G D Shelton

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Evidence for MHC-1-restricted CD8+ T-cell-mediated immunopathology in canine masticatory muscle myositis and polymyositis
    G Diane Shelton
    Muscle Nerve 34:122; author reply 122-3. 2006
  2. ncbi request reprint Comparable myelinated nerve pathology in feline and human diabetes mellitus
    Andrew P Mizisin
    Department of Pathology, School of Medicine, University of California, 9500 Gilman Dr, La Jolla, San Diego, CA 92093 0612, USA
    Acta Neuropathol 113:431-42. 2007
  3. pmc Endoneurial microvascular pathology in feline diabetic neuropathy
    Jeannelyn S Estrella
    Department of Pathology 0612, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0612, USA
    Microvasc Res 75:403-10. 2008
  4. pmc A L2HGDH initiator methionine codon mutation in a Yorkshire terrier with L-2-hydroxyglutaric aciduria
    Fabiana H G Farias
    Department of Veterinary Pathobiology, University of Missouri, Columbia, USA
    BMC Vet Res 8:124. 2012
  5. doi request reprint Degenerative myelopathy associated with a missense mutation in the superoxide dismutase 1 (SOD1) gene progresses to peripheral neuropathy in Pembroke Welsh Corgis and Boxers
    G Diane Shelton
    Department of Pathology, School of Medicine, University of California San Diego, La Jolla, CA 92093 0709, USA
    J Neurol Sci 318:55-64. 2012
  6. pmc Vacuolar myopathy in a dog resembling human sporadic inclusion body myositis
    Jason King
    Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, Davis, CA, USA
    Acta Neuropathol 118:711-7. 2009
  7. ncbi request reprint Muscle pain, cramps and hypertonicity
    G Diane Shelton
    Department of Pathology, School of Medicine, University of California, San Diego, La Jolla, CA 92093 0709, USA
    Vet Clin North Am Small Anim Pract 34:1483-96. 2004
  8. ncbi request reprint Rhabdomyolysis, myoglobinuria, and necrotizing myopathies
    G Diane Shelton
    Department of Pathology, School of Medicine, University of California, San Diego, La Jolla, CA 92093 0709, USA
    Vet Clin North Am Small Anim Pract 34:1469-82. 2004
  9. ncbi request reprint Myopathy with tubulin-reactive inclusions in two cats
    G Diane Shelton
    Department of Pathology 0709, University of California, San Diego, La Jolla, CA 92093 0709, USA
    Acta Neuropathol 114:537-42. 2007
  10. ncbi request reprint Immunopathogenic pathways in canine inflammatory myopathies resemble human myositis
    G Diane Shelton
    Department of Pathology, University of California, San Diego, La Jolla, CA 92093 0709, USA
    Vet Immunol Immunopathol 113:200-14. 2006

Detail Information

Publications80

  1. ncbi request reprint Evidence for MHC-1-restricted CD8+ T-cell-mediated immunopathology in canine masticatory muscle myositis and polymyositis
    G Diane Shelton
    Muscle Nerve 34:122; author reply 122-3. 2006
  2. ncbi request reprint Comparable myelinated nerve pathology in feline and human diabetes mellitus
    Andrew P Mizisin
    Department of Pathology, School of Medicine, University of California, 9500 Gilman Dr, La Jolla, San Diego, CA 92093 0612, USA
    Acta Neuropathol 113:431-42. 2007
    ..These data highlight the potential utility of feline diabetic neuropathy as a model that faithfully replicates the nerve injury in human diabetes mellitus...
  3. pmc Endoneurial microvascular pathology in feline diabetic neuropathy
    Jeannelyn S Estrella
    Department of Pathology 0612, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0612, USA
    Microvasc Res 75:403-10. 2008
    ....
  4. pmc A L2HGDH initiator methionine codon mutation in a Yorkshire terrier with L-2-hydroxyglutaric aciduria
    Fabiana H G Farias
    Department of Veterinary Pathobiology, University of Missouri, Columbia, USA
    BMC Vet Res 8:124. 2012
    ..Neurological signs associated with the disease in humans and dogs include seizures, ataxia and dementia...
