Dean Sheppard

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Killed by leukocytes that don't know when to leave
    Dean Sheppard
    Nat Immunol 3:337-8. 2002
  2. pmc Enteric expression of the integrin alpha(v)beta(6) is essential for nematode-induced mucosal mast cell hyperplasia and expression of the granule chymase, mouse mast cell protease-1
    Pamela A Knight
    Department of Veterinary Clinical Studies, University of Edinburgh, Midlothian, Scotland
    Am J Pathol 161:771-9. 2002
  3. ncbi request reprint Integrin-mediated activation of latent transforming growth factor beta
    Dean Sheppard
    Lung Biology Center, University of California San Francisco, 2922, San Francisco, CA, 94143 2922, USA
    Cancer Metastasis Rev 24:395-402. 2005
  4. ncbi request reprint Partial inhibition of integrin alpha(v)beta6 prevents pulmonary fibrosis without exacerbating inflammation
    Gerald S Horan
    Department of Exploratory Biology, Biogen Idec, 12 Cambridge Center, Cambridge, MA 02142, USA
    Am J Respir Crit Care Med 177:56-65. 2008
  5. pmc ROCKing pulmonary fibrosis
    Dean Sheppard
    Lung Biology Center, Department of Medicine, UCSF, San Francisco, California 94143 2922, USA
    J Clin Invest 123:1005-6. 2013
  6. doi request reprint Modulation of acute lung injury by integrins
    Dean Sheppard
    University of California San Francisco, CA 94143 2922, USA
    Proc Am Thorac Soc 9:126-9. 2012
  7. pmc Transforming growth factor beta: a central modulator of pulmonary and airway inflammation and fibrosis
    Dean Sheppard
    Lung Biology Center and Department of Medicine, University of California San Francisco, Box 2922, San Francisco, CA 94143 2922, USA
    Proc Am Thorac Soc 3:413-7. 2006
  8. pmc Aspen Lung Conference 2010: systems biology of lung diseases--progress in the omics era
    Dean Sheppard
    Lung Biology Center, University of California, San Francisco, San Francisco, CA 94143 2922, USA
    Proc Am Thorac Soc 8:199-202. 2011
  9. pmc Interleukin-1beta causes acute lung injury via alphavbeta5 and alphavbeta6 integrin-dependent mechanisms
    Michael T Ganter
    Laboratory of Surgical Research, Department of Anesthesia, University of California, San Francisco 94110, USA
    Circ Res 102:804-12. 2008
  10. pmc The lymphangiogenic vascular endothelial growth factors VEGF-C and -D are ligands for the integrin alpha9beta1
    Nicholas E Vlahakis
    Lung Biology Center, University of California San Francisco, San Francisco, California, 94143 2922, USA
    J Biol Chem 280:4544-52. 2005

Research Grants

Detail Information

Publications83

  1. ncbi request reprint Killed by leukocytes that don't know when to leave
    Dean Sheppard
    Nat Immunol 3:337-8. 2002
  2. pmc Enteric expression of the integrin alpha(v)beta(6) is essential for nematode-induced mucosal mast cell hyperplasia and expression of the granule chymase, mouse mast cell protease-1
    Pamela A Knight
    Department of Veterinary Clinical Studies, University of Edinburgh, Midlothian, Scotland
    Am J Pathol 161:771-9. 2002
    ....
  3. ncbi request reprint Integrin-mediated activation of latent transforming growth factor beta
    Dean Sheppard
    Lung Biology Center, University of California San Francisco, 2922, San Francisco, CA, 94143 2922, USA
    Cancer Metastasis Rev 24:395-402. 2005
    ....
  4. ncbi request reprint Partial inhibition of integrin alpha(v)beta6 prevents pulmonary fibrosis without exacerbating inflammation
    Gerald S Horan
    Department of Exploratory Biology, Biogen Idec, 12 Cambridge Center, Cambridge, MA 02142, USA
    Am J Respir Crit Care Med 177:56-65. 2008
    ....
  5. pmc ROCKing pulmonary fibrosis
    Dean Sheppard
    Lung Biology Center, Department of Medicine, UCSF, San Francisco, California 94143 2922, USA
    J Clin Invest 123:1005-6. 2013
    ..Because of his advanced age, he is not considered a candidate for lung transplantation. What treatment should you recommend?..
  6. doi request reprint Modulation of acute lung injury by integrins
    Dean Sheppard
    University of California San Francisco, CA 94143 2922, USA
    Proc Am Thorac Soc 9:126-9. 2012
    ..These results identify αvβ6 and αvβ5 as promising therapeutic targets for the treatment of acute lung injury and septic shock...
