V Sharma

Summary

Affiliation: University of West Florida
Country: USA

Publications

  1. ncbi Human T-cell lymphotrophic virus type-I tax gene induces secretion of human macrophage inflammatory protein-1alpha
    V Sharma
    Department of Biology, University of West Florida, Pensacola, Florida, 32514, USA
    Biochem Biophys Res Commun 262:429-32. 1999
  2. ncbi Interleukin-8 expression in AIDS-associated lymphoma B-cell lines
    V Sharma
    Laboratory of Cytokine Research, University of West Florida, Pensacola, Florida 32514, USA
    Biochem Biophys Res Commun 282:369-75. 2001
  3. ncbi Autocrine role of macrophage inflammatory protein-1 beta in human T-cell lymphotropic virus type-I tax-transfected Jurkat T-cells
    V Sharma
    Laboratory of Cytokine Research, University of West Florida, Pensacola, FL 32514 5751, USA
    Biochem Biophys Res Commun 287:910-3. 2001
  4. ncbi Biochemical characterization of MIP-1 alpha nuclear protein
    V Sharma
    Department of Biology, University of West Florida, Pensacola 32514, USA
    Biochem Biophys Res Commun 248:716-21. 1998
  5. ncbi Current perspectives on cytokines for anti-retroviral therapy in AIDS related B-cell lymphomas
    V Sharma
    Laboratory of Cytokine Research, Department of Biology, 11000 University Parkway, University of West Florida, Pensacola, Florida 32514 5751, USA
    Curr Drug Targets Infect Disord 3:137-49. 2003
  6. ncbi Modulation of macrophage inflammatory protein-1alpha and its receptors in human B-cell lines derived from patients with acquired immunodeficiency syndrome and Burkitt's lymphoma
    V Sharma
    Department of Biology, University of West Florida, Pensacola 32514, USA
    Biochem Biophys Res Commun 235:576-81. 1997
  7. ncbi HIV-1 tat induces the expression of a new hematopoietic cell-specific transcription factor and downregulates MIP-1 alpha gene expression in activated T-cells
    V Sharma
    Department of Biology, University of West Florida, Pensacola 32514, USA
    Biochem Biophys Res Commun 223:526-33. 1996
  8. ncbi Juxtacrine function of interleukin-15/interleukin-15 receptor system in tumour derived human B-cell lines
    K Tsukamoto
    Laboratory of Cytokine Research, Department of Biology, University of West Florida, Pensacola, Florida 10032, USA
    Clin Exp Immunol 146:559-66. 2006
  9. ncbi Constitutive expression of interleukin-18 and interleukin-18 receptor mRNA in tumour derived human B-cell lines
    S L Lorey
    Laboratory of Cytokine Research, Department of Biology, University of West Florida, Pensacola, Florida 32514, USA
    Clin Exp Immunol 136:456-62. 2004
  10. ncbi Differential expression of cytokine genes in HIV-1 tat transfected T and B cell lines
    V Sharma
    Division of Hematology and Oncology, Arthur G James Cancer Hospital and Research Institute, Ohio State University, Columbus 43210
    Biochem Biophys Res Commun 208:704-13. 1995

Collaborators

  • L Zhang
  • BRYAN HAUGEN
  • R K Sharma
  • K Tsukamoto
  • Y C Huang
  • S L Lorey
  • C Eicken
  • N S Brown
  • A Sood
  • P S Ahuja
  • T Mohapatra
  • P Gupta
  • W C Dorsey
  • B Carns
  • J C Sacchettini
  • R T Owens
  • D S Pikas
  • T Klabunde
  • D R Jensen
  • P Chambon
  • W Krezel
  • R H Eckel
  • A Smart
  • S A Camper
  • L Greenlee
  • M L Brinkmeier
  • H Lou
  • L Hammond
  • A J Lusis
  • C Palaniappan
  • A Stolz
  • R S Sparkes
  • M E Hudspeth
  • R Meganathan

