DEAN C SHEPPARD

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Induction of an epithelial integrin alphavbeta6 in human cytomegalovirus-infected endothelial cells leads to activation of transforming growth factor-beta1 and increased collagen production
    Takako Tabata
    Department of Cell and Tissue Biology, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0640, USA
    Am J Pathol 172:1127-40. 2008
  2. pmc Spermidine/spermine N1-acetyltransferase specifically binds to the integrin alpha9 subunit cytoplasmic domain and enhances cell migration
    Chun Chen
    Lung Biology Center, Department of Medicine, University of California San Francisco, San Francisco, CA 94110, USA
    J Cell Biol 167:161-70. 2004
  3. ncbi In vivo functions of integrins: lessons from null mutations in mice
    D Sheppard
    Lung Biology Center, Center for Occupational and Environmental Health, Cardiovascular Research Institute, San Francisco, CA 94143, USA
    Matrix Biol 19:203-9. 2000
  4. ncbi Integrin-mediated activation of latent transforming growth factor beta
    Dean Sheppard
    Lung Biology Center, University of California San Francisco, 2922, San Francisco, CA, 94143 2922, USA
    Cancer Metastasis Rev 24:395-402. 2005
  5. ncbi Roles of alphav integrins in vascular biology and pulmonary pathology
    Dean Sheppard
    Lung Biology Center, University of California San Francisco, Box 2922, San Francisco, California 94143 2922, USA
    Curr Opin Cell Biol 16:552-7. 2004
  6. ncbi Functions of pulmonary epithelial integrins: from development to disease
    Dean Sheppard
    University of California, San Francisco, Box 0854, San Francisco, CA 94143 0854, USA
    Physiol Rev 83:673-86. 2003
  7. pmc Endothelial integrins and angiogenesis: not so simple anymore
    Dean Sheppard
    Department of Medicine, Sandler Center for Basic Research in Asthma and the Lung Biology Center, University of California, San Francisco, San Francisco, California 94110, USA
    J Clin Invest 110:913-4. 2002
  8. ncbi Roger S. Mitchell lecture. Uses of expression microarrays in studies of pulmonary fibrosis, asthma, acute lung injury, and emphysema
    Dean Sheppard
    Lung Biology Center, Center for Occupational and Environmental Health, Cardiovascular Research Institute, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    Chest 121:21S-25S. 2002
  9. ncbi Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema
    David G Morris
    Lung Biology Center, Department of Medicine, San Francisco General Hospital, San Francisco, California 94143, USA
    Nature 422:169-73. 2003
  10. pmc Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury
    R Gisli Jenkins
    Lung Biology Center, UCSF, San Francisco, California 94158, USA
    J Clin Invest 116:1606-14. 2006

Collaborators

Detail Information

Publications40

  1. pmc Induction of an epithelial integrin alphavbeta6 in human cytomegalovirus-infected endothelial cells leads to activation of transforming growth factor-beta1 and increased collagen production
    Takako Tabata
    Department of Cell and Tissue Biology, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0640, USA
    Am J Pathol 172:1127-40. 2008
    ..Our results suggest that activation of TGF-beta1 by integrin alphavbeta6 contributes to pathological changes and may impair endothelial cell functions in tissues that are chronically infected with CMV...
  2. pmc Spermidine/spermine N1-acetyltransferase specifically binds to the integrin alpha9 subunit cytoplasmic domain and enhances cell migration
    Chun Chen
    Lung Biology Center, Department of Medicine, University of California San Francisco, San Francisco, CA 94110, USA
    J Cell Biol 167:161-70. 2004
    ..We conclude that SSAT directly binds to the alpha9 cytoplasmic domain and mediates alpha9-dependent enhancement of cell migration, presumably by localized effects on acetylation of polyamines or of unidentified substrates...
  3. ncbi In vivo functions of integrins: lessons from null mutations in mice
    D Sheppard
    Lung Biology Center, Center for Occupational and Environmental Health, Cardiovascular Research Institute, San Francisco, CA 94143, USA
    Matrix Biol 19:203-9. 2000
    ..Studies utilizing integrin knockout mice and cells derived from these mice have provided considerable and sometimes surprising insights into unique functions of individual members of this family...
  4. ncbi Integrin-mediated activation of latent transforming growth factor beta
    Dean Sheppard
    Lung Biology Center, University of California San Francisco, 2922, San Francisco, CA, 94143 2922, USA
    Cancer Metastasis Rev 24:395-402. 2005
    ....
