Research Topics
| G D SheltonSummaryAffiliation: University of California Country: USA Publications
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Publications
Evidence for MHC-1-restricted CD8+ T-cell-mediated immunopathology in canine masticatory muscle myositis and polymyositisG Diane Shelton
Muscle Nerve 34:122; author reply 122-3. 2006- Comparable myelinated nerve pathology in feline and human diabetes mellitusAndrew P Mizisin
Department of Pathology, School of Medicine, University of California, 9500 Gilman Dr, La Jolla, San Diego, CA 92093 0612, USA
Acta Neuropathol 113:431-42. 2007..These data highlight the potential utility of feline diabetic neuropathy as a model that faithfully replicates the nerve injury in human diabetes mellitus... 
Endoneurial microvascular pathology in feline diabetic neuropathyJeannelyn S Estrella
Department of Pathology 0612, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0612, USA
Microvasc Res 75:403-10. 2008....
Degenerative myelopathy associated with a missense mutation in the superoxide dismutase 1 (SOD1) gene progresses to peripheral neuropathy in Pembroke Welsh Corgis and BoxersG Diane Shelton
Department of Pathology, School of Medicine, University of California San Diego, La Jolla, CA 92093 0709, USA
J Neurol Sci 318:55-64. 2012..The results of this study provide further support that canine DM recapitulates one form of the corresponding human disorder and should serve as a valuable animal model to develop therapeutic strategies...- Vacuolar myopathy in a dog resembling human sporadic inclusion body myositisJason King
Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, Davis, CA, USA
Acta Neuropathol 118:711-7. 2009..These observations constitute the first evidence that both the inflammatory and degenerative features of human sIBM can occur in a non-human species... - Myasthenia gravis and disorders of neuromuscular transmissionG Diane Shelton
Department of Pathology, School of Medicine, University of California, San Diego, La Jolla 92093 0612, USA
Vet Clin North Am Small Anim Pract 32:189-206, vii. 2002.... - Gross muscle hypertrophy in whippet dogs is caused by a mutation in the myostatin geneG Diane Shelton
Department of Pathology, University of California San Diego, La Jolla, CA 92093-0709, USA
Neuromuscul Disord 17:721-2. 2007 - Routine and specialized laboratory testing for the diagnosis of neuromuscular diseases in dogs and catsG Diane Shelton
Department of Pathology, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA
Vet Clin Pathol 39:278-95. 2010..This review focuses on both routine and specialized laboratory testing necessary to reach a definitive diagnosis and determine an accurate prognosis for neuromuscular diseases... - What's new in muscle and peripheral nerve diseases?G D Shelton
Department of Pathology, University of California, San Diego, La Jolla, CA 92093 0709, USA
Vet Comp Orthop Traumatol 20:249-55. 2007..This review focuses on recently identified inherited neuromuscular diseases in companion animals... - Inherited polyneuropathy in Leonberger dogs: a mixed or intermediate form of Charcot-Marie-Tooth disease?G Diane Shelton
Department of Pathology, University of California, San Diego, La Jolla 92093 0612, USA
Muscle Nerve 27:471-7. 2003.... - Muscle pain, cramps and hypertonicityG Diane Shelton
Department of Pathology, School of Medicine, University of California, San Diego, La Jolla, CA 92093-0709, USA
Vet Clin North Am Small Anim Pract 34:1483-96. 2004 - Rhabdomyolysis, myoglobinuria, and necrotizing myopathiesG Diane Shelton
Department of Pathology, School of Medicine, University of California, San Diego, La Jolla, CA 92093-0709, USA
Vet Clin North Am Small Anim Pract 34:1469-82. 2004 - From dog to man: the broad spectrum of inflammatory myopathiesG Diane Shelton
Department of Pathology, University of California, San Diego, La Jolla, CA 92093 0709, USA
Neuromuscul Disord 17:663-70. 2007..Other canine myositides, associated with infectious and histiocytic diseases, may also be relevant to similar human disorders... - Canine and feline models of human inherited muscle diseasesG Diane Shelton
Department of Pathology, University of California, San Diego, La Jolla, CA 92093 0709, USA
Neuromuscul Disord 15:127-38. 2005..This review focuses on canine and feline models of human inherited muscle diseases with comparisons to rodent models and an emphasis on the muscular dystrophies... - Immunopathogenic pathways in canine inflammatory myopathies resemble human myositisG Diane Shelton
Department of Pathology, University of California, San Diego, La Jolla, CA 92093 0709, USA
Vet Immunol Immunopathol 113:200-14. 2006..This study strengthens the argument that forms of canine myositis may be important animal models of human myositis and suggests useful biomarkers for therapeutic response using the dog in pre-clinical trials... - Acquired myasthenia gravis: what we have learned from experimental and spontaneous animal modelsG D Shelton
