J W Shay

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc Telomerase in the early detection of cancer
    J W Shay
    Department of Cell Biology and Neuroscience, University of Texas Southwestern Medical Centre at Dallas 75235 9039, USA
    J Clin Pathol 50:106-9. 1997
  2. ncbi request reprint Hayflick, his limit, and cellular ageing
    J W Shay
    University of Texas Southwestern Medical Center at Dallas, Department of Cell Biology, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9039, USA
    Nat Rev Mol Cell Biol 1:72-6. 2000
  3. ncbi request reprint Aging and cancer: are telomeres and telomerase the connection?
    J W Shay
    University of Texas Southwestern Medical Center at Dallas, Department of Cell Biology and Neuroscience 75235 9039, USA
    Mol Med Today 1:378-84. 1995
  4. pmc Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions
    R D Ramirez
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9039, USA
    Genes Dev 15:398-403. 2001
  5. ncbi request reprint Telomere position effect in human cells
    J A Baur
    Department of Cell Biology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390-9039, USA
    Science 292:2075-7. 2001
  6. ncbi request reprint Telomerase and cancer
    J W Shay
    The University of Texas Southwestern Medical Center, Department of Cell Biology, 5323 Harry Hines Boulevard, Dallas, TX 75390 9039, USA
    Hum Mol Genet 10:677-85. 2001
  7. ncbi request reprint Effects of chemopreventive and antitelomerase agents on the spontaneous immortalization of breast epithelial cells
    B S Herbert
    Department of Cell Biology, The University of Texas Southwestern Medical Center, Dallas, TX 75390-9039, USA
    J Natl Cancer Inst 93:39-45. 2001
  8. pmc Normal human chromosomes have long G-rich telomeric overhangs at one end
    W E Wright
    Department of Cell Biology and Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75235 9039 USA
    Genes Dev 11:2801-9. 1997
  9. ncbi request reprint Hallmarks of telomeres in ageing research
    J W Shay
    University of Texas Southwestern Medical Center, Department of Cell Biology, Dallas, TX 75390 9039, USA
    J Pathol 211:114-23. 2007
  10. ncbi request reprint Telomerase immortalization of human myometrial cells
    Jennifer Condon
    Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9032, USA
    Biol Reprod 67:506-14. 2002