  5. doi request reprint Degenerative myelopathy associated with a missense mutation in the superoxide dismutase 1 (SOD1) gene progresses to peripheral neuropathy in Pembroke Welsh Corgis and Boxers
    G Diane Shelton
    Department of Pathology, School of Medicine, University of California San Diego, La Jolla, CA 92093 0709, USA
    J Neurol Sci 318:55-64. 2012
    ..The results of this study provide further support that canine DM recapitulates one form of the corresponding human disorder and should serve as a valuable animal model to develop therapeutic strategies...
  6. pmc Vacuolar myopathy in a dog resembling human sporadic inclusion body myositis
    Jason King
    Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, Davis, CA, USA
    Acta Neuropathol 118:711-7. 2009
    ..These observations constitute the first evidence that both the inflammatory and degenerative features of human sIBM can occur in a non-human species...
  7. ncbi request reprint Muscle pain, cramps and hypertonicity
    G Diane Shelton
    Department of Pathology, School of Medicine, University of California, San Diego, La Jolla, CA 92093 0709, USA
    Vet Clin North Am Small Anim Pract 34:1483-96. 2004
  8. ncbi request reprint Rhabdomyolysis, myoglobinuria, and necrotizing myopathies
    G Diane Shelton
    Department of Pathology, School of Medicine, University of California, San Diego, La Jolla, CA 92093 0709, USA
    Vet Clin North Am Small Anim Pract 34:1469-82. 2004
  9. ncbi request reprint Myopathy with tubulin-reactive inclusions in two cats
    G Diane Shelton
    Department of Pathology 0709, University of California, San Diego, La Jolla, CA 92093 0709, USA
    Acta Neuropathol 114:537-42. 2007
    ..The crystalline structures reacted positively with an antibody against tubulin. This feline myopathy may be the equivalent of the human myopathy with tubulin-positive crystalline inclusions...
  10. ncbi request reprint Immunopathogenic pathways in canine inflammatory myopathies resemble human myositis
    G Diane Shelton
    Department of Pathology, University of California, San Diego, La Jolla, CA 92093 0709, USA
    Vet Immunol Immunopathol 113:200-14. 2006
    ..This study strengthens the argument that forms of canine myositis may be important animal models of human myositis and suggests useful biomarkers for therapeutic response using the dog in pre-clinical trials...
  11. ncbi request reprint From dog to man: the broad spectrum of inflammatory myopathies
    G Diane Shelton
    Department of Pathology, University of California, San Diego, La Jolla, CA 92093 0709, USA
    Neuromuscul Disord 17:663-70. 2007
    ..Other canine myositides, associated with infectious and histiocytic diseases, may also be relevant to similar human disorders...
  12. ncbi request reprint Gross muscle hypertrophy in whippet dogs is caused by a mutation in the myostatin gene
    G Diane Shelton
    Department of Pathology, University of California San Diego, La Jolla, CA 92093 0709, USA
    Neuromuscul Disord 17:721-2. 2007
  13. ncbi request reprint What's new in muscle and peripheral nerve diseases?
    G D Shelton
    Department of Pathology, University of California, San Diego, La Jolla, CA 92093 0709, USA
    Vet Comp Orthop Traumatol 20:249-55. 2007
    ..This review focuses on recently identified inherited neuromuscular diseases in companion animals...
  14. ncbi request reprint Inherited polyneuropathy in Leonberger dogs: a mixed or intermediate form of Charcot-Marie-Tooth disease?
    G Diane Shelton
    Department of Pathology, University of California, San Diego, La Jolla 92093 0612, USA
    Muscle Nerve 27:471-7. 2003
    ....
  15. ncbi request reprint Myofibrillar myopathy with desmin accumulation in a young Australian Shepherd dog
    G Diane Shelton
    Department of Pathology, University of California San Diego, La Jolla, CA 92093 0709, USA
    Neuromuscul Disord 14:399-404. 2004
    ..These observations represent the first report of myofibrillar myopathy in the dog...
