Haiqing Shen

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. pmc Familial defective apolipoprotein B-100 and increased low-density lipoprotein cholesterol and coronary artery calcification in the old order amish
    Haiqing Shen
    Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Arch Intern Med 170:1850-5. 2010
  2. pmc Genome-wide association study identifies genetic variants in GOT1 determining serum aspartate aminotransferase levels
    Haiqing Shen
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Hum Genet 56:801-5. 2011
  3. pmc Glucokinase regulatory protein gene polymorphism affects postprandial lipemic response in a dietary intervention study
    Haiqing Shen
    Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, 660 West Redwood Street, Rm 494, Baltimore, MD 21201, USA
    Hum Genet 126:567-74. 2009
  4. pmc A null mutation in human APOC3 confers a favorable plasma lipid profile and apparent cardioprotection
    Toni I Pollin
    Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Science 322:1702-5. 2008
  5. pmc Genome-wide association scan identifies variants near Matrix Metalloproteinase (MMP) genes on chromosome 11q21-22 strongly associated with serum MMP-1 levels
    Yu Ching Cheng
    Division of Endocrinology, Diabetes and Nutrition, School of Medicine, University of Maryland, Baltimore, MD, USA
    Circ Cardiovasc Genet 2:329-37. 2009
  6. pmc The association of coronary artery calcification and carotid artery intima-media thickness with distinct, traditional coronary artery disease risk factors in asymptomatic adults
    Evadnie Rampersaud
    Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
    Am J Epidemiol 168:1016-23. 2008
  7. pmc Association of single nucleotide polymorphisms on chromosome 9p21.3 with platelet reactivity: a potential mechanism for increased vascular disease
    Kiran Musunuru
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Circ Cardiovasc Genet 3:445-53. 2010
  8. pmc Association of the vitamin D metabolism gene CYP24A1 with coronary artery calcification
    Haiqing Shen
    Division of Endocrinology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Arterioscler Thromb Vasc Biol 30:2648-54. 2010
  9. pmc Physical activity and the association of common FTO gene variants with body mass index and obesity
    Evadnie Rampersaud
    Department of Medicine, University of Maryland, Baltimore, USA
    Arch Intern Med 168:1791-7. 2008
  10. pmc Variants in scavenger receptor class B type I gene are associated with HDL cholesterol levels in younger women
    Caroline G P Roberts
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Hum Hered 64:107-13. 2007

