Ronglai Shen

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc A latent variable approach for meta-analysis of gene expression data from multiple microarray experiments
    Hyungwon Choi
    Department of Statistics and Huck Institute for Life Sciences, Penn State University, University Park, PA, USA
    BMC Bioinformatics 8:364. 2007
  2. pmc Prognostic meta-signature of breast cancer developed by two-stage mixture modeling of microarray data
    Ronglai Shen
    Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA
    BMC Genomics 5:94. 2004
  3. pmc Golgi protein GOLM1 is a tissue and urine biomarker of prostate cancer
    Sooryanarayana Varambally
    Michigan Center for Translational Pathology, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Neoplasia 10:1285-94. 2008
  4. ncbi request reprint Integrative genomics analysis reveals silencing of beta-adrenergic signaling by polycomb in prostate cancer
    Jindan Yu
    Department of Pathology, Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Cancer Cell 12:419-31. 2007
  5. ncbi request reprint Comprehensive assessment of TMPRSS2 and ETS family gene aberrations in clinically localized prostate cancer
    Rohit Mehra
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Mod Pathol 20:538-44. 2007
  6. ncbi request reprint Identification of GATA3 as a breast cancer prognostic marker by global gene expression meta-analysis
    Rohit Mehra
    Department of Pathology, University of Michigan Medical School, Ann Arbor, 48109, USA
    Cancer Res 65:11259-64. 2005
  7. ncbi request reprint Heterogeneity of TMPRSS2 gene rearrangements in multifocal prostate adenocarcinoma: molecular evidence for an independent group of diseases
    Rohit Mehra
    Michigan Center for Translational Pathology, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Cancer Res 67:7991-5. 2007
  8. ncbi request reprint Metastasis suppressor gene Raf kinase inhibitor protein (RKIP) is a novel prognostic marker in prostate cancer
    Zheng Fu
    Department of Urology, University of Michigan, Ann Arbor, Michigan 48109 0940, USA
    Prostate 66:248-56. 2006
  9. ncbi request reprint Androgen-independent prostate cancer is a heterogeneous group of diseases: lessons from a rapid autopsy program
    Rajal B Shah
    Department of Pathology, University of Michigan School of Medicine, Ann Arbor, Michigan, USA
    Cancer Res 64:9209-16. 2004
  10. ncbi request reprint Autoantibody signatures in prostate cancer
    Xiaoju Wang
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    N Engl J Med 353:1224-35. 2005