  16. doi request reprint Routine and specialized laboratory testing for the diagnosis of neuromuscular diseases in dogs and cats
    G Diane Shelton
    Department of Pathology, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    Vet Clin Pathol 39:278-95. 2010
    ..This review focuses on both routine and specialized laboratory testing necessary to reach a definitive diagnosis and determine an accurate prognosis for neuromuscular diseases...
  17. ncbi request reprint Acquired myasthenia gravis: what we have learned from experimental and spontaneous animal models
    G D Shelton
    Department of Pathology, University of California San Diego, La Jolla 92093 0612, USA
    Vet Immunol Immunopathol 69:239-49. 1999
    ....
  18. ncbi request reprint Titin and ryanodine receptor autoantibodies in dogs with thymoma and late-onset myasthenia gravis
    G D Shelton
    Department of Pathology, University of California, San Diego, La Jolla, CA 92093 0612, USA
    Vet Immunol Immunopathol 78:97-105. 2001
    ..From these studies we conclude that titin and RyR antibodies in canine and human MG have a similar association with thymoma, late-onset MG, and possibly with more severe forms of MG...
  19. ncbi request reprint Canine and feline models of human inherited muscle diseases
    G Diane Shelton
    Department of Pathology, University of California, San Diego, La Jolla, CA 92093 0709, USA
    Neuromuscul Disord 15:127-38. 2005
    ..This review focuses on canine and feline models of human inherited muscle diseases with comparisons to rodent models and an emphasis on the muscular dystrophies...
  20. ncbi request reprint Muscular dystrophy in female dogs
    G D Shelton
    Department of Pathology, University of California, San Diego, La Jolla 92093 0612, USA
    J Vet Intern Med 15:240-4. 2001
    ..Two dogs could not be classified. This study demonstrates the occurrence of dystrophin- and laminin alpha2-associated muscular dystrophy and the difficulty in clinical diagnosis of these disorders in female dogs...
  21. ncbi request reprint Spontaneous remission in canine myasthenia gravis: implications for assessing human MG therapies
    G D Shelton
    Department of Pathology, University of California San Diego, La Jolla, CA 92093 0612, USA
    Neurology 57:2139-41. 2001
    ..4 months. Neoplasia was identified in the six dogs that did not spontaneously remit. This study questions the value of using canine MG in studies designed to assess the effect of immunotherapies...
  22. ncbi request reprint Muscular dystrophies and other inherited myopathies
    G Diane Shelton
    Department of Pathology, School of Medicine, University of California, San Diego, La Jolla 92093 0612, USA
    Vet Clin North Am Small Anim Pract 32:103-24. 2002
    ..Second, animals with inherited breed-associated disease should not be bred for generation of companion animals...
  23. ncbi request reprint Myasthenia gravis and disorders of neuromuscular transmission
    G Diane Shelton
    Department of Pathology, School of Medicine, University of California, San Diego, La Jolla 92093 0612, USA
    Vet Clin North Am Small Anim Pract 32:189-206, vii. 2002
    ....
  24. ncbi request reprint Myopathy in horses with pituitary pars intermedia dysfunction (Cushing's disease)
    M Aleman
    Department of Veterinary Medicine and Epidemiology, University of California, Davis, USA
    Neuromuscul Disord 16:737-44. 2006
    ..Similar to other species, this study confirmed atrophy of type 2 fibers as the cause of muscle mass loss in horses with Cushing's disease...
  25. ncbi request reprint Sarcoplasmic masses in equine skeletal muscle
    M Aleman
    Department of Veterinary Surgical and Radiological Sciences, University of California, Tupper Hall 2112, One Shields Avenue, Davis 95616, USA
    Neuromuscul Disord 15:147-53. 2005
    ..The relatively frequent occurrence of sarcoplasmic masses in horses may make this species a good model for studying the pathogenesis of these structures...
