Research Topics
| Jason P SheehanSummaryAffiliation: University of Virginia Country: USA Publications
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Detail Information
Publications
Radiosurgery in the treatment of spinal metastases: tumor control, survival, and quality of life after helical tomotherapyJason P Sheehan
Departments of Neurological Surgery and Radiation Oncology, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
Neurosurgery 65:1052-61; discussion 1061-2. 2009..The effectiveness and limitations of spinal radiosurgery using a helical TomoTherapy system for the treatment of spinal metastases are reviewed in this article...- Gamma Knife surgery for parasellar meningiomas: long-term results including complications, predictive factors, and progression-free survivalBrian J Williams
Department of Neurological Surgery, University of Virginia Health System, Charlottesville, Virginia 22908, USA
J Neurosurg 114:1571-7. 2011..This is particularly true for patients with parasellar meningiomas. In this study, the authors evaluated the outcomes of Gamma Knife surgery (GKS) used to treat parasellar meningiomas... - Gamma Knife surgery for patients with nonfunctioning pituitary macroadenomas: predictors of tumor control, neurological deficits, and hypopituitarismRobert M Starke
Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia 22908, USA
J Neurosurg 117:129-35. 2012..In this study, the authors evaluated outcomes following GKS of nonfunctioning pituitary macroadenomas and assessed predictors of tumor control, neurological deficits, and delayed hypopituitarism... - Gamma Knife surgery of meningiomas located in the posterior fossa: factors predictive of outcome and remissionRobert M Starke
Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia 22908, USA
J Neurosurg 114:1399-409. 2011..In this study, the authors evaluate the outcomes of posterior fossa meningiomas treated with Gamma Knife surgery (GKS). The authors also assess factors predictive of new postoperative neurological deficits and tumor progression... - Cranial nerve dysfunction following Gamma Knife surgery for pituitary adenomas: long-term incidence and risk factorsChristopher P Cifarelli
Department of Neurological Surgery, University of Virginia Health System, Charlottesville, Virginia 22908 0212, USA
J Neurosurg 116:1304-10. 2012..This study evaluates the long-term risks of ophthalmological dysfunction following GKS for recurrent pituitary adenomas... - Timing and risk factors for new brain metastasis formation in patients initially treated only with Gamma Knife surgery. Clinical articleJason P Sheehan
Department of Neurological Surgery, University of Virginia Health System, Charlottesville, Virginia, USA
J Neurosurg 114:763-8. 2011..This study evaluates the timing, number, and risk factors for development of subsequent new brain metastasis in a group of patients treated with stereotactic radiosurgery alone... - Clinical and pathological characteristics of brain metastasis resected after failed radiosurgeryJay Jagannathan
Department of Neurosurgery, University of Virginia Health Sciences Center, Box 800212, Charlottesville, VA 22902, USA
Neurosurgery 66:208-17. 2010..This study evaluates the tumor histopathology and clinical characteristics of patients who underwent resection of their brain metastasis after failed gamma knife radiosurgery... - Gamma Knife surgery for basal ganglia and thalamic arteriovenous malformationsChing Hsiao Cheng
Department of Neurological Surgery, University of Virginia Health System, Charlottesville, VA, USA
J Neurosurg 116:899-908. 2012..The present study aims to investigate the outcomes of GKS for AVMs in the basal ganglia and thalamus... - Gamma Knife radiosurgery to the surgical cavity following resection of brain metastasesJay Jagannathan
Department of Neurological Surgery, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
J Neurosurg 111:431-8. 2009..This study evaluated the efficacy of postoperative Gamma Knife surgery (GKS) to the tumor cavity following gross-total resection of a brain metastasis... 