Detail Information

Publications21

  1. pmc A latent variable approach for meta-analysis of gene expression data from multiple microarray experiments
    Hyungwon Choi
    Department of Statistics and Huck Institute for Life Sciences, Penn State University, University Park, PA, USA
    BMC Bioinformatics 8:364. 2007
    ..With the explosion in data generated using microarray technology by different investigators working on similar experiments, it is of interest to combine results across multiple studies...
  2. pmc Prognostic meta-signature of breast cancer developed by two-stage mixture modeling of microarray data
    Ronglai Shen
    Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA
    BMC Genomics 5:94. 2004
    ..With the accumulating amount of microarray data, one of the most intriguing yet challenging tasks is to develop robust statistical models to integrate the findings...
  3. pmc Golgi protein GOLM1 is a tissue and urine biomarker of prostate cancer
    Sooryanarayana Varambally
    Michigan Center for Translational Pathology, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Neoplasia 10:1285-94. 2008
    ..0009) versus 0.495 for serum PSA (P = .902). Our data indicating the up-regulation of GOLM1 expression and its appearance in patients' urine suggest GOLM1 as a potential novel biomarker for clinically localized prostate cancer...
  4. ncbi request reprint Integrative genomics analysis reveals silencing of beta-adrenergic signaling by polycomb in prostate cancer
    Jindan Yu
    Department of Pathology, Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Cancer Cell 12:419-31. 2007
    ..Taken together, we demonstrate the power of integrating multiple diverse genomic data to decipher targets of disease-related genes...
  5. ncbi request reprint Comprehensive assessment of TMPRSS2 and ETS family gene aberrations in clinically localized prostate cancer
    Rohit Mehra
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Mod Pathol 20:538-44. 2007
    ....
  6. ncbi request reprint Identification of GATA3 as a breast cancer prognostic marker by global gene expression meta-analysis
    Rohit Mehra
    Department of Pathology, University of Michigan Medical School, Ann Arbor, 48109, USA
    Cancer Res 65:11259-64. 2005
    ..Our data suggest that immunohistochemical analysis of GATA3 may be the basis for a new clinically applicable test to predict tumor recurrence early in the progression of breast cancer...
  7. ncbi request reprint Heterogeneity of TMPRSS2 gene rearrangements in multifocal prostate adenocarcinoma: molecular evidence for an independent group of diseases
    Rohit Mehra
    Michigan Center for Translational Pathology, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Cancer Res 67:7991-5. 2007
    ..Understanding this molecular heterogeneity is critical to the future development and utility of diagnostic and prognostic PCA biomarkers...
  8. ncbi request reprint Metastasis suppressor gene Raf kinase inhibitor protein (RKIP) is a novel prognostic marker in prostate cancer
    Zheng Fu
    Department of Urology, University of Michigan, Ann Arbor, Michigan 48109 0940, USA
    Prostate 66:248-56. 2006
    ..However, the prognostic significance of RKIP expression and its association with metastasis in PCa patients is unknown...
  9. ncbi request reprint Androgen-independent prostate cancer is a heterogeneous group of diseases: lessons from a rapid autopsy program
    Rajal B Shah
    Department of Pathology, University of Michigan School of Medicine, Ann Arbor, Michigan, USA
    Cancer Res 64:9209-16. 2004
    ..An appreciation of this heterogeneity is critical to evaluating diagnostic and prognostic biomarkers as well as to designing therapeutic targets for advanced disease...
  10. ncbi request reprint Autoantibody signatures in prostate cancer
    Xiaoju Wang
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    N Engl J Med 353:1224-35. 2005
    ..New biomarkers, such as autoantibody signatures, may improve the early detection of prostate cancer...
  11. ncbi request reprint Eigengene-based linear discriminant model for tumor classification using gene expression microarray data
    Ronglai Shen
    Department of Biostatistics, University of Michigan Ann Arbor, MI 48109 0602, USA
    Bioinformatics 22:2635-42. 2006
    ..The univariate statistics summarize gene expression profiles outside of the gene co-regulation network context, leading to redundant information being included in the selection procedure...
  12. pmc EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells
    Celina G Kleer
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 100:11606-11. 2003
    ..This study provides compelling evidence for a functional link between dysregulated cellular memory, transcriptional repression, and neoplastic transformation...
  13. ncbi request reprint Basal cell cocktail (34betaE12 + p63) improves the detection of prostate basal cells
    Ming Zhou
    Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI, USA
    Am J Surg Pathol 27:365-71. 2003
    ..We recommend this basal cell cocktail for routine Pca diagnostic work-up...
  14. pmc Changes in differential gene expression because of warm ischemia time of radical prostatectomy specimens
    Atreya Dash
    Department of Urology, University of Michigan, Ann Arbor, USA
    Am J Pathol 161:1743-8. 2002
    ....
  15. ncbi request reprint Positional signaling mediated by a receptor-like kinase in Arabidopsis
    Su Hwan Kwak
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109 1048, USA
    Science 307:1111-3. 2005
    ..Further, the SCM gene is expressed throughout the developing root. Therefore, SCM likely enables developing epidermal cells to detect positional cues and establish an appropriate cell-type pattern...
  16. pmc Internet-based Profiler system as integrative framework to support translational research
    Robert Kim
    Department of Pathology, Brigham and Women s Hospital, Boston, USA
    BMC Bioinformatics 6:304. 2005
    ..The Profiler system allows investigator to reliably track, store, and evaluate TMA experiments. Here within we describe the process that has evolved through an empirical basis over the past 5 years at two academic institutions...
  17. pmc Expression of the platelet-derived growth factor receptor in prostate cancer and treatment implications with tyrosine kinase inhibitors
    Matthias D Hofer
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neoplasia 6:503-12. 2004
    ..2-fold downregulation). Taken together, this study suggests that only a small subset of PCas may be amenable to tyrosine kinase inhibitors specific for PDGFR...
  18. ncbi request reprint Usefulness of basal cell cocktail (34betaE12 + p63) in the diagnosis of atypical prostate glandular proliferations
    Rajal B Shah
    Department of Pathology, University of Michigan School of Medicine, Ann Arbor 48109, USA
    Am J Clin Pathol 122:517-23. 2004
    ..The cocktail provides a simple, cost-effective improvement in basal cell immunohistochemical analysis of difficult prostate lesions...
  19. ncbi request reprint Decreased alpha-methylacyl CoA racemase expression in localized prostate cancer is associated with an increased rate of biochemical recurrence and cancer-specific death
    Mark A Rubin
    Department of Pathology Amory 3 195, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 14:1424-32. 2005
    ..This is the first study to show that AMACR expression is significantly associated with prostate cancer progression and suggests that not all surrogate end points may be optimal to define biomarkers of aggressive prostate cancer...
  20. pmc Modeling intra-tumor protein expression heterogeneity in tissue microarray experiments
    Ronglai Shen
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, 307 East 63rd Street, New York, NY 10065, U S A
    Stat Med 27:1944-59. 2008
    ..A general advice is to use the joint model inference whenever results differ between the two-stage methods and the joint analysis...
  21. ncbi request reprint Alpha-methylacyl-CoA racemase protein expression is associated with the degree of differentiation in breast cancer using quantitative image analysis
    Agnieszka K Witkiewicz
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Cancer Epidemiol Biomarkers Prev 14:1418-23. 2005
    ..Quantitative image analysis is a novel way to accurately and reproducibly evaluate immunohistochemistry in breast tissue samples using high-density tissue microarrays...