Affiliation: University of Texas Southwestern Medical Center
Country: USA


  1. Zhang G, Wu L, Mender I, Barzily Rokni M, Hammond M, Ope O, et al. Induction of Telomere Dysfunction Prolongs Disease Control of Therapy-Resistant Melanoma. Clin Cancer Res. 2018;24:4771-4784 pubmed publisher
    ..i>Clin Cancer Res; 24(19); 4771-84. ©2018 AACR See related commentary by Teh and Aplin, p. 4629. ..
  2. Zhang L, Kim S, Luitel K, Shay J. Cholesterol Depletion by TASIN-1 Induces Apoptotic Cell Death through the ER Stress/ROS/JNK Signaling in Colon Cancer Cells. Mol Cancer Ther. 2018;17:943-951 pubmed publisher
    ..2018 aacr. ..
  3. Shay J, Wright W. Telomeres and telomerase: three decades of progress. Nat Rev Genet. 2019;20:299-309 pubmed publisher
    ..We discuss progress in these areas and conclude with challenges and unanswered questions in the field. ..
  4. Luitel K, Bozeman R, Kaisani A, Kim S, Barron S, Richardson J, et al. Proton radiation-induced cancer progression. Life Sci Space Res (Amst). 2018;19:31-42 pubmed publisher
    ..Our conclusion is that exposure to proton irradiation enhances the progression of premalignant lesions to invasive carcinomas through persistent DNA damage, chronic oxidative stress, and immunosuppression. ..
  5. Mender I, LaRanger R, Luitel K, Peyton M, Girard L, Lai T, et al. Telomerase-Mediated Strategy for Overcoming Non-Small Cell Lung Cancer Targeted Therapy and Chemotherapy Resistance. Neoplasia. 2018;20:826-837 pubmed publisher
    ..6-thio-dG, with a known mechanism of action, is a potential novel therapeutic approach to prolong disease control of therapy-resistant lung cancer patients with minimal toxicities. ..
  6. Ludlow A, Shelton D, Wright W, Shay J. ddTRAP: A Method for Sensitive and Precise Quantification of Telomerase Activity. Methods Mol Biol. 2018;1768:513-529 pubmed publisher
    ..The adoptation of the TRAP assay to ddPCR has resulted in improved throughput, increased sensitivity and better repeatability of the TRAP assay. The protocol described below details our procedures for ddTRAP. ..
  7. Shay J. Telomeres and aging. Curr Opin Cell Biol. 2018;52:1-7 pubmed publisher
    ..Overall, telomeres help stabilize the nuclear genome with high fidelity throughout early adult life but diminish in post-reproductive age-associated pathology. ..
  8. Kaisani A, Delgado O, Fasciani G, Kim S, Wright W, Minna J, et al. Branching morphogenesis of immortalized human bronchial epithelial cells in three-dimensional culture. Differentiation. 2014;87:119-26 pubmed publisher
    ..The 3D novel cell culture system recapitulates stromal-epithelial interactions in vitro that can be utilized to understand important aspects of lung development and diseases. ..
  9. Robin J, Ludlow A, Batten K, Magdinier F, Stadler G, Wagner K, et al. Telomere position effect: regulation of gene expression with progressive telomere shortening over long distances. Genes Dev. 2014;28:2464-76 pubmed publisher
    ..Our results suggest a potential novel mechanism for how telomere shortening could contribute to aging and disease initiation/progression in human cells long before the induction of a critical DNA damage response. ..