Department of Pathology, University of California San Diego, La Jolla 92093 0612, USA
Vet Immunol Immunopathol 69:239-49. 1999.... - Myopathy with tubulin-reactive inclusions in two catsG Diane Shelton
Department of Pathology 0709, University of California, San Diego, La Jolla, CA 92093 0709, USA
Acta Neuropathol 114:537-42. 2007..The crystalline structures reacted positively with an antibody against tubulin. This feline myopathy may be the equivalent of the human myopathy with tubulin-positive crystalline inclusions... - Titin and ryanodine receptor autoantibodies in dogs with thymoma and late-onset myasthenia gravisG D Shelton
Department of Pathology, University of California, San Diego, La Jolla, CA 92093 0612, USA
Vet Immunol Immunopathol 78:97-105. 2001..From these studies we conclude that titin and RyR antibodies in canine and human MG have a similar association with thymoma, late-onset MG, and possibly with more severe forms of MG... - Muscular dystrophy in female dogsG D Shelton
Department of Pathology, University of California, San Diego, La Jolla 92093 0612, USA
J Vet Intern Med 15:240-4. 2001..Two dogs could not be classified. This study demonstrates the occurrence of dystrophin- and laminin alpha2-associated muscular dystrophy and the difficulty in clinical diagnosis of these disorders in female dogs... - Spontaneous remission in canine myasthenia gravis: implications for assessing human MG therapiesG D Shelton
Department of Pathology, University of California San Diego, La Jolla, CA 92093 0612, USA
Neurology 57:2139-41. 2001..4 months. Neoplasia was identified in the six dogs that did not spontaneously remit. This study questions the value of using canine MG in studies designed to assess the effect of immunotherapies... - Muscular dystrophies and other inherited myopathiesG Diane Shelton
Department of Pathology, School of Medicine, University of California, San Diego, La Jolla 92093 0612, USA
Vet Clin North Am Small Anim Pract 32:103-24. 2002..Second, animals with inherited breed-associated disease should not be bred for generation of companion animals... - Myofibrillar myopathy with desmin accumulation in a young Australian Shepherd dogG Diane Shelton
Department of Pathology, University of California San Diego, La Jolla, CA 92093 0709, USA
Neuromuscul Disord 14:399-404. 2004..These observations represent the first report of myofibrillar myopathy in the dog... - Myopathy in horses with pituitary pars intermedia dysfunction (Cushing's disease)M Aleman
Department of Veterinary Medicine and Epidemiology, University of California, Davis, USA
Neuromuscul Disord 16:737-44. 2006..Similar to other species, this study confirmed atrophy of type 2 fibers as the cause of muscle mass loss in horses with Cushing's disease... - Sarcoplasmic masses in equine skeletal muscleM Aleman
Department of Veterinary Surgical and Radiological Sciences, University of California, Tupper Hall 2112, One Shields Avenue, Davis 95616, USA
Neuromuscul Disord 15:147-53. 2005..The relatively frequent occurrence of sarcoplasmic masses in horses may make this species a good model for studying the pathogenesis of these structures... - Mast cell-associated Renaut bodies in the peroneal nerve of a dog with a history of mastocytosisK C Dines
Department of Pathology, University of California at San Diego, La Jolla 92093 0612, USA
J Peripher Nerv Syst 4:19-26. 1999..These observations are the first to report an association between mast cells and Renaut bodies. It is possible that mast cells, at least in this case, are involved in the formation of Renaut bodies... - Inherited myopathy of great DanesA Lujan Feliu-Pascual
Comparative Neuromuscular Laboratory, University of California-San Diego, La Jolla, CA 92093-0709, USA
J Small Anim Pract 47:249-54. 2006..Until this myopathy is characterised further, the name inherited myopathy in great Danes is suggested... - Sarcolemma-specific autoantibodies in canine inflammatory myopathySabine Hankel
The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Vet Immunol Immunopathol 113:1-10. 2006..In these breeds, this form of IM could be diagnosed and monitored with a simple serum assay... - Severe myositis associated with Sarcocystis spp. infection in 2 dogsJ E Sykes
Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
J Vet Intern Med 25:1277-83. 2011..Dogs are definitive hosts for numerous species of the intracellular protozoan parasite Sarcocystis. Reports of sarcocysts in muscles of dogs most often represent incidental findings... - CNS hypomyelination in Rat Terrier dogs with congenital goiter and a mutation in the thyroid peroxidase geneR Pettigrew
