T B Shea
Affiliation: University of Massachusetts
Lee S, Zemianek J, Shultz A, Vo A, Maron B, Therrien M, et al
. Synaptic signal streams generated by ex vivo neuronal networks contain non-random, complex patterns. Int J Dev Neurosci. 2014;38:184-94 pubmed publisher
..These findings indicate that the elaboration of complex signal streams comprised of a non-random distribution of signal patterns is an emergent property of ex vivo neuronal networks. ..
Bechtel C, Remington R, Barton B, Barasauskas C, Shea T. Cognitive testing for dementia is adversely affected by administration in a foreign location. BMC Res Notes. 2015;8:66 pubmed publisher
..These findings support the notion that a foreign location can adversely affect performance on cognitive tests, and therefore support cognitive testing in a familiar location. ..
Boumil E, Vohnoutka R, Lee S, Shea T. Early expression of the high molecular weight neurofilament subunit attenuates axonal neurite outgrowth. Neurosci Lett. 2015;604:36-41 pubmed publisher
..These findings support the hypothesis that a developmental delay in NF-H C-terminal phosphorylation is essential to allow appropriate axonal elongation prior to stabilization. ..
Boumil E, Vohnoutka R, Lee S, Pant H, Shea T. Assembly and turnover of neurofilaments in growing axonal neurites. Biol Open. 2018;7: pubmed publisher
..These results are consistent with previous demonstration of a resident NF population within axonal neurites, but suggest that this population is more dynamic than previously considered. ..
Therrien M, Vohnoutka R, Boumil E, Guaraldi M, Lee S, Shea T. Insufficient developmental excitatory neuronal activity fails to foster establishment of normal levels of inhibitory neuronal activity. Int J Dev Neurosci. 2016;55:66-71 pubmed publisher
Shea T, Rogers E, Ashline D, Ortiz D, Sheu M. Apolipoprotein E deficiency promotes increased oxidative stress and compensatory increases in antioxidants in brain tissue. Free Radic Biol Med. 2002;33:1115-20 pubmed
Chan A, Shea T. Effects of dietary supplementation with N-acetyl cysteine, acetyl-L-carnitine and S-adenosyl methionine on cognitive performance and aggression in normal mice and mice expressing human ApoE4. Neuromolecular Med. 2007;9:264-9 pubmed
..Maintenance of neurotransmitter levels and prevention of oxidative damage underscore the efficacy of a therapeutic approach that utilizes a combination of neuroprotective agents. ..
Vohnoutka R, Boumil E, Liu Y, Uchida A, Pant H, Shea T. Influence of a GSK3? phosphorylation site within the proximal C-terminus of Neurofilament-H on neurofilament dynamics. Biol Open. 2017;6:1516-1527 pubmed publisher
..We propose a novel model for sidearm configuration. ..