More Information


  1. Kim S, Zhang L, Barron S, Shay J. Inhibition of microRNA-31-5p protects human colonic epithelial cells against ionizing radiation. Life Sci Space Res (Amst). 2014;1:67-73 pubmed publisher
    ..Targeting this pathway could be a promising therapeutic strategy for future personalized anti-cancer radiotherapy. ..
  2. Mender I, Gryaznov S, Dikmen Z, Wright W, Shay J. Induction of telomere dysfunction mediated by the telomerase substrate precursor 6-thio-2'-deoxyguanosine. Cancer Discov. 2015;5:82-95 pubmed publisher
  3. Shay J, Reddel R, Wright W. Cancer. Cancer and telomeres--an ALTernative to telomerase. Science. 2012;336:1388-90 pubmed publisher
  4. Lai T, Wright W, Shay J. Comparison of telomere length measurement methods. Philos Trans R Soc Lond B Biol Sci. 2018;373: pubmed publisher
    ..This article is part of the theme issue 'Understanding diversity in telomere dynamics'. ..
  5. request reprint
    Zhang L, Theodoropoulos P, Eskiocak U, Wang W, Moon Y, Posner B, et al. Selective targeting of mutant adenomatous polyposis coli (APC) in colorectal cancer. Sci Transl Med. 2016;8:361ra140 pubmed
    ..TASIN-1 represents a potential therapeutic strategy for prevention and intervention in CRC with mutant APC. ..
  6. Shay J. Role of Telomeres and Telomerase in Aging and Cancer. Cancer Discov. 2016;6:584-93 pubmed publisher
    ..This review provides an overview of the current state of the field and how recent advances could affect future research and treatment approaches. Cancer Discov; 6(6); 584-93. ©2016 AACR. ..
  7. Jafri M, Al Qahtani M, SHAY J. Role of miRNAs in human cancer metastasis: Implications for therapeutic intervention. Semin Cancer Biol. 2017;44:117-131 pubmed publisher
    ..This review primarily focuses on the role of miRNAs in the mechanisms of cancer metastasis as well as implications for metastatic cancer treatment. ..
  8. Opresko P, Shay J. Telomere-associated aging disorders. Ageing Res Rev. 2017;33:52-66 pubmed publisher
  9. Wong M, Wright W, Shay J. Alternative splicing regulation of telomerase: a new paradigm?. Trends Genet. 2014;30:430-8 pubmed publisher
    ..We propose that these differential regulatory mechanisms may be widely applicable to other genes and may provide new opportunities for the development of cancer therapeutics. ..
  10. Shay J, Cucinotta F, Sulzman F, Coleman C, Minna J. From mice and men to earth and space: joint NASA-NCI workshop on lung cancer risk resulting from space and terrestrial radiation. Cancer Res. 2011;71:6926-9 pubmed publisher
    ..The workshop examined preclinical models, epidemiology, molecular markers, "omics" technology, radiobiology issues, and lung stem cells that relate to the development of lung cancer. ..
  11. Jafri M, Ansari S, Alqahtani M, Shay J. Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies. Genome Med. 2016;8:69 pubmed publisher
    ..Additionally, recent advances in the clinical development of telomerase inhibitors, as well as potential novel targets, will be summarized. ..
  12. Holohan B, Kim W, Lai T, Hoshiyama H, Zhang N, Alazami A, et al. Impaired telomere maintenance in Alazami syndrome patients with LARP7 deficiency. BMC Genomics. 2016;17:749 pubmed
    ..Together, these experiments demonstrate that in addition to the readily apparent developmental disorder associated with LARP7 deficiency, an underlying telomeropathy exists even in unaffected siblings of these individuals. ..
  13. Singel S, Cornelius C, Zaganjor E, Batten K, Sarode V, Buckley D, et al. KIF14 promotes AKT phosphorylation and contributes to chemoresistance in triple-negative breast cancer. Neoplasia. 2014;16:247-56, 256.e2 pubmed publisher
    ..Together, these findings show an early and critical role for KIF14 in the tumorigenic potential of TNBC, and therapeutic targeting of KIF14 is feasible and effective for TNBC. ..
  14. Min J, Shay J. TERT Promoter Mutations Enhance Telomerase Activation by Long-Range Chromatin Interactions. Cancer Discov. 2016;6:1212-1214 pubmed
    ..This permits recruitment of the transcription factor GABPA in mutant TERT promoters but not in wild-type promoters. Cancer Discov; 6(11); 1212-4. ©2016 AACRSee related article by Ak?nc?lar and colleagues, p. 1276. ..
  15. Huang E, Tedone E, O Hara R, Cornelius C, Lai T, Ludlow A, et al. The Maintenance of Telomere Length in CD28+ T Cells During T Lymphocyte Stimulation. Sci Rep. 2017;7:6785 pubmed publisher
    ..The study of this T-cell subset may lead to a better understanding on how telomerase is regulated and functions in immune cells. ..
  16. Min J, Wright W, Shay J. Alternative Lengthening of Telomeres Mediated by Mitotic DNA Synthesis Engages Break-Induced Replication Processes. Mol Cell Biol. 2017;37: pubmed publisher
  17. Lai T, Zhang N, Noh J, Mender I, Tedone E, Huang E, et al. A method for measuring the distribution of the shortest telomeres in cells and tissues. Nat Commun. 2017;8:1356 pubmed publisher
    ..The results indicate that TeSLA is a robust method that provides a better understanding of the shortest length of telomeres. ..
  18. Kim W, Shay J. Long-range telomere regulation of gene expression: Telomere looping and telomere position effect over long distances (TPE-OLD). Differentiation. 2018;99:1-9 pubmed publisher
    ..In addition to telomere looping, TPE-OLD may be one mechanism of how cells time changes in physiology without initiating a DNA damage response. ..