Research Topics
| Ke ShengSummaryAffiliation: University of Virginia Country: USA Publications
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Detail Information
Publications
3D dose verification using tomotherapy CT detector arrayKe Sheng
Department of Radiation Oncology, University of Virginia, Charlottesville, VA 22908, USA
Int J Radiat Oncol Biol Phys 82:1013-20. 2012..To evaluate a three-dimensional dose verification method based on the exit dose using the onboard detector of tomotherapy...
Intensity-modulated radiation therapy (IMRT) dosimetry of the head and neck: a comparison of treatment plans using linear accelerator-based IMRT and helical tomotherapyKe Sheng
Department of Radiation Oncology, University of Virginia, Charlottesville, VA, USA
Int J Radiat Oncol Biol Phys 65:917-23. 2006..To quantify the dosimetric difference, we compared linac-based and helical tomotherapy-based treatment plans for IMRT of the oropharynx...- A dosimetric comparison of non-coplanar IMRT versus Helical Tomotherapy for nasal cavity and paranasal sinus cancerKe Sheng
Department of Radiation Oncology, University of Virginia, Charlottesville, VA 22908, USA
Radiother Oncol 82:174-8. 2007..HT is capable of delivering highly conformal and uniform target dosimetry. However, HT lacks non-coplanar capability, which is commonly used for linear accelerator-based IMRT for nasal cavity and paranasal sinus tumors... - Is daily CT image guidance necessary for nasal cavity and nasopharyngeal radiotherapy: an investigation based on helical tomotherapyKe Sheng
Department of Radiation Oncology, University of Virginia, Charlottesville, Virginia, USA
J Appl Clin Med Phys 9:2686. 2008..On the other hand, because of the large variance, with low probability, substantial deviation from the original planned dosimetry may occur without IG. Therefore, daily MVCT is preferred as an important safety measure in the IMRT... 
Dynamic MRI of grid-tagged hyperpolarized helium-3 for the assessment of lung motion during breathingJing Cai
Department of Radiation Oncology, University of Virginia, Charlottesville, VA 22908, USA
Int J Radiat Oncol Biol Phys 75:276-84. 2009..To develop a dynamic magnetic resonance imaging (MRI) tagging technique using hyperpolarized helium-3 (HP He-3) to track lung motion...- Tumor cell survival dependence on helical tomotherapy, continuous arc and segmented dose deliveryWensha Yang
Department of Radiation Oncology, University of Virginia, VA, USA
Phys Med Biol 54:6635-43. 2009..The results suggest that continuous dose delivery at a constant dose rate results in superior in vitro tumor cell killing compared with prolonged, segmented or variable dose rate delivery... - A rabbit irradiation platform for outcome assessment of lung stereotactic radiosurgeryJing Cai
Department of Radiation Oncology, University of Virginia, Charlottesville, VA 22908, USA
Int J Radiat Oncol Biol Phys 73:1588-95. 2009.... - Computed tomography-based anatomic assessment overestimates local tumor recurrence in patients with mass-like consolidation after stereotactic body radiotherapy for early-stage non-small cell lung cancerNeal E Dunlap
Department of Radiation Oncology, University of Louisville, Louisville, KY, USA
Int J Radiat Oncol Biol Phys 84:1071-7. 2012..To investigate pulmonary radiologic changes after lung stereotactic body radiotherapy (SBRT), to distinguish between mass-like fibrosis and tumor recurrence... - Reproducibility of interfraction lung motion probability distribution function using dynamic MRI: statistical analysisJing Cai
Department of Radiation Oncology, University of Virginia, Charlottesville, VA 22908, USA
Int J Radiat Oncol Biol Phys 72:1228-35. 2008..To investigate the statistical reproducibility of craniocaudal probability distribution function (PDF) of interfraction lung motion using dynamic magnetic resonance imaging... - Helical tomotherapy planning for lung cancer based on ventilation magnetic resonance imagingJing Cai
