F R Sharp

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. pmc Cerebral ischemia-hypoxia induces intravascular coagulation and autophagy
    Faisal Adhami
    Division of Developmental Biology, Cincinnati Children s Hospital Research Foundation, Room 3464, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    Am J Pathol 169:566-83. 2006
  2. pmc Reperfusion activates metalloproteinases that contribute to neurovascular injury
    Aigang Lu
    Department of Neurology, University of Cincinnati, Cincinnati, OH 45267 0532
    Exp Neurol 210:549-59. 2008
  3. ncbi request reprint Neurogenesis following brain ischemia
    Frank R Sharp
    Department of Neurology and Neuroscience Program, Vontz Center Rm 2327, 3125 Eden Avenue, University of Cincinnati, Cincinnati, OH 45267 0536, USA
    Brain Res Dev Brain Res 134:23-30. 2002
  4. ncbi request reprint HIF1 and oxygen sensing in the brain
    Frank R Sharp
    Department of Neurology, Pediatrics and Neuroscience Program, Vontz Center for Molecular Studies, Room 2327, 3125 Eden Avenue, University of Cincinnati, Cincinnati, Ohio 45267 0536, USA
    Nat Rev Neurosci 5:437-48. 2004
  5. ncbi request reprint Psychosis: pathological activation of limbic thalamocortical circuits by psychomimetics and schizophrenia?
    F R Sharp
    Department of Neurology and Neurosciences Program, University of Cincinnati Vontz Center, 3125 Eden Avenue Rm 2327, Cincinnati, OH 45267 0536, USA
    Trends Neurosci 24:330-4. 2001
  6. pmc Hypoxic preconditioning protects against ischemic brain injury
    Frank R Sharp
    Department of Neurology, University of Cincinnati, Ohio 45267, USA
    NeuroRx 1:26-35. 2004
  7. ncbi request reprint Geldanamycin induces heat shock proteins in brain and protects against focal cerebral ischemia
    Aigang Lu
    Department of Neurology, University of Cincinnati, Ohio 45267 0536, USA
    J Neurochem 81:355-64. 2002
  8. ncbi request reprint Genomic responses of the brain to ischemic stroke, intracerebral haemorrhage, kainate seizures, hypoglycemia, and hypoxia
    Yang Tang
    Department of Neurology and Neuroscience Program, University of Cincinnati, 3125 Eden Avenue, Cincinnati, OH 45267 0536, USA
    Eur J Neurosci 15:1937-52. 2002
  9. ncbi request reprint Prolonged expression of zinc finger immediate-early gene mRNAs and decreased protein synthesis following kainic acid induced seizures
    J Honkaniemi
    Department of Neurology, University of California at San Francisco, USA
    Eur J Neurosci 11:10-7. 1999
  10. ncbi request reprint Brain genomic response following hypoxia and re-oxygenation in the neonatal rat. Identification of genes that might contribute to hypoxia-induced ischemic tolerance
    Myriam Bernaudin
    Department of Neurology and Neuroscience Program, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Biol Chem 277:39728-38. 2002

Detail Information

Publications67

  1. pmc Cerebral ischemia-hypoxia induces intravascular coagulation and autophagy
    Faisal Adhami
    Division of Developmental Biology, Cincinnati Children s Hospital Research Foundation, Room 3464, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    Am J Pathol 169:566-83. 2006
    ..Together, these results suggest that ischemia-hypoxia is a powerful stimulus for spontaneous coagulation leading to reperfusion deficits and autophagic/lysosomal cell death in brain...
  2. pmc Reperfusion activates metalloproteinases that contribute to neurovascular injury
    Aigang Lu
    Department of Neurology, University of Cincinnati, Cincinnati, OH 45267 0532
    Exp Neurol 210:549-59. 2008
    ..Administering AHA 30 min before reperfusion decreased MMP-9 activation and neurovascular injury in ischemic cerebral cortex...
