P Shapshak

Summary

Affiliation: University of Miami
Country: USA

Publications

  1. ncbi request reprint HIV-1 RNA load in needles/syringes from shooting galleries in Miami: a preliminary laboratory report
    P Shapshak
    Comprehensive Drug Research Center, University of Miami and University of Miami School of Medicine, FL 33136, USA
    Drug Alcohol Depend 58:153-7. 2000
  2. ncbi request reprint Quantification of HIV GAG RNA using real time reverse transcriptase PCR
    Paul Shapshak
    Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Miami, FL 33136, USA
    Front Biosci 10:135-42. 2005
  3. ncbi request reprint Brain macrophage surface marker expression with HIV-1 infection and drug abuse: a preliminary study
    Paul Shapshak
    Department of Psychiatry and Behavioral Sciences, Comprehensive Drug Research Center, University of Miami School of Medicine, FL 33136, USA
    J NeuroAIDS 2:37-50. 2002
  4. ncbi request reprint Gene chromosomal organization and expression in cultured human neurons exposed to cocaine and HIV-1 proteins gp120 and tat: drug abuse and NeuroAIDS
    Paul Shapshak
    Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Miami, FL 33136, USA
    Front Biosci 11:1774-93. 2006
  5. ncbi request reprint Analytic approaches to differential gene expression in AIDS versus control brains
    P Shapshak
    Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Miami, FL 33136, USA
    Front Biosci 9:2935-46. 2004
  6. ncbi request reprint Independent evolution of HIV type 1 in different brain regions
    P Shapshak
    Department of Psychiatry and Behavioral Sciences, and Comprehensive Drug Research Center, University of Miami School of Medicine, Florida 33136, USA
    AIDS Res Hum Retroviruses 15:811-20. 1999
  7. ncbi request reprint Elevated expression of IFN-gamma in the HIV-1 infected brain
    Paul Shapshak
    Department of Psychiatry and Behavioral Sciences, University of Miami Medical School, Miami, Florida 33136, USA
    Front Biosci 9:1073-81. 2004
  8. pmc Bereavement is associated with time-dependent decrements in cellular immune function in asymptomatic human immunodeficiency virus type 1-seropositive homosexual men
    K Goodkin
    Department of Psychiatry, University of Miami School of Medicine, Florida 33136 1045, USA
    Clin Diagn Lab Immunol 3:109-18. 1996
  9. ncbi request reprint Cocaine abuse and HIV-1 infection: epidemiology and neuropathogenesis
    K Goodkin
    Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, FL 33136, USA
    J Neuroimmunol 83:88-101. 1998
  10. pmc A bereavement support group intervention is longitudinally associated with salutary effects on the CD4 cell count and number of physician visits
    K Goodkin
    Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Florida 33136 1045, USA
    Clin Diagn Lab Immunol 5:382-91. 1998