Department of Pathology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0709, USA
Vet Pathol 44:50-6. 2007.... - Myelin splitting, Schwann cell injury and demyelination in feline diabetic neuropathyA P Mizisin
Department of Pathology, School of Medicine, University of California, San Diego, La Jolla 92093 0612, USA
Acta Neuropathol 95:171-4. 1998..These observations highlight the significance of Schwann cell injury in the pathogenesis of diabetic neuropathy... - Embryonic expression of the tumor-associated PAX3-FKHR fusion protein interferes with the developmental functions of Pax3M J Anderson
Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA 92093 0660, USA
Proc Natl Acad Sci U S A 98:1589-94. 2001..These data suggest that the tumor-associated PAX3-FKHR fusion protein interferes with normal Pax3 developmental functions as a prelude to transformation... - Assessment of the neurologic effects of dietary deficiencies of phenylalanine and tyrosine in catsPeter J Dickinson
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
Am J Vet Res 65:671-80. 2004..Official present-day recommendations for dietary phenylalanine and tyrosine in cats may be insufficient to support normal long-term neurologic function... - Autoantibodies in canine masticatory muscle myositis recognize a novel myosin binding protein-C family memberXiaohua Wu
Department of Pathology, University of California, San Diego 92101, USA
J Immunol 179:4939-44. 2007..Understanding the role of mMyBP-C in this canine inflammatory myopathy may advance our knowledge of mechanisms of autoimmune inflammatory muscle diseases, not only in dogs, but also in humans... - Antemortem diagnosis of polyneuritis equiM Aleman
Department of Medicine and Epidemiology, University of California, Davis, Davis, CA 95616, USA
J Vet Intern Med 23:665-8. 2009 - Elimination of myostatin does not combat muscular dystrophy in dy mice but increases postnatal lethalityZhi Fang Li
The Burnham Institute, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
Am J Pathol 166:491-7. 2005..Any future therapy based on myostatin may have undesirable side effects... - Neurological complications associated with spontaneously occurring feline diabetes mellitusAndrew P Mizisin
Department of Pathology, School of Medicine, University of California, San Diego, La Jolla 92093-0612, USA
J Neuropathol Exp Neurol 61:872-84. 2002..The occurrence of diabetic neuropathy in the cat, a relatively large animal with a long life span and long nerves, provides unique opportunities to study the development and treatment of this debilitating complication... - Encephalomyelopathy and polyneuropathy associated with neuronal vacuolation in two Boxer littermatesD A Geiger
Bay Area Veterinary Specialists, San Leandro, CA, USA
Vet Pathol 46:1160-5. 2009..The findings in these Boxer dogs, unrelated to the Rottweiler breed, are analogous to the syndrome of neuronal vacuolation and spinocerebellar degeneration reported in Rottweilers... - SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytesRebecca Berdeaux
Peptide Biology Laboratories, Salk Institute for Biological Studies, La Jolla, California 92037, USA
Nat Med 13:597-603. 2007.... - BAG3 deficiency results in fulminant myopathy and early lethalitySachiko Homma
Burnham Institute for Medical Research, La Jolla, CA, USA
Am J Pathol 169:761-73. 2006..We conclude that although BAG3 is not required for muscle development, this co-chaperone appears to be critically important for maintenance of mature skeletal muscle... - The ER-bound RING finger protein 5 (RNF5/RMA1) causes degenerative myopathy in transgenic mice and is deregulated in inclusion body myositisAgnes Delaunay
Signal Transduction, The Burnham Institute for Medical Research, La Jolla, California, USA
PLoS ONE 3:e1609. 2008..While supporting a role for RNF5 Tg mice as model for s-IBM, our study also establishes the importance of RNF5 in muscle physiology and its deregulation in ER stress associated muscular disorders... - Characterization and in vivo functional analysis of splice variants of cypherChengqun Huang
Institute of Molecular Medicine and Department of Medicine, University of California at San Diego, School of Medicine, La Jolla, California 92093 0641, USA
J Biol Chem 278:7360-5. 2003..Although surviving mice exhibit muscle pathology, these results suggest that either isoform is sufficient to rescue the lethality associated with the absence of Cypher... - Congenital myasthenia gravis in Smooth-Haired Miniature Dachshund dogsPeter J Dickinson
Department of Surgical and Radiological Sciences, Tupper Hall, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
J Vet Intern Med 19:920-3. 2005..Unlike most previously reported cases of congenital myasthenia gravis that are relentlessly progressive, clinical signs resolved spontaneously by 6 months of age... 