Detail Information

Publications20

  1. ncbi Human T-cell lymphotrophic virus type-I tax gene induces secretion of human macrophage inflammatory protein-1alpha
    V Sharma
    Department of Biology, University of West Florida, Pensacola, Florida, 32514, USA
    Biochem Biophys Res Commun 262:429-32. 1999
    ..Induced MIP-1alpha expression and secretion in PMA/PHA stimulated tax transfected cells correlate with the noninduction of MNP-1 transcription factor, which is intimately involved in downmodulating the MIP-1alpha gene...
  2. ncbi Interleukin-8 expression in AIDS-associated lymphoma B-cell lines
    V Sharma
    Laboratory of Cytokine Research, University of West Florida, Pensacola, Florida 32514, USA
    Biochem Biophys Res Commun 282:369-75. 2001
    ..Furthermore, IL-8 autocrine loops were not evident since IL-8R was detected only in cell lines that did not secrete IL-8 protein...
  3. ncbi Autocrine role of macrophage inflammatory protein-1 beta in human T-cell lymphotropic virus type-I tax-transfected Jurkat T-cells
    V Sharma
    Laboratory of Cytokine Research, University of West Florida, Pensacola, FL 32514 5751, USA
    Biochem Biophys Res Commun 287:910-3. 2001
    ..These results, coupled with our earlier observations, demonstrate the influence that extracellular Tax protein might have on modulating host chemokines for proliferation and transformation of uninfected cells...
  4. ncbi Biochemical characterization of MIP-1 alpha nuclear protein
    V Sharma
    Department of Biology, University of West Florida, Pensacola 32514, USA
    Biochem Biophys Res Commun 248:716-21. 1998
    ..In this communication we demonstrate by two techniques that MNP-1 and MNP-2 are distinct but related factors, and we present further evidence to show that MNP-1 acts as a heterodimer...
  5. ncbi Current perspectives on cytokines for anti-retroviral therapy in AIDS related B-cell lymphomas
    V Sharma
    Laboratory of Cytokine Research, Department of Biology, 11000 University Parkway, University of West Florida, Pensacola, Florida 32514 5751, USA
    Curr Drug Targets Infect Disord 3:137-49. 2003
    ....
  6. ncbi Modulation of macrophage inflammatory protein-1alpha and its receptors in human B-cell lines derived from patients with acquired immunodeficiency syndrome and Burkitt's lymphoma
    V Sharma
    Department of Biology, University of West Florida, Pensacola 32514, USA
    Biochem Biophys Res Commun 235:576-81. 1997
    ..Furthermore, our results strongly suggest MIP-1alpha autocrine loops in a majority of tumor B-cells as evident by MIP-1alpha-R expression, and also secretion of MIP-1alpha...
  7. ncbi HIV-1 tat induces the expression of a new hematopoietic cell-specific transcription factor and downregulates MIP-1 alpha gene expression in activated T-cells
    V Sharma
    Department of Biology, University of West Florida, Pensacola 32514, USA
    Biochem Biophys Res Commun 223:526-33. 1996
    ..We propose that HIV-1 tat may inhibit MIP-1 alpha expression by inducing MNP-1 expression in T-cells, probably by either competing with MNP-2 for binding to the MIP-1 alpha promoter or by sequestering it into inactive forms...
  8. ncbi Juxtacrine function of interleukin-15/interleukin-15 receptor system in tumour derived human B-cell lines
    K Tsukamoto
    Laboratory of Cytokine Research, Department of Biology, University of West Florida, Pensacola, Florida 10032, USA
    Clin Exp Immunol 146:559-66. 2006
    ..These data imply that the IL-15/IL-15R system requires complex regulatory mechanisms for protein secretion. Taken together, we speculate that these results suggest a juxtacrine, intracrine function for IL-15/IL-15R...
  9. ncbi Constitutive expression of interleukin-18 and interleukin-18 receptor mRNA in tumour derived human B-cell lines
    S L Lorey
    Laboratory of Cytokine Research, Department of Biology, University of West Florida, Pensacola, Florida 32514, USA
    Clin Exp Immunol 136:456-62. 2004
    ..We therefore speculate that IL-18 possibly affects B-cells through paracrine actions...
  10. ncbi Differential expression of cytokine genes in HIV-1 tat transfected T and B cell lines
    V Sharma
    Division of Hematology and Oncology, Arthur G James Cancer Hospital and Research Institute, Ohio State University, Columbus 43210
    Biochem Biophys Res Commun 208:704-13. 1995
    ....