  5. ncbi Roles of alphav integrins in vascular biology and pulmonary pathology
    Dean Sheppard
    Lung Biology Center, University of California San Francisco, Box 2922, San Francisco, California 94143 2922, USA
    Curr Opin Cell Biol 16:552-7. 2004
    ..Studies in mice lacking the beta6 subunit have identified unexpected roles for alphavbeta6-mediated TGFbeta activation in models of pulmonary and renal fibrosis, acute lung injury and pulmonary emphysema...
  6. ncbi Functions of pulmonary epithelial integrins: from development to disease
    Dean Sheppard
    University of California, San Francisco, Box 0854, San Francisco, CA 94143 0854, USA
    Physiol Rev 83:673-86. 2003
    ..Epithelial integrins are thus attractive targets for intervention in a number of common lung disorders...
  7. pmc Endothelial integrins and angiogenesis: not so simple anymore
    Dean Sheppard
    Department of Medicine, Sandler Center for Basic Research in Asthma and the Lung Biology Center, University of California, San Francisco, San Francisco, California 94110, USA
    J Clin Invest 110:913-4. 2002
  8. ncbi Roger S. Mitchell lecture. Uses of expression microarrays in studies of pulmonary fibrosis, asthma, acute lung injury, and emphysema
    Dean Sheppard
    Lung Biology Center, Center for Occupational and Environmental Health, Cardiovascular Research Institute, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    Chest 121:21S-25S. 2002
    ..Together, these examples demonstrate how careful application and thorough analysis of expression microarrays can facilitate the discovery of novel molecular targets for intervening in common lung diseases...
  9. ncbi Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema
    David G Morris
    Lung Biology Center, Department of Medicine, San Francisco General Hospital, San Francisco, California 94143, USA
    Nature 422:169-73. 2003
    ..Furthermore, we show that a functional alteration in the TGF-beta activation pathway affects susceptibility to this disease...
  10. pmc Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury
    R Gisli Jenkins
    Lung Biology Center, UCSF, San Francisco, California 94158, USA
    J Clin Invest 116:1606-14. 2006
    ....
  11. pmc Interleukin-1beta causes acute lung injury via alphavbeta5 and alphavbeta6 integrin-dependent mechanisms
    Michael T Ganter
    Laboratory of Surgical Research, Department of Anesthesia, University of California, San Francisco 94110, USA
    Circ Res 102:804-12. 2008
    ..In summary, these results demonstrate a critical role for the alphavbeta5/beta6 integrins in mediating the IL-1beta-induced ALI and indicate that these integrins could be a potentially attractive therapeutic target in ALI...
  12. pmc The lymphangiogenic vascular endothelial growth factors VEGF-C and -D are ligands for the integrin alpha9beta1
    Nicholas E Vlahakis
    Lung Biology Center, University of California San Francisco, San Francisco, California, 94143 2922, USA
    J Biol Chem 280:4544-52. 2005
    ..The interaction between alpha9beta1 and VEGF-C and/or -D may begin to explain the abnormal lymphatic phenotype of the alpha9 knock-out mice...
  13. ncbi Induction of a homeostatic circuit in lung tissue by microbial compounds
    Kenji Takabayshi
    Department of Medicine, University of California, San Diego, La Jolla, 92093, USA
    Immunity 24:475-87. 2006
    ....
  14. ncbi Genetic admixture and asthma-related phenotypes in Mexican American and Puerto Rican asthmatics
    Keyan Salari
    Department of Medicine, University of California, San Francisco, California 94143 1732, USA
    Genet Epidemiol 29:76-86. 2005
    ..These results suggest that asthma severity may be influenced by genetic factors differentiating Europeans and Native Americans in Mexican Americans, although differing results for Puerto Ricans require further investigation...
  15. ncbi Interleukin-1beta decreases expression of the epithelial sodium channel alpha-subunit in alveolar epithelial cells via a p38 MAPK-dependent signaling pathway
    Jeremie Roux
    Laboratory of Surgical Research, Cardiovascular Research Institute, Department of Anesthesia, University of California, San Francisco 94110, USA
    J Biol Chem 280:18579-89. 2005
    ....
  16. ncbi ADAM33 is not associated with asthma in Puerto Rican or Mexican populations
    Denise L Lind
    University of California at San Francisco, San Francisco, CA 94143 0833, USA
    Am J Respir Crit Care Med 168:1312-6. 2003
    ..We conclude that the ADAM33 gene is not an important risk factor for asthma or for asthma-associated phenotypes in Mexicans or in Puerto Ricans...
  17. ncbi Pharmacogenetic differences in response to albuterol between Puerto Ricans and Mexicans with asthma
    Shweta Choudhry
    University of California San Francisco, San Francisco, CA 94143 0833, USA
    Am J Respir Crit Care Med 171:563-70. 2005
    ..We tested the association of beta(2)AR genotypes with asthma severity and bronchodilator response to albuterol in Puerto Ricans and Mexicans with asthma...