Ablation of Cypher, a PDZ-LIM domain Z-line protein, causes a severe form of congenital myopathyQ Zhou
Institute of Molecular Medicine and Department of Medicine, University of California at San Diego School of Medicine, La Jolla, CA 92093, USA
J Cell Biol 155:605-12. 2001..These results suggest that Cypher functions as a linker-strut to maintain cytoskeletal structure during contraction...- Nesprin 1 is critical for nuclear positioning and anchorageJianlin Zhang
Department of Medicine, University of California San Diego, La Jolla, CA 92093 0613, USA
Hum Mol Genet 19:329-41. 2010..Nuclear deformation testing revealed ineffective strain transmission to nuclei in muscle fibers lacking Nesprin 1. Overall, our data show that Nesprin 1 is essential for normal positioning and anchorage of nuclei in skeletal muscle... - ADAM12 overexpression does not improve outcome in mice with laminin alpha2-deficient muscular dystrophyLing T Guo
The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Neuromuscul Disord 15:786-9. 2005..However, overexpression of ADAM12 had no significant effect on overall health, as evidenced by body weight, and did not improve muscle pathology... - Secretion of amyloidogenic gelsolin progressively compromises protein homeostasis leading to the intracellular aggregation of proteinsLesley J Page
Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 106:11125-30. 2009.... - Congenital myopathy with abundant nemaline rods in a catStephanie A Kube
Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California-Davis, Davis, CA 95616, USA
Neuromuscul Disord 16:188-91. 2006..These findings may represent the occurrence of rod bodies in conjunction with a protein-aggregate myopathy... - A possible new inherited myopathy in a young Labrador retrieverKevin L Cosford
Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan
Can Vet J 49:393-7. 2008..Multiple male littermates and half-siblings were similarly affected... - 'Dropped head sign' in myasthenia gravisG Diane Shelton
Neuromuscul Disord 14:535. 2004 - Newly identified neuromuscular disordersScott J Schatzberg
Cornell University Hospital for Animals, Cornell University, Box 35, Ithaca, NY 14853, USA
Vet Clin North Am Small Anim Pract 34:1497-524. 2004 - Canine inflammatory myopathies: a clinicopathologic review of 200 casesJason Evans
Veterinary Neurological Center, Las Vegas, NV 89108, USA
J Vet Intern Med 18:679-91. 2004..The spectrum of canine inflammatory myopathies can be broad, with infectious etiologies relatively common, and can include preneoplastic and uncharacterized syndromes... - Non-pathogenic protein aggregates in skeletal muscle in MLF1 transgenic miceZhi Fang Li
Burnham Institute for Medical Research, La Jolla, CA 92037, United States
J Neurol Sci 264:77-86. 2008.... - Inherited motor neuron disease in domestic cats: a model of spinal muscular atrophyQianchuan He
Laboratory of Comparative Medical Genetics, Department of Microbiology and Molecular Genetics, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA
Pediatr Res 57:324-30. 2005..A breeding colony has been established for further investigation of this naturally occurring large-animal model of inherited motor neuron disease... - Imaging diagnosis--masticatory muscle myositis in a young dogTodd M Bishop
Red Bank Veterinary Hospital, Department of Neurology and Neurosurgery, Tinton Falls, NJ, USA
Vet Radiol Ultrasound 49:270-2. 2008 - A canine DNM1 mutation is highly associated with the syndrome of exercise-induced collapseEdward E Patterson
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota 55108, USA
Nat Genet 40:1235-9. 2008.... - Canine inflammatory myopathy: analysis of cellular infiltratesMarti Pumarola
Department Medicina i Cirurgia Animals, Facultat de Veterinaria, Universitat Autonoma de Barcelona, Barcelona, Spain
Muscle Nerve 29:782-9. 2004..Thus, generalized IM and MMM appear to be distinct diseases with different mechanisms. Canine generalized IM may be an important animal model for human IM... - Muscular dystrophies: expanding our knowledge in companion animalsG Diane Shelton