Collaborators

Detail Information

Publications31

  1. ncbi request reprint HIV-1 RNA load in needles/syringes from shooting galleries in Miami: a preliminary laboratory report
    P Shapshak
    Comprehensive Drug Research Center, University of Miami and University of Miami School of Medicine, FL 33136, USA
    Drug Alcohol Depend 58:153-7. 2000
    ..The presence of HIV-1 RNA in N/S is an important indication of the risk created by N/S sharing as well as by shared paraphernalia and wash waters by injecting drug users...
  2. ncbi request reprint Quantification of HIV GAG RNA using real time reverse transcriptase PCR
    Paul Shapshak
    Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Miami, FL 33136, USA
    Front Biosci 10:135-42. 2005
    ..The presented method is highly reproducible and the assay's performance is comparable to prior assays. The assay is validated with an 8-log range down to 80 copies...
  3. ncbi request reprint Brain macrophage surface marker expression with HIV-1 infection and drug abuse: a preliminary study
    Paul Shapshak
    Department of Psychiatry and Behavioral Sciences, Comprehensive Drug Research Center, University of Miami School of Medicine, FL 33136, USA
    J NeuroAIDS 2:37-50. 2002
    ..We studied the expression of macrophage surface markers CD11c, CD14, CD68, and HLA-DR and T cell surface markers CD4, and CD8...
  4. ncbi request reprint Gene chromosomal organization and expression in cultured human neurons exposed to cocaine and HIV-1 proteins gp120 and tat: drug abuse and NeuroAIDS
    Paul Shapshak
    Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Miami, FL 33136, USA
    Front Biosci 11:1774-93. 2006
    ....
  5. ncbi request reprint Analytic approaches to differential gene expression in AIDS versus control brains
    P Shapshak
    Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Miami, FL 33136, USA
    Front Biosci 9:2935-46. 2004
    ..Fourth, genes that change extensively by ratio tend to be in the larger k-Means clusters. We conclude that ranking gene expression with the use of expression ratio or by K-means clustering, yield different representations of the data...
  6. ncbi request reprint Independent evolution of HIV type 1 in different brain regions
    P Shapshak
    Department of Psychiatry and Behavioral Sciences, and Comprehensive Drug Research Center, University of Miami School of Medicine, Florida 33136, USA
    AIDS Res Hum Retroviruses 15:811-20. 1999
    ..Specific strains of HIV-1 may be neurotropic or neuroinvasive (replication preference in brain tissue) and may contribute to pathology, cognitive loss, and neuropsychiatric disease...
  7. ncbi request reprint Elevated expression of IFN-gamma in the HIV-1 infected brain
    Paul Shapshak
    Department of Psychiatry and Behavioral Sciences, University of Miami Medical School, Miami, Florida 33136, USA
    Front Biosci 9:1073-81. 2004
    ....
  8. pmc Bereavement is associated with time-dependent decrements in cellular immune function in asymptomatic human immunodeficiency virus type 1-seropositive homosexual men
    K Goodkin
    Department of Psychiatry, University of Miami School of Medicine, Florida 33136 1045, USA
    Clin Diagn Lab Immunol 3:109-18. 1996
    ..The results imply that a bereavement support group intervention merits investigation for an effect on immunological measures and clinical progression of HIV-1 infection as well as grief resolution...
  9. ncbi request reprint Cocaine abuse and HIV-1 infection: epidemiology and neuropathogenesis
    K Goodkin
    Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, FL 33136, USA
    J Neuroimmunol 83:88-101. 1998
    ..The complex context of addressing cocaine abuse in the setting of HIV-1 infection appears more tractable when decomposed into its components...
  10. pmc A bereavement support group intervention is longitudinally associated with salutary effects on the CD4 cell count and number of physician visits
    K Goodkin
    Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Florida 33136 1045, USA
    Clin Diagn Lab Immunol 5:382-91. 1998
    ..Potential effects of such interventions on clinical HIV disease progression are of interest and should be studied...
  11. ncbi request reprint A bereavement support group intervention affects plasma burden of human immunodeficiency virus type 1. Report of a randomized controlled trial
    K Goodkin
    Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Florida 33136 1045, USA
    J Hum Virol 4:44-54. 2001
    ..This study investigates the potential impact of a bereavement support group on plasma viral load...
  12. ncbi request reprint Morphometric analysis of the peripheral neuropathy of AIDS
    W G Bradley
    Department of Neurology, University of Miami School of Medicine, Florida, USA
    Muscle Nerve 21:1188-95. 1998
    ..Reparative processes (axonal regeneration and remyelination) occurred only at the most proximal levels of the nerves...
  13. ncbi request reprint Aging and neuro-AIDS conditions and the changing spectrum of HIV-1-associated morbidity and mortality
    K Goodkin
    Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, 1400 NW 10th Ave, 803 A, Miami, FL 33136, USA
    J Clin Epidemiol 54:S35-43. 2001
    ..Age associations with incidence of these disorders and with treatment foci are specified. Implications for future changes in management are discussed...
  14. ncbi request reprint Medication development of ibogaine as a pharmacotherapy for drug dependence
    D C Mash
    Department of Neurology, University of Miami School of Medicine, Florida 33136, USA
    Ann N Y Acad Sci 844:274-92. 1998
    ..The development of clinical safety studies of ibogaine in humans will help to determine whether there is a rationale for conducting efficacy trials in the future...
  15. ncbi request reprint NeuroAIDS: characteristics and diagnosis of the neurological complications of AIDS
    Alireza Minagar
    Department of Neurology, Louisiana State University Health Sciences Center Shreveport, Shreveport, Louisiana, USA
    Mol Diagn Ther 12:25-43. 2008
    ....
  16. ncbi request reprint HIV-1 RNA concentration and cognitive performance in a cohort of HIV-positive people
    Benedetto Vitiello
    Institute of Mental Health, Bethesda, Maryland 20892, USA
    AIDS 21:1415-22. 2007
    ..To determine whether higher viral concentrations in the cerebrospinal fluid (CSF) and/or peripheral blood were associated with greater severity of cognitive impairment in HIV-1-seropositive subjects with cognitive-motor impairment...