  7. pmc Transforming growth factor beta: a central modulator of pulmonary and airway inflammation and fibrosis
    Dean Sheppard
    Lung Biology Center and Department of Medicine, University of California San Francisco, Box 2922, San Francisco, CA 94143 2922, USA
    Proc Am Thorac Soc 3:413-7. 2006
    ....
  8. pmc Aspen Lung Conference 2010: systems biology of lung diseases--progress in the omics era
    Dean Sheppard
    Lung Biology Center, University of California, San Francisco, San Francisco, CA 94143 2922, USA
    Proc Am Thorac Soc 8:199-202. 2011
    ....
  9. pmc Interleukin-1beta causes acute lung injury via alphavbeta5 and alphavbeta6 integrin-dependent mechanisms
    Michael T Ganter
    Laboratory of Surgical Research, Department of Anesthesia, University of California, San Francisco 94110, USA
    Circ Res 102:804-12. 2008
    ..In summary, these results demonstrate a critical role for the alphavbeta5/beta6 integrins in mediating the IL-1beta-induced ALI and indicate that these integrins could be a potentially attractive therapeutic target in ALI...
  10. pmc The lymphangiogenic vascular endothelial growth factors VEGF-C and -D are ligands for the integrin alpha9beta1
    Nicholas E Vlahakis
    Lung Biology Center, University of California San Francisco, San Francisco, California, 94143 2922, USA
    J Biol Chem 280:4544-52. 2005
    ..The interaction between alpha9beta1 and VEGF-C and/or -D may begin to explain the abnormal lymphatic phenotype of the alpha9 knock-out mice...
  11. ncbi request reprint Population stratification confounds genetic association studies among Latinos
    Shweta Choudhry
    University of California, San Francisco, 94143 0833, USA
    Hum Genet 118:652-64. 2006
    ..Our findings suggest that empirical assessment of the effects of stratification is critical to appropriately interpret the results of case-control studies in admixed populations...
  12. ncbi request reprint Interleukin-1beta decreases expression of the epithelial sodium channel alpha-subunit in alveolar epithelial cells via a p38 MAPK-dependent signaling pathway
    Jeremie Roux
    Laboratory of Surgical Research, Cardiovascular Research Institute, Department of Anesthesia, University of California, San Francisco 94110, USA
    J Biol Chem 280:18579-89. 2005
    ....
  13. ncbi request reprint Genetic admixture and asthma-related phenotypes in Mexican American and Puerto Rican asthmatics
    Keyan Salari
    Department of Medicine, University of California, San Francisco, California 94143 1732, USA
    Genet Epidemiol 29:76-86. 2005
    ..These results suggest that asthma severity may be influenced by genetic factors differentiating Europeans and Native Americans in Mexican Americans, although differing results for Puerto Ricans require further investigation...
  14. pmc Mfge8 diminishes the severity of tissue fibrosis in mice by binding and targeting collagen for uptake by macrophages
    Kamran Atabai
    Lung Biology Center, Cardiovascular Research Institute, UCSF, San Francisco, California, USA
    J Clin Invest 119:3713-22. 2009
    ..These data demonstrate a critical role for Mfge8 in decreasing the severity of murine tissue fibrosis by facilitating the removal of accumulated collagen...
  15. pmc The αvβ6 integrin modulates airway hyperresponsiveness in mice by regulating intraepithelial mast cells
    Kotaro Sugimoto
    Lung Biology Center, Department of Medicine, UCSF, San Francisco, California, USA
    J Clin Invest 122:748-58. 2012
    ....
  16. pmc IL-17A produced by αβ T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction
    Makoto Kudo
    Lung Biology Center, Department of Medicine, University of California, San Francisco, California, USA
    Nat Med 18:547-54. 2012
    ..These data indicate that the IL-17A produced by T(H)17 cells contributes to allergen-induced airway hyper-responsiveness through direct effects on airway smooth muscle...
  17. pmc Integrin alphavbeta5 regulates lung vascular permeability and pulmonary endothelial barrier function
    George Su
    Lung Biology Center, Division of Pulmonary and Critical Care Medicine, Laboratory of Surgical Research, Department of Anesthesia, and Cardiovascular Research Institute, University of California, San Francisco, California 94158, USA
    Am J Respir Cell Mol Biol 36:377-86. 2007
    ..These results identify integrin alphavbeta5 as a central regulator of increased pulmonary vascular permeability and a potentially attractive therapeutic target in ALI...
  18. pmc Squamous metaplasia amplifies pathologic epithelial-mesenchymal interactions in COPD patients
    Jun Araya
    Department of Pathology, Lung Biology Center, UCSF, San Francisco, California 94110, USA
    J Clin Invest 117:3551-62. 2007
    ..Our findings have identified TGF-beta as a potential therapeutic target for COPD...
