Z D Sharp

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. doi request reprint Aging and TOR: interwoven in the fabric of life
    Zelton Dave Sharp
    Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center San Antonio, San Antonio, TX, 78245, USA
    Cell Mol Life Sci 68:587-97. 2011
  2. pmc Rapamycin extends life span of Rb1+/- mice by inhibiting neuroendocrine tumors
    Carolina B Livi
    Department of Molecular Medicine and Institute of Biotechnology, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Aging (Albany NY) 5:100-10. 2013
  3. pmc eRapa restores a normal life span in a FAP mouse model
    Paul Hasty
    15355 Lambda Drive, San Antonio, TX 78145 Phone 210 567 7226 Fax 210 562 4161 E mail Tyler J Curiel, E mail Paul Hasty, Carolina B Livi, Agilent Technologies, 5301 Stevens Creek Boulevard, Santa Clara, CA 95051
    Cancer Prev Res (Phila) 7:169-78. 2014
  4. doi request reprint Aging and cancer: can mTOR inhibitors kill two birds with one drug?
    Zelton Dave Sharp
    Institute of Biotechnology, Department of Molecular Medicine and Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center San Antonio, San Antonio, TX, USA
    Target Oncol 6:41-51. 2011
  5. ncbi request reprint Evidence for down-regulation of phosphoinositide 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR)-dependent translation regulatory signaling pathways in Ames dwarf mice
    Zelton Dave Sharp
    Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, 15355 Lambda Drive, San Antonio, Texas 78245, USA
    J Gerontol A Biol Sci Med Sci 60:293-300. 2005
  6. ncbi request reprint Minimal effects of dietary restriction on neuroendocrine carcinogenesis in Rb+/- mice
    Z Dave Sharp
    Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, 15355 Lambda Drive, San Antonio, TX, USA
    Carcinogenesis 24:179-83. 2003
  7. ncbi request reprint Brain POU-er
    Z D Sharp
    University of Texas Institute of Biotechnology, San Antonio, USA
    Bioessays 18:347-50. 1996
  8. ncbi request reprint Expression of BRC repeats in breast cancer cells disrupts the BRCA2-Rad51 complex and leads to radiation hypersensitivity and loss of G(2)/M checkpoint control
    C F Chen
    Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center, San Antonio, Texas 78245, USA
    J Biol Chem 274:32931-5. 1999
  9. ncbi request reprint Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response
    Q Zhong
    Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center at San Antonio, 15355 Lambda Drive, San Antonio, TX 78245, USA
    Science 285:747-50. 1999
  10. pmc Thyroid hormone, T3-dependent phosphorylation and translocation of Trip230 from the Golgi complex to the nucleus
    Y Chen
    Department of Molecular Medicine and Institute of Biotechnology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78245 3207, USA
    Proc Natl Acad Sci U S A 96:4443-8. 1999

