P W Shaul

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi request reprint Pulmonary NO synthase expression is attenuated in a fetal baboon model of chronic lung disease
    Sam Afshar
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas 75390, USA
    Am J Physiol Lung Cell Mol Physiol 284:L749-58. 2003
  2. ncbi request reprint Inhaled NO improves early pulmonary function and modifies lung growth and elastin deposition in a baboon model of neonatal chronic lung disease
    Donald C McCurnin
    Department of Pediatrics, University of Texas Health Science Center, San Antonio, Texas, USA
    Am J Physiol Lung Cell Mol Physiol 288:L450-9. 2005
  3. ncbi request reprint Novel role of estrogen receptors in vascular endothelium
    P W Shaul
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, 75235 9063, USA
    Semin Perinatol 24:70-4. 2000
  4. ncbi request reprint Rapid activation of endothelial nitric oxide synthase by estrogen
    P W Shaul
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, 75235 9063, USA
    Steroids 64:28-34. 1999
  5. ncbi request reprint Regulation of vasodilator synthesis during lung development
    P W Shaul
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas 75235 9063, USA
    Early Hum Dev 54:271-94. 1999
  6. ncbi request reprint Developmental changes in prostacyclin synthesis are conserved in cultured pulmonary endothelium and vascular smooth muscle
    P W Shaul
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
    Am J Respir Cell Mol Biol 20:113-21. 1999
  7. ncbi request reprint Regulation of endothelial nitric oxide synthase: location, location, location
    Philip W Shaul
    Department of Pediatrics University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9063, USA
    Annu Rev Physiol 64:749-74. 2002
  8. ncbi request reprint Developmental changes in nitric oxide synthase isoform expression and nitric oxide production in fetal baboon lung
    Philip W Shaul
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas 75390, USA
    Am J Physiol Lung Cell Mol Physiol 283:L1192-9. 2002
  9. pmc Endothelial nitric oxide synthase, caveolae and the development of atherosclerosis
    Philip W Shaul
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 9063, USA
    J Physiol 547:21-33. 2003
  10. ncbi request reprint Estrogen receptor alpha and endothelial nitric oxide synthase are organized into a functional signaling module in caveolae
    K L Chambliss
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75235 9063, USA
    Circ Res 87:E44-52. 2000

Collaborators

Detail Information

Publications53

  1. ncbi request reprint Pulmonary NO synthase expression is attenuated in a fetal baboon model of chronic lung disease
    Sam Afshar
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas 75390, USA
    Am J Physiol Lung Cell Mol Physiol 284:L749-58. 2003
    ..It is postulated that these alterations in NOS expression and activity may contribute to the pathogenesis of CLD...
  2. ncbi request reprint Inhaled NO improves early pulmonary function and modifies lung growth and elastin deposition in a baboon model of neonatal chronic lung disease
    Donald C McCurnin
    Department of Pediatrics, University of Texas Health Science Center, San Antonio, Texas, USA
    Am J Physiol Lung Cell Mol Physiol 288:L450-9. 2005
    ..Thus, in the baboon model of CLD, iNO improves early pulmonary function and alters lung growth and extracellular matrix deposition. As such, NO biosynthetic pathway dysfunction may contribute to the pathogenesis of CLD...
  3. ncbi request reprint Novel role of estrogen receptors in vascular endothelium
    P W Shaul
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, 75235 9063, USA
    Semin Perinatol 24:70-4. 2000
    ..Thus, the acute effect of estrogen on eNOS is mediated by ERalpha functioning in a novel, nongenomic manner to activate the enzyme via calcium-dependent, MAP kinase-dependent mechanisms...
  4. ncbi request reprint Rapid activation of endothelial nitric oxide synthase by estrogen
    P W Shaul
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, 75235 9063, USA
    Steroids 64:28-34. 1999
    ....
  5. ncbi request reprint Regulation of vasodilator synthesis during lung development
    P W Shaul
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas 75235 9063, USA
    Early Hum Dev 54:271-94. 1999
    ..A greater understanding of the mechanisms regulating PGI2 and NO synthesis in the developing lung will potentially lead to novel therapies for neonatal pulmonary hypertension aimed at optimizing endogenous vasodilator production...
  6. ncbi request reprint Developmental changes in prostacyclin synthesis are conserved in cultured pulmonary endothelium and vascular smooth muscle
    P W Shaul
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
    Am J Respir Cell Mol Biol 20:113-21. 1999
    ..Further studies with the cultured cell model will enable determination of the factors that directly regulate COX-1 expression in the developing pulmonary vasculature...
