Kathy L Sharpe-Timms

Summary

Affiliation: University of Missouri
Country: USA

Publications

  1. pmc Cellular and molecular basis for endometriosis-associated infertility
    Julie A W Stilley
    Division of Reproductive and Perinatal Research, Department of Obstetrics, Gynecology and Women s Health, The University of Missouri School of Medicine, Columbia, 65212, USA
    Cell Tissue Res 349:849-62. 2012
  2. ncbi request reprint Defining endometrial cells: the need for improved identification at ectopic sites and characterization in eutopic sites for developing novel methods of management for endometriosis
    Kathy L Sharpe-Timms
    Division of Reproductive and Perinatal Research, Department of Obstetrics, Gynecology and Women s Health, University of Missouri Columbia, Columbia, Missouri 65212, USA
    Fertil Steril 84:35-7; discussion 38-9. 2005
  3. ncbi request reprint Understanding endometriosis is the key to successful therapeutic management
    Kathy L Sharpe-Timms
    Department of Obstetrics and Gynecology, School of Medicine, University of Missouri Columbia, Columbia, Missouri 65212, USA
    Fertil Steril 81:1201-3. 2004
  4. pmc Inflammatory cytokines differentially up-regulate human endometrial haptoglobin production in women with endometriosis
    K L Sharpe-Timms
    Department of Obstetrics, Gynecology and Women s Health, The University of Missouri Columbia, 1 Hospital Drive, N 625 HSC, Columbia, MO 65212, USA
    Hum Reprod 25:1241-50. 2010
  5. ncbi request reprint Endometriotic haptoglobin binds to peritoneal macrophages and alters their function in women with endometriosis
    Kathy L Sharpe-Timms
    Department of Obstetrics and Gynecology, University of Missouri Columbia, Columbia, Missouri 65212, USA
    Fertil Steril 78:810-9. 2002
  6. ncbi request reprint Haptoglobin expression by shed endometrial tissue fragments found in peritoneal fluid
    Kathy L Sharpe-Timms
    Division of Reproductive and Perinatal Research, Department of Obstetrics, Gynecology, and Women s Health, University of Missouri Columbia, Columbia, Missouri, USA
    Fertil Steril 84:22-30. 2005
  7. ncbi request reprint Using rats as a research model for the study of endometriosis
    Kathy L Sharpe-Timms
    Department of Obstetrics and Gynecology, University of Missouri Columbia, 65212, USA
    Ann N Y Acad Sci 955:318-27; discussion 340-2, 396-406. 2002
  8. ncbi request reprint Paracrine regulation of matrix metalloproteinase expression in endometriosis
    Kathy L Sharpe-Timms
    Department of Obstetrics and Gynecology, University of Missouri Columbia, 65212, USA
    Ann N Y Acad Sci 955:147-56; discussion 157-8, 396-406. 2002
  9. ncbi request reprint Endometrial anomalies in women with endometriosis
    K L Sharpe-Timms
    Department of Obstetrics and Gynecology and Animal Sciences, University of Missouri Columbia, 65212, USA
    Ann N Y Acad Sci 943:131-47. 2001
  10. pmc Neutralizing TIMP1 restores fecundity in a rat model of endometriosis and treating control rats with TIMP1 causes anomalies in ovarian function and embryo development
    Julie A W Stilley
    Department of Obstetrics, Division of Animal Sciences, College of Agriculture, Food and Natural Resources, University of Missouri Columbia, Columbia, Missouri 65212, USA
    Biol Reprod 83:185-94. 2010

