Paul Shepard

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. ncbi request reprint Micromolar brain levels of kynurenic acid are associated with a disruption of auditory sensory gating in the rat
    Paul D Shepard
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, PO Box 21247, Baltimore, MD 21228, USA
    Neuropsychopharmacology 28:1454-62. 2003
  2. pmc Ether-a-go-go-related gene potassium channels: what's all the buzz about?
    Paul D Shepard
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    Schizophr Bull 33:1263-9. 2007
  3. pmc Schizophrenia in translation: the presence of absence: habenular regulation of dopamine neurons and the encoding of negative outcomes
    Paul D Shepard
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, USA
    Schizophr Bull 32:417-21. 2006
  4. ncbi request reprint Prenatal exposure to a repeated variable stress paradigm elicits behavioral and neuroendocrinological changes in the adult offspring: potential relevance to schizophrenia
    James I Koenig
    Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, P O Box 21247, Baltimore, MD 21228, USA
    Behav Brain Res 156:251-61. 2005
  5. ncbi request reprint Beta (~16 Hz) frequency neural oscillations mediate auditory sensory gating in humans
    L Elliot Hong
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    Psychophysiology 45:197-204. 2008
  6. ncbi request reprint Effects of acute and chronic clozapine on D-amphetamine-induced disruption of auditory gating in the rat
    Brian Joy
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, P O Box 21247, Baltimore, MD 21228, USA
    Psychopharmacology (Berl) 174:274-82. 2004
  7. ncbi request reprint Regional distribution of SK3 mRNA-containing neurons in the adult and adolescent rat ventral midbrain and their relationship to dopamine-containing cells
    Deepak Sarpal
    Maryland Psychiatric Research Center, Department of Psychiatry and Program in Neuroscience, University of Maryland School of Medicine, Baltimore 21228, USA
    Synapse 53:104-13. 2004
  8. ncbi request reprint Lateral habenula stimulation inhibits rat midbrain dopamine neurons through a GABA(A) receptor-mediated mechanism
    Huifang Ji
    Maryland Psychiatric Research Center and Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland 21228, USA
    J Neurosci 27:6923-30. 2007
  9. ncbi request reprint Cortical spreading depression augments kynurenate levels and reduces malonate toxicity in the rat cortex
    Csaba Kiss
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, PO Box 21247, Baltimore, MD 21228, USA
    Brain Res 1002:129-35. 2004
  10. doi request reprint Tuning the excitability of midbrain dopamine neurons by modulating the Ca2+ sensitivity of SK channels
    Huifang Ji
    Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    Eur J Neurosci 29:1883-95. 2009

Research Grants

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Micromolar brain levels of kynurenic acid are associated with a disruption of auditory sensory gating in the rat
    Paul D Shepard
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, PO Box 21247, Baltimore, MD 21228, USA
    Neuropsychopharmacology 28:1454-62. 2003
    ..These observations indicate that the disruption in auditory processing in rats with greatly elevated KYNA levels is not attributable to the compound's antagonist actions at the glycine(B) receptor...
  2. pmc Ether-a-go-go-related gene potassium channels: what's all the buzz about?
    Paul D Shepard
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    Schizophr Bull 33:1263-9. 2007
    ..This change in excitability would be expected to alter dopamine release. Therefore, the therapeutic action of antipsychotic drugs may depend on inhibition of both postsynaptic dopamine receptors and presynaptic ERG K(+) channels...
  3. pmc Schizophrenia in translation: the presence of absence: habenular regulation of dopamine neurons and the encoding of negative outcomes
    Paul D Shepard
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, USA
    Schizophr Bull 32:417-21. 2006
    ..Collectively, these data suggest that the habenula may play a critical role in mediating the feedback-processing deficits of schizophrenia...
  4. ncbi request reprint Prenatal exposure to a repeated variable stress paradigm elicits behavioral and neuroendocrinological changes in the adult offspring: potential relevance to schizophrenia
    James I Koenig
    Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, P O Box 21247, Baltimore, MD 21228, USA
    Behav Brain Res 156:251-61. 2005
    ..Interestingly, the behaviors that are altered have been used to validate animal models of schizophrenia and therefore, suggest that this preparation may be useful to learn more about some aspects of the pathophysiology of schizophrenia...
  5. ncbi request reprint Beta (~16 Hz) frequency neural oscillations mediate auditory sensory gating in humans
    L Elliot Hong
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    Psychophysiology 45:197-204. 2008
    ..The results suggested that beta oscillation indexed a neural process associated with the strength of sensory gating...
  6. ncbi request reprint Effects of acute and chronic clozapine on D-amphetamine-induced disruption of auditory gating in the rat
    Brian Joy
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, P O Box 21247, Baltimore, MD 21228, USA
    Psychopharmacology (Berl) 174:274-82. 2004
    ..The atypical antipsychotic drug clozapine (CLOZ) reverses the disruption of auditory gating in schizophrenic patients. However, its effects on psychostimulant-induced deficits in animals have yet to be assessed...
  7. ncbi request reprint Regional distribution of SK3 mRNA-containing neurons in the adult and adolescent rat ventral midbrain and their relationship to dopamine-containing cells
    Deepak Sarpal
    Maryland Psychiatric Research Center, Department of Psychiatry and Program in Neuroscience, University of Maryland School of Medicine, Baltimore 21228, USA
    Synapse 53:104-13. 2004
    ....
  8. ncbi request reprint Lateral habenula stimulation inhibits rat midbrain dopamine neurons through a GABA(A) receptor-mediated mechanism
    Huifang Ji
    Maryland Psychiatric Research Center and Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland 21228, USA
    J Neurosci 27:6923-30. 2007
    ..The habenulomesencephalic pathway, which is capable of transiently suppressing the activity of dopamine neurons at a population level, may represent an important component of the circuitry involved in encoding reward expectancy...
  9. ncbi request reprint Cortical spreading depression augments kynurenate levels and reduces malonate toxicity in the rat cortex
    Csaba Kiss
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, PO Box 21247, Baltimore, MD 21228, USA
    Brain Res 1002:129-35. 2004
    ..Taken together, these findings indicate that the observed increase in brain KYNA is not responsible for CSD-induced tolerance to malonate-induced neuronal damage...
  10. doi request reprint Tuning the excitability of midbrain dopamine neurons by modulating the Ca2+ sensitivity of SK channels
    Huifang Ji
    Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    Eur J Neurosci 29:1883-95. 2009
    ....
  11. pmc Editorial--modeling negative symptoms: what's missing?
    Paul D Shepard
    Schizophr Bull 32:403-4. 2006
  12. ncbi request reprint Computational model predicts a role for ERG current in repolarizing plateau potentials in dopamine neurons: implications for modulation of neuronal activity
    Carmen C Canavier
    Neuroscience Center, Louisiana State University Health Sciences Center, New Orleans 70112, USA
    J Neurophysiol 98:3006-22. 2007
    ..This study suggests that the ERG current may play a role in burst termination and the relief of depolarization block in vivo...

Research Grants8

  1. CNS DA NEURONS--CELLULAR BASIS OF PATTERNED ACTIVITY
    Paul Shepard; Fiscal Year: 2002
    ..abstract_text> ..
  2. Dopamine cell impulse flow, reward and schizophrenia
    Paul Shepard; Fiscal Year: 2007
    ..abstract_text> ..
  3. Dopamine cell impulse flow, reward and schizophrenia
    Paul Shepard; Fiscal Year: 2007
    ..abstract_text> ..