  7. ncbi request reprint Regulation of endothelial nitric oxide synthase: location, location, location
    Philip W Shaul
    Department of Pediatrics University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9063, USA
    Annu Rev Physiol 64:749-74. 2002
    ..Further understanding of these mechanisms will enable us to take preventive and therapeutic advantage of the powerful actions of NO in multiple cell types...
  8. ncbi request reprint Developmental changes in nitric oxide synthase isoform expression and nitric oxide production in fetal baboon lung
    Philip W Shaul
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas 75390, USA
    Am J Physiol Lung Cell Mol Physiol 283:L1192-9. 2002
    ..Thus, there are developmental increases in pulmonary NOS expression and NO production during the early third trimester in the primate that may enhance airway and parenchymal function in the immediate postnatal period...
  9. pmc Endothelial nitric oxide synthase, caveolae and the development of atherosclerosis
    Philip W Shaul
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 9063, USA
    J Physiol 547:21-33. 2003
    ..These processes may be critically involved in the earliest phases of atherogenesis, which recent studies suggest may occur during fetal life...
  10. ncbi request reprint Estrogen receptor alpha and endothelial nitric oxide synthase are organized into a functional signaling module in caveolae
    K L Chambliss
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75235 9063, USA
    Circ Res 87:E44-52. 2000
    ..The full text of this article is available at http://www.circresaha.org...
  11. ncbi request reprint Effects of chronic estrogen-receptor blockade on ovine perinatal pulmonary circulation
    T A Parker
    The Pediatric Heart Lung Center, Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado 80262, USA
    Am J Physiol Heart Circ Physiol 281:H1005-14. 2001
    ..We speculate that estrogen exposure during late gestation prepares the pulmonary circulation for postnatal adaptation...
  12. ncbi request reprint Establishment of an immortalized fetal intrapulmonary artery endothelial cell line
    M C Pace
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235 9063, USA
    Am J Physiol 277:L106-12. 1999
    ..Immortalized PAECs will provide an excellent model for further studies of eNOS gene expression and function in fetal pulmonary endothelium...
  13. pmc Estrogen upregulates cyclooxygenase-1 gene expression in ovine fetal pulmonary artery endothelium
    S S Jun
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235 9063, USA
    J Clin Invest 102:176-83. 1998
    ..This process may play a critical role in optimizing the capacity for PGI2-mediated pulmonary vasodilation at birth, and it may also be involved in estrogen responsiveness in other vascular beds...
  14. ncbi request reprint Glucocorticoids downregulate cyclooxygenase-1 gene expression and prostacyclin synthesis in fetal pulmonary artery endothelium
    S S Jun
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, TX, USA
    Circ Res 84:193-200. 1999
    ..This mechanism may modulate pulmonary PGI2 production in the perinatal period, and it may also play a role in the effects of glucocorticoids on the systemic circulation at a variety of ages...
  15. ncbi request reprint High-density lipoprotein binding to scavenger receptor-BI activates endothelial nitric oxide synthase
    I S Yuhanna
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Nat Med 7:853-7. 2001
    ..Thus, HDL activates eNOS via SR-BI through a process that requires ApoA-I binding. The resulting increase in nitric-oxide production might be critical to the atheroprotective properties of HDL and ApoA-I...
  16. ncbi request reprint Modulation of endothelial NO production by high-density lipoprotein
    C Mineo
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9063, USA
    Cold Spring Harb Symp Quant Biol 67:459-69. 2002
  17. ncbi request reprint Plasma membrane estrogen receptors are coupled to endothelial nitric-oxide synthase through Galpha(i)
    M H Wyckoff
    Departments of Pediatrics and Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 276:27071-6. 2001
    ..Thus, novel G protein coupling enables a subpopulation of ERalpha to initiate signal transduction at the cell surface. Similar mechanisms may underly the nongenomic actions of other steroid hormones...
  18. pmc Oxygen modulates prostacyclin synthesis in ovine fetal pulmonary arteries by an effect on cyclooxygenase
    P W Shaul
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas 75235 9063
    J Clin Invest 90:2147-55. 1992
    ..This process is due to an effect on cyclooxygenase activity, it causes marked parallel alterations in cAMP production, and it is specific to the pulmonary circulation...