Gamma Knife surgery for Cushing's diseaseJay Jagannathan
Department of Neurological Surgery, University of Virginia Health System, Charlottesville, Virginia 22908 00212, USA
J Neurosurg 106:980-7. 2007..In this study the authors address the efficacy and safety of Gamma Knife surgery (GKS) in patients with adrenocorticotropic hormone-secreting pituitary adenomas...- Benign brain tumors: sellar/parasellar tumorsJay Jagannathan
Department of Neurosurgery, University of Virginia Health System, PO Box 800212, Charlottesville, VA 22908 0711, USA
Neurol Clin 25:1231-49, xi. 2007..Less invasive modalities, such as endoscopic transsphenoidal surgery, specific chemotherapeutic drugs, and stereotactic radiosurgery, show promise as adjuvant treatment modalities... - Gamma Knife radiosurgery after radiation therapy as an adjunctive treatment for glioblastomaNader Pouratian
Department of Neurological Surgery, University of Virginia, Charlottesville, VA 22908, USA
J Neurooncol 94:409-18. 2009..Moreover, SRS may be a viable alternative to open surgery for aggressive management of GBM at the time of recurrence. Prospective studies of SRS for GBM should focus on these two groups of patients... - Gamma knife radiosurgery for acromegaly: outcomes after failed transsphenoidal surgeryJay Jagannathan
Lars Leksell Gamma Knife Center, Department of Neurosurgery, University of Virginia Health Sciences Center, Charlottesville, Virginia, USA
Neurosurgery 62:1262-9; discussion 1269-70. 2008..This study evaluates the safety and efficacy of gamma knife radiosurgery (GKRS) in patients with a growth hormone-secreting adenoma... - Evaluation of the role of Gamma Knife surgery in the treatment of craniopharyngiomasRupa Gopalan
Department of Neurological Surgery, University of Virginia Health System, Charlottesville, Virginia 22908, USA
Neurosurg Focus 24:E5. 2008..The overall morbidity rate resulting from radiosurgery was 4% and the overall mortality rate was 0.5%. These results suggest that GKS may provide a favorable benefit-to-risk profile for many patients with craniopharyngiomas... - Anterior stabilization of three-column thoracolumbar spinal traumaRod J Oskouian
Department of Neurological and Orthopaedic Surgery, University of Virginia Health System, Charlottesville, Virginia 22902, USA
J Neurosurg Spine 5:18-25. 2006..The purpose of this study was to evaluate the results obtained in patients who underwent anterior stabilization for three-column thoracolumbar fractures... - Radiation dose and incidence of new metastasis in the anterior temporal lobe structures of radiosurgically treated patientsBhuvaneswara R Basina
Department of Neurological Surgery, University of Virginia Health System, Charlottesville, Virginia 22908 0212, USA
J Neurosurg 112:122-9. 2010..They also evaluated the incidence and timing of new metastases in the anterior temporal lobes (ATLs) in patient cohorts that underwent GKS with or without whole-brain radiation therapy (WBRT)... - Gamma knife surgery for skull base meningiomasRobert M Starke
Department of Neurological Surgery, University of Virginia Health System, Charlottesville, Virginia 22908, USA
J Neurosurg 116:588-97. 2012..In this study, the authors evaluate the outcomes of skull base meningiomas treated with Gamma Knife surgery (GKS) both as an adjunct to microsurgery and as a primary treatment modality... - Applications of radiotherapy and radiosurgery in the management of pediatric Cushing's disease: a review of the literature and our experienceJay Jagannathan
Department of Neurological Surgery, University of Virginia Health Sciences Center, University of Virginia, Charlottesville, VA 22908, USA
J Neurooncol 90:117-24. 2008..This paper reviews the effectiveness of radiation in the treatment of pediatric Cushing's disease... - Initial experience with the eXtend System: a relocatable frame system for multiple-session gamma knife radiosurgeryFaisal T Sayer
Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia, USA
World Neurosurg 75:665-72. 2011..To present our initial experience with the Elekta eXtend System, a relocatable frame system for multiple-fraction or serial multiple-session radiosurgery... - Radiation therapy and stereotactic radiosurgery for the treatment of Cushing's disease: an evidence-based reviewRobert M Starke
Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia 22908, USA