Department of Radiation Oncology, University of Virginia, Charlottesville, VA 22908, USA
Med Dosim 36:389-96. 2011..Moderate but statistically significant improvements in sparing functional lungs were achieved using helical tomotherapy plans... - Dose as a function of lung volume and planned treatment volume in helical tomotherapy intensity-modulated radiation therapy-based stereotactic body radiation therapy for small lung tumorsJoseph M Baisden
Department of Radiation Oncology, University of Virginia Health System, Charlottesville, VA 22908, USA
Int J Radiat Oncol Biol Phys 68:1229-37. 2007..The Radiation Therapy Oncology Group (RTOG) 0236 protocol is currently evaluating three-dimensional conformal SBRT that delivers 60 Gy in three fractions... - Estimation of error in maximal intensity projection-based internal target volume of lung tumors: a simulation and comparison study using dynamic magnetic resonance imagingJing Cai
Department of Radiation Oncology, University of Virginia, Charlottesville, VA 22908, USA
Int J Radiat Oncol Biol Phys 69:895-902. 2007..To evaluate the error in four-dimensional computed tomography (4D-CT) maximal intensity projection (MIP)-based lung tumor internal target volume determination using a simulation method based on dynamic magnetic resonance imaging (dMRI)... - Effects of breathing variation on gating window internal target volume in respiratory gated radiation therapyJing Cai
Department of Radiation Oncology, Duke University, Durham, North Carolina 27710, USA
Med Phys 37:3927-34. 2010..To investigate the effects of breathing variation on gating window internal target volume (ITVGW) in respiratory gated radiation therapy... - Helical tomotherapy-based STAT stereotactic body radiation therapy: Dosimetric evaluation for a real-time SBRT treatment planning and delivery programNeal Dunlap
Department of Radiation Oncology, University of Virginia, Charlottesville, 22908, USA
Med Dosim 35:312-9. 2010.... - The effect of respiratory motion variability and tumor size on the accuracy of average intensity projection from four-dimensional computed tomography: an investigation based on dynamic MRIJing Cai
Department of Radiation Oncology, University of Virginia, Charlottesville, Virginia 22908, USA
Med Phys 35:4974-81. 2008..Based on our study, normalized respiratory variability appears to be a pertinent parameter to assess the suitability of a 4D-CT image set for ALP-based treatment planning... - Size matters: a comparison of T1 and T2 peripheral non-small-cell lung cancers treated with stereotactic body radiation therapy (SBRT)Neal E Dunlap
Department of Radiation Oncology, University of Virginia, Charlottesville, VA 22908, USA
J Thorac Cardiovasc Surg 140:583-9. 2010..The purpose of this study was to compare the outcomes and local control rates of patients with peripheral T1 and T2 non-small-cell lung cancer treated with stereotactic body radiation therapy... - A motion phantom study on helical tomotherapy: the dosimetric impacts of delivery technique and motionBrian Kanagaki
Department of Engineering Physics, University of Virginia, Charlottesville, VA 22908, USA
Phys Med Biol 52:243-55. 2007..The lack of adverse synchronization patterns from both results validate that HT is a safe technique for treating moving target and hypofractionation... - Chest wall volume receiving >30 Gy predicts risk of severe pain and/or rib fracture after lung stereotactic body radiotherapyNeal E Dunlap
University of Virginia, Charlottesville, VA 22908, USA
Int J Radiat Oncol Biol Phys 76:796-801. 2010..To identify the dose-volume parameters that predict the risk of chest wall (CW) pain and/or rib fracture after lung stereotactic body radiotherapy... - Helical tomotherapy simultaneous integrated boost provides a dosimetric advantage in the treatment of primary intracranial tumorsJoseph M Baisden
Department of Radiation Oncology, University of Virginia, Charlottesville, VA 22908, USA
