Roh Yu Shen

Summary

Affiliation: University at Buffalo
Country: USA

Publications

  1. ncbi request reprint Ethanol withdrawal reduces the number of spontaneously active ventral tegmental area dopamine neurons in conscious animals
    Roh Yu Shen
    Research Institute on Addictions, 1021 Main Street, Buffalo, NY 14203, USA
    J Pharmacol Exp Ther 307:566-72. 2003
  2. ncbi request reprint Long-term reduction in ventral tegmental area dopamine neuron population activity following repeated stimulant or ethanol treatment
    Roh Yu Shen
    Research Institute on Addictions, University at Buffalo, Buffalo, New York 14203, USA
    Biol Psychiatry 61:93-100. 2007
  3. ncbi request reprint Different adaptations in ventral tegmental area dopamine neurons in control and ethanol exposed rats after methylphenidate treatment
    Roh Yu Shen
    Research Institute on Addictions, State University of New York at Buffalo, Buffalo, New York 14203, USA
    Biol Psychiatry 59:635-42. 2006
  4. ncbi request reprint Methylphenidate restores ventral tegmental area dopamine neuron activity in prenatal ethanol-exposed rats by augmenting dopamine neurotransmission
    Kar Chan Choong
    Research Institute on Addictions, 1021 Main Street, Buffalo, NY 14203, USA
    J Pharmacol Exp Ther 309:444-51. 2004
  5. ncbi request reprint The wake-promoting peptide orexin-B inhibits glutamatergic transmission to dorsal raphe nucleus serotonin neurons through retrograde endocannabinoid signaling
    Samir Haj-Dahmane
    Research Institute on Addictions, University at Buffalo, State University of New York, Buffalo, New York 14203, USA
    J Neurosci 25:896-905. 2005
  6. pmc Endocannabinoids mediate the glucocorticoid-induced inhibition of excitatory synaptic transmission to dorsal raphe serotonin neurons
    Jue Wang
    Research Institute on Addictions, University at Buffalo, 1021 Main Street, Buffalo, NY 14203, USA
    J Physiol 590:5795-808. 2012
  7. pmc Modulation of the serotonin system by endocannabinoid signaling
    Samir Haj-Dahmane
    Research Institute on Addictions, University at Buffalo, State University of New York, 1021 Main Street, Buffalo, NY 14203, USA
    Neuropharmacology 61:414-20. 2011
  8. pmc Regulation of plasticity of glutamate synapses by endocannabinoids and the cyclic-AMP/protein kinase A pathway in midbrain dopamine neurons
    Samir Haj-Dahmane
    University at Buffalo, Research Institute on Addictions, 1021 Main Street, Buffalo, NY 14203, USA
    J Physiol 588:2589-604. 2010
  9. ncbi request reprint Effects of prenatal ethanol exposure on the excitability of ventral tegmental area dopamine neurons in vitro
    Jue Wang
    Research Institute on Addictions, 1021 Main St, Buffalo, NY 14203, USA
    J Pharmacol Exp Ther 319:857-63. 2006
  10. ncbi request reprint Prenatal alcohol exposure causes attention deficits in male rats
    Kathryn A Hausknecht
    Department of Psychology, University at Buffalo, The State University of New York, Buffalo, NY, USA
    Behav Neurosci 119:302-10. 2005

