Rajiv Sharma

Summary

Affiliation: University of Illinois at Chicago
Country: USA

Publications

  1. ncbi request reprint Valproic acid and chromatin remodeling in schizophrenia and bipolar disorder: preliminary results from a clinical population
    Rajiv P Sharma
    The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612, USA
    Schizophr Res 88:227-31. 2006
  2. ncbi request reprint Depolarization induces downregulation of DNMT1 and DNMT3a in primary cortical cultures
    Rajiv P Sharma
    Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Epigenetics 3:74-80. 2008
  3. pmc Chromatin from peripheral blood mononuclear cells as biomarkers for epigenetic abnormalities in schizophrenia
    David P Gavin
    The Psychiatric Institute, University of Illinois at Chicago, 1601 W Taylor St, Chicago, IL 60612, USA
    Cardiovasc Psychiatry Neurol 2009:409562. 2009
  4. pmc Heterochromatin as an incubator for pathology and treatment non-response: implication for neuropsychiatric illness
    R P Sharma
    The Psychiatric Institute, University of Illinois at Chicago, Chicago, IL 60612, USA
    Pharmacogenomics J 12:361-7. 2012
  5. pmc Blood chromatin as a biosensor of the epigenetic milieu: a tool for studies in living psychiatric patients
    Rajiv P Sharma
    The Psychiatric Institute, University of Illinois at Chicago, 1601 W Taylor St, Chicago, IL 60612, USA
    Epigenomics 4:551-9. 2012
  6. pmc CpG methylation in neurons: message, memory, or mask?
    Rajiv P Sharma
    The Psychiatric Institute, Department of Psychiatry, University of Illinois, Chicago, USA
    Neuropsychopharmacology 35:2009-20. 2010
  7. pmc Histone deactylase 1 expression is increased in the prefrontal cortex of schizophrenia subjects: analysis of the National Brain Databank microarray collection
    Rajiv P Sharma
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, College of Medicine, 912 S Wood St, Chicago, IL 60612, United States
    Schizophr Res 98:111-7. 2008
  8. pmc Chromatin, DNA methylation and neuron gene regulation--the purpose of the package
    Rajiv P Sharma
    The Psychiatric Institute, University of Illinois at Chicago, Chicago, IL 60612, USA
    J Psychiatry Neurosci 30:257-63. 2005
  9. ncbi request reprint CSF thyrotropin-releasing hormone concentrations differ in patients with schizoaffective disorder from patients with schizophrenia or mood disorders
    R P Sharma
    Department of Psychiatry, University of Illinois at Chicago, The Psychiatric Institute, 1601 W Taylor St, Chicago, IL 60612, USA
    J Psychiatr Res 35:287-91. 2001
  10. ncbi request reprint Schizophrenia, epigenetics and ligand-activated nuclear receptors: a framework for chromatin therapeutics
    Rajiv P Sharma
    Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612, USA
    Schizophr Res 72:79-90. 2005