  19. ncbi request reprint Pulmonary endothelial nitric oxide synthase gene expression is decreased in a rat model of congenital diaphragmatic hernia
    A J North
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas 75235, USA
    Am J Respir Cell Mol Biol 13:676-82. 1995
    ..Paralleling the decline in eNOS protein expression, eNOS mRNA was decreased in CDH versus control lung (22 +/- 8 versus 100 +/- 31% of control, n = 4).(ABSTRACT TRUNCATED AT 250 WORDS)..
  20. ncbi request reprint Ontogeny of beta-adrenergic receptors in pulmonary arterial smooth muscle, bronchial smooth muscle, and alveolar lining cells in the rat
    D N Schell
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas 75235
    Am J Respir Cell Mol Biol 7:317-24. 1992
    ..In contrast, receptor density in BSM cells did not change from 1 to 13 days, but it increased 65% from 13 to 20 days, rose another 47% from 20 days to 3 mo, and increased an additional 24% from 3 to 6 mo.(ABSTRACT TRUNCATED AT 250 WORDS)..
  21. ncbi request reprint Comparison of beta adrenergic receptor binding characteristics and coupling to adenylate cyclase in rat pulmonary artery versus aorta
    P W Shaul
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas
    J Pharmacol Exp Ther 252:86-92. 1990
    ..9 vs. 125.5 +/- 19.1 pmol of cAMP per mg of protein, P less than .001), as was basal adenylate cyclase activity (10.8 +/- 1.2 vs. 5.7 +/- 1.3 pmol of cAMP per mg of protein per min, P less than .05).(ABSTRACT TRUNCATED AT 250 WORDS)..
  22. ncbi request reprint Inhaled nitric oxide: effects on cerebral growth and injury in a baboon model of premature delivery
    Sandra M Rees
    Department of Anatomy and Cell Biology, University of Melbourne, Parkville, Victoria, 3010, Australia
    Pediatr Res 61:552-8. 2007
    ..Overall, iNO did not alter the extent of brain damage but did result in the presence of hematomas. These results do not confirm any protective or major injurious effect of nitric oxide therapy on the developing brain...
  23. ncbi request reprint Pulmonary and systemic nitric oxide metabolites in a baboon model of neonatal chronic lung disease
    David A Munson
    Joseph Stokes Jr Research Institute, Children s Hospital of Philadelphia, 3516 Civic Center Blvd, 416D Abramson Research Center, Philadelphia, PA 19104, USA
    Am J Respir Cell Mol Biol 33:582-8. 2005
    ..Thus, a deficiency in NO production and biological function in the premature baboon was not apparent by the detection and quantification of these surrogate markers of NO production...
  24. ncbi request reprint Biochemical consequences of the NOS3 Glu298Asp variation in human endothelium: altered caveolar localization and impaired response to shear
    Mandar S Joshi
    Center for Cardiovascular Medicine, Columbus Children s Research Institute, 700 Children s Dr, Columbus, OH 43205, USA
    FASEB J 21:2655-63. 2007
    ....
  25. pmc HDL action on the vascular wall: is the answer NO?
    Philip W Shaul
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Clin Invest 113:509-13. 2004
    ..A new study shows that HDL-associated lysophospholipids stimulate the production of the potent antiatherogenic signaling molecule NO by the vascular endothelium...
  26. ncbi request reprint HDL stimulation of endothelial nitric oxide synthase: a novel mechanism of HDL action
    Chieko Mineo
    Department of Pediatrics, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Trends Cardiovasc Med 13:226-31. 2003
    ....
  27. ncbi request reprint Nitric oxide attenuates epithelial-mesenchymal transition in alveolar epithelial cells
    Shilpa Vyas-Read
    Division of Neonatal Perinatal Medicine, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9063, USA
    Am J Physiol Lung Cell Mol Physiol 293:L212-21. 2007
    ..NO-mediated regulation of AEC fate may have important implications in the pathophysiology and treatment of diseases such as IPF and BPD...
  28. pmc Cholesterol binding, efflux, and a PDZ-interacting domain of scavenger receptor-BI mediate HDL-initiated signaling
    Chatchawin Assanasen
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Clin Invest 115:969-77. 2005
    ..Thus, HDL signaling requires cholesterol binding and efflux and C-terminal domains of SR-BI, and SR-BI serves as a cholesterol sensor on the plasma membrane...
  29. ncbi request reprint Dissecting the basis of nongenomic activation of endothelial nitric oxide synthase by estradiol: role of ERalpha domains with known nuclear functions
    Ken L Chambliss
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
    Mol Endocrinol 19:277-89. 2005
    ..Thus, dimerization is not required for ERalpha coupling to eNOS; however, NLS2/NLS3 plays a role in Src activation, and the DNA binding region is involved in the dynamic interaction between ERalpha and PI3 kinase...