  19. ncbi request reprint Pharmacogenetic differences in response to albuterol between Puerto Ricans and Mexicans with asthma
    Shweta Choudhry
    University of California San Francisco, San Francisco, CA 94143 0833, USA
    Am J Respir Crit Care Med 171:563-70. 2005
    ..We tested the association of beta(2)AR genotypes with asthma severity and bronchodilator response to albuterol in Puerto Ricans and Mexicans with asthma...
  20. ncbi request reprint Integrin alpha9beta1 directly binds to vascular endothelial growth factor (VEGF)-A and contributes to VEGF-A-induced angiogenesis
    Nicholas E Vlahakis
    Lung Biology Center, University of California, San Francisco, California 94143 2922, USA
    J Biol Chem 282:15187-96. 2007
    ....
  21. pmc Induction of an epithelial integrin alphavbeta6 in human cytomegalovirus-infected endothelial cells leads to activation of transforming growth factor-beta1 and increased collagen production
    Takako Tabata
    Department of Cell and Tissue Biology, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0640, USA
    Am J Pathol 172:1127-40. 2008
    ..Our results suggest that activation of TGF-beta1 by integrin alphavbeta6 contributes to pathological changes and may impair endothelial cell functions in tissues that are chronically infected with CMV...
  22. doi request reprint Effective treatment of mouse sepsis with an inhibitory antibody targeting integrin αvβ5
    George Su
    Lung Biology Center, University of California, San Francisco, CA, USA
    Crit Care Med 41:546-53. 2013
    ..Integrin αvβ5 has been identified as a regulator of vascular leak and endothelial permeability. We hypothesized that targeting αvβ5 could represent a viable treatment strategy for sepsis...
  23. pmc Integrin α9β1 in airway smooth muscle suppresses exaggerated airway narrowing
    Chun Chen
    Lung Biology Center, Department of Medicine, UCSF, San Francisco, CA 94143 2922, USA
    J Clin Invest 122:2916-27. 2012
    ..Targeting key components of this pathway could thus lead to new treatment strategies for asthma...
  24. pmc Differential enzymatic activity of common haplotypic versions of the human acidic Mammalian chitinase protein
    Max A Seibold
    Department of Medicine, Howard Hughes Medical Institute, University of California, San Francisco, California 94143, USA
    J Biol Chem 284:19650-8. 2009
    ..The structural, kinetic, and genetic data regarding the AMCase isoforms are consistent with the Th2-priming effects of environmental chitin and a role for AMCase in negatively regulating this stimulus...
  25. pmc Integrin beta6 mediates phospholipid and collectin homeostasis by activation of latent TGF-beta1
    Laura L Koth
    Lung Biology Center, Department of Medicine, San Francisco General Hospital, California, USA
    Am J Respir Cell Mol Biol 37:651-9. 2007
    ..These findings show that alphavbeta6 and TGF-beta1 regulate homeostasis of phospholipids and collectins in adult mouse lungs and may have implications for anti-fibrotic therapeutics that inhibit active TGF-beta in the lung...
  26. pmc The alpha9beta1 integrin enhances cell migration by polyamine-mediated modulation of an inward-rectifier potassium channel
    Gregory W DeHart
    Lung Biology Center, Department of Medicine, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 105:7188-93. 2008
    ..These results identify a pathway through which the alpha9 integrin subunit stimulates cell migration by localized polyamine catabolism and modulation of Kir channel function...
  27. pmc ADAM33 is not essential for growth and development and does not modulate allergic asthma in mice
    Chun Chen
    Lung Biology Center, University of California San Francisco, Box 2922, San Francisco, CA 94143 2922, USA
    Mol Cell Biol 26:6950-6. 2006
    ..Our results demonstrate that ADAM33 is not essential for growth or reproduction in the mouse and does not modulate baseline or allergen-induced airway responsiveness...
  28. ncbi request reprint The Integrin alpha9beta1 contributes to granulopoiesis by enhancing granulocyte colony-stimulating factor receptor signaling
    Chun Chen
    Lung Biology Center, Department of Medicine, University of California, San Francisco, San Francisco, California 94158, USA
    Immunity 25:895-906. 2006
    ....
  29. pmc The phosphatase CD148 promotes airway hyperresponsiveness through SRC family kinases
    Tamiko R Katsumoto
    Division of Rheumatology and Rosalind Russell Medical Research Center for Arthritis, University of California San Francisco UCSF, San Francisco, California, USA
    J Clin Invest 123:2037-48. 2013
    ..Our studies identify CD148 and the SFKs it regulates in ASM as potential targets for the treatment of AHR...
  30. pmc Short form of α9 promotes α9β1 integrin-dependent cell adhesion by modulating the function of the full-length α9 subunit
    Shigeyuki Kon
    Lung Biology Center, Department of Medicine, University of California, San Francisco, CA 94143, USA
    Exp Cell Res 317:1774-84. 2011
    ..This promoting effect of SFα9 requires the authentic cytoplasmic domain of the co-expressed full-length α9 subunit. Thus, SFα9 is a novel functional modulator of α9β1 integrin by inside-out signaling...
