelial FIZZ1 expression that promotes airway fibrosis and epithelial thicknessTaylor A Doherty
Department of Medicine, University of California San Diego, La Jolla, CA 92093 0635, USA
J Immunol 188:2622-9. 2012..This may provide some insight into the uniquely pathogenic aspects of Alternaria-associated asthma... - Mice lacking the integrin beta5 subunit have accelerated osteoclast maturation and increased activity in the estrogen-deficient stateNancy E Lane
Department of Medicine, University of California at San Francisco, San Francisco, California 94143, USA
J Bone Miner Res 20:58-66. 2005..These preliminary data suggest alphavbeta5 integrin's presence on osteoclast precursors may inhibit of osteoclast formation... - Mfge8 is critical for mammary gland remodeling during involutionKamran Atabai
Lung Biology Center, Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143, USA
Mol Biol Cell 16:5528-37. 2005..These data demonstrate that Mfge8 regulates the clearance of apoptotic epithelial cells during mammary gland involution and that the absence of Mfge8 leads to inflammation and abnormal mammary gland remodeling... - Lower bronchodilator responsiveness in Puerto Rican than in Mexican subjects with asthmaEsteban Gonzalez Burchard
University of California, San Francisco, 94143 0833, USA
Am J Respir Crit Care Med 169:386-92. 2004..We conclude that Puerto Ricans with asthma respond less to albuterol than do Mexicans with asthma. These findings underscore the need for additional research on racial/ethnic differences in asthma morbidity and response to therapy... - Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrixKevin K Kim
Department of Medicine and Cardiovascular Research Institute, University of California, San Francisco, 94143, USA
Proc Natl Acad Sci U S A 103:13180-5. 2006..These data reveal alveolar epithelial cells as progenitors for fibroblasts in vivo and implicate the provisional extracellular matrix as a key regulator of epithelial transdifferentiation during fibrogenesis... - Cross talk among TGF-β signaling pathways, integrins, and the extracellular matrixJohn S Munger
Department of Medicine, New York University, New York, New York 10016, USA
Cold Spring Harb Perspect Biol 3:a005017. 2011..Mutant mice defective in integrin-mediated activators, and humans and mice with fibrillin gene mutations, show the critical role of ECM and integrins in regulating TGF-β signaling... - Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthmaDouglas A Kuperman
Lung Biology Center, Department of Medicine and Cardiovascular Research Institute, University of California San Francisco School of Medicine, San Francisco, California, USA
Nat Med 8:885-9. 2002..These results demonstrate the importance of direct effects of IL-13 on epithelial cells in causing two central features of asthma... - Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contractionFen Huang
Howard Hughes Medical Institute and Department of Physiology, University of California, San Francisco, CA 94158, USA
Proc Natl Acad Sci U S A 109:16354-9. 2012..TMEM16A-CaCC blockers, including those identified here, may positively impact multiple causes of asthma symptoms... - Absence of integrin αvβ3 enhances vascular leak in mice by inhibiting endothelial cortical actin formationGeorge Su
Lung Biology Center, University of California San Francisco, San Francisco, CA 94121, USA
Am J Respir Crit Care Med 185:58-66. 2012..Sepsis and acute lung injury (ALI) have devastatingly high mortality rates. Both are associated with increased vascular leak, a process regulated by complex molecular mechanisms... - Phosphorylation of Trask by Src kinases inhibits integrin clustering and functions in exclusion with focal adhesion signalingDanislav S Spassov
Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 1387, USA
Mol Cell Biol 31:766-82. 2011..These data provide considerable insight into how Trask functions to regulate cell adhesion and reveal a novel pathway through which Src kinases can oppose integrin-mediated cell adhesion... - The integrin alpha(v)beta8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-beta1Dezhi Mu
Department of Pathology, University of California at San Francisco Mt Zion Cancer Center, San Francisco, CA 94143, USA
J Cell Biol 157:493-507. 2002..These data elucidate a novel mechanism of cellular homeostasis achieved through the coordination of the activities of members of three major gene families involved in cell-matrix interactions... - Functions of pulmonary epithelial integrins: from development to diseaseDean Sheppard
University of California, San Francisco, Box 0854, San Francisco, CA 94143 0854, USA
Physiol Rev 83:673-86. 2003..Epithelial integrins are thus attractive targets for intervention in a number of common lung disorders... - Identification and molecular characterization of multiple phenotypes in integrin knockout miceChun Chen
