Bruce J Shenker

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi Mercury-induced apoptosis in human lymphocytes: caspase activation is linked to redox status
    Bruce J Shenker
    Department of Pathology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA 19104 6002, USA
    Antioxid Redox Signal 4:379-89. 2002
  2. ncbi Inhibition of mast cell degranulation by a chimeric toxin containing a novel phosphatidylinositol-3,4,5-triphosphate phosphatase
    Bruce J Shenker
    Department of Pathology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA 19104 6030, USA
    Mol Immunol 48:203-10. 2010
  3. ncbi A novel mode of action for a microbial-derived immunotoxin: the cytolethal distending toxin subunit B exhibits phosphatidylinositol 3,4,5-triphosphate phosphatase activity
    Bruce J Shenker
    Department of Pathology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA 19104, USA
    J Immunol 178:5099-108. 2007
  4. ncbi Exposure of lymphocytes to high doses of Actinobacillus actinomycetemcomitans cytolethal distending toxin induces rapid onset of apoptosis-mediated DNA fragmentation
    Bruce J Shenker
    Department of Pathology, University of Pennsylvania School of Dental Medicine, 240 South 40th Street, Philadelphia, PA 19104 2030, USA
    Infect Immun 74:2080-92. 2006
  5. ncbi Cytolethal distending toxin-induced cell cycle arrest of lymphocytes is dependent upon recognition and binding to cholesterol
    Kathleen Boesze-Battaglia
    Departments of Biochemistry and Pathology, University of Pennsylvania School of Dental Medicine, Pennsylvania 19104 6030, USA
    J Biol Chem 284:10650-8. 2009
  6. ncbi Induction of cell cycle arrest in lymphocytes by Actinobacillus actinomycetemcomitans cytolethal distending toxin requires three subunits for maximum activity
    Bruce J Shenker
    Department of Pathology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA 19104, USA
    J Immunol 174:2228-34. 2005
  7. ncbi Cholesterol-rich membrane microdomains mediate cell cycle arrest induced by Actinobacillus actinomycetemcomitans cytolethal-distending toxin
    Kathleen Boesze-Battaglia
    Department of Biochemistry, University of Pennsylvania School of Dental Medicine, Philadelphia, PA, USA
    Cell Microbiol 8:823-36. 2006
  8. ncbi Actinobacillus actinomycetemcomitans cytolethal distending toxin (Cdt): evidence that the holotoxin is composed of three subunits: CdtA, CdtB, and CdtC
    Bruce J Shenker
    Department of Pathology, University of Pennsylvania School of Dental Medicine, 240 South 40th Street, Philadelphia, PA 19104 6030, USA
    J Immunol 172:410-7. 2004
  9. ncbi PIP3 regulation as promising targeted therapy of mast-cell-mediated diseases
    Bruce J Shenker
    Department of Pathology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA 19104 6030, USA
    Curr Pharm Des 17:3815-22. 2011
  10. ncbi Immune function effects of dental amalgam in children: a randomized clinical trial
    Bruce J Shenker
    Department of Pathology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Am Dent Assoc 139:1496-505. 2008

Collaborators

Detail Information

Publications10

  1. ncbi Mercury-induced apoptosis in human lymphocytes: caspase activation is linked to redox status
    Bruce J Shenker
    Department of Pathology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA 19104 6002, USA
    Antioxid Redox Signal 4:379-89. 2002
    ..Additonally, mercury acts as a genotoxin significantly altering the expression of genes that affect cell survival and apoptosis...
  2. ncbi Inhibition of mast cell degranulation by a chimeric toxin containing a novel phosphatidylinositol-3,4,5-triphosphate phosphatase
    Bruce J Shenker
    Department of Pathology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA 19104 6030, USA
    Mol Immunol 48:203-10. 2010
    ..Moreover, these studies provide evidence for the utilization of CdtB as a novel therapeutic agent for targeting the PI-3K signaling pathway...
  3. ncbi A novel mode of action for a microbial-derived immunotoxin: the cytolethal distending toxin subunit B exhibits phosphatidylinositol 3,4,5-triphosphate phosphatase activity
    Bruce J Shenker
    Department of Pathology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA 19104, USA
    J Immunol 178:5099-108. 2007
    ..Collectively, these studies show that the CdtB not only exhibits PI-3,4,5-P(3) phosphatase activity, but also that toxicity in lymphocytes is related to this activity...
  4. ncbi Exposure of lymphocytes to high doses of Actinobacillus actinomycetemcomitans cytolethal distending toxin induces rapid onset of apoptosis-mediated DNA fragmentation
    Bruce J Shenker
    Department of Pathology, University of Pennsylvania School of Dental Medicine, 240 South 40th Street, Philadelphia, PA 19104 2030, USA
    Infect Immun 74:2080-92. 2006
    ..However, the cells retained the ability to undergo G2 arrest in the presence of the toxin. Thus, it appears that high doses of Cdt induce rapid onset of DNA degradation resulting from activation of the apoptotic cascade...
  5. ncbi Cytolethal distending toxin-induced cell cycle arrest of lymphocytes is dependent upon recognition and binding to cholesterol
    Kathleen Boesze-Battaglia
    Departments of Biochemistry and Pathology, University of Pennsylvania School of Dental Medicine, Pennsylvania 19104 6030, USA
    J Biol Chem 284:10650-8. 2009
    ..Collectively, these observations indicate that membrane cholesterol serves as an essential ligand for Cdt and that this association can be blocked by either depleting membranes of cholesterol or mutation of the CRAC site...
  6. ncbi Induction of cell cycle arrest in lymphocytes by Actinobacillus actinomycetemcomitans cytolethal distending toxin requires three subunits for maximum activity
    Bruce J Shenker
    Department of Pathology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA 19104, USA
    J Immunol 174:2228-34. 2005
    ..The implications of our results with respect to the function and structure of the Cdt holotoxin are discussed...
  7. ncbi Cholesterol-rich membrane microdomains mediate cell cycle arrest induced by Actinobacillus actinomycetemcomitans cytolethal-distending toxin
    Kathleen Boesze-Battaglia
    Department of Biochemistry, University of Pennsylvania School of Dental Medicine, Philadelphia, PA, USA
    Cell Microbiol 8:823-36. 2006
    ..Thus, lipid raft integrity is vital to the action of Cdt on host cells. The implications of our observations with respect to Cdt mode of action are discussed...
  8. ncbi Actinobacillus actinomycetemcomitans cytolethal distending toxin (Cdt): evidence that the holotoxin is composed of three subunits: CdtA, CdtB, and CdtC
    Bruce J Shenker
    Department of Pathology, University of Pennsylvania School of Dental Medicine, 240 South 40th Street, Philadelphia, PA 19104 6030, USA
    J Immunol 172:410-7. 2004
    ..These studies suggest that the active Cdt holotoxin is a heterotrimer composed of truncated CdtA, CdtB, and CdtC, and all three peptides appear to associate with lymphocytes...
  9. ncbi PIP3 regulation as promising targeted therapy of mast-cell-mediated diseases
    Bruce J Shenker
    Department of Pathology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA 19104 6030, USA
    Curr Pharm Des 17:3815-22. 2011
    ....
  10. ncbi Immune function effects of dental amalgam in children: a randomized clinical trial
    Bruce J Shenker
    Department of Pathology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Am Dent Assoc 139:1496-505. 2008
    ..The objective of this study was to evaluate a subpopulation of the participants in the New England Children's Amalgam Trial for in vitro manifestations of immunotoxic effects of dental amalgam...