  3. ncbi request reprint Neurogenesis following brain ischemia
    Frank R Sharp
    Department of Neurology and Neuroscience Program, Vontz Center Rm 2327, 3125 Eden Avenue, University of Cincinnati, Cincinnati, OH 45267 0536, USA
    Brain Res Dev Brain Res 134:23-30. 2002
    ..It is proposed that ischemia-induced neurogenesis contributes to the recovery of function, and specifically may serve to improve anterograde and retrograde recent memory function that is lost following global ischemia in animals and man...
  4. ncbi request reprint HIF1 and oxygen sensing in the brain
    Frank R Sharp
    Department of Neurology, Pediatrics and Neuroscience Program, Vontz Center for Molecular Studies, Room 2327, 3125 Eden Avenue, University of Cincinnati, Cincinnati, Ohio 45267 0536, USA
    Nat Rev Neurosci 5:437-48. 2004
  5. ncbi request reprint Psychosis: pathological activation of limbic thalamocortical circuits by psychomimetics and schizophrenia?
    F R Sharp
    Department of Neurology and Neurosciences Program, University of Cincinnati Vontz Center, 3125 Eden Avenue Rm 2327, Cincinnati, OH 45267 0536, USA
    Trends Neurosci 24:330-4. 2001
    ..Pathological activation of thalamocortical circuits might also mediate the psychosis produced by NMDA-receptor antagonists in humans, and might contribute to psychosis in schizophrenia...
  6. pmc Hypoxic preconditioning protects against ischemic brain injury
    Frank R Sharp
    Department of Neurology, University of Cincinnati, Ohio 45267, USA
    NeuroRx 1:26-35. 2004
    ..Understanding the mechanisms and genes involved in hypoxic tolerance may provide new therapeutic targets to treat ischemic injury and enhance recovery...
  7. ncbi request reprint Geldanamycin induces heat shock proteins in brain and protects against focal cerebral ischemia
    Aigang Lu
    Department of Neurology, University of Cincinnati, Ohio 45267 0536, USA
    J Neurochem 81:355-64. 2002
    ..The data show that geldanamycin protects brain from focal ischemia and that this may be due, at least in part, to geldanamycin stimulation of heat shock gene transcription...
  8. ncbi request reprint Genomic responses of the brain to ischemic stroke, intracerebral haemorrhage, kainate seizures, hypoglycemia, and hypoxia
    Yang Tang
    Department of Neurology and Neuroscience Program, University of Cincinnati, 3125 Eden Avenue, Cincinnati, OH 45267 0536, USA
    Eur J Neurosci 15:1937-52. 2002
    ..In contrast, there was only a single gene that was down-regulated by all of the injury conditions suggesting there is not a common gene down-regulation response to injury...
  9. ncbi request reprint Prolonged expression of zinc finger immediate-early gene mRNAs and decreased protein synthesis following kainic acid induced seizures
    J Honkaniemi
    Department of Neurology, University of California at San Francisco, USA
    Eur J Neurosci 11:10-7. 1999
    ....
  10. ncbi request reprint Brain genomic response following hypoxia and re-oxygenation in the neonatal rat. Identification of genes that might contribute to hypoxia-induced ischemic tolerance
    Myriam Bernaudin
    Department of Neurology and Neuroscience Program, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Biol Chem 277:39728-38. 2002
    ..These results suggest that a number of endogenous molecular mechanisms may explain how hypoxic preconditioning protects against subsequent ischemia, and may provide novel therapeutic targets for treatment of cerebral ischemia...
  11. ncbi request reprint Role of hypoxia-inducible factor-1 in hypoxia-induced ischemic tolerance in neonatal rat brain
    M Bergeron
    Department of Neurology, University of Cincinnati, OH 45267 0536, USA
    Ann Neurol 48:285-96. 2000
    ..Thus, HIF-1 activation could contribute to protective brain preconditioning, which could be used in high-risk deliveries and other clinical situations...