  31. pmc Expression of αvβ8 integrin on dendritic cells regulates Th17 cell development and experimental autoimmune encephalomyelitis in mice
    Andrew C Melton
    Lung Biology Center, Department of Medicine, University of California, San Francisco, California, USA
    J Clin Invest 120:4436-44. 2010
    ..Our results therefore suggest that the integrin αvβ8 pathway is biologically important and that αvβ8 expression on DCs could be a therapeutic target for the treatment of Th17-driven autoimmune disease...
  32. pmc Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury
    R Gisli Jenkins
    Lung Biology Center, UCSF, San Francisco, California 94158, USA
    J Clin Invest 116:1606-14. 2006
    ....
  33. ncbi request reprint Induction of a homeostatic circuit in lung tissue by microbial compounds
    Kenji Takabayshi
    Department of Medicine, University of California, San Diego, La Jolla, 92093, USA
    Immunity 24:475-87. 2006
    ....
  34. ncbi request reprint Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema
    David G Morris
    Lung Biology Center, Department of Medicine, San Francisco General Hospital, San Francisco, California 94143, USA
    Nature 422:169-73. 2003
    ..Furthermore, we show that a functional alteration in the TGF-beta activation pathway affects susceptibility to this disease...
  35. pmc Spatiotemporally separated antigen uptake by alveolar dendritic cells and airway presentation to T cells in the lung
    Emily E Thornton
    Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA
    J Exp Med 209:1183-99. 2012
    ....
  36. pmc Epithelial cells utilize cortical actin/myosin to activate latent TGF-β through integrin α(v)β(6)-dependent physical force
    Marilyn M Giacomini
    Lung Biology Center, Department of Medicine, University of California, San Francisco, CA, USA
    Exp Cell Res 318:716-22. 2012
    ....
  37. pmc Loss of integrin alpha(v)beta8 on dendritic cells causes autoimmunity and colitis in mice
    Mark A Travis
    Lung Biology Center, Department of Medicine, University of California San Francisco, 1550 4th Street, Room 545, San Francisco, California 94158, USA
    Nature 449:361-5. 2007
    ....
  38. ncbi request reprint Transforming growth factor-beta1 decreases expression of the epithelial sodium channel alphaENaC and alveolar epithelial vectorial sodium and fluid transport via an ERK1/2-dependent mechanism
    James Frank
    Laboratory of Surgical Research, Cardiovascular Research Institute, Lung Biology Center, Departments of Anesthesia, Surgery, and Medicine, University of California, San Francisco, California 94110, USA
    J Biol Chem 278:43939-50. 2003
    ..This reduction in sodium and fluid transport is attributable in large part to a reduction in apical membrane alphaENaC expression mediated through an ERK1/2-dependent inhibition of the alphaENaC promoter activity...
  39. pmc Activation of transforming growth factor-beta by the integrin alphavbeta8 delays epithelial wound closure
    Claus Neurohr
    Department of Medicine, Lung Biology Center, University of California, San Francisco, 94143 2922, USA
    Am J Respir Cell Mol Biol 35:252-9. 2006
    ..Wounding induced activation of TGF-beta through effects of both integrins, but antibodies against alphavbeta8 enhanced the degree of wound closure, whereas antibodies against alphavbeta6 did not...
  40. pmc Alternaria induces STAT6-dependent acute airway eosinophilia and epithelial FIZZ1 expression that promotes airway fibrosis and epithelial thickness
    Taylor A Doherty
    Department of Medicine, University of California San Diego, La Jolla, CA 92093 0635, USA
    J Immunol 188:2622-9. 2012
    ..This may provide some insight into the uniquely pathogenic aspects of Alternaria-associated asthma...
  41. pmc Epistatic interactions between Tgfb1 and genetic loci, Tgfbm2 and Tgfbm3, determine susceptibility to an asthmatic stimulus
    Julia Freimuth
    Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 109:18042-7. 2012
    ..TGFβ antagonists for treatment of lung diseases might therefore give diverse outcomes, dependent on genetic variation...
  42. ncbi request reprint Mice lacking the integrin beta5 subunit have accelerated osteoclast maturation and increased activity in the estrogen-deficient state
    Nancy E Lane
    Department of Medicine, University of California at San Francisco, San Francisco, California 94143, USA
    J Bone Miner Res 20:58-66. 2005
    ..These preliminary data suggest alphavbeta5 integrin's presence on osteoclast precursors may inhibit of osteoclast formation...