Curr Opin Endocrinol Diabetes Obes 17:356-64. 2010..g. maximal dose, tumor margin dose), length of follow-up, tumor-control rate, complications, rate of hormone normalization, newly onset loss of pituitary function, and method used to assess endocrine remission... - Gamma knife radiosurgery for intracranial hemangioblastomas--outcome at 3 yearsFaisal T Sayer
Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia, USA
World Neurosurg 75:99-105; discussion 45-8. 2011..To define the role of Gamma Knife radiosurgery (GKRS) for the treatment of patients with hemangioblastomas... - Stereotactic radiosurgery for pituitary adenomas: a comprehensive review of indications, techniques and long-term results using the Gamma KnifeJay Jagannathan
Department of Neurological Surgery, University of Virginia Health Sciences Center, Box 800212, Charlottesville, VA 22908, USA
J Neurooncol 92:345-56. 2009..This study reviews the long-term clinical results of stereotactic radiosurgery in the treatment of pituitary adenoma patients... - Gamma Knife surgery for pituitary adenomas: factors related to radiological and endocrine outcomesJason P Sheehan
Department of Neurological Surgery, University of Virginia Health System, Charlottesville, Virginia 22908, USA
J Neurosurg 114:303-9. 2011..This study evaluates a large cohort of patients with a pituitary adenoma to characterize factors related to endocrine remission, control of tumor growth, and development of pituitary deficiency... - Gamma knife surgery for lymphocytic hypophysitisDibyendu Kumar Ray
Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia, USA
J Neurosurg 112:118-21. 2010..Follow-up MR images demonstrated no evidence of recurrence of lymphocytic hypophysitis. For persistent lymphocytic hypophysitis, GKS is a reasonable treatment option... - Bevacizumab used for the treatment of severe, refractory perilesional edema due to an arteriovenous malformation treated with stereotactic radiosurgeryBrian J Williams
Department of Neurological Surgery, University of Virginia Health System, Charlottesville, Virginia 22908, USA
J Neurosurg 116:972-7. 2012..This is the first time that bevacizumab has been used to control severe refractory perilesional edema related to an intracranial arteriovenous malformation... - Gamma knife radiosurgery for brain metastasis of nonsmall cell lung cancer: is there a difference in outcome between morning and afternoon treatment?Douglas A Rahn
Department of Radiation Oncology, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
Cancer 117:414-20. 2011..The purpose of this study was to determine whether outcomes of single-session gamma knife radiosurgery (GKRS) for metastatic nonsmall cell lung cancer (NSCLC) differ based on treatment time... - Gamma Knife surgery for adrenocorticotropic hormone-producing pituitary adenomas after bilateral adrenalectomyWilliam J Mauermann
Lars Leksell Gamma Knife Center, University of Virginia Health System, Charlottesville, Virginia, USA
J Neurosurg 106:988-93. 2007..These patients with Nelson's syndrome can be treated with Gamma Knife surgery (GKS)... - Gamma Knife surgery for arteriovenous malformations in childrenChun Po Yen
Department of Neurological Surgery, University of Virginia Health System, Charlottesville, Virginia 22908, USA
J Neurosurg Pediatr 6:426-34. 2010..The aim of this study was to evaluate the long-term imaging and clinical outcomes of intracranial arteriovenous malformations (AVMs) in children treated with Gamma Knife surgery (GKS)... - Leksell GammaPlan version 10.0 preview: performance of the new inverse treatment planning algorithm applied to Gamma Knife surgery for pituitary adenomaDavid J Schlesinger
Department of Neurological Surgery, University of Virginia Health System, Charlottesville, Virginia 22908, USA
J Neurosurg 113:144-8. 2010..In this study the authors compared the FP and IP approaches to Gamma Knife surgery... - Trans sodium crocetinate: functional neuroimaging studies in a hypoxic brain tumorJason P Sheehan
Department of Neurological Surgery, University of Virginia Health System, Charlottesville, Virginia 22908, USA
J Neurosurg 115:749-53. 2011..In this research, the authors use oxygen-sensitive PET studies to evaluate the extent of hypoxia in vivo in a glioblastoma model and the effect of TSC on the baseline oxygenation of the tumor... - Stereotactic radiosurgery for WHO grade I meningiomasJason P Sheehan