Collaborators

Detail Information

Publications15

  1. doi request reprint Aging and TOR: interwoven in the fabric of life
    Zelton Dave Sharp
    Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center San Antonio, San Antonio, TX, 78245, USA
    Cell Mol Life Sci 68:587-97. 2011
    ..That the life-extending response to reducing its activity is highly conserved from yeast to mammals is consistent with the evolution of aging as a strategy to preserve reproductive potential of young cells and animals...
  2. pmc Rapamycin extends life span of Rb1+/- mice by inhibiting neuroendocrine tumors
    Carolina B Livi
    Department of Molecular Medicine and Institute of Biotechnology, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Aging (Albany NY) 5:100-10. 2013
    ..In this model, eRapa appears to act differently than DR, suggesting diverse mechanisms of action on survival and anti-tumor effects. In particular the beneficial effects of rapamycin did not depend on the dose of Rb1...
  3. pmc eRapa restores a normal life span in a FAP mouse model
    Paul Hasty
    15355 Lambda Drive, San Antonio, TX 78145 Phone 210 567 7226 Fax 210 562 4161 E mail Tyler J Curiel, E mail Paul Hasty, Carolina B Livi, Agilent Technologies, 5301 Stevens Creek Boulevard, Santa Clara, CA 95051
    Cancer Prev Res (Phila) 7:169-78. 2014
    ..eRapa or other mTORC1 inhibitors could serve as effective cancer preventatives for people with FAP without suppressing the immune system, thus reducing the dependency on surgery as standard therapy...
  4. doi request reprint Aging and cancer: can mTOR inhibitors kill two birds with one drug?
    Zelton Dave Sharp
    Institute of Biotechnology, Department of Molecular Medicine and Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center San Antonio, San Antonio, TX, USA
    Target Oncol 6:41-51. 2011
    ....
  5. ncbi request reprint Evidence for down-regulation of phosphoinositide 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR)-dependent translation regulatory signaling pathways in Ames dwarf mice
    Zelton Dave Sharp
    Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, 15355 Lambda Drive, San Antonio, Texas 78245, USA
    J Gerontol A Biol Sci Med Sci 60:293-300. 2005
    ..Consistent with these binding data, significantly less phosphorylation of 4E-BP1 was documented in dwarf liver. These data suggest a link between GH signaling and translation control in a model of extended longevity...
  6. ncbi request reprint Minimal effects of dietary restriction on neuroendocrine carcinogenesis in Rb+/- mice
    Z Dave Sharp
    Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, 15355 Lambda Drive, San Antonio, TX, USA
    Carcinogenesis 24:179-83. 2003
    ..They also introduce the possibility that RB is required for the tumor-repressive effects of DR...
  7. ncbi request reprint Brain POU-er
    Z D Sharp
    University of Texas Institute of Biotechnology, San Antonio, USA
    Bioessays 18:347-50. 1996
    ..In addition, they show that a sub-family of homeodomain factors, the POU-domain proteins, play a critical role in coordinating the respective ontogenies of the hypothalamus and the pituitary...
  8. ncbi request reprint Expression of BRC repeats in breast cancer cells disrupts the BRCA2-Rad51 complex and leads to radiation hypersensitivity and loss of G(2)/M checkpoint control
    C F Chen
    Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center, San Antonio, Texas 78245, USA
    J Biol Chem 274:32931-5. 1999
    ..These results strongly suggest that the interaction between BRCA2 and Rad51 mediated by BRC repeats is critical for the cellular response to DNA damage...
  9. ncbi request reprint Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response
    Q Zhong
    Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center at San Antonio, 15355 Lambda Drive, San Antonio, TX 78245, USA
    Science 285:747-50. 1999
    ..These data suggest that BRCA1 is important for the cellular responses to DNA damage that are mediated by the hRad50-hMre11-p95 complex...
  10. pmc Thyroid hormone, T3-dependent phosphorylation and translocation of Trip230 from the Golgi complex to the nucleus
    Y Chen
    Department of Molecular Medicine and Institute of Biotechnology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78245 3207, USA
    Proc Natl Acad Sci U S A 96:4443-8. 1999
    ..These findings provided a novel mechanism for the regulation of nuclear hormone transcription factors by hormone-responsive phosphorylation and nuclear import of cytoplasmically located coactivators...
  11. ncbi request reprint Binding of CtIP to the BRCT repeats of BRCA1 involved in the transcription regulation of p21 is disrupted upon DNA damage
    S Li
    Departments of Molecular Medicine Institute of Biotechnology, University of Texas Health Science Center, San Antonio, Texas 78245, USA
    J Biol Chem 274:11334-8. 1999
    ..These results suggest that the binding of the BRCT repeats of BRCA1 to CtIP/CtBP is critical in mediating transcriptional regulation of p21 in response to DNA damage...
  12. ncbi request reprint Application of exogenously regulatable promoter systems to transgenic models for the study of aging
    W W Morgan
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, USA
    J Gerontol A Biol Sci Med Sci 54:B30-40; discussion B41-2. 1999
    ....
  13. ncbi request reprint The nuclear localization sequences of the BRCA1 protein interact with the importin-alpha subunit of the nuclear transport signal receptor
    C F Chen
    Department of Molecular Medicine, Institute of Biotechnology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78245 3207, USA
    J Biol Chem 271:32863-8. 1996
    ..These data support the possibility that the mislocation of the BRCA1 protein in breast cancer cells may be due to a defect in the cellular machinery involved in the NLS receptor-mediated pathway of nuclear import...
  14. ncbi request reprint HEC binds to the seventh regulatory subunit of the 26 S proteasome and modulates the proteolysis of mitotic cyclins
    Y Chen
    Department of Molecular Medicine and Institute of Biotechnology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78245 3207, USA
    J Biol Chem 272:24081-7. 1997
    ..These results show that HEC is a negative regulator of MSS1 and suggest that it may modulate M phase progression, in part, through the regulation of proteasome-mediated degradation of cell cycle regulatory proteins...
  15. pmc The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment
    P L Chen
    Department of Molecular Medicine and Institute of Biotechnology, University of Texas Health Science Center, San Antonio, TX 78245, USA
    Proc Natl Acad Sci U S A 95:5287-92. 1998
    ..These results suggest that the interaction between the BRC repeats of BRCA2 and RAD51 is critical for cellular response to DNA damage caused by MMS...