C E Shelburne

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Serum antibodies to Porphyromonas gingivalis chaperone HtpG predict health in periodontitis susceptible patients
    Charles E Shelburne
    Department of Biologic and Materials Sciences, The University of Michigan School of Dentistry, Ann Arbor, Michigan, United States of America
    PLoS ONE 3:e1984. 2008
  2. ncbi HtpG, the Porphyromonas gingivalis HSP-90 homologue, induces the chemokine CXCL8 in human monocytic and microvascular vein endothelial cells
    Charles E Shelburne
    Department of Biologic and Materials Sciences, School of Dentistry, The University of Michigan, Ann Arbor, MI 48108, USA
    Cell Microbiol 9:1611-9. 2007
  3. pmc Induction of {beta}-defensin resistance in the oral anaerobe Porphyromonas gingivalis
    Charles E Shelburne
    Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, 1210 Eisenhower Pl, Room 117, Ann Arbor, MI 48108, USA
    Antimicrob Agents Chemother 49:183-7. 2005
  4. ncbi Differential display analysis of Porphyromonas gingivalis gene activation response to heat and oxidative stress
    C E Shelburne
    Department of Biologic and Materials Sciences, School of Dentistry, The University of Michigan, Ann Arbor, 48108, USA
    Oral Microbiol Immunol 20:233-8. 2005
  5. ncbi The spectrum of antimicrobial activity of the bacteriocin subtilosin A
    Charles E Shelburne
    Department of Biologic and Materials Sciences, The University of Michigan School of Dentistry, 1210 Eisenhower Place, Ann Arbor, MI 48108, USA
    J Antimicrob Chemother 59:297-300. 2007
  6. pmc Immunoglobulin G (IgG) class, but Not IgA or IgM, antibodies to peptides of the Porphyromonas gingivalis chaperone HtpG predict health in subjects with periodontitis by a fluorescence enzyme-linked immunosorbent assay
    Domenica G Sweier
    Department of Cariology, Restorative Sciences and Endodontics, The University of Michigan School of Dentistry, Ann Arbor, Michigan, USA
    Clin Vaccine Immunol 16:1766-73. 2009
  7. pmc Antimicrobial and membrane disrupting activities of a peptide derived from the human cathelicidin antimicrobial peptide LL37
    Sathiah Thennarasu
    Department of Biophysics, University of Michigan, Ann Arbor, Michigan, USA
    Biophys J 98:248-57. 2010
  8. doi MAPK signaling is required for LPS-induced VEGF in pulp stem cells
    T M Botero
    Department of Cariology, Restorative Sciences, and Endodontics, University of Michigan School of Dentistry, 1011 N University, Rm 1376 D, Ann Arbor, Michigan 48109 1078, USA
    J Dent Res 89:264-9. 2010
  9. ncbi Quantitative real-time PCR detection of oral Enterococcus faecalis in humans
    C M Sedgley
    Department of Cariology, Restorative Sciences, and Endodontics, University of Michigan, Ann Arbor, MI 48109 1078, USA
    Arch Oral Biol 50:575-83. 2005
  10. pmc Deletion of all cysteines in tachyplesin I abolishes hemolytic activity and retains antimicrobial activity and lipopolysaccharide selective binding
    Ayyalusamy Ramamoorthy
    Department of Chemistry and Biophysics Research Division, The University of Michigan, Ann Arbor, Michigan 48109 1055, USA
    Biochemistry 45:6529-40. 2006