  43. pmc Mfge8 is critical for mammary gland remodeling during involution
    Kamran Atabai
    Lung Biology Center, Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143, USA
    Mol Biol Cell 16:5528-37. 2005
    ..These data demonstrate that Mfge8 regulates the clearance of apoptotic epithelial cells during mammary gland involution and that the absence of Mfge8 leads to inflammation and abnormal mammary gland remodeling...
  44. ncbi request reprint Lower bronchodilator responsiveness in Puerto Rican than in Mexican subjects with asthma
    Esteban Gonzalez Burchard
    University of California, San Francisco, 94143 0833, USA
    Am J Respir Crit Care Med 169:386-92. 2004
    ..We conclude that Puerto Ricans with asthma respond less to albuterol than do Mexicans with asthma. These findings underscore the need for additional research on racial/ethnic differences in asthma morbidity and response to therapy...
  45. pmc Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix
    Kevin K Kim
    Department of Medicine and Cardiovascular Research Institute, University of California, San Francisco, 94143, USA
    Proc Natl Acad Sci U S A 103:13180-5. 2006
    ..These data reveal alveolar epithelial cells as progenitors for fibroblasts in vivo and implicate the provisional extracellular matrix as a key regulator of epithelial transdifferentiation during fibrogenesis...
  46. pmc Cross talk among TGF-β signaling pathways, integrins, and the extracellular matrix
    John S Munger
    Department of Medicine, New York University, New York, New York 10016, USA
    Cold Spring Harb Perspect Biol 3:a005017. 2011
    ..Mutant mice defective in integrin-mediated activators, and humans and mice with fibrillin gene mutations, show the critical role of ECM and integrins in regulating TGF-β signaling...
  47. ncbi request reprint Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma
    Douglas A Kuperman
    Lung Biology Center, Department of Medicine and Cardiovascular Research Institute, University of California San Francisco School of Medicine, San Francisco, California, USA
    Nat Med 8:885-9. 2002
    ..These results demonstrate the importance of direct effects of IL-13 on epithelial cells in causing two central features of asthma...
  48. pmc Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction
    Fen Huang
    Howard Hughes Medical Institute and Department of Physiology, University of California, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 109:16354-9. 2012
    ..TMEM16A-CaCC blockers, including those identified here, may positively impact multiple causes of asthma symptoms...
  49. pmc Absence of integrin αvβ3 enhances vascular leak in mice by inhibiting endothelial cortical actin formation
    George Su
    Lung Biology Center, University of California San Francisco, San Francisco, CA 94121, USA
    Am J Respir Crit Care Med 185:58-66. 2012
    ..Sepsis and acute lung injury (ALI) have devastatingly high mortality rates. Both are associated with increased vascular leak, a process regulated by complex molecular mechanisms...
  50. ncbi request reprint Functions of pulmonary epithelial integrins: from development to disease
    Dean Sheppard
    University of California, San Francisco, Box 0854, San Francisco, CA 94143 0854, USA
    Physiol Rev 83:673-86. 2003
    ..Epithelial integrins are thus attractive targets for intervention in a number of common lung disorders...
  51. pmc Phosphorylation of Trask by Src kinases inhibits integrin clustering and functions in exclusion with focal adhesion signaling
    Danislav S Spassov
    Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 1387, USA
    Mol Cell Biol 31:766-82. 2011
    ..These data provide considerable insight into how Trask functions to regulate cell adhesion and reveal a novel pathway through which Src kinases can oppose integrin-mediated cell adhesion...
  52. pmc The integrin alpha(v)beta8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-beta1
    Dezhi Mu
    Department of Pathology, University of California at San Francisco Mt Zion Cancer Center, San Francisco, CA 94143, USA
    J Cell Biol 157:493-507. 2002
    ..These data elucidate a novel mechanism of cellular homeostasis achieved through the coordination of the activities of members of three major gene families involved in cell-matrix interactions...
  53. ncbi request reprint Identification and molecular characterization of multiple phenotypes in integrin knockout mice
    Chun Chen
    Lung Biology Center, Department of Medicine, University of California, San Francisco, San Francisco, California, USA
    Methods Enzymol 426:291-305. 2007
    ..In this article, we review approaches that can contribute to optimal use of this valuable resource...
  54. ncbi request reprint Roles of alphav integrins in vascular biology and pulmonary pathology
    Dean Sheppard
    Lung Biology Center, University of California San Francisco, Box 2922, San Francisco, California 94143 2922, USA
    Curr Opin Cell Biol 16:552-7. 2004
    ..Studies in mice lacking the beta6 subunit have identified unexpected roles for alphavbeta6-mediated TGFbeta activation in models of pulmonary and renal fibrosis, acute lung injury and pulmonary emphysema...
  55. pmc Roles of the innate immune system in mammary gland remodeling during involution
    Kamran Atabai
    Lung Biology Center, Cardiovascular Research Institute, Department of Medicine, University of California, San Francisco, CA 94143 2922, USA
    J Mammary Gland Biol Neoplasia 12:37-45. 2007
    ..g. mammary epithelial cells). This review will discuss the evidence that supports a role for innate immune cells in mammary gland remodeling during involution...