Collaborators

Detail Information

Publications25

  1. pmc Cellular and molecular basis for endometriosis-associated infertility
    Julie A W Stilley
    Division of Reproductive and Perinatal Research, Department of Obstetrics, Gynecology and Women s Health, The University of Missouri School of Medicine, Columbia, 65212, USA
    Cell Tissue Res 349:849-62. 2012
    ....
  2. ncbi request reprint Defining endometrial cells: the need for improved identification at ectopic sites and characterization in eutopic sites for developing novel methods of management for endometriosis
    Kathy L Sharpe-Timms
    Division of Reproductive and Perinatal Research, Department of Obstetrics, Gynecology and Women s Health, University of Missouri Columbia, Columbia, Missouri 65212, USA
    Fertil Steril 84:35-7; discussion 38-9. 2005
    ..Currently, histologic confirmation of laparoscopic findings is paramount for diagnosis of endometriosis and evidence is evolving suggesting that the pathogenesis of endometriosis is related to endometrial anomalies...
  3. ncbi request reprint Understanding endometriosis is the key to successful therapeutic management
    Kathy L Sharpe-Timms
    Department of Obstetrics and Gynecology, School of Medicine, University of Missouri Columbia, Columbia, Missouri 65212, USA
    Fertil Steril 81:1201-3. 2004
    ..Understanding endometriosis on a molecular, biochemical, and genetic level will lead to better methods for the diagnosis and therapeutic management of this enigmatic disease...
  4. pmc Inflammatory cytokines differentially up-regulate human endometrial haptoglobin production in women with endometriosis
    K L Sharpe-Timms
    Department of Obstetrics, Gynecology and Women s Health, The University of Missouri Columbia, 1 Hospital Drive, N 625 HSC, Columbia, MO 65212, USA
    Hum Reprod 25:1241-50. 2010
    ..We hypothesized that differences in endometrial haptoglobin (eHp) mRNA and protein levels exist between eutopic endometrium from US-E and US-C and that inflammatory mediators may be involved...
  5. ncbi request reprint Endometriotic haptoglobin binds to peritoneal macrophages and alters their function in women with endometriosis
    Kathy L Sharpe-Timms
    Department of Obstetrics and Gynecology, University of Missouri Columbia, Columbia, Missouri 65212, USA
    Fertil Steril 78:810-9. 2002
    ..To evaluate the effects of endometriotic haptoglobin on peritoneal macrophage function...
  6. ncbi request reprint Haptoglobin expression by shed endometrial tissue fragments found in peritoneal fluid
    Kathy L Sharpe-Timms
    Division of Reproductive and Perinatal Research, Department of Obstetrics, Gynecology, and Women s Health, University of Missouri Columbia, Columbia, Missouri, USA
    Fertil Steril 84:22-30. 2005
    ..To confirm the endometrial glandular epithelial and stromal cells in tissue fragments recovered from peritoneal fluid and to quantify haptoglobin expression...
  7. ncbi request reprint Using rats as a research model for the study of endometriosis
    Kathy L Sharpe-Timms
    Department of Obstetrics and Gynecology, University of Missouri Columbia, 65212, USA
    Ann N Y Acad Sci 955:318-27; discussion 340-2, 396-406. 2002
    ..Similar alterations in gene expression and protein production have been observed in endometriotic tissues from rats and humans that may, in part, be causative agents involved in the pathogenesis or pathophysiologies of endometriosis...
  8. ncbi request reprint Paracrine regulation of matrix metalloproteinase expression in endometriosis
    Kathy L Sharpe-Timms
    Department of Obstetrics and Gynecology, University of Missouri Columbia, 65212, USA
    Ann N Y Acad Sci 955:147-56; discussion 157-8, 396-406. 2002
    ..The mechanisms by which MMP and TIMP expression are misregulated warrant further investigation as such information may provide insight into novel therapeutic modalities for endometriosis...
  9. ncbi request reprint Endometrial anomalies in women with endometriosis
    K L Sharpe-Timms
    Department of Obstetrics and Gynecology and Animal Sciences, University of Missouri Columbia, 65212, USA
    Ann N Y Acad Sci 943:131-47. 2001
    ....
  10. pmc Neutralizing TIMP1 restores fecundity in a rat model of endometriosis and treating control rats with TIMP1 causes anomalies in ovarian function and embryo development
    Julie A W Stilley
    Department of Obstetrics, Division of Animal Sciences, College of Agriculture, Food and Natural Resources, University of Missouri Columbia, Columbia, Missouri 65212, USA
    Biol Reprod 83:185-94. 2010
    ..Collectively, these results showed that excessive TIMP1 was deleterious to ovulation and embryo development. Thus, novel TIMP1-modulating therapies may be developed to alleviate infertility in women with endometriosis...
  11. pmc Reduced fecundity in female rats with surgically induced endometriosis and in their daughters: a potential role for tissue inhibitors of metalloproteinase 1
    Julie A W Stilley
    Department of Obstetrics, Gynecology and Women s Health, University of Missouri, Columbia, Missouri 65212, USA
    Biol Reprod 80:649-56. 2009
    ..We predict that developmental exposure to endometriosis leads to permanent epigenetic changes in subsequent generations...
  12. pmc Elevated peritoneal fluid TNF-α incites ovarian early growth response factor 1 expression and downstream protease mediators: a correlation with ovulatory dysfunction in endometriosis
    Julie A Birt
    Department of Obstetrics and Gynecology and Women s Health, The University of Missouri, Columbia, MO 65212, USA