  30. ncbi request reprint Abnormal vascular function and hypertension in mice deficient in estrogen receptor beta
    Yan Zhu
    Molecular Cardiology Research Institute, New England Medical Center and Department of Medicine, Tufts University School of Medicine, Boston, MA 02111, USA
    Science 295:505-8. 2002
    ..Furthermore, ERbeta-deficient mice develop sustained systolic and diastolic hypertension as they age. These data support an essential role for ERbeta in the regulation of vascular function and blood pressure...
  31. ncbi request reprint Rapid activation of endothelial NO synthase by estrogen: evidence for a steroid receptor fast-action complex (SRFC) in caveolae
    Ken L Chambliss
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Steroids 67:413-9. 2002
    ..Emphasizing the dependence on cell surface-associated receptors, these observations provide evidence for the existence of a steroid receptor fast-action complex, or SRFC, in caveolae...
  32. ncbi request reprint Estrogen acutely activates prostacyclin synthesis in ovine fetal pulmonary artery endothelium
    Todd S Sherman
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9063, USA
    Am J Respir Cell Mol Biol 26:610-6. 2002
    ..These mechanisms may play a role in pulmonary vasodilation in the perinatal period...
  33. ncbi request reprint ERbeta has nongenomic action in caveolae
    Ken L Chambliss
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Mol Endocrinol 16:938-46. 2002
    ..These findings in the ER-eNOS signaling paradigm indicate that endogenous ERbeta has nongenomic action in caveolae...
  34. ncbi request reprint Conventional estrogen receptors are found in the plasma membrane of vaginal epithelial cells of the rat
    Shashi Singh
    Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500007, India
    Steroids 67:757-64. 2002
    ..Besides a role in signal transduction events induced by estradiol, the membrane estrogen receptors may have an important role to play in translocation of the steroid to the cytosolic compartment...
  35. ncbi request reprint Estrogen modulation of endothelial nitric oxide synthase
    Ken L Chambliss
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    Endocr Rev 23:665-86. 2002
    ..In addition, they serve as excellent paradigms for further elucidation of novel mechanisms of steroid hormone action...
  36. ncbi request reprint High density lipoprotein-induced endothelial nitric-oxide synthase activation is mediated by Akt and MAP kinases
    Chieko Mineo
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 278:9142-9. 2003
    ..These results indicate that HDL stimulates eNOS through common upstream, Src-mediated signaling, which leads to parallel activation of Akt and MAP kinases and their resultant independent modulation of the enzyme...
  37. ncbi request reprint Estrogen causes dynamic alterations in endothelial estrogen receptor expression
    Christopher E Ihionkhan
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas 75390 9063, USA
    Circ Res 91:814-20. 2002
    ..We postulate that E2-induced changes in ERalpha and ERbeta expression modify the effects of the hormone on vascular endothelium...
  38. ncbi request reprint Molecular basis of estrogen-induced cyclooxygenase type 1 upregulation in endothelial cells
    Linda L Gibson
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, TX 75390, USA
    Circ Res 96:518-25. 2005
    ..In addition, the process may be initiated by cytoplasmic ERalpha, and critical receptor elements reside within the amino terminus...
  39. ncbi request reprint Surfactant composition and function in a primate model of infant chronic lung disease: effects of inhaled nitric oxide
    Philip L Ballard
    Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, 19104, USA
    Pediatr Res 59:157-62. 2006
    ..NO treatment improves the apparent ability of hydrophobic SP to promote low surface tension, perhaps secondary to less protein inactivation of surfactant, and improves lung volume by a process unrelated to surfactant function...
  40. ncbi request reprint Hypoxia-induced left ventricular dysfunction in myoglobin-deficient mice
    Pradeep P A Mammen
    Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 8573, USA
    Am J Physiol Heart Circ Physiol 285:H2132-41. 2003
    ..These new data establish that myoglobin is an important cytoplasmic cardiac hemoprotein that functions in regulating NO homeostasis within cardiomyocytes...
  41. ncbi request reprint Role of high-density lipoprotein and scavenger receptor B type I in the promotion of endothelial repair
    Chieko Mineo
    Division of Pulmonary and Vascular Biology, Department of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Trends Cardiovasc Med 17:156-61. 2007
    ..As such, signaling initiated by HDL-SR-BI promotes endothelial repair, and this novel mechanism of action may be critically involved in the impact of the lipoprotein on vascular health and disease...