  18. pmc Roles of the innate immune system in mammary gland remodeling during involution
    Kamran Atabai
    Lung Biology Center, Cardiovascular Research Institute, Department of Medicine, University of California, San Francisco, CA 94143 2922, USA
    J Mammary Gland Biol Neoplasia 12:37-45. 2007
    ..g. mammary epithelial cells). This review will discuss the evidence that supports a role for innate immune cells in mammary gland remodeling during involution...
  19. pmc Transforming growth factor beta: a central modulator of pulmonary and airway inflammation and fibrosis
    Dean Sheppard
    Lung Biology Center and Department of Medicine, University of California San Francisco, Box 2922, San Francisco, CA 94143 2922, USA
    Proc Am Thorac Soc 3:413-7. 2006
    ....
  20. ncbi The importance of race and ethnic background in biomedical research and clinical practice
    Esteban Gonzalez Burchard
    Lung Biology Center, University of California, San Francisco, CA 94143 0833, USA
    N Engl J Med 348:1170-5. 2003
  21. pmc Integrin beta6 mediates phospholipid and collectin homeostasis by activation of latent TGF-beta1
    Laura L Koth
    Lung Biology Center, Department of Medicine, San Francisco General Hospital, California, USA
    Am J Respir Cell Mol Biol 37:651-9. 2007
    ..These findings show that alphavbeta6 and TGF-beta1 regulate homeostasis of phospholipids and collectins in adult mouse lungs and may have implications for anti-fibrotic therapeutics that inhibit active TGF-beta in the lung...
  22. ncbi Lower bronchodilator responsiveness in Puerto Rican than in Mexican subjects with asthma
    Esteban Gonzalez Burchard
    University of California, San Francisco, 94143 0833, USA
    Am J Respir Crit Care Med 169:386-92. 2004
    ..We conclude that Puerto Ricans with asthma respond less to albuterol than do Mexicans with asthma. These findings underscore the need for additional research on racial/ethnic differences in asthma morbidity and response to therapy...
  23. ncbi Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma
    Douglas A Kuperman
    Lung Biology Center, Department of Medicine and Cardiovascular Research Institute, University of California San Francisco School of Medicine, San Francisco, California, USA
    Nat Med 8:885-9. 2002
    ..These results demonstrate the importance of direct effects of IL-13 on epithelial cells in causing two central features of asthma...
  24. pmc The integrin alpha(v)beta8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-beta1
    Dezhi Mu
    Department of Pathology, University of California at San Francisco Mt Zion Cancer Center, San Francisco, CA 94143, USA
    J Cell Biol 157:493-507. 2002
    ..These data elucidate a novel mechanism of cellular homeostasis achieved through the coordination of the activities of members of three major gene families involved in cell-matrix interactions...
  25. ncbi Mice lacking the integrin beta5 subunit have accelerated osteoclast maturation and increased activity in the estrogen-deficient state
    Nancy E Lane
    Department of Medicine, University of California at San Francisco, San Francisco, California 94143, USA
    J Bone Miner Res 20:58-66. 2005
    ..These preliminary data suggest alphavbeta5 integrin's presence on osteoclast precursors may inhibit of osteoclast formation...
  26. pmc Integrin alphavbeta5 regulates lung vascular permeability and pulmonary endothelial barrier function
    George Su
    Lung Biology Center, Division of Pulmonary and Critical Care Medicine, Laboratory of Surgical Research, Department of Anesthesia, and Cardiovascular Research Institute, University of California, San Francisco, California 94158, USA
    Am J Respir Cell Mol Biol 36:377-86. 2007
    ..These results identify integrin alphavbeta5 as a central regulator of increased pulmonary vascular permeability and a potentially attractive therapeutic target in ALI...
  27. ncbi Integrin alpha9beta1 directly binds to vascular endothelial growth factor (VEGF)-A and contributes to VEGF-A-induced angiogenesis
    Nicholas E Vlahakis
    Lung Biology Center, University of California, San Francisco, California 94143 2922, USA
    J Biol Chem 282:15187-96. 2007
    ....
  28. pmc ADAM33 is not essential for growth and development and does not modulate allergic asthma in mice
    Chun Chen
    Lung Biology Center, University of California San Francisco, Box 2922, San Francisco, CA 94143 2922, USA
    Mol Cell Biol 26:6950-6. 2006
    ..Our results demonstrate that ADAM33 is not essential for growth or reproduction in the mouse and does not modulate baseline or allergen-induced airway responsiveness...