  12. ncbi request reprint Hypoxia-inducible factor in brain
    F R Sharp
    Department of Neurology, University of Cincinnati, OH, USA
    Adv Exp Med Biol 502:273-91. 2001
    ..Thus, HIF-1 activation could contribute to protective brain preconditioning...
  13. ncbi request reprint 17-beta-estradiol induces heat shock proteins in brain arteries and potentiates ischemic heat shock protein induction in glia and neurons
    Aigang Lu
    Department of Neurology and Neurosciences Program, Vontz Center for Molecular Studies, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Cereb Blood Flow Metab 22:183-95. 2002
    ..The induction of HSPs may be an important mechanism for estrogen protection against cerebral ischemia and other types of injury...
  14. pmc Gene expression in blood is associated with risperidone response in children with autism spectrum disorders
    L Lit
    Department of Neurology, University of California, Davis, MIND Institute, Davis, CA 95817, USA
    Pharmacogenomics J 12:368-71. 2012
    ..Future studies will be needed to confirm these results and determine whether this expression profile is associated with risperidone response in other disorders, or alternative antipsychotic response within ASD...
  15. ncbi request reprint Genomics of the periinfarction cortex after focal cerebral ischemia
    Aigang Lu
    Department of Neurology, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Cereb Blood Flow Metab 23:786-810. 2003
    ..Genes regulated acutely after stroke may modulate cell survival and death; also, late regulated genes may be related to tissue repair and functional recovery...
  16. doi request reprint Down-regulation of interleukin 7 mRNA by hypoxia is calcium dependent
    Aigang Lu
    Vontz Center for Molecular Studies, Department of Neurology, University of Cincinnati, Cincinnati, OH 45267 0532, USA
    Neurol Res 31:545-9. 2009
    ..Hypoxia affects neurological disease states in part by modulating expression of many early and late response genes. The present work used cultured PC12 cells to investigate the effect of hypoxia on IL-7 expression...
  17. pmc Hsp70 promotes TNF-mediated apoptosis by binding IKK gamma and impairing NF-kappa B survival signaling
    Ruiqiong Ran
    Department of Neurology, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Genes Dev 18:1466-81. 2004
    ..These results provide significant novel insights into the molecular mechanism for the pro-apoptotic behavior of Hsp70 in death-receptor-mediated cell death...
  18. pmc Hsp70 mutant proteins modulate additional apoptotic pathways and improve cell survival
    Ruiqiong Ran
    Department of Neurology, Vontz Center for Molecular Studies, University of Cincinnati, Room 2327, 3125 Eden Avenue, Cincinnati, OH 45267 0536, USA
    Cell Stress Chaperones 9:229-42. 2004
    ..Hsp70 mutants represent a possible approach to antiapoptotic biotherapeutics. Similar rational designs could be used to engineer inhibitors of additional caspase family members...
  19. ncbi request reprint Bilirubin oxidation products (BOXes) and their role in cerebral vasospasm after subarachnoid hemorrhage
    Joseph F Clark
    Department of Neurology, Vontz Center for Molecular Studies, University of Cincinnati, Cincinnati, Ohio 45267 0536, USA
    J Cereb Blood Flow Metab 26:1223-33. 2006
    ....
  20. ncbi request reprint Repeated cocaine administration induces gene expression changes through the dopamine D1 receptors
    Dongsheng Zhang
    Department of Cell Biology, Neurobiology and Anatomy, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0521, USA
    Neuropsychopharmacology 30:1443-54. 2005
    ....
  21. ncbi request reprint Heme and iron metabolism: role in cerebral hemorrhage
    Kenneth R Wagner
    Departments of Neurology, Pediatrics and Neuroscience Programl, Unviersity of Cincinnati College of Medicine, Cincinnati, Ohio 45220, USA
    J Cereb Blood Flow Metab 23:629-52. 2003
    ..The present review will examine the uptake and metabolism of heme and iron in the brain and will relate these processes to blood removal and to the potential mechanisms underlying brain injury following cerebral hemorrhage...