  56. ncbi request reprint Roger S. Mitchell lecture. Uses of expression microarrays in studies of pulmonary fibrosis, asthma, acute lung injury, and emphysema
    Dean Sheppard
    Lung Biology Center, Center for Occupational and Environmental Health, Cardiovascular Research Institute, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    Chest 121:21S-25S. 2002
    ..Together, these examples demonstrate how careful application and thorough analysis of expression microarrays can facilitate the discovery of novel molecular targets for intervening in common lung diseases...
  57. ncbi request reprint ADAM33 is not associated with asthma in Puerto Rican or Mexican populations
    Denise L Lind
    University of California at San Francisco, San Francisco, CA 94143 0833, USA
    Am J Respir Crit Care Med 168:1312-6. 2003
    ..We conclude that the ADAM33 gene is not an important risk factor for asthma or for asthma-associated phenotypes in Mexicans or in Puerto Ricans...
  58. pmc Spermidine/spermine N1-acetyltransferase specifically binds to the integrin alpha9 subunit cytoplasmic domain and enhances cell migration
    Chun Chen
    Lung Biology Center, Department of Medicine, University of California San Francisco, San Francisco, CA 94110, USA
    J Cell Biol 167:161-70. 2004
    ..We conclude that SSAT directly binds to the alpha9 cytoplasmic domain and mediates alpha9-dependent enhancement of cell migration, presumably by localized effects on acetylation of polyamines or of unidentified substrates...
  59. pmc Blocking TGFβ via Inhibition of the αvβ6 Integrin: A Possible Therapy for Systemic Sclerosis Interstitial Lung Disease
    Tamiko R Katsumoto
    Department of Medicine, Critical Care, Allergy and Sleep Medicine, University of California, San Francisco, CA 94143, USA
    Int J Rheumatol 2011:208219. 2011
    ..Here we discuss the biology of αvβ6 and present this integrin as a potentially attractive target for inhibition in the setting of SSc ILD...
  60. pmc Endothelial integrins and angiogenesis: not so simple anymore
    Dean Sheppard
    Department of Medicine, Sandler Center for Basic Research in Asthma and the Lung Biology Center, University of California, San Francisco, San Francisco, California 94110, USA
    J Clin Invest 110:913-4. 2002
  61. ncbi request reprint The importance of race and ethnic background in biomedical research and clinical practice
    Esteban Gonzalez Burchard
    Lung Biology Center, University of California, San Francisco, CA 94143 0833, USA
    N Engl J Med 348:1170-5. 2003
  62. pmc Gene expression analysis reveals matrilysin as a key regulator of pulmonary fibrosis in mice and humans
    Fengrong Zuo
    Roche Bioscience, Palo Alto, CA 94304 Functional Genomics, and Institute of Respiratory Medicine, Sheba Medical Center, Tel Hashomer, 52621 Israel
    Proc Natl Acad Sci U S A 99:6292-7. 2002
    ..They also illustrate the power of global gene expression analysis of human tissue samples to identify molecular pathways involved in clinical disease...
  63. pmc ADAM disintegrin-like domain recognition by the lymphocyte integrins alpha4beta1 and alpha4beta7
    Lance C Bridges
    Department of Biochemistry and Molecular Biology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190, USA
    Biochem J 387:101-8. 2005
    ..These results establish that ADAM7 and ADAM28 are recognized by the leucocyte integrins alpha4beta1, alpha4beta7 and alpha9beta1. ADAM33 exclusively supported only alpha9beta1-dependent adhesion...
  64. pmc Loss of synchronized retinal phagocytosis and age-related blindness in mice lacking alphavbeta5 integrin
    Emeline F Nandrot
    Margaret M Dyson Vision Research Institute, Department of Ophthalmology, Weill Medical College of Cornell University, 1300 York Ave, New York, NY 10021, USA
    J Exp Med 200:1539-45. 2004
    ..Furthermore, they identify the beta5-/- integrin mouse strain as a new animal model of age-related retinal dysfunction...
  65. pmc Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling
    Brian P Eliceiri
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Cell Biol 157:149-60. 2002
    ..Our findings indicate that Src can coordinate specific growth factor and extracellular matrix inputs by recruiting integrin alpha(v)beta5 into a FAK-containing signaling complex during growth factor-mediated biological responses...
  66. ncbi request reprint Use of oligonucleotide microarrays to analyze gene expression patterns in pulmonary fibrosis reveals distinct patterns of gene expression in mice and humans
    Naftali Kaminski
    Functional Genomics, Sheba Medical Center, Tel Hashomer, Israel
    Chest 121:31S-32S. 2002
  67. pmc Transcriptional activation of integrin beta6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma
    Richard C Bates
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 115:339-47. 2005
    ..These findings define the alphavbeta6 integrin as an important risk factor for early-stage disease and a novel therapeutic candidate for colorectal cancer...