Neurol Res 33:820-4. 2011.... - Tracking brain motion during the cardiac cycle using spiral cine-DENSE MRIXiaodong Zhong
Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22908, USA
Med Phys 36:3413-9. 2009..These preliminary results demonstrated that the spiral cine-DENSE MRI technique can be used to measure cardiac-synchronized pulsatile brain motion on the pixel-by-pixel basis with high temporal/spatial resolution and sensitivity... - Evaluation of the reproducibility of lung motion probability distribution function (PDF) using dynamic MRIJing Cai
Department of Radiation Oncology, The University of Virginia, Charlottesville, VA, and Department of Radiology, Children s Hospital of Philadelphia, PA, USA
Phys Med Biol 52:365-73. 2007..As the key component of the PDF-based treatment planning, the reproducibility of the PDF affects the dosimetric accuracy substantially. This study provides a reference for acquiring MR-based PDF of structures in the lung... - Evaluation of thoracic spinal cord motion using dynamic MRIJing Cai
Department of Radiation Oncology, University of Virginia, Charlottesville, VA 22908, USA
Radiother Oncol 84:279-82. 2007..We found that the mean motion range at different thoracic levels is typically within 0.5mm. The good stability makes this an excellent position for stereotactic radiotherapy (SBRT)... - Comparison of Elekta VMAT with helical tomotherapy and fixed field IMRT: plan quality, delivery efficiency and accuracyMin Rao
Department of Radiation Oncology, Swedish Cancer Institute, 1221 Madison St, Seattle, Washington 98104, USA
Med Phys 37:1350-9. 2010..The objective of this study is to compare VMAT to both HT and fixed field IMRT in terms of plan quality, delivery efficiency, and accuracy... - Helical tomotherapy-based STAT RT: Dosimetric evaluation for clinical implementation of a rapid radiation palliation programAlyson McIntosh
Department of Radiation Oncology, University of Virginia, Charlottesville, USA
Med Dosim 35:280-6. 2010..STAT RT facilitates rapid treatment planning and delivery for palliative radiation of patients with metastatic disease, with relative sparing of adjacent OARs compared with standard 3D conformal plans... - Helical TomoTherapy in the treatment of central nervous system metastasisJoseph M Baisden
Department of Radiation Oncology, University of Virginia Health System, Charlottesville, Virginia 22908, USA
Neurosurg Focus 22:E8. 2007..Helical TomoTherapy offers distinct advantages for patients with CNS metastatic disease by sparing normal tissue when intracranial or extracranial disease is targeted... - Feasibility of non-coplanar tomotherapy for lung cancer stereotactic body radiation therapyWensha Yang
Department of Radiation Oncology University of Virginia 1335 Lee Street, Box 800383 Charlottesville, VA 22908, USA
Technol Cancer Res Treat 10:307-15. 2011..Therefore we conclude that non-coplanar HT arcs significantly improve critical organ sparing in lung SBRT without changing the PTV dose coverage... - Semiconductor nanoparticles as energy mediators for photosensitizer-enhanced radiotherapyWensha Yang
Department of Radiation Oncology, University of Virginia, Charlottesville, VA, USA
Int J Radiat Oncol Biol Phys 72:633-5. 2008.... - Direct measurement of lung motion using hyperpolarized helium-3 MR taggingJing Cai
Department of Radiation Oncology, University of Virginia, Charlottesville, VA 22908, USA
Int J Radiat Oncol Biol Phys 68:650-3. 2007..To measure lung motion between end-inhalation and end-exhalation using a hyperpolarized helium-3 (HP (3)He) magnetic resonance (MR) tagging technique... - Tumor cell apoptosis induced by nanoparticle conjugate in combination with radiation therapyLi Wang
Department of Radiation Oncology, University of Virginia, Virginia, USA
Nanotechnology 21:475103. 2010.... - Dosimetric comparison of 6 MV and 15 MV single arc rapidarc to helical TomoTherapy for the treatment of pancreatic cancerJing Cai
Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
