Research Topics
| J A ShepherdSummaryAffiliation: University of California Country: USA Publications
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Publications
Cross-calibration and minimum precision standards for dual-energy X-ray absorptiometry: the 2005 ISCD Official PositionsJohn A Shepherd
Department of Radiology, University of California, San Francisco, CA 94143 0946, USA
J Clin Densitom 9:31-6. 2006..We present here the ISCD Official Positions on these topics that were established as a result of the 2005 PDC, together with the associated rationales and supportive evidence...
Does standardized BMD still remove differences between Hologic and GE-Lunar state-of-the-art DXA systems?B Fan
Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA
Osteoporos Int 21:1227-36. 2010..Spine L1-L4 and L2-L4 sBMD mean differences between the two systems were 0.042 g/cm(2) (4.1%) and 0.035 g/cm(2) (3.2%), respectively...
Optimal monitoring time interval between DXA measures in childrenJohn A Shepherd
Department of Radiology, Bone and Breast Density Research Group, University of California, San Francisco, San Francisco, CA, USA
J Bone Miner Res 26:2745-52. 2011..MTI was neither useful nor stable in late adolescence and young adulthood. Alternative criteria to determine scan intervals must be used in this age range...
Breast density assessment in adolescent girls using dual-energy X-ray absorptiometry: a feasibility studyJohn A Shepherd
Musuloskeletal and Quantitative Imaging Research Group, Department of Radiology, University of California at San Francisco, San Francisco, CA 94143 0946, USA
Cancer Epidemiol Biomarkers Prev 17:1709-13. 2008..4% and 16.6 cm(3)). These pilot data indicate that dedicated DXA breast scans may be useful in studies exploring breast density in girls...
Comparison of BMD precision for Prodigy and Delphi spine and femur scansJ A Shepherd
Department of Radiology, University of California, 185 Berry Street, STE 350, San Francisco, CA 94143 0946, USA
Osteoporos Int 17:1303-8. 2006..Minimization and characterization of these errors is essential for reliable assessment of BMD change over time...
Metacarpal index and bone mineral density in healthy African-American womenJ A Shepherd
Department of Radiology, University of California, San Francisco, 185 Berry Street, Suite 350, San Francisco, CA 94107 0946, USA
Osteoporos Int 16:1621-6. 2005..The differences were found to be entirely due to larger bone size, cortical diameter and bone width in the African-American women...
Novel use of single X-ray absorptiometry for measuring breast densityJohn A Shepherd
Musuloskeletal and Quantitative Imaging Research Group, Department of Radiology, University of California, San Francisco, CA 94143, USA
Technol Cancer Res Treat 4:173-82. 2005..Using phantoms, BD(SXA) has been shown to have a long-term repeatability of better than 2% for a breast composition range of 0 to 100% fibroglandular density...
Improved precision with Hologic Apex softwareB Fan
Department of Radiology, University of California, 185 Berry Street, Suite 350, San Francisco, CA 94107, USA
Osteoporos Int 19:1597-602. 2008..2 software and is comparable to GE Lunar Prodigy v7.5 software. Apex and Delphi precisions were, respectively, 1.0% vs. 1.2% (L1-L4 spine), 1.l % vs. 1.3% (total femur), 1.6% vs. 1.9% (femoral neck), and 0.7% vs. 0.9% (dual total femur)...
Evaluation of a gel-coupled quantitative ultrasound device for bone status assessmentC F Njeh
Osteoporosis and Arthritis Research Group, Department of Radiology, University of California San Francisco, 94143-1349, USA
J Ultrasound Med 20:1219-28. 2001....
Towards standardization of dual X-ray absorptiometry (DXA) at the forearm: a common region of interest (ROI) improves the comparability among DXA devicesS Prevrhal
Department of Radiology, University of California, San Francisco, California, USA
Calcif Tissue Int 76:348-54. 2005..ROI standardization dramatically improves interdevice comparability...
Clinical comparison of a novel breast DXA technique to mammographic densityJohn A Shepherd
Musculoskeletal and Quantitative Imaging Research Group, Department of Radiology, University of California, San Francisco, California 94143, USA
Med Phys 33:1490-8. 2006..We conclude that breast composition can be precisely evaluated and assessed with clinical DXA densitometers at a lower dose than with mammographic breast density methods...
Compositional breast imaging using a dual-energy mammography protocolAurelie D Laidevant
Department of Radiology and Biomedical Imaging, University of California, San Francisco, California 94143, USA
Med Phys 37:164-74. 2010..This article describes a novel approach to dual-energy mammography, full-field digital compositional mammography (FFDCM), which can independently image the three compositional components of breast tissue: water, lipid, and protein...
Vertebral fractures in osteoporosis: a new method for clinical assessmentH K Genant
Osteoporosis and Arthritis Research Group, Department of Radiology, University of California, San Francisco, CA 94143 0628, USA
J Clin Densitom 3:281-90. 2000..We also review clinical data supporting the feasibility of visual evaluation of lateral spine images obtained using a fan-beam DXA system, and discuss the potential positive impact of this new methodology on clinical patient evaluation...
Does osteoporosis classification using heel BMD agree across manufacturers?M Grigorian
Osteoporosis and Arthritis Research Group, Department of Radiology, University of California at San Francisco, San Francisco, CA, USA
Osteoporos Int 13:613-7. 2002..We found that PIXI and Apollo are highly correlated. Differences in BMD values are mainly due to different region of interest (ROI) definitions and additional T-score disagreement reflects the difference in normative databases...