Lung Biology Center, Department of Medicine, University of California, San Francisco, San Francisco, California, USA
Methods Enzymol 426:291-305. 2007..In this article, we review approaches that can contribute to optimal use of this valuable resource... - Roles of alphav integrins in vascular biology and pulmonary pathologyDean Sheppard
Lung Biology Center, University of California San Francisco, Box 2922, San Francisco, California 94143 2922, USA
Curr Opin Cell Biol 16:552-7. 2004..Studies in mice lacking the beta6 subunit have identified unexpected roles for alphavbeta6-mediated TGFbeta activation in models of pulmonary and renal fibrosis, acute lung injury and pulmonary emphysema... - Roles of the innate immune system in mammary gland remodeling during involutionKamran Atabai
Lung Biology Center, Cardiovascular Research Institute, Department of Medicine, University of California, San Francisco, CA 94143 2922, USA
J Mammary Gland Biol Neoplasia 12:37-45. 2007..g. mammary epithelial cells). This review will discuss the evidence that supports a role for innate immune cells in mammary gland remodeling during involution... - Roger S. Mitchell lecture. Uses of expression microarrays in studies of pulmonary fibrosis, asthma, acute lung injury, and emphysemaDean Sheppard
Lung Biology Center, Center for Occupational and Environmental Health, Cardiovascular Research Institute, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
Chest 121:21S-25S. 2002..Together, these examples demonstrate how careful application and thorough analysis of expression microarrays can facilitate the discovery of novel molecular targets for intervening in common lung diseases... - ADAM33 is not associated with asthma in Puerto Rican or Mexican populationsDenise L Lind
University of California at San Francisco, San Francisco, CA 94143-0833, USA
Am J Respir Crit Care Med 168:1312-6. 2003..We conclude that the ADAM33 gene is not an important risk factor for asthma or for asthma-associated phenotypes in Mexicans or in Puerto Ricans... - Spermidine/spermine N1-acetyltransferase specifically binds to the integrin alpha9 subunit cytoplasmic domain and enhances cell migrationChun Chen
Lung Biology Center, Department of Medicine, University of California San Francisco, San Francisco, CA 94110, USA
J Cell Biol 167:161-70. 2004..We conclude that SSAT directly binds to the alpha9 cytoplasmic domain and mediates alpha9-dependent enhancement of cell migration, presumably by localized effects on acetylation of polyamines or of unidentified substrates... - Endothelial integrins and angiogenesis: not so simple anymoreDean Sheppard
Department of Medicine, Sandler Center for Basic Research in Asthma and the Lung Biology Center, University of California, San Francisco, San Francisco, California 94110, USA
J Clin Invest 110:913-4. 2002 - The importance of race and ethnic background in biomedical research and clinical practiceEsteban Gonzalez Burchard
Lung Biology Center, University of California, San Francisco, CA 94143 0833, USA
N Engl J Med 348:1170-5. 2003 - Blocking TGFβ via Inhibition of the αvβ6 Integrin: A Possible Therapy for Systemic Sclerosis Interstitial Lung DiseaseTamiko R Katsumoto
Department of Medicine, Critical Care, Allergy and Sleep Medicine, University of California, San Francisco, CA 94143, USA
Int J Rheumatol 2011:208219. 2011..Here we discuss the biology of αvβ6 and present this integrin as a potentially attractive target for inhibition in the setting of SSc ILD... - Essential role for MFG-E8 as ligand for alphavbeta5 integrin in diurnal retinal phagocytosisEmeline F Nandrot
Dyson Vision Research Institute, Department of Ophthalmology, Weill Medical College of Cornell University, New York, NY 10021, USA
Proc Natl Acad Sci U S A 104:12005-10. 2007..Thus, MFG-E8 stimulates rhythmic POS phagocytosis by ligating apical alphavbeta5 receptors of the RPE. These results identify MFG-E8 as the first extracellular ligand in the retina that is essential for diurnal POS phagocytosis... - Alpha9beta1: a novel osteoclast integrin that regulates osteoclast formation and functionHongwei Rao
Medicine Hematology Oncology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
J Bone Miner Res 21:1657-65. 2006..Antibody to alpha(9) inhibited OCL formation in human marrow cultures, and OCLs from alpha(9) knockout mice had a defect in actin ring reorganization and an impaired bone resorption capacity... - ADAM disintegrin-like domain recognition by the lymphocyte integrins alpha4beta1 and alpha4beta7Lance C Bridges
Department of Biochemistry and Molecular Biology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190, USA
