Research Topics
Species | Wen T ShenSummaryAffiliation: University of California Country: USA Publications
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Publications
Staying healthy during surgery residencyWen T Shen
Department of Surgery, University of California, San Francisco, 94111, USA
Curr Surg 62:240-1. 2005- Treatment of thyroid cancer with histone deacetylase inhibitors and peroxisome proliferator-activated receptor-gamma agonistsWen T Shen
Department of Surgery, UCSF Mt Zion Medical Center, San Francisco, California, USA
Thyroid 15:594-9. 2005..In this article we review the molecular mechanisms, in vitro and in vivo studies, and clinical applications of the histone deacetylase inhibitors and PPAR-gamma agonists in the treatment of thyroid cancer... 
Prospective evaluation of the rate and impact of hemolysis on intraoperative parathyroid hormone (IOPTH) assay resultsJacob Moalem
Department of Surgery, University of Rochester Medical Center, Rochester, NY, USA
Ann Surg Oncol 17:2963-9. 2010..Retrospective evidence suggested that hemolysis may artificially lower IOPTH results. Falsely decreased IOPTH measurements could result in either failed parathyroidectomy or unnecessary bilateral neck exploration...- Serum thyroglobulin is a poor diagnostic biomarker of malignancy in follicular and Hurthle-cell neoplasms of the thyroidInsoo Suh
Department of Surgery, University of California San Francisco, 513 Parnassus Ave, San Francisco, CA 94143 0470, USA
Am J Surg 200:41-6. 2010..However, some clinicians measure preoperative Tg as a diagnostic cancer marker despite lack of supporting evidence. We examined whether Tg accurately predicts malignancy in follicular or Hürthle-cell neoplasms... - The number of needle passes affects the accuracy of parathyroid hormone assay with intraoperative parathyroid aspirationMarlon A Guerrero
Department of Surgery, University of Arizona, Tucson, AZ 85724, USA
Am J Surg 200:701-5; discussion 705-6. 2010..However, the reported aspiration technique varies in the literature. We sought to determine if the number of passes affected the accuracy of PTH analysis... - Adrenal incidentaloma: does an adequate workup rule out surprises?Raymon H Grogan
Department of Endocrine Surgery, University of California San Francisco, San Francisco, CA 94143, USA
Surgery 148:392-7. 2010..We sought to determine how accurately these guidelines identify functioning incidentalomas and how often these guidelines result in adrenalectomy for benign tumors... - Patterns of antibiotic prophylaxis use for thyroidectomy and parathyroidectomy: results of an international survey of endocrine surgeonsJacob Moalem
Department of Surgery, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
J Am Coll Surg 210:949-56. 2010..Although cervical endocrine operations are classified as clean cases, and prophylactic antibiotics (pABX) are generally not indicated, practice patterns vary... - A population-based prospective cohort study of complications after thyroidectomy in the elderlyRaymon H Grogan
Endocrine Surgery Research Program, Department of Surgery, Section of Endocrine Surgery, University of Chicago Medical Center, Chicago, Illinois 60637, USA
J Clin Endocrinol Metab 97:1645-53. 2012..Data on the risk of postthyroidectomy complications in elderly patients are sparse, unclear, and conflicting... - Distinct loci on chromosome 1q21 and 6q22 predispose to familial nonmedullary thyroid cancer: a SNP array-based linkage analysis of 38 familiesInsoo Suh
Department of Surgery, University of California, San Francisco, CA, USA
Surgery 146:1073-80. 2009..We aimed to identify loci linked to FNMTC susceptibility using single-nucleotide polymorphism (SNP) array-based linkage analysis in a broad sampling of affected families... - Central neck lymph node dissection for papillary thyroid cancer: the reliability of surgeon judgment in predicting which patients will benefitWen T Shen
Department of Surgery, University of California, San Francisco Mt Zion Medical Center, San Francisco, CA 94115, USA
Surgery 148:398-403. 2010..We perform CLND for PTC only in patients with enlarged nodes as determined by preoperative ultrasound and intraoperative inspection and palpation... - Extent of surgery for papillary thyroid cancer: preoperative imaging and role of prophylactic and therapeutic neck dissectionRobin M Cisco
Mt Zion Medical Center, University of California, San Francisco, San Francisco, CA 94115, USA
Curr Treat Options Oncol 13:1-10. 2012..Reoperative lymph node dissection is typically undertaken upon detection and fine needle aspiration (FNA) of involved lymph nodes 0.8 cm or greater in size... 