  42. pmc 27-hydroxycholesterol is an endogenous selective estrogen receptor modulator
    Carolyn D DuSell
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Endocrinol 22:65-77. 2008
    ..Moreover, given the product-precursor relationship between 27HC and cholesterol, our findings have implications with respect to breast cancer risk in obese/hypercholesteremic individuals...
  43. ncbi request reprint 27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen
    Michihisa Umetani
    Department of Pharmacology and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, Texas 75390 9050, USA
    Nat Med 13:1185-92. 2007
    ..Taken together, these studies point to 27HC as a contributing factor in the loss of estrogen protection from vascular disease...
  44. ncbi request reprint Direct Interactions with G alpha i and G betagamma mediate nongenomic signaling by estrogen receptor alpha
    Premlata Kumar
    Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9063, USA
    Mol Endocrinol 21:1370-80. 2007
    ..Thus, through direct interactions, ER alpha mediates a novel mechanism of G protein activation that provides greater diversity of function of both the steroid hormone receptor and G proteins...
  45. pmc Endothelin-1 induces alveolar epithelial-mesenchymal transition through endothelin type A receptor-mediated production of TGF-beta1
    Raksha Jain
    Division of Pulmonary and Vascular Biology, Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9063, USA
    Am J Respir Cell Mol Biol 37:38-47. 2007
    ..These findings increase our basic understanding of the role of ET-1 in pulmonary fibrosis and suggest potential roles for AEC-derived ET-1 in the pathogenesis of other alveolar epithelial-mediated lung diseases...
  46. ncbi request reprint C-reactive protein causes downregulation of vascular angiotensin subtype 2 receptors and systolic hypertension in mice
    Wanpen Vongpatanasin
    Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    Circulation 115:1020-8. 2007
    ..Chronic elevations in circulating C-reactive protein (CRP) are associated with a greater risk of hypertension. Whether elevations in CRP cause hypertension is unknown...
  47. ncbi request reprint Endothelial and antithrombotic actions of HDL
    Chieko Mineo
    Division of Pulmonary and Vascular Biology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9063, USA
    Circ Res 98:1352-64. 2006
    ..With further investigation and resulting greater depth of understanding, these mechanisms may be harnessed to provide new prophylactic and therapeutic strategies to combat atherosclerosis and thrombotic disorders...
  48. ncbi request reprint Circulating cardiovascular disease risk factors and signaling in endothelial cell caveolae
    Chieko Mineo
    Division of Pulmonary and Vascular Biology, Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX, USA
    Cardiovasc Res 70:31-41. 2006
    ..Thus, signaling events in caveolae invoked by known circulating cardiovascular disease risk factors have major impact on endothelial cell phenotypes of importance to cardiovascular health and disease...
  49. ncbi request reprint FcgammaRIIB mediates C-reactive protein inhibition of endothelial NO synthase
    Chieko Mineo
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Circ Res 97:1124-31. 2005
    ..Thus FcgammaRIIB mediates CRP inhibition of eNOS via PP2A, providing a mechanistic link between CRP and endothelial dysfunction...
  50. pmc Effect of ductus ligation on cardiopulmonary function in premature baboons
    Donald C McCurnin
    Southwest Foundation for Biomedical Research, San Antonio, TX, USA
    Am J Respir Crit Care Med 172:1569-74. 2005
    ..The role of the patent ductus arteriosus in the development of chronic lung disease in surfactant-treated premature newborns remains unclear...
  51. ncbi request reprint Vasomodulation by skeletal muscle-derived nitric oxide requires alpha-syntrophin-mediated sarcolemmal localization of neuronal Nitric oxide synthase
    Gail D Thomas
    Department of Internal Medicine, Division of Hypertension, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Tex 75390 8586, USA
    Circ Res 92:554-60. 2003
    ....
  52. ncbi request reprint Caveolin-1 is not required for murine intestinal cholesterol transport
    Mark A Valasek
    Department of Physiology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    J Biol Chem 280:28103-9. 2005
    ..These results demonstrate that CAV1 is not required for cholesterol absorption or ezetimibe sensitivity in the mouse...
  53. doi request reprint The scavenger receptor class B type I adaptor protein PDZK1 maintains endothelial monolayer integrity
    Weifei Zhu
    Division of Pulmonary and Vascular Biology, Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas, USA
    Circ Res 102:480-7. 2008
    ..Thus, PDZK1 is uniquely required for HDL/SR-BI signaling in endothelium, and through these mechanisms, it is critically involved in the maintenance of endothelial monolayer integrity...