    Reprod Sci 20:514-23. 2013
    ..Preliminary studies identified similar patterns of EGR1 protein localization in human ovaries from women with endometriosis and compared to those without endometriosis...
  13. pmc Developmental exposure of fetal ovaries and fetal germ cells to endometriosis in an endometriosis model causes differential gene expression in the preimplantation embryos of the first-generation and second-generation embryos
    Julie A Birt
    Department of Obstetrics, Gynecology, and Women s Health, University of Missouri, Columbia, Missouri Division of Animal Sciences, College of Food and Natural Resources, University of Missouri, Columbia, Missouri
    Fertil Steril 100:1436-43. 2013
    ..To characterize multigenerational gene expression anomalies in eight-cell stage embryos associated with developmental exposure to endometriosis...
  14. pmc TIMP1 contributes to ovarian anomalies in both an MMP-dependent and -independent manner in a rat model
    Julie A W Stilley
    The Department of Obstetrics, Gynecology and Women s Health, School of Medicine, The University of Missouri, Columbia, 65212, USA
    Biol Reprod 86:47. 2012
    ..Collectively, excessive peritoneal TIMP1 causes changes in ovarian dynamics, both dependently and independently of MMP inhibition...
  15. ncbi request reprint Expression and proteasomal degradation of the major vault protein (MVP) in mammalian oocytes and zygotes
    Peter Sutovsky
    Department of Animal Science, University of Missouri, Columbia, MO 65203, USA
    Reproduction 129:269-82. 2005
    ..Similar to carcinoma cells, MVP could fulfill a cell-protecting function during early embryonic development...
  16. ncbi request reprint Haptoglobin expression in endometrioid adenocarcinoma of the uterus
    Henda Nabli
    Division of Reproductive and Perinatal Research, The Department of Obstetrics and Gynecology and Women s Health, The University of Missouri Columbia, Columbia, Missouri 65212, USA
    Reprod Sci 17:47-55. 2010
    ....
  17. ncbi request reprint HLA-G is expressed by the glandular epithelium of peritoneal endometriosis but not in eutopic endometrium
    B F Barrier
    Department of Obstetrics, Gynecology and Women s Health, Division of Reproductive and Perinatal Research, University of Missouri Columbia, Missouri 65212, USA
    Hum Reprod 21:864-9. 2006
    ..We evaluated peritoneal endometriosis and eutopic endometrium for the expression of HLA-G protein and gene transcript...
  18. ncbi request reprint Tissue inhibitor of metalloproteinase-1 concentrations are attenuated in peritoneal fluid and sera of women with endometriosis and restored in sera by gonadotropin-releasing hormone agonist therapy
    K L Sharpe-Timms
    Department of Obstetrics and Gynecology, University of Missouri, Columbia 65212, USA
    Fertil Steril 69:1128-34. 1998
    ..To establish tissue inhibitor of metalloproteinase-1 (TIMP-1) concentrations in peritoneal fluid (PF) and sera of women with endometriosis and compare them to disease-free controls...
  19. ncbi request reprint Endometriotic lesions synthesize and secrete a haptoglobin-like protein
    K L Sharpe-Timms
    Department of Obstetrics and Gynecology, The University of Missouri, Columbia 65212, USA
    Biol Reprod 58:988-94. 1998
    ..If ENDO-I possesses similar activities, it may be involved with anomalies of the immune system or the etiology and pathophysiology of endometriosis...
  20. pmc Aberrant gene expression profile in a mouse model of endometriosis mirrors that observed in women
    Katherine E Pelch
    Department of Obstetrics, Gynecology and Women s Health, University of Missouri, Columbia, Missouri 65212, USA
    Fertil Steril 93:1615-1627.e18. 2010
    ..To define the altered gene expression profile of endometriotic lesions in a mouse model of surgically induced endometriosis...
  21. pmc The interplay of cell-cell and cell-matrix interactions in the invasive properties of brain tumors
    Balazs Hegedus
    Department of Physics, University of Missouri, Columbia, Missouri 65211, USA
    Biophys J 91:2708-16. 2006
    ....
  22. ncbi request reprint Glycosylation and over-expression of endometriosis-associated peritoneal haptoglobin
    Marta Piva
    Department of Obstetrics and Gynecology, The University of Missouri, Columbia, MO 65212, USA
    Glycoconj J 19:33-41. 2002
    ....
  23. ncbi request reprint Differential expression and localization of de-novo synthesized endometriotic haptoglobin in endometrium and endometriotic lesions
    K L Sharpe-Timms
    Department of Obstetrics and Gynecology, University of Missouri, Columbia, MO 65212, USA
    Hum Reprod 15:2180-5. 2000
    ....
  24. ncbi request reprint Expression of soluble adhesion molecules in sera of women with stage III and IV endometriosis
    Breton F Barrier
    Department of Obstetrics and Gynecology, University of Missouri, Columbia, Missouri, USA
    J Soc Gynecol Investig 9:98-101. 2002
    ..To determine the effect of stage III and IV endometriosis on serum concentration of soluble intracellular adhesion molecule-1 (ICAM-1), vascular cellular adhesion molecule-1 (VCAM-1), and E-selectin...
  25. ncbi request reprint Decidualization regulates the expression of the endometrial chorionic gonadotropin receptor in the primate
    Paula Cameo
    Department of Obstetrics and Gynecology, University of Illinois at Chicago, Chicago, Illinois 60212 7313, USA
    Biol Reprod 75:681-9. 2006
    ..This inhibition of LHCGR expression also coincides with the decrease of measurable CG in peripheral circulation...