  22. ncbi request reprint Blood genomic expression profile for neuronal injury
    Yang Tang
    Department of Neurology, Neuroscience Program, University of Cincinnati, Vontz Center for Molecular Studies Room 2327, 3125 Eden Avenue, Cincinnati, OH 45267 0536, USA
    J Cereb Blood Flow Metab 23:310-9. 2003
    ....
  23. pmc Mechanical reperfusion is associated with post-ischemic hemorrhage in rat brain
    Aigang Lu
    Department of Neurology, Vontz Center for Molecular Studies, University of Cincinnati, Cincinnati, OH 45267 0532, USA
    Exp Neurol 216:407-12. 2009
    ..Whether pharmacological treatments prior to reperfusion attenuate post-ischemic HT requires further study...
  24. ncbi request reprint Oxidation of bilirubin produces compounds that cause prolonged vasospasm of rat cerebral vessels: a contributor to subarachnoid hemorrhage-induced vasospasm
    Joseph F Clark
    Department of Neurology and Neuroscience Program, University of Cincinnati, Cincinnati, Ohio 45267 0536, USA
    J Cereb Blood Flow Metab 22:472-8. 2002
    ....
  25. pmc Transient ischemic attacks characterized by RNA profiles in blood
    X Zhan
    Department of Neurology, MIND Institute Research Wet Labs Room 2415, University of California at Davis, 2805 50 Street, Sacramento, CA 95817, USA
    Neurology 77:1718-24. 2011
    ..We sought to determine whether gene expression profiles in blood could better characterize the proinflammatory and procoagulant states in TIA patients...
  26. ncbi request reprint Microglia/macrophages proliferate in striatum and neocortex but not in hippocampus after brief global ischemia that produces ischemic tolerance in gerbil brain
    J Liu
    Department of Neurology, University of California at San Francisco, San Francisco, California, USA
    J Cereb Blood Flow Metab 21:361-73. 2001
    ..Because there is no apparent neuronal death, it is postulated that the microglia/macrophage proliferation occurs in response to an unknown nonlethal injury to neurons or glia and may be beneficial...
  27. doi request reprint Corticosteroid effects on blood gene expression in Duchenne muscular dystrophy
    L Lit
    Department of Neurology, MIND Institute, University of California at Davis, Sacramento, CA 95817, USA
    Pharmacogenomics J 9:411-8. 2009
    ..These genes and pathways help explain mechanisms of efficacy and side effects of corticosteroids, and could provide new treatment targets for DMD and other neuromuscular disorders...
  28. ncbi request reprint Atypical antipsychotics and a Src kinase inhibitor (PP1) prevent cortical injury produced by the psychomimetic, noncompetitive NMDA receptor antagonist MK-801
    Jon Dickerson
    Neurosciences Graduate Program, University of Cincinnati, Cincinnati, OH, USA
    Neuropsychopharmacology 31:1420-30. 2006
    ....
  29. ncbi request reprint Human blood genomics: distinct profiles for gender, age and neurofibromatosis type 1
    Yang Tang
    Department of Neurology, University of Cincinnati, Vontz Center, Room 2327, 3125 Eden Avenue, Cincinnati, OH 45267 0536, USA
    Brain Res Mol Brain Res 132:155-67. 2004
    ....
  30. ncbi request reprint Blood gene expression profiling of neurologic diseases: a pilot microarray study
    Yang Tang
    Department of Neurology and Neuroscience Program, University of Cincinnati, OH, USA
    Arch Neurol 62:210-5. 2005
    ..Tissue gene expression profiling with arrays measures the transcription of thousands of genes. However, this approach cannot be readily used to guide clinical neurologic practice...
  31. pmc Relative expression of D3 dopamine receptor and alternative splice variant D3nf mRNA in high and low responders to novelty
    Laurel M Pritchard
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Brain Res Bull 70:296-303. 2006
    ..Additionally, these findings are consistent with the hypothesis that alternative splicing may contribute to regulation of D3 dopamine receptor function...