Collaborators

Detail Information

Publications17

  1. pmc Serum antibodies to Porphyromonas gingivalis chaperone HtpG predict health in periodontitis susceptible patients
    Charles E Shelburne
    Department of Biologic and Materials Sciences, The University of Michigan School of Dentistry, Ann Arbor, Michigan, United States of America
    PLoS ONE 3:e1984. 2008
    ..We hypothesized that antibodies to the HSP90 homologue of P. gingivalis (HtpG) might be associated with protection/resistance against destructive periodontitis...
  2. ncbi HtpG, the Porphyromonas gingivalis HSP-90 homologue, induces the chemokine CXCL8 in human monocytic and microvascular vein endothelial cells
    Charles E Shelburne
    Department of Biologic and Materials Sciences, School of Dentistry, The University of Michigan, Ann Arbor, MI 48108, USA
    Cell Microbiol 9:1611-9. 2007
    ..A P. gingivalis HtpG disruption mutant also induced less CXCL8 mRNA and protein. These results suggest that P. gingivalis HtpG might be involved in CXCL8-mediated immunopathogenesis...
  3. pmc Induction of {beta}-defensin resistance in the oral anaerobe Porphyromonas gingivalis
    Charles E Shelburne
    Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, 1210 Eisenhower Pl, Room 117, Ann Arbor, MI 48108, USA
    Antimicrob Agents Chemother 49:183-7. 2005
    ..gingivalis. Such resistance may have an effect on the ability of oral pathogens to persist in the mouth and to withstand innate human immunity...
  4. ncbi Differential display analysis of Porphyromonas gingivalis gene activation response to heat and oxidative stress
    C E Shelburne
    Department of Biologic and Materials Sciences, School of Dentistry, The University of Michigan, Ann Arbor, 48108, USA
    Oral Microbiol Immunol 20:233-8. 2005
    ....
  5. ncbi The spectrum of antimicrobial activity of the bacteriocin subtilosin A
    Charles E Shelburne
    Department of Biologic and Materials Sciences, The University of Michigan School of Dentistry, 1210 Eisenhower Place, Ann Arbor, MI 48108, USA
    J Antimicrob Chemother 59:297-300. 2007
    ..Subtilosin A is a bacteriocin produced by Bacillus subtilis that has activity against Listeria monocytogenes, which might indicate antimicrobial activity unusual for bacteriocins...
  6. pmc Immunoglobulin G (IgG) class, but Not IgA or IgM, antibodies to peptides of the Porphyromonas gingivalis chaperone HtpG predict health in subjects with periodontitis by a fluorescence enzyme-linked immunosorbent assay
    Domenica G Sweier
    Department of Cariology, Restorative Sciences and Endodontics, The University of Michigan School of Dentistry, Ann Arbor, Michigan, USA
    Clin Vaccine Immunol 16:1766-73. 2009
    ..05). We suggest that anti-P. gingivalis HtpG P18alpha antibodies are protective in periodontal disease and may have prognostic value for guidance of individual patient treatment...
  7. pmc Antimicrobial and membrane disrupting activities of a peptide derived from the human cathelicidin antimicrobial peptide LL37
    Sathiah Thennarasu
    Department of Biophysics, University of Michigan, Ann Arbor, Michigan, USA
    Biophys J 98:248-57. 2010
    ..These results explain the susceptibility of bacteria and the resistance of erythrocytes to LL7-27, and may have implications for the design of membrane-selective therapeutic agents...
  8. doi MAPK signaling is required for LPS-induced VEGF in pulp stem cells
    T M Botero
    Department of Cariology, Restorative Sciences, and Endodontics, University of Michigan School of Dentistry, 1011 N University, Rm 1376 D, Ann Arbor, Michigan 48109 1078, USA
    J Dent Res 89:264-9. 2010
    ..Analysis of these data, collectively, unveils a signaling pathway responsible for synthesis of VEGF by pulp cells and suggests a novel therapeutic target for the management of vascular responses in teeth with pulpitis...
  9. ncbi Quantitative real-time PCR detection of oral Enterococcus faecalis in humans
    C M Sedgley
    Department of Cariology, Restorative Sciences, and Endodontics, University of Michigan, Ann Arbor, MI 48109 1078, USA
    Arch Oral Biol 50:575-83. 2005
    ..faecalis in the human mouth have been demonstrated by culture techniques. Quantitative detection strategies more sensitive than culturing, such as quantitative PCR (qPCR), could provide more illuminating data...
  10. pmc Deletion of all cysteines in tachyplesin I abolishes hemolytic activity and retains antimicrobial activity and lipopolysaccharide selective binding
    Ayyalusamy Ramamoorthy
    Department of Chemistry and Biophysics Research Division, The University of Michigan, Ann Arbor, Michigan 48109 1055, USA
    Biochemistry 45:6529-40. 2006
    ..These properties help to explain that cysteine residues may not contribute to antimicrobial activity and that the loss of hemolytic activity is due to lack of hydrophobicity and amphipathicity...
  11. ncbi Localizing antibody-defined immunoreactivity in Porphyromonas gingivalis HtpG recognized by human serum utilizing selective protein expression
    Domenica G Sweier
    Department of Biologic and Materials Sciences, School of Dentistry, The University of Michigan, 1011 North University Avenue, Campus Box 1078, Ann Arbor, MI 48109 1078, USA
    J Immunol Methods 285:165-70. 2004
    ..The development of methods to rapidly localize dominant immunoreactive regions in protein antigens may prove useful for the development of screening tests, vaccines and therapeutics in periodontal and other infectious diseases...
  12. ncbi Construction and characterization of a Porphyromonas gingivalis htpG disruption mutant
    Domenica G Sweier
    Department of Biologic and Materials Sciences, School of Dentistry, The University of Michigan, Ann Arbor, MI 48109 1078, USA
    FEMS Microbiol Lett 225:101-6. 2003
    ..The disruption of the htpG gene did not significantly affect growth, and had no effect on Pg adherence to and invasion of cultured human cells...
  13. doi Using fluorous amino acids to modulate the biological activity of an antimicrobial peptide
    Lindsey M Gottler
    Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA
    Chembiochem 9:370-3. 2008
  14. doi Using fluorous amino acids to probe the effects of changing hydrophobicity on the physical and biological properties of the beta-hairpin antimicrobial peptide protegrin-1
    Lindsey M Gottler
    Department of Chemistry, Dental School, University of Michigan, Ann Arbor, Michigan 48109, USA
    Biochemistry 47:9243-50. 2008
    ....
  15. ncbi TLR4 mediates LPS-induced VEGF expression in odontoblasts
    Tatiana M Botero
    Department of Cariology, Restorative Sciences and Endodontics, University of Michigan, School of Dentistry, Ann Arbor, Michigan 48109 1078, USA
    J Endod 32:951-5. 2006
    ..These results demonstrate that odontoblast-like cells express CD14 and TLR4, and that LPS-induced VEGF expression is mediated, at least in part, by TLR4 signaling...
  16. ncbi Quantitative reverse transcription polymerase chain reaction analysis of Porphyromonas gingivalis gene expression in vivo
    Charles E Shelburne
    BioMaterials Technology Center, 3M Company, St Paul, MN, USA
    J Microbiol Methods 49:147-56. 2002
    ..When sorted by disease status, we detected correlations between disease status and elevated expression of dnaK and htpG...
  17. ncbi Human atherosclerotic plaque contains viable invasive Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis
    Emil V Kozarov
    Arterioscler Thromb Vasc Biol 25:e17-8. 2005