Research Grants

Collaborators

Detail Information

Publications14

  1. ncbi request reprint Ethanol withdrawal reduces the number of spontaneously active ventral tegmental area dopamine neurons in conscious animals
    Roh Yu Shen
    Research Institute on Addictions, 1021 Main Street, Buffalo, NY 14203, USA
    J Pharmacol Exp Ther 307:566-72. 2003
    ....
  2. ncbi request reprint Long-term reduction in ventral tegmental area dopamine neuron population activity following repeated stimulant or ethanol treatment
    Roh Yu Shen
    Research Institute on Addictions, University at Buffalo, Buffalo, New York 14203, USA
    Biol Psychiatry 61:93-100. 2007
    ..We investigated changes in the electrical activity of VTA DA neurons after cessation from treatment with several stimulants and ethanol...
  3. ncbi request reprint Different adaptations in ventral tegmental area dopamine neurons in control and ethanol exposed rats after methylphenidate treatment
    Roh Yu Shen
    Research Institute on Addictions, State University of New York at Buffalo, Buffalo, New York 14203, USA
    Biol Psychiatry 59:635-42. 2006
    ..However, this possibility is based on observations in normal animals and may not apply to animals with attention problems linked to compromised DA function such as prenatal ethanol exposed (PE) animals...
  4. ncbi request reprint Methylphenidate restores ventral tegmental area dopamine neuron activity in prenatal ethanol-exposed rats by augmenting dopamine neurotransmission
    Kar Chan Choong
    Research Institute on Addictions, 1021 Main Street, Buffalo, NY 14203, USA
    J Pharmacol Exp Ther 309:444-51. 2004
    ..The normalized VTA DA neuron activity in prenatal ethanol-exposed animals may contribute to a restoration of DA neurotransmission and the therapeutic effect of methylphenidate in attention problems in children with FASD...
  5. ncbi request reprint The wake-promoting peptide orexin-B inhibits glutamatergic transmission to dorsal raphe nucleus serotonin neurons through retrograde endocannabinoid signaling
    Samir Haj-Dahmane
    Research Institute on Addictions, University at Buffalo, State University of New York, Buffalo, New York 14203, USA
    J Neurosci 25:896-905. 2005
    ..Therefore, our findings reveal a previously unsuspected mechanism by which postsynaptic orexin receptors can modulate glutamatergic synaptic transmission to DRN 5-HT neurons...
  6. pmc Endocannabinoids mediate the glucocorticoid-induced inhibition of excitatory synaptic transmission to dorsal raphe serotonin neurons
    Jue Wang
    Research Institute on Addictions, University at Buffalo, 1021 Main Street, Buffalo, NY 14203, USA
    J Physiol 590:5795-808. 2012
    ..Together, these findings unravel a novel mechanism by which glucocorticoids control the excitability of DR 5-HT neurons and provide new insight into the rapid effects of stress hormones on the function of the 5-HT system...
  7. pmc Modulation of the serotonin system by endocannabinoid signaling
    Samir Haj-Dahmane
    Research Institute on Addictions, University at Buffalo, State University of New York, 1021 Main Street, Buffalo, NY 14203, USA
    Neuropharmacology 61:414-20. 2011
    ....
  8. pmc Regulation of plasticity of glutamate synapses by endocannabinoids and the cyclic-AMP/protein kinase A pathway in midbrain dopamine neurons
    Samir Haj-Dahmane
    University at Buffalo, Research Institute on Addictions, 1021 Main Street, Buffalo, NY 14203, USA
    J Physiol 588:2589-604. 2010
    ..Taken together, these results reveal a critical role of eCBs in controlling the long-term plasticity of glutamate synapses in VTA DA neurons...
  9. ncbi request reprint Effects of prenatal ethanol exposure on the excitability of ventral tegmental area dopamine neurons in vitro
    Jue Wang
    Research Institute on Addictions, 1021 Main St, Buffalo, NY 14203, USA
    J Pharmacol Exp Ther 319:857-63. 2006
    ....
  10. ncbi request reprint Prenatal alcohol exposure causes attention deficits in male rats
    Kathryn A Hausknecht
    Department of Psychology, University at Buffalo, The State University of New York, Buffalo, NY, USA
    Behav Neurosci 119:302-10. 2005
    ..In addition, it was found that, similar to children with FASD, the ethanol-exposed rats had more false alarms. Thus, rats with prenatal ethanol exposure show attention deficits that are similar to those of children with FASD and ADHD...
  11. pmc Endocannabinoids suppress excitatory synaptic transmission to dorsal raphe serotonin neurons through the activation of presynaptic CB1 receptors
    Samir Haj-Dahmane
    Research Institute on Addictions, State University of New York, Buffalo, 14203, USA
    J Pharmacol Exp Ther 331:186-96. 2009
    ..Together, these results indicate that eCBs play a role in modulating glutamatergic synaptic transmission to DR 5-HT neurons...
  12. pmc Prenatal stress exposure increases the excitation of dopamine neurons in the ventral tegmental area and alters their reponses to psychostimulants
    Kathryn Hausknecht
    Research Institute on Addictions, University at Buffalo, Buffalo, NY 14203, USA
    Neuropsychopharmacology 38:293-301. 2013
    ..The reversal effect on VTA DA neuron in PSE animals represents an actual increase in the impulse activity. This effect might contribute to increased responding to psychostimulants and mediate increased addiction risk after PSE...
  13. ncbi request reprint A role for hypocretin (orexin) in male sexual behavior
    John W Muschamp
    Department of Psychology and Program in Neuroscience, Florida State University, Tallahassee, Florida 32306, USA
    J Neurosci 27:2837-45. 2007
    ..Together, these data support the view that hcrt/orx peptides may act in a steroid-sensitive manner to facilitate the energized pursuit of natural rewards like sex via activation of the mesolimbic DA system...
  14. ncbi request reprint D2-like dopamine receptors depolarize dorsal raphe serotonin neurons through the activation of nonselective cationic conductance
    Teresa K Aman
    Institute for Neuroscience, Northwestern University, Evanston, Illinois, USA
    J Pharmacol Exp Ther 320:376-85. 2007
    ..These results reveal previously unsuspected mechanism by which D2-like DA receptors induce membrane depolarization and enhance the excitability of DR 5-HT neurons...

Research Grants8

  1. Addiction Propensity After Prenatal Ethanol Exposure
    Roh Yu Shen; Fiscal Year: 2011
    ....
  2. DOPAMINE FUNCTION AFTER PRENATAL ETHANOL EXPOSURE
    Roh Yu Shen; Fiscal Year: 2003
    ..The results of these studies will better our understanding in the etiology of behavioral symptoms in FAE/FAS and help us to develop more appropriate animal models to advance the pharmacological treatment of FAE/FAS. ..
  3. DOPAMINE FUNCTION AFTER PRENATAL ETHANOL EXPOSURE
    Roh Yu Shen; Fiscal Year: 2007
    ..The information obtained from the proposed studies may help us to elucidate the etiology and treatment options of ADHD symptoms observed in many individuals with FASD. ..