  26. ncbi request reprint Mast cell-associated Renaut bodies in the peroneal nerve of a dog with a history of mastocytosis
    K C Dines
    Department of Pathology, University of California at San Diego, La Jolla 92093 0612, USA
    J Peripher Nerv Syst 4:19-26. 1999
    ..These observations are the first to report an association between mast cells and Renaut bodies. It is possible that mast cells, at least in this case, are involved in the formation of Renaut bodies...
  27. ncbi request reprint Inherited myopathy of great Danes
    A Lujan Feliu-Pascual
    Comparative Neuromuscular Laboratory, University of California San Diego, La Jolla, CA 92093 0709, USA
    J Small Anim Pract 47:249-54. 2006
    ..Until this myopathy is characterised further, the name inherited myopathy in great Danes is suggested...
  28. ncbi request reprint Sarcolemma-specific autoantibodies in canine inflammatory myopathy
    Sabine Hankel
    The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Vet Immunol Immunopathol 113:1-10. 2006
    ..In these breeds, this form of IM could be diagnosed and monitored with a simple serum assay...
  29. doi request reprint Severe myositis associated with Sarcocystis spp. infection in 2 dogs
    J E Sykes
    Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    J Vet Intern Med 25:1277-83. 2011
    ..Dogs are definitive hosts for numerous species of the intracellular protozoan parasite Sarcocystis. Reports of sarcocysts in muscles of dogs most often represent incidental findings...
  30. ncbi request reprint Myelin splitting, Schwann cell injury and demyelination in feline diabetic neuropathy
    A P Mizisin
    Department of Pathology, School of Medicine, University of California, San Diego, La Jolla 92093 0612, USA
    Acta Neuropathol 95:171-4. 1998
    ..These observations highlight the significance of Schwann cell injury in the pathogenesis of diabetic neuropathy...
  31. ncbi request reprint CNS hypomyelination in Rat Terrier dogs with congenital goiter and a mutation in the thyroid peroxidase gene
    R Pettigrew
    Department of Pathology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0709, USA
    Vet Pathol 44:50-6. 2007
    ....
  32. pmc Embryonic expression of the tumor-associated PAX3-FKHR fusion protein interferes with the developmental functions of Pax3
    M J Anderson
    Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA 92093 0660, USA
    Proc Natl Acad Sci U S A 98:1589-94. 2001
    ..These data suggest that the tumor-associated PAX3-FKHR fusion protein interferes with normal Pax3 developmental functions as a prelude to transformation...
  33. ncbi request reprint Autoantibodies in canine masticatory muscle myositis recognize a novel myosin binding protein-C family member
    Xiaohua Wu
    Department of Pathology, University of California, San Diego 92101, USA
    J Immunol 179:4939-44. 2007
    ..Understanding the role of mMyBP-C in this canine inflammatory myopathy may advance our knowledge of mechanisms of autoimmune inflammatory muscle diseases, not only in dogs, but also in humans...
  34. ncbi request reprint Assessment of the neurologic effects of dietary deficiencies of phenylalanine and tyrosine in cats
    Peter J Dickinson
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Am J Vet Res 65:671-80. 2004
    ..To determine the neurologic effects of reduced intake of phenylalanine and tyrosine in black-haired cats...
  35. ncbi request reprint Antemortem diagnosis of polyneuritis equi
    M Aleman
    Department of Medicine and Epidemiology, University of California, Davis, Davis, CA 95616, USA
    J Vet Intern Med 23:665-8. 2009
  36. pmc Elimination of myostatin does not combat muscular dystrophy in dy mice but increases postnatal lethality
    Zhi Fang Li
    The Burnham Institute, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    Am J Pathol 166:491-7. 2005
    ..Any future therapy based on myostatin may have undesirable side effects...