Dual-energy and low-kVp CT in the abdomenBenjamin M Yeh
Department of Radiology and Biomedical Imaging, University of California, San Francisco, Box 0628, M 372, 505 Parnassus Ave, San Francisco, CA 94143 0628, USA
AJR Am J Roentgenol 193:47-54. 2009..Further clinical research and technique refinement will be needed as the usage of these exciting technologies spreads...
Single x-ray absorptiometry method for the quantitative mammographic measure of fibroglandular tissue volumeSerghei Malkov
Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California 94143, USA
Med Phys 36:5525-36. 2009....
Measurement of breast density with dual X-ray absorptiometry: feasibilityJohn A Shepherd
Department of Radiology, Osteoporosis and Arthritis Research Group, University of California at San Francisco, 94143, USA
Radiology 223:554-7. 2002..998) and with density at mammography (r(adjusted) = 0.83). DXA precision (SD) was 0.5% without and 1.1% with breast repositioning. DXA devices can be used to accurately and precisely estimate breast tissue density...
A generalized least significant change for individuals measured on different DXA systemsJohn A Shepherd
Department of Radiology, University of California, San Francisco, CA 94143 0946, USA
J Clin Densitom 10:249-58. 2007..We conclude that the GLSC, defined using commonly used clinical cross-calibration and precision assessments, is the most accurate method to compare scans between dual-energy X-ray absorptiometry systems...
Comparing BMD results between two similar DXA systems using the generalized least significant changeJohn A Shepherd
Department of Radiology, University of California at San Francisco, San Francisco, CA 94143 0946, USA
J Clin Densitom 11:237-42. 2008..A revision of the International Society for Clinical Densitometry's policies for comparing scans from systems of the same technology may be appropriate...
Dual-energy X-ray absorptiometry with serum ferritin predicts liver iron concentration and changes in concentration better than ferritin aloneJohn A Shepherd
Department of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, CA 94115, USA
J Clin Densitom 13:399-406. 2010....
Comparison of DXA hip structural analysis with volumetric QCTSven Prevrhal
Department of Radiology, UCSF, San Francisco, CA 94107, USA
J Clin Densitom 11:232-6. 2008..5 for CSMI) and standard DXA at the neck (r2=0.82 for BMD). HSA and volumetric QCT compared favorably, which supports the validity of a projective technique such as DXA to derive geometrical properties of the proximal hip...
Universal standardization of forearm bone densitometryJohn A Shepherd
Department of Radiology, University of California San Francisco, 94143-1349, USA
J Bone Miner Res 17:734-45. 2002....
Accuracy of CT-based thickness measurement of thin structures: modeling of limited spatial resolution in all three dimensionsSven Prevrhal
Osteoporosis and Arthritis Research Group, Department of Radiology, University of California-San Francisco, San Francisco, California 94117, USA
Med Phys 30:1-8. 2003....
Accuracy of mammographic breast density analysis: results of formal operator trainingSven Prevrhal
Department of Radiology, University of California, San Francisco, California 94143-1250, USA
Cancer Epidemiol Biomarkers Prev 11:1389-93. 2002....
T-scores and Z-scoresJohn A Shepherd
Department of Radiology, University of California, San Francisco, CA, USA
J Clin Densitom 10:349-50. 2007
Computer-assisted technique to delineate osteolytic lesions around the femoral component in total hip arthroplastySven Prevrhal
Department of Radiology, University of California, San Francisco, California 94107, USA
J Arthroplasty 23:833-8. 2008..2% to 4.8%. The new technique compares favorably to precision of qualitative visual assessment and permits more accurate detection and quantitation of osteolytic lesions...
Growth and metabolic consequences of bladder augmentation in children with myelomeningocele and bladder exstrophyGerald C Mingin
Department of Urology, University of California, San Francisco, Children's Hospital, San Francisco, California 94143-0738, USA
Pediatrics 110:1193-8. 2002..CONCLUSION: Bladder augmentation is safe and does not impact negatively on the linear growth or bone densities of patients with myelomeningocele or bladder exstrophy...
The bone mineral density in childhood study: bone mineral content and density according to age, sex, and raceHeidi J Kalkwarf
Division of General and Community Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
J Clin Endocrinol Metab 92:2087-99. 2007..Low bone mass may increase risk of fracture. Several chronic medical conditions, medications, and lifestyle factors affect bone mineral accrual. Appropriate reference values are essential for identification of children with bone deficits...
Peripheral dual-energy X-ray absorptiometry in the management of osteoporosis: the 2007 ISCD Official PositionsDidier B Hans
Geneva University Hospital, Geneva, Switzerland
J Clin Densitom 11:188-206. 2008....
Osteoporosis assessment by whole body region vs. site-specific DXAL Joseph Melton
Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First Street S.W, Rochester, MN 55905, USA
Osteoporos Int 16:1558-64. 2005....
Recalculation of the NHANES database SD improves T-score agreement and reduces osteoporosis prevalenceNeil Binkley
University of Wisconsin Osteoporosis Clinical Center and Research Program, Madison, Wisconsin, USA
J Bone Miner Res 20:195-201. 2005..Use of a recalculated young-normal SD for the GE Lunar-adjusted NHANES III database improved diagnostic agreement and is recommended...
Effect of random BMD measurement errors on diagnostic classification using T-scoresGlen M Blake
J Clin Densitom 10:415-7; author reply 417-8. 2007
Official positions of the international society for clinical densitometryE Michael Lewiecki
New Mexico Clinical Research and Osteoporosis Center, Albuquerque, New Mexico 87106, USA
J Clin Endocrinol Metab 89:3651-5. 2004..Recommendations that are accepted become the Official Positions of the ISCD. This Special Report summarizes the methodology of the ISCD Position Development Conferences and presents selected Official Positions of general interest...