  32. doi request reprint Gene expression in blood of subjects with Duchenne muscular dystrophy
    Brenda Wong
    Department of Pediatric Neurology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Neurogenetics 10:117-25. 2009
    ..The regulated genes might be used to monitor therapy or provide novel targets for immune-directed therapy for DMD...
  33. ncbi request reprint Developmental expression of heme oxygenase-1 (HSP32) in rat brain: an immunocytochemical study
    M Bergeron
    Department of Neurology, Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Brain Res Dev Brain Res 105:181-94. 1998
    ..These results show that HO-1 protein expression is regulated in different cell types of specific regions of the rat brain during development...
  34. ncbi request reprint Acute phencyclidine neurotoxicity in rat forebrain: induction of haem oxygenase-1 and attenuation by the antioxidant dimethylthiourea
    S Rajdev
    Department of Neurology, University of California, San Francisco 94143, USA
    Eur J Neurosci 10:3840-52. 1998
    ..This suggests that the neurotoxicity of N-methyl-D-aspartate antagonists is due in part to the oxidative stress and may be amenable to therapeutic interventions...
  35. ncbi request reprint Blood genomic responses differ after stroke, seizures, hypoglycemia, and hypoxia: blood genomic fingerprints of disease
    Y Tang
    Department of Neurology, University of Cincinnati, OH 45267-0536, USA
    Ann Neurol 50:699-707. 2001
    ..Blood genomic response patterns were different for each condition. These results demonstrate the potential of blood gene expression profiling for diagnostic, mechanistic, and therapeutic assessment of a wide variety of disease states...
  36. pmc Blood-brain barrier breakdown and repair by Src after thrombin-induced injury
    Da Zhi Liu
    Department of Neurology, University of California at Davis, Sacramento, CA 95817, USA
    Ann Neurol 67:526-33. 2010
    ..Thrombin mediates the life-threatening cerebral edema that occurs after intracerebral hemorrhage. Therefore, we examined the mechanisms of thrombin-induced injury to the blood-brain barrier (BBB) and subsequent mechanisms of BBB repair...
  37. ncbi request reprint Glutamate receptor blockade attenuates glucose hypermetabolism in perihematomal brain after experimental intracerebral hemorrhage in rat
    Timothy D Ardizzone
    Department of Neurology, University of Cincinnati College of Medicine, Ohio, USA
    Stroke 35:2587-91. 2004
    ..To develop successful treatments, we must learn more about the effects of hemorrhage on brain tissue. In this study, we investigated the acute metabolic effects of intrastriatal hemorrhage in rat brain...
  38. ncbi request reprint The impact of excitotoxic blockade on the evolution of injury following combined mechanical and hypoxic insults in primary rat neuronal culture
    Todd F Glass
    Division of Pediatric Emergency Medicine, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Neurobiol Dis 17:378-84. 2004
    ..We conclude that excitotoxic processes are more prominent after combined than isolated injuries in neurons and that increased cell death is mediated by both NMDA and AMPA receptor activation following combined injuries...
  39. ncbi request reprint Genomic profiles of stroke in blood
    Frank R Sharp
    Department of Neurology, University of California at Davis, Davis, CA, USA
    Stroke 38:691-3. 2007
    ..These studies show that gene expression changes in most patients by 2 to 3 hours after ischemic stroke, and in all patients studied by 24 hours...
  40. ncbi request reprint Translational stroke research in the developing brain
    Zinaida S Vexler
    Department of Neurology, University of California San Francisco, San Francisco, California 94143 0663, USA
    Pediatr Neurol 34:459-63. 2006
    ..These issues need to be carefully addressed in designing future clinical trials...
  41. ncbi request reprint Hypoxia preconditioning in the brain
    Ruiqiong Ran
    Department of Neurology, M I N D Institute, University of California at Davis, Davis, CA 95817, USA
    Dev Neurosci 27:87-92. 2005
    ..This hypoxia preconditioning has potential clinical usefulness in protecting high-risk newborns or to provide protection prior to surgery...