  68. ncbi request reprint Enhanced pathological angiogenesis in mice lacking beta3 integrin or beta3 and beta5 integrins
    Louise E Reynolds
    Cell Adhesion and Disease Laboratory, Richard Dimbleby Department, Imperial Cancer Research Fund, St Thomas Hospital, London, UK
    Nat Med 8:27-34. 2002
    ....
  69. ncbi request reprint Function-blocking integrin alphavbeta6 monoclonal antibodies: distinct ligand-mimetic and nonligand-mimetic classes
    Paul H Weinreb
    Biogen Idec, Inc, Cambridge, Massachusetts 02142, USA
    J Biol Chem 279:17875-87. 2004
    ..These antibodies should provide valuable tools to study the ligand-receptor interactions of alpha(v)beta(6) as well as the role of alpha(v)beta(6) in vivo...
  70. pmc Integrin alphavbeta1 is a receptor for foot-and-mouth disease virus
    Terry Jackson
    Department of Molecular Biology, Institute for Animal Health, Pirbright, Surrey GU24 ONF, UK
    J Virol 76:935-41. 2002
    ..In addition, data are presented suggesting that amino acid residues near the RGD motif may be important for differentiating between the binding specificities of alphavbeta1 and alphavbeta6...
  71. pmc Alphav beta6 integrin regulates renal fibrosis and inflammation in Alport mouse
    Kyungmin Hahm
    Department of Exploratory Biology, Biogen Idec, 12 Cambridge Center, Cambridge, MA 02142, USA
    Am J Pathol 170:110-25. 2007
    ..These findings demonstrate that alpha v beta6 can contribute to the regulation of renal fibrosis and suggest this integrin as a potential therapeutic target...
  72. pmc Alpha9beta1: a novel osteoclast integrin that regulates osteoclast formation and function
    Hongwei Rao
    Medicine Hematology Oncology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Bone Miner Res 21:1657-65. 2006
    ..Antibody to alpha(9) inhibited OCL formation in human marrow cultures, and OCLs from alpha(9) knockout mice had a defect in actin ring reorganization and an impaired bone resorption capacity...
  73. pmc Transforming growth factor-beta-dependent and -independent pathways of induction of tubulointerstitial fibrosis in beta6(-/-) mice
    Li Jun Ma
    Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Am J Pathol 163:1261-73. 2003
    ....
  74. pmc Essential role for MFG-E8 as ligand for alphavbeta5 integrin in diurnal retinal phagocytosis
    Emeline F Nandrot
    Dyson Vision Research Institute, Department of Ophthalmology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 104:12005-10. 2007
    ..Thus, MFG-E8 stimulates rhythmic POS phagocytosis by ligating apical alphavbeta5 receptors of the RPE. These results identify MFG-E8 as the first extracellular ligand in the retina that is essential for diurnal POS phagocytosis...
  75. ncbi request reprint Future research directions in idiopathic pulmonary fibrosis: summary of a National Heart, Lung, and Blood Institute working group
    Ronald G Crystal
    Division of Pulmonary and Critical Care Medicine, Weill Medical College of Cornell University, New York, New York, USA
    Am J Respir Crit Care Med 166:236-46. 2002
    ....
  76. ncbi request reprint Structural requirements of MLD-containing disintegrins for functional interaction with alpha 4 beta 1 and alpha 9 beta1 integrins
    Stanislawa Bazan-Socha
    Department of Biology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
    Biochemistry 43:1639-47. 2004
    ..These data describe a useful set of potent and selective integrin antagonists and suggest conformational requirements of human and mouse integrins for interaction with ligands...
  77. ncbi request reprint The EIIIA segment of fibronectin is a ligand for integrins alpha 9beta 1 and alpha 4beta 1 providing a novel mechanism for regulating cell adhesion by alternative splicing
    Yung Feng Liao
    Center for Engineering in Medicine and Surgical Service, Massachusetts General Hospital and Harvard Medical School, the Shriners Burns Hospital, Boston, Massachusetts 02114, USA
    J Biol Chem 277:14467-74. 2002
    ..Our observation that two integrins bind the EIIIA segment establishes a novel mechanism by which cell adhesion to fibronectin is regulated by alternative splicing...
  78. ncbi request reprint Functional classification of ADAMs based on a conserved motif for binding to integrin alpha 9beta 1: implications for sperm-egg binding and other cell interactions
    Koji Eto
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 277:17804-10. 2002
    ..As alpha(9)beta(1) is a receptor for many ADAM disintegrins and alpha(9)beta(1) and ADAMs are widely expressed, alpha(9)beta(1)-ADAM interaction may be of a broad biological importance...