Fluorodeoxyglucose-positron emission tomography scan-positive recurrent papillary thyroid cancer and the prognosis and implications for surgical managementJennifer M J Schreinemakers
Department of Surgery, University of California, 1600 Divisadero Street, Box 1711, San Francisco, CA 94115, USA
World J Surg Oncol 10:192. 2012....- Modulation of matrix metalloproteinase activity in human thyroid cancer cell lines using demethylating agents and histone deacetylase inhibitorsElliot J Mitmaker
Department of Surgery, University of California, San Francisco, CA, USA
Surgery 149:504-11. 2011.... - Central neck lymph node dissection for papillary thyroid cancer: comparison of complication and recurrence rates in 295 initial dissections and reoperationsWen T Shen
Department of Surgery, University of California, San Francisco Mt Zion Medical Center, 1600 Divisadero Street, San Francisco, CA 94115, USA
Arch Surg 145:272-5. 2010..Critics of this approach argue that reoperative CLND has higher complication and recurrence rates than initial CLND. We sought to test this argument, using it as our hypothesis... - One hundred two patients with pheochromocytoma treated at a single institution since the introduction of laparoscopic adrenalectomyWen T Shen
University of California San Francisco Mount Zion Medical Center, 1600 Divisadero Street, San Francisco, CA 94115, USA
Arch Surg 145:893-7. 2010..Pheochromocytoma can be safely treated laparoscopically; "subclinical" pheochromocytoma is increasingly common... - Practice patterns and job satisfaction in fellowship-trained endocrine surgeonsMichael Tsinberg
Department of Surgery, University of California San Francisco, San Francisco, CA 94115, USA
Surgery 152:953-6. 2012..Debates about the difficult job market for young endocrine surgeons are ongoing. This study aimed to analyze the practice patterns and work-related satisfaction levels of recently trained endocrine surgeons... - Hemolysis falsely decreases intraoperative parathyroid hormone levelsJacob Moalem
University of California, San Francisco, CA, USA
Am J Surg 197:222-6. 2009..Falsely decreased IOPTH measurements could result in false-negative or false-positive results and lead to failed parathyroidectomy or unnecessary additional exploration... - Clinical spectrum of pheochromocytomaMarlon A Guerrero
Department of Surgery, University of California, 1600 Divisadero St, San Francisco, CA 94115, USA
J Am Coll Surg 209:727-32. 2009..The goal of this study was to determine if tumor size and hormone level correlate according to the clinical presentation at diagnosis... - Adrenocortical carcinoma in the United States: treatment utilization and prognostic factorsKarl Y Bilimoria
Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
Cancer 113:3130-6. 2008..The authors' objectives were to examine treatment utilization and factors associated with long-term survival after resection of ACC in a large, national, patient population... - Two hundred and two consecutive operations for secondary hyperparathyroidism: has medical management changed the profiles of patients requiring parathyroidectomy?Wen T Shen
Department of Surgery, University of California, San Francisco, CA 94115, USA
Surgery 146:296-9. 2009..Because of improvements in the medical management of end-stage renal disease, some surgeons perceive that they now perform fewer operations for secondary hyperparathyroidism, and that current patients have more advanced disease... - Mitogen-inducible gene-6 is a multifunctional adaptor protein with tumor suppressor-like activity in papillary thyroid cancerChi Iou Lin
Department of Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Clin Endocrinol Metab 96:E554-65. 2011..Low tumoral expression of mitogen-inducible gene-6 (Mig-6) is associated with papillary thyroid cancer (PTC) recurrence after thyroidectomy... - Selective use of steroid replacement after adrenalectomy: lessons from 331 consecutive casesWen T Shen
Department of Surgery, University of California, San Francisco, USA
Arch Surg 141:771-4; discussion 774-6. 2006..Patients undergoing adrenalectomy for unilateral non-Cushing adrenal tumors do not require postoperative steroid replacement... - Risk assessment in 457 adrenal cortical carcinomas: how much does tumor size predict the likelihood of malignancy?Cord Sturgeon
Department of Surgery, University of California, San Francisco, USA
J Am Coll Surg 202:423-30. 2006..The recent NIH consensus conference did not make a definitive recommendation about management of 4- to 6-cm nonfunctioning incidentalomas... - Valproic acid inhibits growth, induces apoptosis, and modulates apoptosis-regulatory and differentiation gene expression in human thyroid cancer cellsWen T Shen
Department of Surgery, Endocrine Surgery Laboratory, UCSF/Mt. Zion Medical Center, San Francisco, CA 94143-1674, USA
Surgery 138:979-84; discussion 984-5. 2005..These findings suggest that VA may be useful clinically for patients with thyroid cancers of follicular cell origin...