Med Dosim 36:317-20. 2011..Dosimetric advantages might be gained by using RA over HT by reducing the dose to OARs and total MUs used for treatment... - Standardized evaluation of simultaneous integrated boost plans on volumetric modulated arc therapyWensha Yang
Department of Radiation Oncology, University of Virginia, VA, USA
Phys Med Biol 56:327-39. 2011..A maximal therapeutic ratio can be achieved with BTV dose 50-100% higher than the PTV dose, depending on the shape and position of the tumor... - The implication of non-cyclic intrafractional longitudinal motion in SBRT by TomoTherapyWensha Yang
Department of Radiation Oncology, University of Virginia, Charlottesville, VA, USA
Phys Med Biol 54:2875-84. 2009..Our studies demonstrate that a small longitudinal motion may cause a dose error that is difficult to compensate; however, dividing a SBRT fraction into smaller passes is helpful to reduce such adverse effects... - Radiation therapy of post-mastectomy patients with positive nodes using fixed beam tomotherapyRyan Jones
Department of Radiation Oncology, University of Virginia, VA, USA
Radiother Oncol 100:247-52. 2011..To develop an optimized dosimetric class solution for post-mastectomy irradiation for fixed beam tomotherapy (FBT)... - Outcomes of patients with head-and-neck cancer of unknown primary origin treated with intensity-modulated radiotherapyAsal Shoushtari
Department of Radiation Oncology, University of Virginia, Charlottesville, VA 22908, USA
Int J Radiat Oncol Biol Phys 81:e83-91. 2011..To analyze survival, failure patterns, and toxicity in patients with head-and-neck carcinoma of unknown primary origin (HNCUP) treated with intensity-modulated radiotherapy (IMRT)... - Imaging dose management using multi-resolution in CT-guided radiation therapyKe Sheng
Radiation Oncology Department, University of Virginia, VA, USA
Phys Med Biol 50:1205-19. 2005..Compared with extrapolation methods, errors are further reduced to improve the detection of low contrast and fine structures... - Dose as a function of liver volume and planning target volume in helical tomotherapy, intensity-modulated radiation therapy-based stereotactic body radiation therapy for hepatic metastasisJoseph M Baisden
Department of Radiation Oncology, Medical School, University of Virginia Health System, Charlottesville, VA 22908, USA
Int J Radiat Oncol Biol Phys 66:620-5. 2006..CONCLUSIONS: These data provide a framework for predicting the likely MTD for patients considered for Helical TomoTherapy liver SBRT... - Use of megavoltage computed tomography with image registration for high-dose rate treatment planning of an oral tongue cancer using a custom oral mold applicator with embedded lead shieldingBruce Libby
Department of Radiation Oncology, University of Virginia, Charlottesville, VA 22908, USA
Brachytherapy 10:340-4. 2011.... - Evaluation of coplanar partial left breast irradiation using tomotherapy-based topotherapyAlyson McIntosh
Department of Radiation Oncology, University of Virginia, Charlottesville, VA 22908, USA
Int J Radiat Oncol Biol Phys 71:603-10. 2008.... - A computer simulated phantom study of tomotherapy dose optimization based on probability density functions (PDF) and potential errors caused by low reproducibility of PDFKe Sheng
Department of Radiation Oncology, University of Virginia, Charlottesville, Virginia 22908, USA
Med Phys 33:3321-6. 2006..By correlating the dosimetric error and PDF error together, a useful guideline for PDF data acquisition and patient qualification for PDF based planning can be derived... - Intensity-modulated radiotherapy outcomes for oropharyngeal squamous cell carcinoma patients stratified by p16 statusAsal Shoushtari
Department of Radiation Oncology, University of Virginia, Charlottesville, Virginia, USA
Cancer 116:2645-54. 2010..Patients with oropharyngeal squamous cell carcinoma (OPSCC) treated with intensity-modulated radiotherapy (IMRT) were stratified by p16 status, neck dissection, and chemotherapy to correlate these factors with outcomes...