  42. ncbi request reprint Modeling both the mechanical and hypoxic features of traumatic brain injury in vitro in rats
    Todd F Glass
    Department of Pediatric Emergency Medicine Location C 2008, Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Neurosci Lett 328:133-6. 2002
    ..05) on both assays. Stretch+Hypoxia (4 or 6 h) resulted in significantly greater injury as compared with controls (P<0.05), and as compared with either isolated Stretch or Hypoxia (1, 2, 4 or 6 h) alone (P<0.05)...
  43. ncbi request reprint Genomic abnormalities in patients with migraine and chronic migraine: preliminary blood gene expression suggests platelet abnormalities
    Andrew D Hershey
    Children s Hospital Medical Center, Department of Neurology, Cincinnati, OH, USA
    Headache 44:994-1004. 2004
    ..It is hypothesized that gene expression changes in peripheral blood cells can be used to detect the interaction of these influences...
  44. pmc Hypoxia-ischemia induces DNA synthesis without cell proliferation in dying neurons in adult rodent brain
    Chia Yi Kuan
    Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Neurosci 24:10763-72. 2004
    ..Manipulating the aberrant apoptosis-associated DNA synthesis that occurs with hypoxia-ischemia and perhaps neurodegenerative diseases could promote neuronal survival and neurogenesis...
  45. ncbi request reprint Heat shock proteins and neuromuscular disease
    Robert N Nishimura
    Department of Neurology, Veterans Affairs Greater Los Angeles Healthcare System, 16111 Plummer Street, Sepulveda, California 91343, USA
    Muscle Nerve 32:693-709. 2005
    ..The goal of this review is to summarize the evidence linking heat shock proteins with neuromuscular disease and to provide some insight into the roles or functions of these proteins in disease states...
  46. ncbi request reprint A novel 165-kDa Golgin protein induced by brain ischemia and phosphorylated by Akt protects against apoptosis
    Ruiqiong Ran
    M I N D Institute and Department of Neurology, University of California at Davis Medical Center, University of California at Davis, Sacramento, CA 95817, USA
    Mol Cell Neurosci 36:392-407. 2007
    ..These data show that Akt phosphorylation of IIGP165 protects against apoptotic cell death, and add to evidence that the Golgi apparatus also plays a role in regulating apoptosis...
  47. ncbi request reprint Gene expression changes in children with autism
    Jeffrey P Gregg
    Department of Pathology, University of California at Davis Medical Center, Sacramento, CA 95817, USA University of California at Davis, Davis, CA 95616, USA
    Genomics 91:22-9. 2008
    ..05). We conclude that the gene expression data support emerging evidence for abnormalities in peripheral blood leukocytes in autism that could represent a genetic and/or environmental predisposition to the disorder...
  48. ncbi request reprint Molecular identification of the ischemic penumbra
    Philip R Weinstein
    Department of Neurological Surgery, San Francisco Veterans Affairs Medical Center and University of California, San Francisco, 505 Parnassus Avenue, M 779, San Francisco, CA 94143, USA
    Stroke 35:2666-70. 2004
    ..Future studies may define endogenous cytotoxic and cytoprotective molecular penumbras that can be exploited to improve outcome after temporary focal ischemia...
  49. ncbi request reprint Brain genomics of intracerebral hemorrhage
    Aigang Lu
    MIND Institute and Department of Neurology, University of California at Davis, Sacramento, California 95817, USA
    J Cereb Blood Flow Metab 26:230-52. 2006
    ..These genomic responses to ICH potentially provide new therapeutic targets for treatment...
  50. ncbi request reprint Genomic profiles for human peripheral blood T cells, B cells, natural killer cells, monocytes, and polymorphonuclear cells: comparisons to ischemic stroke, migraine, and Tourette syndrome
    Xinli Du
    MIND Institute, University of California at Davis, 2805 50th Street, Sacramento, CA 95817, USA
    Genomics 87:693-703. 2006
    ..These specific gene expression, cell-type-related profiles will need to be confirmed in larger data sets and could be used to study these and many other neurological diseases...