Vet J 168:6-8. 2004 - Muscular dystrophy with truncated dystrophin in a family of Japanese Spitz dogsBoyd R Jones
Department of Small Animal Clinical Studies, University College, Dublin, Ireland
J Neurol Sci 217:143-9. 2004..Immunoblot analysis in two affected dogs showed a truncated dystrophin protein of approximately 70-80 kDa. The severity of disease showed that this fragment was not large enough to protect from the dystrophic process... - L-2-Hydroxyglutaric aciduria in Staffordshire Bull TerriersCarley J Abramson
Neurology Unit, Centre for Small Animal Studies, The Animal Health Trust, Newmarket, Suffolk, UK
J Vet Intern Med 17:551-6. 2003.... - Neonatal cerebellar ataxia in Coton de Tulear dogsJoan R Coates
Department of Veterinary Small Animal Medicine and Surgery, College of Veterinary Medicine Texas A and M University, College Station, TX 77843 4474, USA
J Vet Intern Med 16:680-9. 2002..An autosomal recessive trait affecting development of the cerebellum is suspected... - Dystrophin-deficient muscular dystrophy in a Labrador retrieverRobert L Bergman
Department of Small Animal Clinical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, Blacksburg, Virginia 24061, USA
J Am Anim Hosp Assoc 38:255-61. 2002..A correct diagnosis and classification of these two disorders are critical for breeders and owners since both the mode of inheritance and the prognosis differ... - Expanded repeat in canine epilepsyHannes Lohi
The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
Science 307:81. 2005..Clinicopathologic characterization establishes affected animals as a model for Lafora disease, the most severe teenage-onset human epilepsy... - A variant form of neuronal ceroid lipofuscinosis in American bulldogsJason Evans
Veterinary Neurological Center, Las Vegas, NV 89108, USA
J Vet Intern Med 19:44-51. 2005..Pedigree analysis supports an autosomal-recessive mode of inheritance. NCL has not been previously reported in the American Bulldog and these findings suggest a variant form of the canine disease... - Sensory and motor neuropathy in a Border CollieKenneth R Harkin
Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA
J Am Vet Med Assoc 227:1263-5, 1250. 2005..A hereditary link was not established, but a littermate was similarly affected. The hereditary characteristic of this disease requires further investigation... - Canine spongiform leukoencephalomyelopathy is associated with a missense mutation in cytochrome bFang Yuan Li
Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin Madison, 2015 Linden Drive, Madison, WI 53706, USA
Neurobiol Dis 21:35-42. 2006..Western blot analysis showed increased levels of core I and core II but decreased level of cytochrome c1 of the complex III and cytochrome c oxidase of the complex IV of the respiratory chain... - Inherited myopathy in a young Great DaneChantal J McMillan
Small Animal Clinical Sciences, Western College of Veterinary Medicine, Saskatoon, Saskatchewan
Can Vet J 47:891-3. 2006..Clinical features of this inherited myopathy are described... - Identification of a canine model of pyruvate dehydrogenase phosphatase 1 deficiencyJessie M Cameron
Metabolic Research Programme, Research Institute, The Hospital for Sick Children, 555 University Avenue, Toronto, Ont, Canada M5G 1X8
Mol Genet Metab 90:15-23. 2007..Pharmacological and genetic therapies for PDP1 deficiency can now be investigated and the role of PDP2 can be fully characterized... - Magnetic resonance imaging in the diagnosis of canine inflammatory myopathies in three dogsSimon R Platt
Centre for Small Animal Studies, The Animal Health Trust, Newmarket, Suffolk CB87UU, UK
Vet Radiol Ultrasound 47:532-7. 2006..A good association existed between the MR images and muscle inflammation identified histopathologically. MR imaging may be a useful adjunctive procedure for canine inflammatory myopathies... - Myasthenia gravis and hypothyroidism in a dog with meningomyelitisJonathan M Levine