  37. ncbi request reprint Neurological complications associated with spontaneously occurring feline diabetes mellitus
    Andrew P Mizisin
    Department of Pathology, School of Medicine, University of California, San Diego, La Jolla 92093 0612, USA
    J Neuropathol Exp Neurol 61:872-84. 2002
    ..The occurrence of diabetic neuropathy in the cat, a relatively large animal with a long life span and long nerves, provides unique opportunities to study the development and treatment of this debilitating complication...
  38. doi request reprint Encephalomyelopathy and polyneuropathy associated with neuronal vacuolation in two Boxer littermates
    D A Geiger
    Bay Area Veterinary Specialists, San Leandro, CA, USA
    Vet Pathol 46:1160-5. 2009
    ..The findings in these Boxer dogs, unrelated to the Rottweiler breed, are analogous to the syndrome of neuronal vacuolation and spinocerebellar degeneration reported in Rottweilers...
  39. pmc BAG3 deficiency results in fulminant myopathy and early lethality
    Sachiko Homma
    Burnham Institute for Medical Research, La Jolla, CA, USA
    Am J Pathol 169:761-73. 2006
    ..We conclude that although BAG3 is not required for muscle development, this co-chaperone appears to be critically important for maintenance of mature skeletal muscle...
  40. ncbi request reprint Characterization and in vivo functional analysis of splice variants of cypher
    Chengqun Huang
    Institute of Molecular Medicine and Department of Medicine, University of California at San Diego, School of Medicine, La Jolla, California 92093 0641, USA
    J Biol Chem 278:7360-5. 2003
    ..Although surviving mice exhibit muscle pathology, these results suggest that either isoform is sufficient to rescue the lethality associated with the absence of Cypher...
  41. ncbi request reprint SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes
    Rebecca Berdeaux
    Peptide Biology Laboratories, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Nat Med 13:597-603. 2007
    ....
  42. ncbi request reprint Congenital myasthenia gravis in Smooth-Haired Miniature Dachshund dogs
    Peter J Dickinson
    Department of Surgical and Radiological Sciences, Tupper Hall, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    J Vet Intern Med 19:920-3. 2005
    ..Unlike most previously reported cases of congenital myasthenia gravis that are relentlessly progressive, clinical signs resolved spontaneously by 6 months of age...
  43. pmc The ER-bound RING finger protein 5 (RNF5/RMA1) causes degenerative myopathy in transgenic mice and is deregulated in inclusion body myositis
    Agnes Delaunay
    Signal Transduction, The Burnham Institute for Medical Research, La Jolla, California, USA
    PLoS ONE 3:e1609. 2008
    ..While supporting a role for RNF5 Tg mice as model for s-IBM, our study also establishes the importance of RNF5 in muscle physiology and its deregulation in ER stress associated muscular disorders...
  44. pmc Ablation of Cypher, a PDZ-LIM domain Z-line protein, causes a severe form of congenital myopathy
    Q Zhou
    Institute of Molecular Medicine and Department of Medicine, University of California at San Diego School of Medicine, La Jolla, CA 92093, USA
    J Cell Biol 155:605-12. 2001
    ..These results suggest that Cypher functions as a linker-strut to maintain cytoskeletal structure during contraction...
  45. pmc Nesprin 1 is critical for nuclear positioning and anchorage
    Jianlin Zhang
    Department of Medicine, University of California San Diego, La Jolla, CA 92093 0613, USA
    Hum Mol Genet 19:329-41. 2010
    ..Nuclear deformation testing revealed ineffective strain transmission to nuclei in muscle fibers lacking Nesprin 1. Overall, our data show that Nesprin 1 is essential for normal positioning and anchorage of nuclei in skeletal muscle...
  46. ncbi request reprint ADAM12 overexpression does not improve outcome in mice with laminin alpha2-deficient muscular dystrophy
    Ling T Guo
    The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuromuscul Disord 15:786-9. 2005
    ..However, overexpression of ADAM12 had no significant effect on overall health, as evidenced by body weight, and did not improve muscle pathology...