  51. ncbi request reprint Correlation between changes in apparent diffusion coefficient and induction of heat shock protein, cell-specific injury marker expression, and protein synthesis reduction on diffusion-weighted magnetic resonance images after temporary focal cerebral ische
    Yasuaki Kokubo
    Department of Neurological Surgery, University of California at San Francisco, 94143, USA
    J Neurosurg 96:1084-93. 2002
    ....
  52. ncbi request reprint Gene expression in blood changes rapidly in neutrophils and monocytes after ischemic stroke in humans: a microarray study
    Yang Tang
    MIND Institute and Department of Neurology, University of California at Davis, Sacramento, California 95817, USA
    J Cereb Blood Flow Metab 26:1089-102. 2006
    ..These data provide insights into the inflammatory responses after stroke in humans, and should be helpful in diagnosis, understanding etiology and pathogenesis, and guiding acute treatment and development of new treatments for stroke...
  53. ncbi request reprint Methods to detect hypoxia-induced ischemic tolerance in the brain
    Myriam Bernaudin
    UMR CNRS 6551, Cyceron, Bd Henri Becquerel, France
    Methods Enzymol 381:399-416. 2004
  54. ncbi request reprint Heme oxygenase-2 protects against lipid peroxidation-mediated cell loss and impaired motor recovery after traumatic brain injury
    Edward F Chang
    Department of Neurosurgery, University of California, San Francisco, San Francisco, California 94143 0520, USA
    J Neurosci 23:3689-96. 2003
    ..These findings demonstrate that HO-2 expression protects neurons against TBI by reducing lipid peroxidation via the catabolism of free heme...
  55. ncbi request reprint Differential cerebral protein synthesis and heat shock protein 70 expression in the core and penumbra of rat brain after transient focal ischemia
    Yasuaki Kokubo
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143, USA
    Neurosurgery 53:186-90; discussion 190-1. 2003
    ..The purpose of this study was to correlate the cerebral protein synthesis (CPS) reductions in the ischemic core and penumbra with the metabolic stress response indicated by heat shock protein 70 (HSP70) synthesis...
  56. ncbi request reprint Cyclooxygenase-2 mRNA expression is associated with c-fos mRNA expression and transient water ADC reduction detected with diffusion MRI during acute focal ischemia in rats
    Anthony Mancuso
    Department of Radiology 6069, University of Pennsylvania, Molecular Imaging Laboratory, B6 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6069, USA
    Brain Res 961:121-30. 2003
    ..The results suggest that cox-2 mRNA expression during acute MCA occlusion is caused by either or both spreading depression and transient ischemic depolarization...
  57. ncbi request reprint Suppressive effects of ansamycins on inducible nitric oxide synthase expression and the development of experimental autoimmune encephalomyelitis
    Patricia Murphy
    Department of Anesthesiology, University of Illinois, 1819 West Polk Street, Chicago, IL 60612, USA
    J Neurosci Res 67:461-70. 2002
    ..These results indicate that ansamycins can exert potent anti-inflammatory effects on brain glial cells which may provide therapeutic benefit in neuroinflammatory diseases...
  58. ncbi request reprint In Vivo Delivery of a Bcl-xL Fusion Protein Containing the TAT Protein Transduction Domain Protects against Ischemic Brain Injury and Neuronal Apoptosis
    Guodong Cao
    Department of Neurology and Pittsburgh Institute for Neurodegenerative Disorders, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 22:5423-31. 2002
    ....
  59. pmc Empirical Bayes accomodation of batch-effects in microarray data using identical replicate reference samples: application to RNA expression profiling of blood from Duchenne muscular dystrophy patients
    Wynn L Walker
    Department of Neurology and MIND Institute, University of California at Davis, Sacramento, California, USA
    BMC Genomics 9:494. 2008
    ..Existing methods can correct for batch effects only when samples from all biological groups are represented in every batch...