Department of Small Animal Medicine, College of Veterinary Medicine, Texas A and M University, College Station, Texas 77843, USA
J Am Anim Hosp Assoc 41:247-51. 2005..It was unclear whether the identified conditions evolved from a shared etiopathogenesis or were merely coincidental... - Dysphagia as the primary clinical abnormality in two dogs with inflammatory myopathyL Rachael Ryckman
Veterinary Teaching Hospital, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996-4566, USA
J Am Vet Med Assoc 226:1519-23, 1501. 2005..A diagnosis of chronic inflammatory myopathy was made. The clinical importance of reduced staining for integrin alpha7 could not be determined but was considered to be a result of the myopathy... - Muscle regeneration, inflammation, and connective tissue expansion in canine inflammatory myopathyClaudia Salvadori
Department of Animal Pathology, Faculty of Veterinary Medicine, Pisa, Italy
Muscle Nerve 31:192-8. 2005..The extensive regeneration demonstrates that muscle may survive this adverse environment if inflammation and fibrosis can be stopped or reduced... - Treatment of canine pediatric Neospora caninum myositis following immunohistochemical identification of tachyzoites in muscle biopsiesJennifer L Crookshanks
Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4
Can Vet J 48:506-8. 2007..Neospora caninum myositis was diagnosed by histopathologic and serologic examination and immunohistochemical staining of muscle. Substantial clinical improvement was noted after 18 weeks of treatment with clindamycin... - Expression of major histocompatibility complex class I and class II antigens in canine masticatory muscle myositisOrlando Paciello
Department of Pathology and Animal Health Unit of Anatomic Pathology, University of Naples Federico II, 80137 Naples, Italy
Neuromuscul Disord 17:313-20. 2007.... - Glycogen storage disease type IIIa in curly-coated retrieversBrittany L Gregory
Laboratory of Comparative Medical Genetics, Department of Microbiology and Molecular Genetics, College of Veterinary Medicine, Michigan State University, East Lansing 48824, USA
J Vet Intern Med 21:40-6. 2007..The glycogen storage diseases are a category of such disorders that are typed by enzyme analysis, but deoxyribonucleic acid (DNA) based carrier tests are needed for definitive, noninvasive diagnosis and to prevent at-risk matings... - Myasthenia gravis in a polar bear (Ursus maritimus)David E Kenny
Denver Zoological Gardens, City Park, E. 2300 Steele Street, Denver, Colorado 80205-4899, USA
J Zoo Wildl Med 35:409-11. 2004..Although the AChR antibody test has not been validated in the polar bear, we are confident in the postmortem diagnosis of MG, which is commonly associated with thymoma in other species... - Primary orthostatic tremor in Great DanesLaurent S Garosi
Animal Health Trust, Centre for Small Animal Studies, Lanwades Park, Kentford, Newmarket, UK
J Vet Intern Med 19:606-9. 2005 - Myokymia and neuromyotonia in a catHeather R Galano
Veterinary Teaching Hospital, College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA
J Am Vet Med Assoc 227:1608-12, 1591. 2005..However, the myokymic and neuromyotonic discharges were still present, albeit with a substantial decrease in frequency... - D-lactic acidosis secondary to exocrine pancreatic insufficiency in a catRebecca A Packer
Department of Veterinary Medicine and Surgery, Veterinary Medical Teaching Hospital, Columbia, MO 65211, USA
J Vet Intern Med 19:106-10. 2005 - Neurological disease in wild loggerhead sea turtles Caretta carettaElliott R Jacobson
College of Veterinary Medicine, University of Florida, Gainesville, Florida 32610, USA
Dis Aquat Organ 70:139-54. 2006..We speculate that the clinical signs and pathologic changes seen in the affected LST resulted from combined heavy spirorchiid parasitism and possible chronic exposure to a novel toxin present in the diet of LST...