Affiliation: University of Nebraska Medical Center
Shcherbakova P, Fijalkowska I. Translesion synthesis DNA polymerases and control of genome stability. Front Biosci. 2006;11:2496-517 pubmed
..Finally, we discuss the relationship between the functions of TLS polymerases and human disease. ..
Xing X, Kane D, Bulock C, Moore E, Sharma S, Chabes A, et al
. A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme. Nat Commun. 2019;10:374 pubmed publisher
..We propose that the ultramutator effect results from increased polymerase activity amplifying the contribution of Polε errors to the genomic mutation rate. ..
Barbari S, Kane D, Moore E, Shcherbakova P. Functional Analysis of Cancer-Associated DNA Polymerase ε Variants in Saccharomyces cerevisiae. G3 (Bethesda). 2018;8:1019-1029 pubmed publisher
..Finally, the analysis of Polε variants found in MMR-deficient tumors suggested that the majority cause no mutator phenotype alone but some can synergize with MMR deficiency to increase the mutation rate. ..
Mertz T, Sharma S, Chabes A, Shcherbakova P. Colon cancer-associated mutator DNA polymerase Î´ variant causes expansion of dNTP pools increasing its own infidelity. Proc Natl Acad Sci U S A. 2015;112:E2467-76 pubmed publisher
Barbari S, Shcherbakova P. Replicative DNA polymerase defects in human cancers: Consequences, mechanisms, and implications for therapy. DNA Repair (Amst). 2017;56:16-25 pubmed publisher
..We also discuss likely explanations for a high recurrence of some but not other polymerase variants and new ideas for therapeutic interventions emerging from the mechanistic studies. ..