Research Topics
Genomes and Genes | Rajiv SharmaSummaryAffiliation: University of Illinois at Chicago Country: USA Publications
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Publications
Valproic acid and chromatin remodeling in schizophrenia and bipolar disorder: preliminary results from a clinical populationRajiv P Sharma
The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612, USA
Schizophr Res 88:227-31. 2006..The authors consider these results in the context of future application of HDAC inhibitors to the treatment of psychiatric disorders...- Depolarization induces downregulation of DNMT1 and DNMT3a in primary cortical culturesRajiv P Sharma
Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, Chicago, Illinois 60612, USA
Epigenetics 3:74-80. 2008..Our results support the idea that a reduction in DNA methyltransferase activity in the activated and depolarized neuron could contribute to the enhanced intensity and multiplicity of gene expression frequently reported... 
Heterochromatin as an incubator for pathology and treatment non-response: implication for neuropsychiatric illnessR P Sharma
The Psychiatric Institute, University of Illinois at Chicago, Chicago, IL 60612, USA
Pharmacogenomics J 12:361-7. 2012..From a therapeutic perspective, the durable nature of heterochromatin implies that it may require disassembly before the full genomic-potential of standard pharmacotherapies is achieved, especially in treatment resistant patients...
Blood chromatin as a biosensor of the epigenetic milieu: a tool for studies in living psychiatric patientsRajiv P Sharma
The Psychiatric Institute, University of Illinois at Chicago, 1601 W Taylor St, Chicago, IL 60612, USA
Epigenomics 4:551-9. 2012..Finally, chromatin measurements in peripheral tissue will retain the influences of a patient's lifestyle and unique genomic background...- CpG methylation in neurons: message, memory, or mask?Rajiv P Sharma
The Psychiatric Institute, Department of Psychiatry, University of Illinois, Chicago, USA
Neuropsychopharmacology 35:2009-20. 2010..These include the regulation in post-mitotic neurons of the executor proteins, such as the DNA methyltransferases, the elusive and putative demethylases, and the interactions with histone modifying enzymes... - Histone deactylase 1 expression is increased in the prefrontal cortex of schizophrenia subjects: analysis of the National Brain Databank microarray collectionRajiv P Sharma
The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, College of Medicine, 912 S Wood St, Chicago, IL 60612, United States
Schizophr Res 98:111-7. 2008..These findings provide additional support for the proposal that epigenetic factors are operative in the brain pathology of patients with schizophrenia... - CSF thyrotropin-releasing hormone concentrations differ in patients with schizoaffective disorder from patients with schizophrenia or mood disordersR P Sharma
Department of Psychiatry, University of Illinois at Chicago, The Psychiatric Institute, 1601 W Taylor St, Chicago, IL 60612, USA
J Psychiatr Res 35:287-91. 2001..To determine if there were differences in CSF-TRH concentrations among several acute major psychiatric disorders and to investigate the effects of antipsychotic treatment on CSF-TRH levels... - Chromatin, DNA methylation and neuron gene regulation--the purpose of the packageRajiv P Sharma
The Psychiatric Institute, University of Illinois at Chicago, Chicago, IL 60612, USA
J Psychiatry Neurosci 30:257-63. 2005..Because chromatin structure can be modified by conventional pharmacologic therapy, a novel approach to the regulation of neuronal gene expression in clinical populations is possible... - Schizophrenia, epigenetics and ligand-activated nuclear receptors: a framework for chromatin therapeuticsRajiv P Sharma
Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612, USA
Schizophr Res 72:79-90. 2005.... - DNA methyltransferase 1 regulates reelin mRNA expression in mouse primary cortical culturesJai Sung Noh
Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois, 1601 West Taylor Street, Chicago, IL 60612, USA
Proc Natl Acad Sci U S A 102:1749-54. 2005..These data support the hypothesis that the reduced amounts of reelin and GAD67 mRNAs documented in postmortem schizophrenia brain may be the consequence of a Dnmt1-mediated hypermethylation of the corresponding promoters... - On the epigenetic regulation of the human reelin promoterYing Chen
Psychiatric Institute, Department of Psychiatry, 1601 West Taylor Street, M C 912, College of Medicine, University of Illinois, Chicago, IL 60612, USA
Nucleic Acids Res 30:2930-9. 2002..Our data also raise the interesting possibility that the down-regulation of reelin expression documented in psychiatric patients might be the consequence of inappropriate promoter hypermethylation... - Histone deacetylase inhibitors and candidate gene expression: An in vivo and in vitro approach to studying chromatin remodeling in a clinical populationDavid P Gavin
The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor St, Chicago, IL 60612, USA