Research Grants

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Valproic acid and chromatin remodeling in schizophrenia and bipolar disorder: preliminary results from a clinical population
    Rajiv P Sharma
    The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612, USA
    Schizophr Res 88:227-31. 2006
    ..The authors consider these results in the context of future application of HDAC inhibitors to the treatment of psychiatric disorders...
  2. ncbi request reprint Depolarization induces downregulation of DNMT1 and DNMT3a in primary cortical cultures
    Rajiv P Sharma
    Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Epigenetics 3:74-80. 2008
    ..Our results support the idea that a reduction in DNA methyltransferase activity in the activated and depolarized neuron could contribute to the enhanced intensity and multiplicity of gene expression frequently reported...
  3. pmc Chromatin from peripheral blood mononuclear cells as biomarkers for epigenetic abnormalities in schizophrenia
    David P Gavin
    The Psychiatric Institute, University of Illinois at Chicago, 1601 W Taylor St, Chicago, IL 60612, USA
    Cardiovasc Psychiatry Neurol 2009:409562. 2009
    ..This approach may provide an informed method for selecting chromatin modifying agents for psychiatric disorders...
  4. pmc Heterochromatin as an incubator for pathology and treatment non-response: implication for neuropsychiatric illness
    R P Sharma
    The Psychiatric Institute, University of Illinois at Chicago, Chicago, IL 60612, USA
    Pharmacogenomics J 12:361-7. 2012
    ..From a therapeutic perspective, the durable nature of heterochromatin implies that it may require disassembly before the full genomic-potential of standard pharmacotherapies is achieved, especially in treatment resistant patients...
  5. pmc Blood chromatin as a biosensor of the epigenetic milieu: a tool for studies in living psychiatric patients
    Rajiv P Sharma
    The Psychiatric Institute, University of Illinois at Chicago, 1601 W Taylor St, Chicago, IL 60612, USA
    Epigenomics 4:551-9. 2012
    ..Finally, chromatin measurements in peripheral tissue will retain the influences of a patient's lifestyle and unique genomic background...
  6. pmc CpG methylation in neurons: message, memory, or mask?
    Rajiv P Sharma
    The Psychiatric Institute, Department of Psychiatry, University of Illinois, Chicago, USA
    Neuropsychopharmacology 35:2009-20. 2010
    ..These include the regulation in post-mitotic neurons of the executor proteins, such as the DNA methyltransferases, the elusive and putative demethylases, and the interactions with histone modifying enzymes...
  7. pmc Histone deactylase 1 expression is increased in the prefrontal cortex of schizophrenia subjects: analysis of the National Brain Databank microarray collection
    Rajiv P Sharma
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, College of Medicine, 912 S Wood St, Chicago, IL 60612, United States
    Schizophr Res 98:111-7. 2008
    ..These findings provide additional support for the proposal that epigenetic factors are operative in the brain pathology of patients with schizophrenia...
  8. pmc Chromatin, DNA methylation and neuron gene regulation--the purpose of the package
    Rajiv P Sharma
    The Psychiatric Institute, University of Illinois at Chicago, Chicago, IL 60612, USA
    J Psychiatry Neurosci 30:257-63. 2005
    ..Because chromatin structure can be modified by conventional pharmacologic therapy, a novel approach to the regulation of neuronal gene expression in clinical populations is possible...
  9. ncbi request reprint CSF thyrotropin-releasing hormone concentrations differ in patients with schizoaffective disorder from patients with schizophrenia or mood disorders
    R P Sharma
    Department of Psychiatry, University of Illinois at Chicago, The Psychiatric Institute, 1601 W Taylor St, Chicago, IL 60612, USA
    J Psychiatr Res 35:287-91. 2001
    ..To determine if there were differences in CSF-TRH concentrations among several acute major psychiatric disorders and to investigate the effects of antipsychotic treatment on CSF-TRH levels...
  10. ncbi request reprint Schizophrenia, epigenetics and ligand-activated nuclear receptors: a framework for chromatin therapeutics
    Rajiv P Sharma
    Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612, USA
    Schizophr Res 72:79-90. 2005
    ....
  11. pmc DNA methyltransferase 1 regulates reelin mRNA expression in mouse primary cortical cultures
    Jai Sung Noh
    Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois, 1601 West Taylor Street, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 102:1749-54. 2005
    ..These data support the hypothesis that the reduced amounts of reelin and GAD67 mRNAs documented in postmortem schizophrenia brain may be the consequence of a Dnmt1-mediated hypermethylation of the corresponding promoters...
  12. pmc On the epigenetic regulation of the human reelin promoter
    Ying Chen
    Psychiatric Institute, Department of Psychiatry, 1601 West Taylor Street, M C 912, College of Medicine, University of Illinois, Chicago, IL 60612, USA
    Nucleic Acids Res 30:2930-9. 2002
    ..Our data also raise the interesting possibility that the down-regulation of reelin expression documented in psychiatric patients might be the consequence of inappropriate promoter hypermethylation...
  13. doi request reprint Histone deacetylase inhibitors and candidate gene expression: An in vivo and in vitro approach to studying chromatin remodeling in a clinical population
    David P Gavin
    The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor St, Chicago, IL 60612, USA
    J Psychiatr Res 43:870-6. 2009