  29. ncbi Transforming growth factor-beta1 decreases expression of the epithelial sodium channel alphaENaC and alveolar epithelial vectorial sodium and fluid transport via an ERK1/2-dependent mechanism
    James Frank
    Laboratory of Surgical Research, Cardiovascular Research Institute, Lung Biology Center, Departments of Anesthesia, Surgery, and Medicine, University of California, San Francisco, California 94110, USA
    J Biol Chem 278:43939-50. 2003
    ..This reduction in sodium and fluid transport is attributable in large part to a reduction in apical membrane alphaENaC expression mediated through an ERK1/2-dependent inhibition of the alphaENaC promoter activity...
  30. pmc Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix
    Kevin K Kim
    Department of Medicine and Cardiovascular Research Institute, University of California, San Francisco, 94143, USA
    Proc Natl Acad Sci U S A 103:13180-5. 2006
    ..These data reveal alveolar epithelial cells as progenitors for fibroblasts in vivo and implicate the provisional extracellular matrix as a key regulator of epithelial transdifferentiation during fibrogenesis...
  31. pmc Activation of transforming growth factor-beta by the integrin alphavbeta8 delays epithelial wound closure
    Claus Neurohr
    Department of Medicine, Lung Biology Center, University of California, San Francisco, 94143 2922, USA
    Am J Respir Cell Mol Biol 35:252-9. 2006
    ..Wounding induced activation of TGF-beta through effects of both integrins, but antibodies against alphavbeta8 enhanced the degree of wound closure, whereas antibodies against alphavbeta6 did not...
  32. pmc Mfge8 is critical for mammary gland remodeling during involution
    Kamran Atabai
    Lung Biology Center, Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143, USA
    Mol Biol Cell 16:5528-37. 2005
    ..These data demonstrate that Mfge8 regulates the clearance of apoptotic epithelial cells during mammary gland involution and that the absence of Mfge8 leads to inflammation and abnormal mammary gland remodeling...
  33. pmc Squamous metaplasia amplifies pathologic epithelial-mesenchymal interactions in COPD patients
    Jun Araya
    Department of Pathology, Lung Biology Center, UCSF, San Francisco, California 94110, USA
    J Clin Invest 117:3551-62. 2007
    ..Our findings have identified TGF-beta as a potential therapeutic target for COPD...
  34. ncbi Identification and molecular characterization of multiple phenotypes in integrin knockout mice
    Chun Chen
    Lung Biology Center, Department of Medicine, University of California, San Francisco, San Francisco, California, USA
    Methods Enzymol 426:291-305. 2007
    ..In this article, we review approaches that can contribute to optimal use of this valuable resource...
  35. pmc Loss of integrin alpha(v)beta8 on dendritic cells causes autoimmunity and colitis in mice
    Mark A Travis
    Lung Biology Center, Department of Medicine, University of California San Francisco, 1550 4th Street, Room 545, San Francisco, California 94158, USA
    Nature 449:361-5. 2007
    ....
  36. ncbi The Integrin alpha9beta1 contributes to granulopoiesis by enhancing granulocyte colony-stimulating factor receptor signaling
    Chun Chen
    Lung Biology Center, Department of Medicine, University of California, San Francisco, San Francisco, California 94158, USA
    Immunity 25:895-906. 2006
    ....
  37. pmc The alpha9beta1 integrin enhances cell migration by polyamine-mediated modulation of an inward-rectifier potassium channel
    Gregory W DeHart
    Lung Biology Center, Department of Medicine, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 105:7188-93. 2008
    ..These results identify a pathway through which the alpha9 integrin subunit stimulates cell migration by localized polyamine catabolism and modulation of Kir channel function...
  38. pmc Differential enzymatic activity of common haplotypic versions of the human acidic Mammalian chitinase protein
    Max A Seibold
    Department of Medicine, Howard Hughes Medical Institute, University of California, San Francisco, California 94143, USA
    J Biol Chem 284:19650-8. 2009
    ..The structural, kinetic, and genetic data regarding the AMCase isoforms are consistent with the Th2-priming effects of environmental chitin and a role for AMCase in negatively regulating this stimulus...
  39. ncbi Population stratification confounds genetic association studies among Latinos
    Shweta Choudhry
    University of California, San Francisco, 94143 0833, USA
    Hum Genet 118:652-64. 2006
    ..Our findings suggest that empirical assessment of the effects of stratification is critical to appropriately interpret the results of case-control studies in admixed populations...
  40. pmc Mfge8 diminishes the severity of tissue fibrosis in mice by binding and targeting collagen for uptake by macrophages
    Kamran Atabai
    Lung Biology Center, Cardiovascular Research Institute, UCSF, San Francisco, California, USA
    J Clin Invest 119:3713-22. 2009
    ..These data demonstrate a critical role for Mfge8 in decreasing the severity of murine tissue fibrosis by facilitating the removal of accumulated collagen...