  17. pmc Comparative study of methods for detecting sequence compartmentalization in human immunodeficiency virus type 1
    Selene Zárate
    Antiviral Research Center, 150 W Washington St, Ste 100, San Diego, CA 92103, USA
    J Virol 81:6643-51. 2007
    ....
  18. ncbi request reprint Crack cocaine: effect modifier of RNA viral load and CD4 count in HIV infected African American women
    Robert Duncan
    University of Miami School of Medicine, Department of Epidemiology and Public Health, Miami, FL 33136, USA
    Front Biosci 12:1488-95. 2007
    ..This report supports a view of deleterious effects due to cocaine use in humans...
  19. ncbi request reprint Detection of HIV-1 in injection paraphernalia: risk in an era of heightened awareness
    J Bryan Page
    Department of Anthropology, University of Miami, Miller School of Medicine, Miami, Florida, USA
    AIDS Patient Care STDS 20:576-85. 2006
    ....
  20. ncbi request reprint Cerebrospinal and peripheral human immunodeficiency virus type 1 load in a multisite, randomized, double-blind, placebo-controlled trial of D-Ala1-peptide T-amide for HIV-1-associated cognitive-motor impairment
    Karl Goodkin
    Department of Psychiatry and Behavioral Sciences, University if Miami School of Medicine, Miami, Florida 33136, USA
    J Neurovirol 12:178-89. 2006
    ..Future studies should be undertaken to confirm the existence of this result and the CSF-periphery dissociation observed with respect to HIV-1-associated cognitive-motor impairment...
  21. ncbi request reprint Regional quantitative comparison of multispliced to unspliced ratios of HIV-1 RNA copy number in infected human brain
    Robert K Fujimura
    Geriatric Research, Education, Clinical Center, Veterans Administration Medical Center, and the Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, FL 33125, USA
    J NeuroAIDS 2:45-60. 2004
    ..The current study was preformed to produce results on gross differences in neuroanatomical locations at cm distances. Future studies will be performed to compare different regions with microscopic anatomic specificity...
  22. ncbi request reprint Increased density of neurons containing NADPH diaphorase and nitric oxide synthase in the cerebral cortex of patients with HIV-1 infection and drug abuse
    Rodrigo O Kuljis
    Deparment of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, FL, USA
    J NeuroAIDS 2:19-36. 2002
    ....
  23. ncbi request reprint Cellular immunology in HIV-1 positive African American women using alcohol and cocaine
    Francesco Chiappelli
    Division of Oral Biology and Medicine, UCLA School of Dentistry, Los Angeles, CA 90095 1668, USA
    Front Biosci 11:2434-41. 2006
    ..of TH1 and TH2 cytokines during progression to AIDS...
  24. ncbi request reprint Older age and plasma viral load in HIV-1 infection
    Karl Goodkin
    Departments of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Miami, FL 33136, USA
    AIDS 18:S87-98. 2004
    ..The purpose of the study was to examine the relationship between age and plasma viral load in HIV-1-infected individuals...
  25. ncbi request reprint The prevalence of human immunodeficiency virus type 1 and hepatitis C virus among injection drug users who use high risk inner-city locales in Miami, Florida
    Clyde B McCoy
    Department of Epidemiology and Public Health, University of Miami School of Medicine, Highland Professional Building, 801 NW 9th Avenue, Miami, FL 33136, USA
    Mem Inst Oswaldo Cruz 99:789-93. 2004
    ..07, 1.24) and for HIV-1/HCV co-infection (odds ratio = 1.17; 95% confidence interval = 1.09, 1.26). This paper demonstrates that HIV-1/HCV co-infection is highly prevalent among so called "shooting galleries"...
  26. ncbi request reprint HIV-associated dementia, Alzheimer's disease, multiple sclerosis, and schizophrenia: gene expression review
    Alireza Minagar
    Department of Neurology, Louisiana State University School of Medicine, Shreveport 71130, USA
    J Neurol Sci 224:3-17. 2004
    ....
  27. ncbi request reprint Impaired cytokine production and suppressed lymphocyte proliferation activity in HCV-infected cocaine and heroin ("speedball") users
    Eddy Rios-Olivares
    Department of Microbiology and Immunology, Universidad Central del Caribe, School of Medicine, Laurel Ave Urb Santa Juanita, Bayamón 00960 6032, PR, USA
    Drug Alcohol Depend 85:236-43. 2006
    ..These immunologic abnormalities, coupled with the range of response between the two TH-types in HCV-infected "speedball" users, suggest impairment in the regulatory mechanism of the TH1-TH2 system...
  28. ncbi request reprint The role of macrophage/microglia and astrocytes in the pathogenesis of three neurologic disorders: HIV-associated dementia, Alzheimer disease, and multiple sclerosis
    Alireza Minagar
    Department of Neurology, Louisiana State University School of Medicine, Shreveport, LA 71130, USA
    J Neurol Sci 202:13-23. 2002
    ..This review describes the role of M phi and astrocytes in the pathogenesis of these three progressive neurological diseases, examining both beneficent and deleterious effects in each disease...
  29. ncbi request reprint Presenilin-1 detection in brain neurons and FOXP3 in peripheral blood mononuclear cells: normalizer gene selection for real time reverse transcriptase pcr using the deltadeltaCt method
    Elda M Duran
    Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Miami, FL 33136, USA
    Front Biosci 10:2955-65. 2005
    ..We find that use of GAPDH is the optimum normalizer gene for the genes analyzed in neurons from human brain and in PBMNCs...
  30. ncbi request reprint Computational prediction of SEG (single exon gene) function in humans
    Meena K Sakharkar
    School of Mechanical and Production Engineering, Nanyang Center for Supercomputing and Visualization, Nanyang Technological University, Singapore 639798
    Front Biosci 10:1382-95. 2005
    ..A complete understanding of SEG function will help to explore their role in cellular environment. The derived datasets from these analyses are available at http://sege.ntu.edu.sg/wester/intronless/human/...
  31. ncbi request reprint A report on single exon genes (SEG) in eukaryotes
    Meena Kishore Sakharkar
    Scool of Mechanical and Production Engineering, Nanyang Technological University, Singapore
    Front Biosci 9:3262-7. 2004
    ..The comparison suggests that the SEG fraction decreases with gene count (r = -0.80) and increases with gene density (r = 0.88) in these genomes. We also examined the distribution patterns of their protein lengths in different genomes...