    ..The emerging field of psychiatric epigenetics is constrained by the dearth of research methods feasible in living patients. With this focus, we report on two separate approaches, one in vitro and one in vivo, developed in our laboratory...
  14. doi request reprint Is there a future for histone deacetylase inhibitors in the pharmacotherapy of psychiatric disorders?
    Dennis R Grayson
    Department of Psychiatry, University of Illinois, Chicago, IL 60612, USA
    Mol Pharmacol 77:126-35. 2010
    ..Before we consider the clinical use of additional HDAC inhibitors to treat schizophrenia or unipolar depression, there are a number of key issues that need to be resolved...
  15. pmc Histone modifications, DNA methylation, and schizophrenia
    David P Gavin
    The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612, USA
    Neurosci Biobehav Rev 34:882-8. 2010
    ..We suggest that the ability to appropriately modify chromatin structure may be a factor in treatment response. Several pharmacological approaches for targeting epigenetic processes are reviewed...
  16. pmc Reelin promoter hypermethylation in schizophrenia
    Dennis R Grayson
    Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois, 1601 West Taylor Street, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 102:9341-6. 2005
    ..Collectively, the data show that this promoter region has positive and negative properties and that the function of this complex cis element relates to its methylation status...
  17. ncbi request reprint Neurocognitive effects of repetitive transcranial magnetic stimulation in severe major depression
    Brian Martis
    Department of Psychiatry, Psychiatric Clinical Research Center and Center for Cognitive Medicine, University of Illinois at Chicago, 912 South Wood Street Suite 137 MC 913, Chicago, IL 60612, USA
    Clin Neurophysiol 114:1125-32. 2003
    ..We evaluated neurocognitive effects of a 1-4 week course (mean 3 weeks) of rTMS using an aggressive set of parameters, in 15 severely depressed subjects...
  18. ncbi request reprint Subjective evaluations of research participation by persons with mental illness
    Cherise Rosen
    Department of Psychiatry, University of Illinois, Chicago, Illinois 60612, USA
    J Nerv Ment Dis 195:430-5. 2007
    ..Further studies should explore the source of this perception and attempt to separate the effect of "therapeutic misconception" from possible real benefit of protocol-driven assessment and treatment in a reputable clinical environment...
  19. ncbi request reprint The human reelin gene: transcription factors (+), repressors (-) and the methylation switch (+/-) in schizophrenia
    Dennis R Grayson
    Department of Psychiatry, The Psychiatric Institute, College of Medicine, University of Illinois at Chicago, 1601 W Taylor St, 60612, USA
    Pharmacol Ther 111:272-86. 2006
    ....
  20. doi request reprint The melatonin receptor MT1 is required for the differential regulatory actions of melatonin on neuronal 'clock' gene expression in striatal neurons in vitro
    Marta Imbesi
    Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, Chicago, IL, USA
    J Pineal Res 46:87-94. 2009
    ..Therefore, by controlling clock gene expression we propose melatonin receptors (i.e., MT1) as novel therapeutic targets for the pathobiologies of dopamine-related behaviors and mood...
  21. ncbi request reprint Protein kinase C and phospholipase C activity and expression of their specific isozymes is decreased and expression of MARCKS is increased in platelets of bipolar but not in unipolar patients
    Ghanshyam N Pandey
    Psychiatric Institute, Department of Psychiatry College of Medicine, University of Illinois at Chicago, 60612, USA
    Neuropsychopharmacology 26:216-28. 2002
    ..These results suggest that alterations in PKC, PLC, and MARCKS may be involved in the pathophysiology of bipolar illness...
  22. ncbi request reprint Repetitive transcranial magnetic stimulation versus electroconvulsive therapy for major depression: preliminary results of a randomized trial
    Philip G Janicak
    Department of Psychiatry, University of Illinois at Chicago, 1601 W Taylor Street, Chicago, IL 60612, USA
    Biol Psychiatry 51:659-67. 2002
    ..Repetitive transcranial magnetic stimulation (rTMS) has been reported to benefit depression. We compared rTMS to electroconvulsive therapy (ECT) in severely ill, depressed patients...
  23. pmc Dimethylated lysine 9 of histone 3 is elevated in schizophrenia and exhibits a divergent response to histone deacetylase inhibitors in lymphocyte cultures
    David P Gavin
    The Psychiatric Institute, University of Illinois at Chicago, Chicago, IL, USA
    J Psychiatry Neurosci 34:232-7. 2009
    ....
  24. ncbi request reprint 5-Lipoxygenase inhibitor MK-886 increases GluR1 phosphorylation in neuronal cultures in vitro and in the mouse cortex in vivo
    Marta Imbesi
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, MC912, Chicago, IL 60612, USA
    Brain Res 1147:148-53. 2007
    ....
  25. pmc Minocycline increases phosphorylation and membrane insertion of neuronal GluR1 receptors
    Marta Imbesi
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
    Neurosci Lett 447:134-7. 2008
    ..Increased GluR1 phosphorylation and minocycline treatment have been associated with antidepressant and memory-enhancing activities. Direct consequences of minocycline-increased GluR1 phosphorylation are yet to be established...
  26. pmc Reduced baseline acetylated histone 3 levels, and a blunted response to HDAC inhibition in lymphocyte cultures from schizophrenia subjects
    David P Gavin
    Schizophr Res 103:330-2. 2008

Research Grants2

  1. EPIGENETIC MODIFICATIONS OF GABA NEURONS IN PSYCHOSIS
    Rajiv Sharma; Fiscal Year: 2007
    ..Because epigenetic mechanisms are modifiable by drug interventions, this work has immediate relevance to the development of novel therapeutics. ..