  47. pmc Secretion of amyloidogenic gelsolin progressively compromises protein homeostasis leading to the intracellular aggregation of proteins
    Lesley J Page
    Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 106:11125-30. 2009
    ....
  48. ncbi request reprint Imaging diagnosis--masticatory muscle myositis in a young dog
    Todd M Bishop
    Red Bank Veterinary Hospital, Department of Neurology and Neurosurgery, Tinton Falls, NJ, USA
    Vet Radiol Ultrasound 49:270-2. 2008
  49. ncbi request reprint Canine inflammatory myopathy: analysis of cellular infiltrates
    Marti Pumarola
    Department Medicina i Cirurgia Animals, Facultat de Veterinaria, Universitat Autonoma de Barcelona, Barcelona, Spain
    Muscle Nerve 29:782-9. 2004
    ..Thus, generalized IM and MMM appear to be distinct diseases with different mechanisms. Canine generalized IM may be an important animal model for human IM...
  50. ncbi request reprint Muscular dystrophies: expanding our knowledge in companion animals
    G Diane Shelton
    Vet J 168:6-8. 2004
  51. ncbi request reprint Muscular dystrophy with truncated dystrophin in a family of Japanese Spitz dogs
    Boyd R Jones
    Department of Small Animal Clinical Studies, University College, Dublin, Ireland
    J Neurol Sci 217:143-9. 2004
    ..Immunoblot analysis in two affected dogs showed a truncated dystrophin protein of approximately 70-80 kDa. The severity of disease showed that this fragment was not large enough to protect from the dystrophic process...
  52. ncbi request reprint Non-pathogenic protein aggregates in skeletal muscle in MLF1 transgenic mice
    Zhi Fang Li
    Burnham Institute for Medical Research, La Jolla, CA 92037, United States
    J Neurol Sci 264:77-86. 2008
    ....
  53. doi request reprint A canine DNM1 mutation is highly associated with the syndrome of exercise-induced collapse
    Edward E Patterson
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota 55108, USA
    Nat Genet 40:1235-9. 2008
    ....
  54. ncbi request reprint L-2-Hydroxyglutaric aciduria in Staffordshire Bull Terriers
    Carley J Abramson
    Neurology Unit, Centre for Small Animal Studies, The Animal Health Trust, Newmarket, Suffolk, UK
    J Vet Intern Med 17:551-6. 2003
    ....
  55. ncbi request reprint Neonatal cerebellar ataxia in Coton de Tulear dogs
    Joan R Coates
    Department of Veterinary Small Animal Medicine and Surgery, College of Veterinary Medicine Texas A and M University, College Station, TX 77843 4474, USA
    J Vet Intern Med 16:680-9. 2002
    ..An autosomal recessive trait affecting development of the cerebellum is suspected...
  56. ncbi request reprint Dysphagia as the primary clinical abnormality in two dogs with inflammatory myopathy
    L Rachael Ryckman
    Veterinary Teaching Hospital, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996 4566, USA
    J Am Vet Med Assoc 226:1519-23, 1501. 2005
    ..A diagnosis of chronic inflammatory myopathy was made. The clinical importance of reduced staining for integrin alpha7 could not be determined but was considered to be a result of the myopathy...
  57. pmc A possible new inherited myopathy in a young Labrador retriever
    Kevin L Cosford
    Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan
    Can Vet J 49:393-7. 2008
    ..Multiple male littermates and half-siblings were similarly affected...
  58. ncbi request reprint Expression of major histocompatibility complex class I and class II antigens in canine masticatory muscle myositis
    Orlando Paciello
    Department of Pathology and Animal Health Unit of Anatomic Pathology, University of Naples Federico II, 80137 Naples, Italy
    Neuromuscul Disord 17:313-20. 2007
    ....
  59. ncbi request reprint Glycogen storage disease type IIIa in curly-coated retrievers
    Brittany L Gregory
    Laboratory of Comparative Medical Genetics, Department of Microbiology and Molecular Genetics, College of Veterinary Medicine, Michigan State University, East Lansing 48824, USA
    J Vet Intern Med 21:40-6. 2007
    ..The glycogen storage diseases are a category of such disorders that are typed by enzyme analysis, but deoxyribonucleic acid (DNA) based carrier tests are needed for definitive, noninvasive diagnosis and to prevent at-risk matings...