Department of Neurological Surgery, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
J Neurooncol 99:407-16. 2010..Longitudinal follow-up including neurologic and radiologic assessment is required. Single and multisession stereotactic radiosurgery will likely play an expanded role in the treatment of patients with meningiomas... - Hemorrhage risk of cerebral arteriovenous malformations before and during the latency period after GAMMA knife radiosurgeryChun Po Yen
Lars Leksell Center for Gamma Surgery, Department of Neurological Surgery, University of Virginia Health Sciences System, 1215 Lee Street, Room G512, Charlottesville, VA 22908, USA
Stroke 42:1691-6. 2011..To evaluate the hemorrhage rates of cerebral arteriovenous malformations (AVM) and the risk factors of hemorrhage before and after Gamma Knife radiosurgery (GKS)... - Early brain tumor metastasis reduction following Gamma Knife surgeryArnaldo Neves Da Silva
The Lars Leksell Gamma Knife Center, Department of Neurosurgery, University of Virginia Health System, Charlottesville, Virginia 22908, USA
J Neurosurg 110:547-52. 2009..Unlike whole-brain radiation therapy, Gamma Knife surgery (GKS) is delivered in a single session for the treatment of brain metastases. The extent to which GKS can facilitate early tumor control was the focus of this study... 
Tracking brain motion during the cardiac cycle using spiral cine-DENSE MRIXiaodong Zhong
Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22908, USA
Med Phys 36:3413-9. 2009..These preliminary results demonstrated that the spiral cine-DENSE MRI technique can be used to measure cardiac-synchronized pulsatile brain motion on the pixel-by-pixel basis with high temporal/spatial resolution and sensitivity...- High-intensity focused ultrasound surgery of the brain: part 1--A historical perspective with modern applicationsJay Jagannathan
Department of Neurological Surgery, University of Virginia Health Sciences Center, Charlottesville, Virginia 22902, USA
Neurosurgery 64:201-10; discussion 210-1. 2009..The remaining 2 articles in this series will focus on the physical principles of modern MRgFUS as well as current and future avenues for investigation... - Gamma Knife surgery for the management of glomus tumors: a multicenter studyJason P Sheehan
Department of Neurological Surgery, University of Virginia Health System, Charlottesville, Virginia 22908, USA
J Neurosurg 117:246-54. 2012..Stereotactic radiosurgery has gained an increasing role in the management of glomus tumors. The authors of this study examine the outcomes after radiosurgery in a large, multicenter patient population... - Gamma Knife® radiosurgery for trigeminal neuralgiaChun Po Yen
Department of Neurological Surgery, University of Virginia Health Sciences Center, Charlottesville, VA, USA
Expert Rev Med Devices 8:709-21. 2011..Long-term follow-up for recurrence as well as for radiation-induced complications is required in all patients undergoing stereotactic radiosurgery for trigeminal neuralgia... - Magnetic resonance-guided focused ultrasound surgery: Part 2: A review of current and future applicationsRicky Medel
Department of Neurosurgery, University of Virginia Health Sciences Center, University of University, Charlottesville, Virginia 22902, USA
Neurosurgery 71:755-63. 2012..Although clinically in its infancy, preclinical and early-phase I clinical trials in neurosurgery suggest a promising future for MRgFUS. Further investigation is necessary to define its true potential and impact... - Evaluation and management of Cushing syndrome in cases of negative sellar magnetic resonance imagingJay Jagannathan
Department of Neurosurgery, University of Virginia Health Sciences Center, University of Virginia, Charlottesville, Virginia 22908, USA
Neurosurg Focus 23:E3. 2007..Radiosurgery is an effective treatment option in patients with persistent Cushing disease. When a target cannot be found on MR imaging, one can target the entire sellar region with radiosurgery... - Gamma knife radiosurgery for dural arteriovenous fistulasChristopher P Cifarelli
Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia, USA
