Shaohu Sheng

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. request reprint
    Sheng S, Perry C, Kashlan O, Kleyman T. Side chain orientation of residues lining the selectivity filter of epithelial Na+ channels. J Biol Chem. 2005;280:8513-22 pubmed
    ....
  2. request reprint
    Sheng S, Maarouf A, Bruns J, Hughey R, Kleyman T. Functional role of extracellular loop cysteine residues of the epithelial Na+ channel in Na+ self-inhibition. J Biol Chem. 2007;282:20180-90 pubmed
    ....
  3. request reprint
    Sheng S, Bruns J, Kleyman T. Extracellular histidine residues crucial for Na+ self-inhibition of epithelial Na+ channels. J Biol Chem. 2004;279:9743-9 pubmed
    ..These results suggest that these two histidine residues within the extracellular loops are crucial structural determinants for Na(+) self-inhibition. ..
  4. Ray E, Chen J, Kelly T, He J, Hamm L, Gu D, et al. Human epithelial Na+ channel missense variants identified in the GenSalt study alter channel activity. Am J Physiol Renal Physiol. 2016;311:F908-F914 pubmed publisher
    ..This study identifies novel functional human ENaC variants and demonstrates that some variants alter channel cell surface expression and/or Na+ self-inhibition. ..
  5. Agrawal P, Wang R, Li H, Schmitz Abe K, Simone Roach C, Chen J, et al. The Epithelial Sodium Channel Is a Modifier of the Long-Term Nonprogressive Phenotype Associated with F508del CFTR Mutations. Am J Respir Cell Mol Biol. 2017;57:711-720 pubmed publisher
    ..Our data suggest a potential role for δ-ENaC in controlling sodium reabsorption in the airways, and advance the plausibility of ENaC as a therapeutic target in CF. ..

Locale

Detail Information

Publications5

  1. request reprint
    Sheng S, Perry C, Kashlan O, Kleyman T. Side chain orientation of residues lining the selectivity filter of epithelial Na+ channels. J Biol Chem. 2005;280:8513-22 pubmed
    ....
  2. request reprint
    Sheng S, Maarouf A, Bruns J, Hughey R, Kleyman T. Functional role of extracellular loop cysteine residues of the epithelial Na+ channel in Na+ self-inhibition. J Biol Chem. 2007;282:20180-90 pubmed
    ....
  3. request reprint
    Sheng S, Bruns J, Kleyman T. Extracellular histidine residues crucial for Na+ self-inhibition of epithelial Na+ channels. J Biol Chem. 2004;279:9743-9 pubmed
    ..These results suggest that these two histidine residues within the extracellular loops are crucial structural determinants for Na(+) self-inhibition. ..
  4. Ray E, Chen J, Kelly T, He J, Hamm L, Gu D, et al. Human epithelial Na+ channel missense variants identified in the GenSalt study alter channel activity. Am J Physiol Renal Physiol. 2016;311:F908-F914 pubmed publisher
    ..This study identifies novel functional human ENaC variants and demonstrates that some variants alter channel cell surface expression and/or Na+ self-inhibition. ..
  5. Agrawal P, Wang R, Li H, Schmitz Abe K, Simone Roach C, Chen J, et al. The Epithelial Sodium Channel Is a Modifier of the Long-Term Nonprogressive Phenotype Associated with F508del CFTR Mutations. Am J Respir Cell Mol Biol. 2017;57:711-720 pubmed publisher
    ..Our data suggest a potential role for δ-ENaC in controlling sodium reabsorption in the airways, and advance the plausibility of ENaC as a therapeutic target in CF. ..