  11. ncbi Molecular and immunological characterization of cytochrome c: a potential cross-reactive allergen in fungi and grasses
    V Sharma
    Institute of Genomics and Integrative Biology, Delhi, India
    Allergy 63:189-97. 2008
    ..Recombinant allergens are required for component-resolved diagnosis/therapy of allergic disorders. The study was aimed to express and characterize an allergenic protein from Curvularia lunata and study its cross-reactivity...
  12. ncbi Crystal structure of Lyme disease antigen outer surface protein C from Borrelia burgdorferi
    C Eicken
    Department of Biochemistry and Biophysics, Texas A and M University, College Station, Texas 77843-2128, USA
    J Biol Chem 276:10010-5. 2001
    ..As vaccination with recombinant OspC has been shown to elicit a protective immune response in mice, these regions are candidates for peptide-based vaccines...
  13. ncbi Thyroid hormone resistance and increased metabolic rate in the RXR-gamma-deficient mouse
    N S Brown
    Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Clin Invest 106:73-9. 2000
    ....
  14. ncbi Menaquinone (vitamin K2) biosynthesis: evidence that the Escherichia coli menD gene encodes both 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid synthase and alpha-ketoglutarate decarboxylase activities
    C Palaniappan
    Department of Biological Sciences, Northern Illinois University, DeKalb 60115
    J Bacteriol 174:8111-8. 1992
    ..Consistent with the requirement for TPP in the decarboxylation of alpha-ketoglutarate, the translated amino acid sequence contains the characteristic TPP-binding motif present in all well-characterized TPP-requiring enzymes...
  15. ncbi Crystal structure of quinolinic acid phosphoribosyltransferase from Mmycobacterium tuberculosis: a potential TB drug target
    V Sharma
    Department of Biochemistry and Biophysics, Texas A and M University, College Station, TX 77843, USA
    Structure 6:1587-99. 1998
    ..Quinolinic acid phosphoribosyltransferase (QAPRTase), a key enzyme in the de novo biosynthesis of NAD, provides an attractive target for designing novel antitubercular drugs...
  16. ncbi Menaquinone (vitamin K2) biosynthesis: localization and characterization of the menE gene from Escherichia coli
    V Sharma
    Department of Biological Sciences, Northern Illinois University, DeKalb, 60115, USA
    Gene 168:43-8. 1996
    ..The region 5' of menB contains an an additional ORF of unknown function (orf241) and establishes the order of genes in the men cluster as menD, orf241, menB, menC and menE. All loci are transcribed counter-clockwise...
  17. ncbi Menaquinone (vitamin K2) biosynthesis: cloning, nucleotide sequence, and expression of the menC gene from Escherichia coli
    V Sharma
    Department of Biological Sciences, Plant Molecular Biology Center, Northern Illinois University, DeKalb 60115
    J Bacteriol 175:4917-21. 1993
    ..Consistent with this suggestion, the menB promoter can initiate transcription of the menC gene...
  18. ncbi Genomic organization and chromosomal localization of a novel human hepatic dihydrodiol dehydrogenase with high affinity bile acid binding
    H Lou
    Division of Gastrointestinal and Liver Diseases, University of Southern California School of Medicine, Los Angeles 90033
    J Biol Chem 269:8416-22. 1994
    ..Human hepatic DDH mRNA was identified in both human hepatoma Hep G2 and human lung carcinoma cell line NCI-H322 by RN'ase protection; thus, these cell lines will be useful in examining the regulation of the gene...
  19. ncbi Menaquinone (vitamin K2) biosynthesis: nucleotide sequence and expression of the menB gene from Escherichia coli
    V Sharma
    Department of Biological Sciences, Northern Illinois University, DeKalb 60115 2861
    J Bacteriol 174:5057-62. 1992
    ..However, multicopy plasmids containing menB fail to generate the expected levels of enzymatic activity...
  20. ncbi Evaluation of rice and sugarcane SSR markers for phylogenetic and genetic diversity analyses in bamboo
    R K Sharma
    Division of Biotechnology, Institute of Himalayan Bioresource Technology, Post Box 6, Palampur, H P, 176061, India
    Genome 51:91-103. 2008
    ..Further, cluster analysis revealed that the major grouping was in accordance with the taxonomical classification of bamboo. Thus, the rice and sugarcane SSRs can be utilized for phylogenetic and genetic diversity studies in bamboo...