Neurosurgery 67:1230-5; discussion 1235. 2010..The current management of intracranial dural arteriovenous fistulas (dAVFs) incorporates a multimodal approach involving microneurosurgery, endovascular embolization, and radiosurgery... - Impact of the Accreditation Council for Graduate Medical Education work-hour regulations on neurosurgical resident education and productivityJay Jagannathan
Departments of Neurological Surgery, University of Virginia Health Sciences Center, Charlottesville, Virginia, USA
J Neurosurg 110:820-7. 2009..The authors have evaluated multiple objective surrogate markers of resident performance and quality of training to determine the impact of the 80-hour workweek... - Treatment of glomus jugulare tumors with gamma knife radiosurgeryPhilip G Chen
Department of Otolaryngology, Head and Neck Surgery, University of Virginia, Charlottesville, Virginia, USA
Laryngoscope 120:1856-62. 2010..However, the optimal treatment of these tumors remains unclear. The authors report their data on treatment of GJTs with gamma knife radiosurgery (GKS)... - Gamma Knife radiosurgery for trigeminal neuralgia: the impact of magnetic resonance imaging-detected vascular impingement of the affected nerveJason P Sheehan
Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia, USA
J Neurosurg 113:53-8. 2010.... - Gamma knife surgery for glioblastoma multiformeR Webster Crowley
Department of Neurological Surgery, University of Virginia Health System, Charlottesville, Virginia 22908-0212, USA
Neurosurg Focus 20:E17. 2006..In this paper, the authors review the pathophysiological mechanisms of GKS and its applications for GBM management... - Treatment of intracranial solitary fibrous tumors with gamma knife radiosurgery: report of two cases and review of literatureDavis L Reames
Department of Neurosurgery, University of Virginia Health System, Charlottesville, VA, USA
Neurosurgery 69:E1023-8; discussion E1028. 2011..Gamma knife radiosurgery (GKRS) as a treatment option has not been described in the management of typical intracranial solitary fibrous tumors... - Review of spinal radiosurgery: a minimally invasive approach for the treatment of spinal and paraspinal metastasesJason P Sheehan
Department of Neurosurgery, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
Neurosurg Focus 25:E18. 2008..Spinal radiosurgery has expanded the neurosurgical treatment armamentarium for patients with spinal and paraspinal metastasis... - Resident perceptions of radiosurgical training and the effect of a focused resident training seminarJason P Sheehan
Department of Neurological Surgery, University of Virginia Health System, Charlottesville, Virginia 22908, USA
J Neurosurg 113:59-63. 2010..This study evaluates the opinions of residents on current radiosurgical training and the effect of a focused educational course on those residents... - Gamma Knife surgery for brain metastases from gastrointestinal cancerArnaldo Neves Da Silva
The Lars Leksell Gamma Knife Center, Department of Neurological Surgery, University of Virginia Health System, Charlottesville, Virginia 22908, USA
J Neurosurg 111:423-30. 2009..The purpose of this study was to evaluate the efficacy of Gamma Knife surgery (GKS) for the treatment of brain metastases from gastrointestinal cancers... - Stereotactic radiosurgery for pituitary adenomas: a review of the literature and our experienceJason P Sheehan
Lars Leksell Gamma Knife Center, Department of Neurological Surgery, Health Sciences Center, University of Virginia, Charlottesville, VA 22908, USA
Front Horm Res 34:185-205. 2006.... - Gamma Knife surgery for nonvestibular schwannomas: radiological and clinical outcomesMohamed Elsharkawy
Department of Neurological Surgery, University of Virginia Health System, Charlottesville, Virginia, USA
J Neurosurg 116:66-72. 2012..We evaluate the efficacy of Gamma Knife surgery on nonvestibular schwannomas including trigeminal, hypoglossal, abducent, facial, trochlear, oculomotor, glossopharyngeal, and jugular foramen tumors... - Natural history of cerebral arteriovenous malformations and the risk of hemorrhage after radiosurgeryChun Po Yen
Department of Neurological Surgery, University of Virginia, Charlottesville, VA 22908, USA
Prog Neurol Surg 27:5-21. 2013..5%; this rate is very similar to the 2.0% one computed prior to radiosurgery by assuming AVMs to be congenital. Once angiographic obliteration was confirmed after GKS, the hemorrhage rate dropped to zero... - Gamma knife surgery for low-grade gliomasPeter A Heppner