  79. ncbi request reprint Genomics and proteomics of lung disease: conference summary
    J Usha Raj
    Division of Neonatology, Harbor UCLA Medical Center, Geffen School of Medicine at University of California, and Los Angeles Biomedical Research Institute, Los Angeles, California, USA
    Am J Physiol Lung Cell Mol Physiol 293:L45-51. 2007
  80. pmc An essential role for fibronectin extra type III domain A in pulmonary fibrosis
    Andres F Muro
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, 6301 MSRB III 0642, 1150 W Medical Center Drive, Ann Arbor, MI 48109 0642, USA
    Am J Respir Crit Care Med 177:638-45. 2008
    ..Fibronectin containing extra type III domain A (EDA) is implicated in the regulation of wound healing. EDA-containing fibronectin is deposited during wound repair, and its presence precedes that of collagen...
  81. ncbi request reprint Role of multiple beta1 integrins in cell adhesion to the disintegrin domains of ADAMs 2 and 3
    Monika Tomczuk
    Department of Cell Biology, University of Virginia, Charlottesville, VA 22908 0732, USA
    Exp Cell Res 290:68-81. 2003
    ....
  82. pmc Integrin alpha v beta 6 is an RGD-dependent receptor for coxsackievirus A9
    Cigdem H Williams
    Department of Biological Sciences, University of Essex, Colchester CO4 3SQ, United Kingdom
    J Virol 78:6967-73. 2004
    ..Thus, integrin alpha(v)beta(6) is an RGD-dependent receptor for CAV9 and may be important in natural CAV9 infections...
  83. ncbi request reprint Pulmonary emphysema: when more is less
    David G Morris
    Respiratory Research, Roche Palo Alto, LLC, F Hoffman LaRoche, Ltd, Palo Alto
    Physiology (Bethesda) 21:396-403. 2006
    ..Capitalizing on an improved molecular understanding of emphysema with improved therapeutics has the potential to enhance both the survival and quality of life of patients with this common lung disease...

Research Grants36

  1. IN VIVO FUNCTION OF PULMONARY INTERGRINS
    Dean Sheppard; Fiscal Year: 2003
    ..This will be accomplished by cross breeding b6-/- mice with transgenic mice that develop sub-epithelial fibrosis due to overexpression of IL-6, IL-11 or IL-13. ..
  2. Integrin-Mediated Development of the Thoracic Duct
    Dean Sheppard; Fiscal Year: 2007
    ....
  3. NOVEL LEUKOCYTE INTEGRINS
    Dean Sheppard; Fiscal Year: 2009
    ..abstract_text> ..
  4. IN VIVO FUNCTION OF PULMONARY INTEGRINS
    Dean Sheppard; Fiscal Year: 2007
    ..They should also identify important targets that could be used to design treatments to intervene in acute lung injury, pulmonary fibrosis and emphysema. ..
  5. Regulation of Pulmonary Vascular Permeability by Integrin AlphaVBeta5
    Dean Sheppard; Fiscal Year: 2007
    ..Through the proposed studies we hope to determine whether av¿5 or other components of this pathway are attractive targets for intervention in acute lung injury. ..
  6. THE NHLBI-BAY AREA FUNCTIONAL GENOMICS CONSORTIUM
    Dean Sheppard; Fiscal Year: 2007
    ..A fourth objective is to generate a limited number of genetically modified mice, for the purpose of defining the relevance of specific genes to cardiopulmonary development and disease (Component 4-6). ..
  7. Regulation of Pulmonary Vascular Permeability by Integrin AlphaVBeta5
    Dean Sheppard; Fiscal Year: 2009
    ..Through the proposed studies we hope to determine whether avp5 or other components of this pathway are attractive targets for intervention in acute lung injury. ..
  8. CONFERENCE ON FIBRONECTIN, INTEGRINS & RELATED MOLECULES
    Dean Sheppard; Fiscal Year: 2007
    ..This cross-pollination is a most effective way of stimulating new waves of insight and information. ..
  9. IN VIVO FUNCTIONS OF PULMONARY INTEGRINS
    Dean Sheppard; Fiscal Year: 1999
    ....
  10. ROLE OF A NEUTROPHIL INTEGRIN IN LUNG INFLAMMATION
    Dean Sheppard; Fiscal Year: 2003
    ..These studies should provide insight into key steps in neutrophil recruitment and could lead to the development of novel interventions for the treatment of diseases characterized by neutrophil-mediated tissue injury. ..
  11. Integrin-mediated Regulation of Airway Smooth Muscle
    Dean Sheppard; Fiscal Year: 2011
    ..In this proposal we will determine how this integrin normally prevents airway narrowing, a process that could be perturbed in diseases such as asthma. ..