  60. ncbi request reprint Inherited motor neuron disease in domestic cats: a model of spinal muscular atrophy
    Qianchuan He
    Laboratory of Comparative Medical Genetics, Department of Microbiology and Molecular Genetics, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA
    Pediatr Res 57:324-30. 2005
    ..A breeding colony has been established for further investigation of this naturally occurring large-animal model of inherited motor neuron disease...
  61. ncbi request reprint A variant form of neuronal ceroid lipofuscinosis in American bulldogs
    Jason Evans
    Veterinary Neurological Center, Las Vegas, NV 89108, USA
    J Vet Intern Med 19:44-51. 2005
    ..Pedigree analysis supports an autosomal-recessive mode of inheritance. NCL has not been previously reported in the American Bulldog and these findings suggest a variant form of the canine disease...
  62. ncbi request reprint Muscle regeneration, inflammation, and connective tissue expansion in canine inflammatory myopathy
    Claudia Salvadori
    Department of Animal Pathology, Faculty of Veterinary Medicine, Pisa, Italy
    Muscle Nerve 31:192-8. 2005
    ..The extensive regeneration demonstrates that muscle may survive this adverse environment if inflammation and fibrosis can be stopped or reduced...
  63. ncbi request reprint Myasthenia gravis and hypothyroidism in a dog with meningomyelitis
    Jonathan M Levine
    Department of Small Animal Medicine, College of Veterinary Medicine, Texas A and M University, College Station, Texas 77843, USA
    J Am Anim Hosp Assoc 41:247-51. 2005
    ..It was unclear whether the identified conditions evolved from a shared etiopathogenesis or were merely coincidental...
  64. ncbi request reprint Canine spongiform leukoencephalomyelopathy is associated with a missense mutation in cytochrome b
    Fang Yuan Li
    Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin Madison, 2015 Linden Drive, Madison, WI 53706, USA
    Neurobiol Dis 21:35-42. 2006
    ..Western blot analysis showed increased levels of core I and core II but decreased level of cytochrome c1 of the complex III and cytochrome c oxidase of the complex IV of the respiratory chain...
  65. ncbi request reprint Congenital myopathy with abundant nemaline rods in a cat
    Stephanie A Kube
    Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA
    Neuromuscul Disord 16:188-91. 2006
    ..These findings may represent the occurrence of rod bodies in conjunction with a protein-aggregate myopathy...
  66. ncbi request reprint Canine inflammatory myopathies: a clinicopathologic review of 200 cases
    Jason Evans
    Veterinary Neurological Center, Las Vegas, NV 89108, USA
    J Vet Intern Med 18:679-91. 2004
    ..The spectrum of canine inflammatory myopathies can be broad, with infectious etiologies relatively common, and can include preneoplastic and uncharacterized syndromes...
  67. ncbi request reprint Newly identified neuromuscular disorders
    Scott J Schatzberg
    Cornell University Hospital for Animals, Cornell University, Box 35, Ithaca, NY 14853, USA
    Vet Clin North Am Small Anim Pract 34:1497-524. 2004
  68. ncbi request reprint 'Dropped head sign' in myasthenia gravis
    G Diane Shelton
    Neuromuscul Disord 14:535. 2004
  69. ncbi request reprint Dystrophin-deficient muscular dystrophy in a Labrador retriever
    Robert L Bergman
    Department of Small Animal Clinical Sciences, Virginia Maryland Regional College of Veterinary Medicine, Blacksburg, Virginia 24061, USA
    J Am Anim Hosp Assoc 38:255-61. 2002
    ..A correct diagnosis and classification of these two disorders are critical for breeders and owners since both the mode of inheritance and the prognosis differ...