Detail Information

Publications20

  1. pmc Familial defective apolipoprotein B-100 and increased low-density lipoprotein cholesterol and coronary artery calcification in the old order amish
    Haiqing Shen
    Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Arch Intern Med 170:1850-5. 2010
    ..Elevated low-density lipoprotein cholesterol (LDL-C) levels are a major cardiovascular disease risk factor. Genetic factors are an important determinant of LDL-C levels...
  2. pmc Genome-wide association study identifies genetic variants in GOT1 determining serum aspartate aminotransferase levels
    Haiqing Shen
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Hum Genet 56:801-5. 2011
    ..This finding will help us to understand structure and function of the enzyme and would be useful for predicting serum AST levels...
  3. pmc Glucokinase regulatory protein gene polymorphism affects postprandial lipemic response in a dietary intervention study
    Haiqing Shen
    Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, 660 West Redwood Street, Rm 494, Baltimore, MD 21201, USA
    Hum Genet 126:567-74. 2009
    ..03). Our data indicate that the rs1260326 T allele of GCKR is associated with both higher fasting levels of TG as well as the postprandial TG response, which may result in higher atherogenic risk...
  4. pmc A null mutation in human APOC3 confers a favorable plasma lipid profile and apparent cardioprotection
    Toni I Pollin
    Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Science 322:1702-5. 2008
    ..Subclinical atherosclerosis, as measured by coronary artery calcification, was less common in carriers than noncarriers, which suggests that lifelong deficiency of apoC-III has a cardioprotective effect...
  5. pmc Genome-wide association scan identifies variants near Matrix Metalloproteinase (MMP) genes on chromosome 11q21-22 strongly associated with serum MMP-1 levels
    Yu Ching Cheng
    Division of Endocrinology, Diabetes and Nutrition, School of Medicine, University of Maryland, Baltimore, MD, USA
    Circ Cardiovasc Genet 2:329-37. 2009
    ..Matrix metalloproteinase (MMP)-1 may play a role in cardiovascular disease susceptibility by influencing plaque rupture via its ability to degrade extracellular collagens...
  6. pmc The association of coronary artery calcification and carotid artery intima-media thickness with distinct, traditional coronary artery disease risk factors in asymptomatic adults
    Evadnie Rampersaud
    Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
    Am J Epidemiol 168:1016-23. 2008
    ..Results suggest that some of the same genes influence variation in CAC and low density lipoprotein cholesterol, whereas a different set of genes influences variation in CIMT and waist circumference...
  7. pmc Association of single nucleotide polymorphisms on chromosome 9p21.3 with platelet reactivity: a potential mechanism for increased vascular disease
    Kiran Musunuru
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Circ Cardiovasc Genet 3:445-53. 2010
    ..To gain insights into the mechanisms underlying these associations, we hypothesized that single nucleotide polymorphisms (SNPs) in this region would be associated with platelet reactivity across multiple populations...
  8. pmc Association of the vitamin D metabolism gene CYP24A1 with coronary artery calcification
    Haiqing Shen
    Division of Endocrinology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Arterioscler Thromb Vasc Biol 30:2648-54. 2010
    ..We hypothesized that DNA sequence variation in genes regulating vitamin D metabolism and signaling pathways might influence variation in coronary artery calcification (CAC)...
  9. pmc Physical activity and the association of common FTO gene variants with body mass index and obesity
    Evadnie Rampersaud
    Department of Medicine, University of Maryland, Baltimore, USA
    Arch Intern Med 168:1791-7. 2008
    ..The role of lifestyle factors (such as physical activity) in those with an underlying FTO genetic predisposition is unknown...
  10. pmc Variants in scavenger receptor class B type I gene are associated with HDL cholesterol levels in younger women
    Caroline G P Roberts
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Hum Hered 64:107-13. 2007
    ....
  11. pmc Associations between genetic variants in the NOS1AP (CAPON) gene and cardiac repolarization in the old order Amish
    Wendy Post
    Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
    Hum Hered 64:214-9. 2007
    ..The purpose of the current study was to replicate this association in the Old Order Amish...
  12. pmc A common variant in fibroblast growth factor binding protein 1 (FGFBP1) is associated with bone mineral density and influences gene expression in vitro
    Nicole Hoppman
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Bone 47:272-80. 2010
    ..Collectively, these findings suggest that sequence variation in FGFBP1 may contribute to variation in BMD, possibly influencing osteoporosis risk...
  13. pmc Aspirin Resistance in healthy drug-naive men versus women (from the Heredity and Phenotype Intervention Heart Study)
    Haiqing Shen
    Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Am J Cardiol 104:606-12. 2009
    ....
  14. pmc From the Cover: Whole-genome association study identifies STK39 as a hypertension susceptibility gene
    Ying Wang
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 106:226-31. 2009
    ..Thus, variants in STK39 may influence BP by increasing STK39 expression and consequently altering renal Na(+) excretion, thus unifying rare and common BP-regulating alleles in the same physiological pathway...
  15. pmc Decreased bone mineral density in subjects carrying familial defective apolipoprotein B-100
    Laura M Yerges-Armstrong
    Baltimore, MD 21201
    J Clin Endocrinol Metab 98:E1999-2005. 2013
    ..One hypothesis is that hyperlipidemia may be a common predisposing factor to both atherosclerotic heart disease and bone fragility...
  16. pmc The genetic response to short-term interventions affecting cardiovascular function: rationale and design of the Heredity and Phenotype Intervention (HAPI) Heart Study
    Braxton D Mitchell
    Division of Endocrinology, Department of Medicine, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Am Heart J 155:823-8. 2008
    ..Efforts to identify genes influencing CVD risk have met with limited success to date, likely because of the small effect sizes of common CVD risk alleles and the presence of gene by gene and gene by environment interactions...
  17. ncbi request reprint Identification of novel candidate genes for type 2 diabetes from a genome-wide association scan in the Old Order Amish: evidence for replication from diabetes-related quantitative traits and from independent populations
    Evadnie Rampersaud
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, 660 West Redwood St, Room 494, Baltimore, MD 21201, USA
    Diabetes 56:3053-62. 2007
    ..We sought to identify type 2 diabetes susceptibility genes through a genome-wide association scan (GWAS) in the Amish...
  18. ncbi request reprint Determinants of coronary artery and aortic calcification in the Old Order Amish
    Wendy Post
    Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Circulation 115:717-24. 2007
    ..Our goal was to characterize risk factors for CAC and AC and to estimate the genetic contribution to their variation...
  19. ncbi request reprint Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: replication and evidence for a role in both insulin secretion and insulin resistance
    Coleen M Damcott
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Diabetes 55:2654-9. 2006
    ..04 and P = 0.007, respectively). These data provide replicating evidence that variants in TCF7L2 increase the risk for type 2 diabetes and novel evidence that the variants likely influence both insulin secretion and insulin sensitivity...
  20. pmc Effects of novel capsinoid treatment on fatness and energy metabolism in humans: possible pharmacogenetic implications
    Soren Snitker
    University of Maryland School of Medicine, Baltimore, MD 21209, USA
    Am J Clin Nutr 89:45-50. 2009
    ..Capsinoids from the Capsicum genus of plants are nonpungent capsaicin-related substances with effects on metabolism and body weight in animals...