Elizabeth R Sharlow

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. pmc Discovery of diverse small molecule chemotypes with cell-based PKD1 inhibitory activity
    Elizabeth R Sharlow
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia, United States of America
    PLoS ONE 6:e25134. 2011
  2. doi request reprint Auranofin is an apoptosis-simulating agent with in vitro and in vivo anti-leishmanial activity
    Elizabeth R Sharlow
    Departments of Pharmacology and Chemistry, University of Virginia, Charlottesville, Virginia 22908, United States
    ACS Chem Biol 9:663-72. 2014
  3. ncbi request reprint Investigational inhibitors of PTP4A3 phosphatase as antineoplastic agents
    Elizabeth R Sharlow
    University of Virginia, Department of Pharmacology, 409 Lane Road, Charlottesville, VA 22908, USA
    Expert Opin Investig Drugs 23:661-73. 2014
  4. pmc Pharmacologic profiling of phosphoinositide 3-kinase inhibitors as mitigators of ionizing radiation-induced cell death
    John S Lazo
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia J S L, E R S, A L, S L Departments of Radiation Oncology M W E, J S G, Chemistry E M S, P W, and Pharmaceutical Sciences P W, University of Pittsburgh, Pittsburgh, Pennsylvania
    J Pharmacol Exp Ther 347:669-80. 2013

Collaborators

  • John S Lazo
  • Michael W Epperly
  • Erin M Skoda
  • Stephanie Leimgruber
  • Joel S Greenberger
  • Peter Wipf
  • Ana Lira

Detail Information

Publications4

  1. pmc Discovery of diverse small molecule chemotypes with cell-based PKD1 inhibitory activity
    Elizabeth R Sharlow
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia, United States of America
    PLoS ONE 6:e25134. 2011
    ..In summary, we have discovered novel PKD1 inhibitors with in vitro and cell-based inhibitory activity, thus successfully expanding the structural diversity of small molecule inhibitors available for this important pharmacological target...
  2. doi request reprint Auranofin is an apoptosis-simulating agent with in vitro and in vivo anti-leishmanial activity
    Elizabeth R Sharlow
    Departments of Pharmacology and Chemistry, University of Virginia, Charlottesville, Virginia 22908, United States
    ACS Chem Biol 9:663-72. 2014
    ..Thus, auranofin may represent a prototype drug that can be used to identify signaling pathways within the parasite and host cell critical for parasite growth and survival. ..
  3. ncbi request reprint Investigational inhibitors of PTP4A3 phosphatase as antineoplastic agents
    Elizabeth R Sharlow
    University of Virginia, Department of Pharmacology, 409 Lane Road, Charlottesville, VA 22908, USA
    Expert Opin Investig Drugs 23:661-73. 2014
    ..While there are a significant number of clinically approved inhibitors of protein Tyr kinases, there are no drugs specifically targeting protein Tyr phosphatases in clinical use despite the attractiveness of the molecular target...
  4. pmc Pharmacologic profiling of phosphoinositide 3-kinase inhibitors as mitigators of ionizing radiation-induced cell death
    John S Lazo
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia J S L, E R S, A L, S L Departments of Radiation Oncology M W E, J S G, Chemistry E M S, P W, and Pharmaceutical Sciences P W, University of Pittsburgh, Pittsburgh, Pennsylvania
    J Pharmacol Exp Ther 347:669-80. 2013
    ..Treatment with LY294002 or PX-867 decreased γIR-induced DNA damage as measured by γH2AX, suggesting reduced DNA damage. These results indicate pharmacologic inhibition of PI3K after IR abrogated cell death. ..