J Psychiatr Res 43:870-6. 2009..The emerging field of psychiatric epigenetics is constrained by the dearth of research methods feasible in living patients. With this focus, we report on two separate approaches, one in vitro and one in vivo, developed in our laboratory... - Reelin promoter hypermethylation in schizophreniaDennis R Grayson
Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois, 1601 West Taylor Street, Chicago, IL 60612, USA
Proc Natl Acad Sci U S A 102:9341-6. 2005..Collectively, the data show that this promoter region has positive and negative properties and that the function of this complex cis element relates to its methylation status... - Is there a future for histone deacetylase inhibitors in the pharmacotherapy of psychiatric disorders?Dennis R Grayson
Department of Psychiatry, University of Illinois, Chicago, IL 60612, USA
Mol Pharmacol 77:126-35. 2010..Before we consider the clinical use of additional HDAC inhibitors to treat schizophrenia or unipolar depression, there are a number of key issues that need to be resolved... - Histone modifications, DNA methylation, and schizophreniaDavid P Gavin
The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612, USA
Neurosci Biobehav Rev 34:882-8. 2010..We suggest that the ability to appropriately modify chromatin structure may be a factor in treatment response. Several pharmacological approaches for targeting epigenetic processes are reviewed... - Subjective evaluations of research participation by persons with mental illnessCherise Rosen
Department of Psychiatry, University of Illinois, Chicago, Illinois 60612, USA
J Nerv Ment Dis 195:430-5. 2007.... - Neurocognitive effects of repetitive transcranial magnetic stimulation in severe major depressionBrian Martis
Department of Psychiatry, Psychiatric Clinical Research Center and Center for Cognitive Medicine, University of Illinois at Chicago, 912 South Wood Street Suite 137 MC 913, Chicago, IL 60612, USA
Clin Neurophysiol 114:1125-32. 2003..We evaluated neurocognitive effects of a 1-4 week course (mean 3 weeks) of rTMS using an aggressive set of parameters, in 15 severely depressed subjects... - The human reelin gene: transcription factors (+), repressors (-) and the methylation switch (+/-) in schizophreniaDennis R Grayson
Department of Psychiatry, The Psychiatric Institute, College of Medicine, University of Illinois at Chicago, 1601 W Taylor St, 60612, USA
Pharmacol Ther 111:272-86. 2006.... - Repetitive transcranial magnetic stimulation versus electroconvulsive therapy for major depression: preliminary results of a randomized trialPhilip G Janicak
Department of Psychiatry, University of Illinois at Chicago, 1601 W Taylor Street, Chicago, IL 60612, USA
Biol Psychiatry 51:659-67. 2002..We did not observe any differences between groups on the secondary measures. CONCLUSIONS: A 2-4 week randomized, prospective trial comparing rTMS to ECT produced comparable therapeutic effects in severely depressed patients... - Protein kinase C and phospholipase C activity and expression of their specific isozymes is decreased and expression of MARCKS is increased in platelets of bipolar but not in unipolar patientsGhanshyam N Pandey
Psychiatric Institute, Department of Psychiatry College of Medicine, University of Illinois at Chicago, 60612, USA
Neuropsychopharmacology 26:216-28. 2002..These results suggest that alterations in PKC, PLC, and MARCKS may be involved in the pathophysiology of bipolar illness... - The melatonin receptor MT1 is required for the differential regulatory actions of melatonin on neuronal 'clock' gene expression in striatal neurons in vitroMarta Imbesi
Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, Chicago, IL, USA
J Pineal Res 46:87-94. 2009..Therefore, by controlling clock gene expression we propose melatonin receptors (i.e., MT1) as novel therapeutic targets for the pathobiologies of dopamine-related behaviors and mood... - Dimethylated lysine 9 of histone 3 is elevated in schizophrenia and exhibits a divergent response to histone deacetylase inhibitors in lymphocyte culturesDavid P Gavin
The Psychiatric Institute, University of Illinois at Chicago, Chicago, IL, USA
J Psychiatry Neurosci 34:232-7. 2009.... - 5-Lipoxygenase inhibitor MK-886 increases GluR1 phosphorylation in neuronal cultures in vitro and in the mouse cortex in vivoMarta Imbesi
The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, MC912, Chicago, IL 60612, USA
Brain Res 1147:148-53. 2007.... - Minocycline increases phosphorylation and membrane insertion of neuronal GluR1 receptorsMarta Imbesi
The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
Neurosci Lett 447:134-7. 2008..Increased GluR1 phosphorylation and minocycline treatment have been associated with antidepressant and memory-enhancing activities. Direct consequences of minocycline-increased GluR1 phosphorylation are yet to be established... - Reduced baseline acetylated histone 3 levels, and a blunted response to HDAC inhibition in lymphocyte cultures from schizophrenia subjectsDavid P Gavin
Schizophr Res 103:330-2. 2008
Research Grants
- EPIGENETIC MODIFICATIONS OF GABA NEURONS IN PSYCHOSISRajiv Sharma; Fiscal Year: 2007..Because epigenetic mechanisms are modifiable by drug interventions, this work has immediate relevance to the development of novel therapeutics. ..