Research Grants7

  1. ENDOMETRIOTIC HAPTOGLOBIN ALTERS MACROPHAGE FUNCTION
    KATHY TIMMS; Fiscal Year: 2003
    ..As a result, novel non-invasive strategies for early detection and innovative treatment of endometriosis may be developed that markedly reduce the health burden of this malady. ..
  2. ENDOMETRIOTIC HAPTOGLOBIN ALTERS MACROPHAGE FUNCTION
    KATHY TIMMS; Fiscal Year: 2004
    ..As a result, novel non-invasive strategies for early detection and innovative treatment of endometriosis may be developed that markedly reduce the health burden of this malady. ..
  3. ENDOMETRIOTIC HAPTOGLOBIN ALTERS MACROPHAGE FUNCTION
    KATHY TIMMS; Fiscal Year: 2005
    ..As a result, novel non-invasive strategies for early detection and innovative treatment of endometriosis may be developed that markedly reduce the health burden of this malady. ..
  4. ENDOMETRIOTIC HAPTOGLOBIN ALTERS MACROPHAGE FUNCTION
    KATHY TIMMS; Fiscal Year: 2006
    ..As a result, novel non-invasive strategies for early detection and innovative treatment of endometriosis may be developed that markedly reduce the health burden of this malady. ..
  5. Mechanisms of Reduced Fecundity in Endometriosis: A role for MMPs and TIMPs
    KATHY TIMMS; Fiscal Year: 2009
    ..As it is known that TIMP-1 highly regulates MMPs critical for follicular development, ovulation and embryo development, we propose endometriotic TIMP-1 is blocking MMPs required for normal function and reducing fecundity. ..
  6. Mechanisms of Reduced Fecundity in Endometriosis: A role for MMPs and TIMPs
    KATHY L TIMMS; Fiscal Year: 2010
    ..As it is known that TIMP-1 highly regulates MMPs critical for follicular development, ovulation and embryo development, we propose endometriotic TIMP-1 is blocking MMPs required for normal function and reducing fecundity. ..