  60. ncbi request reprint Cloning and expression of short interspersed elements B1 and B2 in ischemic brain
    Juha Pekka Kalkkila
    Department of Neurology and Rehabilitation, University of Tampere and Tampere University Hospital, Finn Medi 3, Lenkkeilijänkatu 10, 33014 Tampereen yliopisto, Finland
    Eur J Neurosci 19:1199-206. 2004
    ..Together with the previous data demonstrating the inducibility of the SINE transcripts using in vitro stress models, the present study shows that SINE transcripts are stress-inducible factors in the central nervous system...
  61. ncbi request reprint SRC kinase inhibition improves acute outcomes after experimental intracerebral hemorrhage
    Timothy D Ardizzone
    Medical Investigation of Neurodevelopmental Diseases Institute and Department of Neurology, University of California at Davis Medical Center, Sacramento, CA 95817, USA
    Stroke 38:1621-5. 2007
    ..In this study, we begin to test the hypothesis that intracerebral hemorrhage activates Src kinases that phosphorylate other molecules to produce cell injury and behavioral deficits after intracerebral hemorrhage (ICH)...
  62. ncbi request reprint Hemin induces heme oxygenase-1 in spinal cord vasculature and attenuates barrier disruption and neutrophil infiltration in the injured murine spinal cord
    Toshihiro Yamauchi
    Department of Neurological Surgery, University of California at San Francisco, San Francisco, California, USA
    J Neurotrauma 21:1017-30. 2004
    ....
  63. ncbi request reprint The future of genomic profiling of neurological diseases using blood
    Frank R Sharp
    Department of Neurology and Medical Investigation of Neurodevelopmental Disorders Institute, University of California Davis Medical Center, Sacramento, CA 95817, USA
    Arch Neurol 63:1529-36. 2006
    ..Although all of these studies are still preliminary basic scientific endeavors, they suggest that this approach will have clinical applications to neurological diseases in humans...
  64. ncbi request reprint Genomics of brain and blood: progress and pitfalls
    Frank R Sharp
    Department of Neurology and the M I N D Institute, University of California at Davis, Sacramento, California 95817, USA
    Epilepsia 47:1603-7. 2006
    ..Gene expression profiles in brain and blood of animals and humans can be useful for diagnosis, prognosis, and treatment of epilepsy. This article reviews recent progress and prospects for the future...
  65. ncbi request reprint Expression of proinflammatory cytokines tumor necrosis factor-alpha and interleukin-1beta in the brain during experimental group B streptococcal meningitis
    Young S Kim
    Division of Infectious Diseases, Drexel University College of Medicine, Philadelphia, PA, USA
    Brain Res Mol Brain Res 128:95-102. 2004
    ..Induction of IL-1beta mRNA was seen in vessels within the brain cortex. Neutrophilic infiltrate at all time points examined was minimal and could not account for the observed cytokine expression...
  66. ncbi request reprint Blood expression profiles for tuberous sclerosis complex 2, neurofibromatosis type 1, and Down's syndrome
    Yang Tang
    Department of Neurology and MIND Institute, University of California at Davis, Sacramento, CA, USA
    Ann Neurol 56:808-14. 2004
    ..These findings suggest that blood gene expression profiling on a broader basis might be useful for genetic disease screening/diagnosis and might help elucidate mechanisms and pathways that lead to genotype-phenotype differences...
  67. doi request reprint Gene expression in peripheral blood differs after cardioembolic compared with large-vessel atherosclerotic stroke: biomarkers for the etiology of ischemic stroke
    Huichun Xu
    Department of Neurology and MIND Institute, University of California at Davis, Sacramento, California 95817, USA
    J Cereb Blood Flow Metab 28:1320-8. 2008
    ..These results have wide ranging implications for similar disorders...