The Lars Leksell Gamma Knife Center, Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia, USA
Neurosurgery 57:1132-9; discussion. 2005..CONCLUSION: Gamma knife radiosurgery is a safe treatment for low-grade gliomas and may be considered in patients with residual or recurrent disease... - Gamma knife radiosurgery of meningiomas involving the foramen magnumRobert M Starke
Department of Neurological Surgery, University of Virginia, Charlottesville, VA, USA
J Craniovertebr Junction Spine 1:23-8. 2010..For some patients, stereotactic radiosurgery may be used as the primary treatment modality. We evaluatedthe long-term outcome of Gamma Knife radiosurgery (GKRS) for the treatment of patientswith a foramen magnum meningioma... - Inhibition of glioma growth by microbubble activation in a subcutaneous model using low duty cycle ultrasound without significant heatingCaitlin W Burke
Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22908, USA
J Neurosurg 114:1654-61. 2011..In this study, the authors sought determine whether microbubble (MB) destruction with pulsed low duty cycle ultrasound can be used to reduce brain tumor perfusion and growth through nonthermal microvascular ablation... - Stress fracture of the pedicle after extensive decompression and contralateral posterior fusion for lumbar stenosis. Report of three casesJason P Sheehan
Department of Neurological Surgery, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
Neurosurg Focus 13:E9. 2002..Removal of the fractured pedicle, additional decompression, and enhanced bone fusion are recommended when the symptoms warrant surgical intervention... - Intramedullary spinal cysticercosis. Case report and review of the literatureJason P Sheehan
Department of Neurological Surgery, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
Neurosurg Focus 12:e10. 2002..The authors present a case of isolated intramedullary cysticercosis of the cervical spine and review the literature... - External beam radiation therapy and stereotactic radiosurgery for pituitary adenomasJason P Sheehan
Department of Neurological Surgery, University of Virginia, Charlottesville, VA 22908, USA
Neurosurg Clin N Am 23:571-86. 2012..Specific techniques are discussed. In addition, indications and outcomes, including complications, are detailed... - Pioneers in the development of neurological surgery in Auckland, New Zealand: Robertson, Wrightson, and MackenzieJason P Sheehan
Department of Neurological Surgery, University of Virginia, Health Sciences Center, Charlottesville, Virginia 22908, USA
Neurosurgery 57:364-8; discussion 364-8. 2005..To demonstrate the development of neurosurgery in Auckland, New Zealand, which has diverse roots and was influenced by geographical, socioeconomic, and international forces... - Brain abscess in childrenJason P Sheehan
Department of Neurosurgery, University of Virginia Health System, Charlottesville, Virginia, USA
Neurosurg Focus 24:E6. 2008..Although the effectiveness of medical management has improved and some children may be treated with antimicrobial therapy alone, surgical evaluation remains an important component of the treatment algorithm for most pediatric patients... - Single-center experience with pediatric Cushing's diseaseAdam S Kanter
Department of Neurological Surgery, University of Virginia Health System, Charlottesville, Virginia 22908, USA
J Neurosurg 103:413-20. 2005..Three patients (9%) remain with persistent disease. CONCLUSIONS: Pediatric Cushing's disease is a rare condition, often requiring a multidisciplinary diagnostic and a multimodal therapeutic approach for successful long-term remission... - Cerebellar mutism in adults after posterior fossa surgery: a report of 2 casesJonathan H Sherman
Department of Neurological Surgery, University of Virginia, Charlottesville, VA 22908, USA
Surg Neurol 63:476-9. 2005..Characteristics of CMS include complete absence of speech without impaired consciousness, other cranial nerve deficits, or long tract signs... - Evaluation of thoracic spinal cord motion using dynamic MRIJing Cai
Department of Radiation Oncology, University of Virginia, Charlottesville, VA 22908, USA
Radiother Oncol 84:279-82. 2007..We found that the mean motion range at different thoracic levels is typically within 0.5mm. The good stability makes this an excellent position for stereotactic radiotherapy (SBRT)...