  70. ncbi request reprint Magnetic resonance imaging in the diagnosis of canine inflammatory myopathies in three dogs
    Simon R Platt
    Centre for Small Animal Studies, The Animal Health Trust, Newmarket, Suffolk CB87UU, UK
    Vet Radiol Ultrasound 47:532-7. 2006
    ..A good association existed between the MR images and muscle inflammation identified histopathologically. MR imaging may be a useful adjunctive procedure for canine inflammatory myopathies...
  71. ncbi request reprint Identification of a canine model of pyruvate dehydrogenase phosphatase 1 deficiency
    Jessie M Cameron
    Metabolic Research Programme, Research Institute, The Hospital for Sick Children, 555 University Avenue, Toronto, Ont, Canada M5G 1X8
    Mol Genet Metab 90:15-23. 2007
    ..Pharmacological and genetic therapies for PDP1 deficiency can now be investigated and the role of PDP2 can be fully characterized...
  72. pmc Inherited myopathy in a young Great Dane
    Chantal J McMillan
    Small Animal Clinical Sciences, Western College of Veterinary Medicine, Saskatoon, Saskatchewan
    Can Vet J 47:891-3. 2006
    ..Clinical features of this inherited myopathy are described...
  73. ncbi request reprint Sensory and motor neuropathy in a Border Collie
    Kenneth R Harkin
    Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA
    J Am Vet Med Assoc 227:1263-5, 1250. 2005
    ..A hereditary link was not established, but a littermate was similarly affected. The hereditary characteristic of this disease requires further investigation...
  74. pmc Treatment of canine pediatric Neospora caninum myositis following immunohistochemical identification of tachyzoites in muscle biopsies
    Jennifer L Crookshanks
    Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4
    Can Vet J 48:506-8. 2007
    ..Neospora caninum myositis was diagnosed by histopathologic and serologic examination and immunohistochemical staining of muscle. Substantial clinical improvement was noted after 18 weeks of treatment with clindamycin...
  75. ncbi request reprint Expanded repeat in canine epilepsy
    Hannes Lohi
    The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Science 307:81. 2005
    ..Clinicopathologic characterization establishes affected animals as a model for Lafora disease, the most severe teenage-onset human epilepsy...
  76. ncbi request reprint Primary orthostatic tremor in Great Danes
    Laurent S Garosi
    Animal Health Trust, Centre for Small Animal Studies, Lanwades Park, Kentford, Newmarket, UK
    J Vet Intern Med 19:606-9. 2005
  77. ncbi request reprint Myasthenia gravis in a polar bear (Ursus maritimus)
    David E Kenny
    Denver Zoological Gardens, City Park, E 2300 Steele Street, Denver, Colorado 80205 4899, USA
    J Zoo Wildl Med 35:409-11. 2004
    ..Although the AChR antibody test has not been validated in the polar bear, we are confident in the postmortem diagnosis of MG, which is commonly associated with thymoma in other species...
  78. ncbi request reprint Myokymia and neuromyotonia in a cat
    Heather R Galano
    Veterinary Teaching Hospital, College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA
    J Am Vet Med Assoc 227:1608-12, 1591. 2005
    ..However, the myokymic and neuromyotonic discharges were still present, albeit with a substantial decrease in frequency...
  79. ncbi request reprint Neurological disease in wild loggerhead sea turtles Caretta caretta
    Elliott R Jacobson
    College of Veterinary Medicine, University of Florida, Gainesville, Florida 32610, USA
    Dis Aquat Organ 70:139-54. 2006
    ..We speculate that the clinical signs and pathologic changes seen in the affected LST resulted from combined heavy spirorchiid parasitism and possible chronic exposure to a novel toxin present in the diet of LST...
  80. ncbi request reprint D-lactic acidosis secondary to exocrine pancreatic insufficiency in a cat
    Rebecca A Packer
    Department of Veterinary Medicine and Surgery, Veterinary Medical Teaching Hospital, Columbia, MO 65211, USA
    J Vet Intern Med 19:106-10. 2005