Biochem J 387:101-8. 2005..These results establish that ADAM7 and ADAM28 are recognized by the leucocyte integrins alpha4beta1, alpha4beta7 and alpha9beta1. ADAM33 exclusively supported only alpha9beta1-dependent adhesion... - Loss of synchronized retinal phagocytosis and age-related blindness in mice lacking alphavbeta5 integrinEmeline F Nandrot
Margaret M Dyson Vision Research Institute, Department of Ophthalmology, Weill Medical College of Cornell University, 1300 York Ave, New York, NY 10021, USA
J Exp Med 200:1539-45. 2004..Furthermore, they identify the beta5-/- integrin mouse strain as a new animal model of age-related retinal dysfunction... - Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signalingBrian P Eliceiri
Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
J Cell Biol 157:149-60. 2002..Our findings indicate that Src can coordinate specific growth factor and extracellular matrix inputs by recruiting integrin alpha(v)beta5 into a FAK-containing signaling complex during growth factor-mediated biological responses... - Use of oligonucleotide microarrays to analyze gene expression patterns in pulmonary fibrosis reveals distinct patterns of gene expression in mice and humansNaftali Kaminski
Functional Genomics, Sheba Medical Center, Tel Hashomer, Israel
Chest 121:31S-32S. 2002 - Transcriptional activation of integrin beta6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinomaRichard C Bates
Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
J Clin Invest 115:339-47. 2005..These findings define the alphavbeta6 integrin as an important risk factor for early-stage disease and a novel therapeutic candidate for colorectal cancer... - Enhanced pathological angiogenesis in mice lacking beta3 integrin or beta3 and beta5 integrinsLouise E Reynolds
Cell Adhesion and Disease Laboratory, Richard Dimbleby Department, Imperial Cancer Research Fund, St Thomas Hospital, London, UK
Nat Med 8:27-34. 2002.... - Gene expression analysis reveals matrilysin as a key regulator of pulmonary fibrosis in mice and humansFengrong Zuo
Roche Bioscience, Palo Alto, CA 94304 Functional Genomics, and Institute of Respiratory Medicine, Sheba Medical Center, Tel Hashomer, 52621 Israel
Proc Natl Acad Sci U S A 99:6292-7. 2002..They also illustrate the power of global gene expression analysis of human tissue samples to identify molecular pathways involved in clinical disease... - Integrin alphavbeta1 is a receptor for foot-and-mouth disease virusTerry Jackson
Department of Molecular Biology, Institute for Animal Health, Pirbright, Surrey GU24 ONF, UK
J Virol 76:935-41. 2002..In addition, data are presented suggesting that amino acid residues near the RGD motif may be important for differentiating between the binding specificities of alphavbeta1 and alphavbeta6... - Transforming growth factor-beta-dependent and -independent pathways of induction of tubulointerstitial fibrosis in beta6(-/-) miceLi Jun Ma
Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
Am J Pathol 163:1261-73. 2003.... - Alphav beta6 integrin regulates renal fibrosis and inflammation in Alport mouseKyungmin Hahm
Department of Exploratory Biology, Biogen Idec, 12 Cambridge Center, Cambridge, MA 02142, USA
Am J Pathol 170:110-25. 2007..These findings demonstrate that alpha v beta6 can contribute to the regulation of renal fibrosis and suggest this integrin as a potential therapeutic target... - Function-blocking integrin alphavbeta6 monoclonal antibodies: distinct ligand-mimetic and nonligand-mimetic classesPaul H Weinreb
Biogen Idec, Inc, Cambridge, Massachusetts 02142, USA
J Biol Chem 279:17875-87. 2004..These antibodies should provide valuable tools to study the ligand-receptor interactions of alpha(v)beta(6) as well as the role of alpha(v)beta(6) in vivo... - The EIIIA segment of fibronectin is a ligand for integrins alpha 9beta 1 and alpha 4beta 1 providing a novel mechanism for regulating cell adhesion by alternative splicingYung-Feng Liao
Center for Engineering in Medicine and Surgical Service, Massachusetts General Hospital and Harvard Medical School, the Shriners Burns Hospital, Boston, Massachusetts 02114, USA
J Biol Chem 277:14467-74. 2002..Our observation that two integrins bind the EIIIA segment establishes a novel mechanism by which cell adhesion to fibronectin is regulated by alternative splicing... - Genomics and proteomics of lung disease: conference summaryJ Usha Raj
Division of Neonatology, Harbor-UCLA Medical Center, Geffen School of Medicine at University of California, and Los Angeles Biomedical Research Institute, Los Angeles, California, USA
Am J Physiol Lung Cell Mol Physiol 293:L45-51. 2007 - Functional classification of ADAMs based on a conserved motif for binding to integrin alpha 9beta 1: implications for sperm-egg binding and other cell interactionsKoji Eto
Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
J Biol Chem 277:17804-10. 2002..As alpha(9)beta(1) is a receptor for many ADAM disintegrins and alpha(9)beta(1) and ADAMs are widely expressed, alpha(9)beta(1)-ADAM interaction may be of a broad biological importance... - Structural requirements of MLD-containing disintegrins for functional interaction with alpha 4 beta 1 and alpha 9 beta1 integrinsStanislawa Bazan-Socha
Department of Biology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
Biochemistry 43:1639-47. 2004..These data describe a useful set of potent and selective integrin antagonists and suggest conformational requirements of human and mouse integrins for interaction with ligands... - Role of multiple beta1 integrins in cell adhesion to the disintegrin domains of ADAMs 2 and 3Monika Tomczuk
Department of Cell Biology, University of Virginia, Charlottesville, VA 22908 0732, USA
Exp Cell Res 290:68-81. 2003.... - An essential role for fibronectin extra type III domain A in pulmonary fibrosisAndres F Muro
Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, 6301 MSRB III 0642, 1150 W Medical Center Drive, Ann Arbor, MI 48109 0642, USA
Am J Respir Crit Care Med 177:638-45. 2008..Fibronectin containing extra type III domain A (EDA) is implicated in the regulation of wound healing. EDA-containing fibronectin is deposited during wound repair, and its presence precedes that of collagen... - Integrin alpha v beta 6 is an RGD-dependent receptor for coxsackievirus A9Cigdem H Williams
Department of Biological Sciences, University of Essex, Colchester CO4 3SQ, United Kingdom
J Virol 78:6967-73. 2004..Thus, integrin alpha(v)beta(6) is an RGD-dependent receptor for CAV9 and may be important in natural CAV9 infections... - Pulmonary emphysema: when more is lessDavid G Morris
Respiratory Research, Roche Palo Alto, LLC, F. Hoffman-LaRoche, Ltd, Palo Alto
Physiology (Bethesda) 21:396-403. 2006..Capitalizing on an improved molecular understanding of emphysema with improved therapeutics has the potential to enhance both the survival and quality of life of patients with this common lung disease... - Future research directions in idiopathic pulmonary fibrosis: summary of a National Heart, Lung, and Blood Institute working groupRonald G Crystal
Division of Pulmonary and Critical Care Medicine, Weill Medical College of Cornell University, New York, New York, USA
Am J Respir Crit Care Med 166:236-46. 2002....
Research Grants
- IN VIVO FUNCTION OF PULMONARY INTERGRINSDean Sheppard; Fiscal Year: 2003..This will be accomplished by cross breeding b6-/- mice with transgenic mice that develop sub-epithelial fibrosis due to overexpression of IL-6, IL-11 or IL-13. ..
- Integrin-Mediated Development of the Thoracic DuctDean Sheppard; Fiscal Year: 2007....
- NOVEL LEUKOCYTE INTEGRINSDean Sheppard; Fiscal Year: 2009..abstract_text> ..
- IN VIVO FUNCTION OF PULMONARY INTEGRINSDean Sheppard; Fiscal Year: 2007..They should also identify important targets that could be used to design treatments to intervene in acute lung injury, pulmonary fibrosis and emphysema. ..
- Regulation of Pulmonary Vascular Permeability by Integrin AlphaVBeta5Dean Sheppard; Fiscal Year: 2007..Through the proposed studies we hope to determine whether av¿5 or other components of this pathway are attractive targets for intervention in acute lung injury. ..
- THE NHLBI-BAY AREA FUNCTIONAL GENOMICS CONSORTIUMDean Sheppard; Fiscal Year: 2007..A fourth objective is to generate a limited number of genetically modified mice, for the purpose of defining the relevance of specific genes to cardiopulmonary development and disease (Component 4-6). ..
- Regulation of Pulmonary Vascular Permeability by Integrin AlphaVBeta5Dean Sheppard; Fiscal Year: 2009..Through the proposed studies we hope to determine whether avp5 or other components of this pathway are attractive targets for intervention in acute lung injury. ..
- CONFERENCE ON FIBRONECTIN, INTEGRINS & RELATED MOLECULESDean Sheppard; Fiscal Year: 2007..This cross-pollination is a most effective way of stimulating new waves of insight and information. ..
- IN VIVO FUNCTIONS OF PULMONARY INTEGRINSDean Sheppard; Fiscal Year: 1999....
- ROLE OF A NEUTROPHIL INTEGRIN IN LUNG INFLAMMATIONDean Sheppard; Fiscal Year: 2003..These studies should provide insight into key steps in neutrophil recruitment and could lead to the development of novel interventions for the treatment of diseases characterized by neutrophil-mediated tissue injury. ..
- Integrin-mediated Regulation of Airway Smooth MuscleDean Sheppard; Fiscal Year: 2011..In this proposal we will determine how this integrin normally prevents airway narrowing, a process that could be perturbed in diseases such as asthma. ..