Collaborators

Detail Information

Publications26

  1. pmc Telomerase in the early detection of cancer
    J W Shay
    Department of Cell Biology and Neuroscience, University of Texas Southwestern Medical Centre at Dallas 75235 9039, USA
    J Clin Pathol 50:106-9. 1997
    ..Basic scientists and clinicians must work together if this strategy is to mature. Telomerase inhibitors in the treatment of cancer are awaited with great anticipation...
  2. ncbi request reprint Hayflick, his limit, and cellular ageing
    J W Shay
    University of Texas Southwestern Medical Center at Dallas, Department of Cell Biology, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9039, USA
    Nat Rev Mol Cell Biol 1:72-6. 2000
    ....
  3. ncbi request reprint Aging and cancer: are telomeres and telomerase the connection?
    J W Shay
    University of Texas Southwestern Medical Center at Dallas, Department of Cell Biology and Neuroscience 75235 9039, USA
    Mol Med Today 1:378-84. 1995
    ..The interrelationships between telomere shortening and aging, and how activation of telomerase may be necessary for cells to become immortal and malignant, are reviewed here...
  4. pmc Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions
    R D Ramirez
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9039, USA
    Genes Dev 15:398-403. 2001
    ..These results do not support a telomere-independent mechanism of replicative aging...
  5. ncbi request reprint Telomere position effect in human cells
    J A Baur
    Department of Cell Biology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390-9039, USA
    Science 292:2075-7. 2001
    ..The dependence of TPE on telomere length provides a mechanism for the modification of gene expression throughout the replicative life-span of human cells...
  6. ncbi request reprint Telomerase and cancer
    J W Shay
    The University of Texas Southwestern Medical Center, Department of Cell Biology, 5323 Harry Hines Boulevard, Dallas, TX 75390 9039, USA
    Hum Mol Genet 10:677-85. 2001
    ..This review covers recent advances in the field including the use of telomerase in cancer diagnostics and an overview of anti-telomerase cancer therapeutic approaches...
  7. ncbi request reprint Effects of chemopreventive and antitelomerase agents on the spontaneous immortalization of breast epithelial cells
    B S Herbert
    Department of Cell Biology, The University of Texas Southwestern Medical Center, Dallas, TX 75390-9039, USA
    J Natl Cancer Inst 93:39-45. 2001
    ..The results also suggest that the telomerase ribonucleoprotein complex may be an important molecular target for breast cancer prevention...
  8. pmc Normal human chromosomes have long G-rich telomeric overhangs at one end
    W E Wright
    Department of Cell Biology and Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75235 9039 USA
    Genes Dev 11:2801-9. 1997
    ..Our results do not exclude the possibility that nuclease processing events following leading strand synthesis result in short overhangs on one end...
  9. ncbi request reprint Hallmarks of telomeres in ageing research
    J W Shay
    University of Texas Southwestern Medical Center, Department of Cell Biology, Dallas, TX 75390 9039, USA
    J Pathol 211:114-23. 2007
    ..This indicates that telomerase-induced telomere length manipulations may have utility for tissue engineering and for dissecting the molecular mechanisms underlying genetic diseases, including cancer...
  10. ncbi request reprint Telomerase immortalization of human myometrial cells
    Jennifer Condon
    Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9032, USA
    Biol Reprod 67:506-14. 2002
    ..The expression of various smooth muscle/myometrium cell markers suggests that these cells may be an appropriate model system to study certain aspects of human myometrial function...
  11. pmc Quantitation of telomerase components and hTERT mRNA splicing patterns in immortal human cells
    X Yi
    Department of Cell Biology, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390-9039, USA
    Nucleic Acids Res 29:4818-25. 2001
    ..We also found that most telomerase-positive cell lines only contain a few molecules of potentially functional hTERT mRNA, and there is a correlation between telomerase activity and the levels of both hTR and hTERT +alpha+beta mRNA...
  12. ncbi request reprint Cellular senescence as a tumor-protection mechanism: the essential role of counting
    W E Wright
    Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9039, USA
    Curr Opin Genet Dev 11:98-103. 2001
    ....
  13. ncbi request reprint Normal human telomeres are not late replicating
    W E Wright
    Department of Cell Biology and Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75235, USA
    Exp Cell Res 251:492-9. 1999
    ..Therefore, the timings of replication and processing of human telomeres are very different from those of yeast...
  14. pmc Is telomerase a viable target in cancer?
    C M Buseman
    The University of Texas Southwestern Medical Center, Department of Cell Biology, Dallas, TX 75390 9039, USA
    Mutat Res 730:90-7. 2012
    ..A frank and balanced assessment of the current state of telomerase inhibitors with caveats and potential limitations will be included...
  15. pmc Characterisation of telomerase immortalised normal human oesophageal squamous cells
    C P Morales
    Department of Veterans Affairs Medical Center, Dallas, Texas, USA
    Gut 52:327-33. 2003
    ..We have used telomerase technology to establish normal human oesophageal cell lines...
  16. ncbi request reprint Telomerase can inhibit the recombination-based pathway of telomere maintenance in human cells
    L P Ford
    Department of Cell Biology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390-9039, USA
    J Biol Chem 276:32198-203. 2001
    ....
  17. ncbi request reprint Ageing and cancer: the telomere and telomerase connection
    J W Shay
    University of Texas Southwestern Medical Center at Dallas, Department of Cell Biology, 5323 Harry Hines Boulevard, Dallas, TX 75390-9039, USA
    Novartis Found Symp 235:116-25; discussion 125-9, 146-9. 2001
    ..This indicates that telomerase-induced telomere length manipulations may have utility for tissue engineering and for dissecting the molecular mechanisms underlying genetic diseases including cancer...
  18. ncbi request reprint Telomeres and telomerase: implications for cancer and aging
    J W Shay
    The University of Texas Southwestern Medical Center, Department of Cell Biology, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9039, USA
    Radiat Res 155:188-193. 2001
    ..Thus telomerase may also be a promising target for cancer therapy...
  19. ncbi request reprint Characterization of paired tumor and non-tumor cell lines established from patients with breast cancer
    A F Gazdar
    Hamon Center for Therapeutic Oncology Research, Department of Pathology, University of Texas Southwestern Medical Center, Dallas 75235 8593, USA
    Int J Cancer 78:766-74. 1998
    ..Our panel of paired tumor and non-malignant cell lines should provide important new reagents for breast cancer research...
  20. ncbi request reprint Characterization of a breast cancer cell line derived from a germ-line BRCA1 mutation carrier
    G E Tomlinson
    Department of Pediatrics, and the Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas 75235 8593, USA
    Cancer Res 58:3237-42. 1998
    ..This breast tumor-derived cell line may provide a useful model system for the study of familial breast cancer pathogenesis and for elucidating BRCA1 function and localization...
  21. doi request reprint Aneuploid human colonic epithelial cells are sensitive to AICAR-induced growth inhibition through EGFR degradation
    P Ly
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Oncogene 32:3139-46. 2013
    ..Our data collectively support the pharmacological compound AICAR as a novel inhibitor of EGFR protein abundance and as a potential anticancer agent for aneuploidy-driven colorectal cancer. ..
  22. pmc Telomerase and breast cancer
    B S Herbert
    Department of Cell Biology, The University of Texas Southwestern Medical Center at Dallas, Texas 75390-9039, USA
    Breast Cancer Res 3:146-9. 2001
    ..We address the use of telomerase in the diagnostics of breast pathology, as well as the use of telomerase inhibitors in the treatment and prevention of breast cancer...
  23. pmc Targeting telomerase for cancer therapeutics
    J W Shay
    Department of Cell Biology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 9030, USA
    Br J Cancer 98:677-83. 2008
    ..Several clinical trials have been initiated, and in this review we highlight some of the most promising approaches and conclude by speculating on the role of telomerase in cancer stem cells...
  24. pmc An alternate splicing variant of the human telomerase catalytic subunit inhibits telomerase activity
    X Yi
    Department of Cell Biology, The University of Texas Southwestern Medical Center at Dallas, 75390 9039, USA
    Neoplasia 2:433-40. 2000
    ..This alternately spliced dominant-negative variant may be important in understanding telomerase regulation during development, differentiation and in cancer progression...
  25. doi request reprint Bone marrow progenitor cells contribute to esophageal regeneration and metaplasia in a rat model of Barrett's esophagus
    G Sarosi
    Dallas VA Medical Center, Dallas, Texas 75216, USA
    Dis Esophagus 21:43-50. 2008
    ..These observations suggest that multi-potential progenitor cells of bone marrow origin contribute to esophageal regeneration and metaplasia in this rat model of Barrett's esophagus...
  26. pmc Functional requirement of p23 and Hsp90 in telomerase complexes
    S E Holt
    Department of Cell Biology and Neuroscience, University of Texas UT Southwestern Medical Center, Dallas, Texas 75235 USA
    Genes Dev 13:817-26. 1999
    ..Consistent with in vitro results, inhibition of Hsp90 function in cells blocks assembly of active telomerase. To our knowledge, p23 and Hsp90 are the first telomerase-associated proteins demonstrated to contribute to telomerase activity...