Research Topics
Species | Lee A ShapiroSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
Origin, migration and fate of newly generated neurons in the adult rodent piriform cortexLee A Shapiro
Department of Anatomy and Neurobiology, School of Medicine, University of California at Irvine, Irvine, CA 92697 1275, USA
Brain Struct Funct 212:133-48. 2007....- Newly born dentate granule neurons after pilocarpine-induced epilepsy have hilar basal dendrites with immature synapsesLee A Shapiro
Department of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, CA 92697-1275, United States
Epilepsy Res 69:53-66. 2006..The data also suggest that the synapses on DCX-labeled hilar basal dendrites contribute to the persistence of hilar basal dendrites on neurons born after pilocarpine-induced seizures... - Newly generated granule cells show rapid neuroplastic changes in the adult rat dentate gyrus during the first five days following pilocarpine-induced seizuresLee A Shapiro
Department of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, CA 92697 1275, USA
Eur J Neurosci 26:583-92. 2007..The presence of synapses, albeit developing ones, on hilar basal dendrites during this period indicates that newly generated granule cells become rapidly incorporated into dentate gyrus circuitry following seizures... - Olfactory enrichment enhances the survival of newly born cortical neurons in adult miceLee A Shapiro
Department of Anatomy and Neurobiology, University of California at Irvine, Irvine, California 92697 1275, USA
Neuroreport 18:981-5. 2007..These results confirm that neurogenesis occurs in the piriform cortex of rodents and suggest that it may play a neuroplastic role there... 
Microglia-associated granule cell death in the normal adult dentate gyrusCharles E Ribak
Department of Anatomy and Neurobiology, School of Medicine, University of California at Irvine, Irvine, CA 92697 1275, USA
Brain Struct Funct 214:25-35. 2009..Based on the morphological evidence, this type of cell death differs from either apoptosis or necrosis...- GFAP-expressing radial glia-like cell bodies are involved in a one-to-one relationship with doublecortin-immunolabeled newborn neurons in the adult dentate gyrusLee A Shapiro
Department of Anatomy and Neurobiology, College of Medicine, University of California, Irvine, CA 92697 1275, USA
Brain Res 1040:81-91. 2005..These data show that GFAP-expressing radial glia-like cells in the dentate gyrus cradle newborn neurons in the subgranular zone and that their radial processes provide a scaffold for neuronal process outgrowth... 
Rapid astrocyte and microglial activation following pilocarpine-induced seizures in ratsLee A Shapiro
Department of Anatomy and Neurobiology, School of Medicine, University of California at Irvine, Irvine, California 92697 1275, USA
Epilepsia 49:33-41. 2008..The differential response patterns of astrocytes and microglial cells following pilocarpine-induced seizures may signify their detrimental role in neuroinflammation after seizures...- Spatiotemporal profile of dendritic outgrowth from newly born granule cells in the adult rat dentate gyrusLee A Shapiro
Department of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, CA 92697 1275, USA
Brain Res 1149:30-7. 2007.... - Structural changes for adult-born dentate granule cells after status epilepticusLee A Shapiro
Department of Anatomy and Neurobiology, University of California, Irvine, California 92697 1275, USA
Epilepsia 49:13-8. 2008..This article will describe these structural alterations of granule cells found in the dentate gyrus after SE and will also discuss the time course of these events and possible underlying causes... - Ultrastructure and synaptic connectivity of cell types in the adult rat dentate gyrusCharles E Ribak
Department of Anatomy and Neurobiology, University of California at Irvine, Irvine, CA 92697 1275, USA
Prog Brain Res 163:155-66. 2007..This chapter provides a review of the ultrastructural features and synaptic connectivity of both projection cells and local circuit neurons in the dentate gyrus... - Dendritic development of newly generated neurons in the adult brainCharles E Ribak
Department of Anatomy and Neurobiology, University of California at Irvine, Irvine, CA 92697 1275, USA
Brain Res Rev 55:390-4. 2007..Therefore, similarities and differences exist for dendritic outgrowth from newborn neurons in the developing and adult brain... - Integration of newly born dentate granule cells into adult brains: hypotheses based on normal and epileptic rodentsLee A Shapiro
Department of Anatomy and Neurobiology, College of Medicine, University of California, Irvine, Irvine, CA 92697, USA
Brain Res Brain Res Rev 48:43-56. 2005..In this review, granule cell development is discussed with relevance to the creation of the recurrent excitatory circuitry in rodent models of temporal lobe epilepsy... - In DRG11 knock-out mice, trigeminal cell death is extensive and does not account for failed brainstem patterningMark F Jacquin
Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Neurosci 28:3577-85. 2008..Thus, apoptotic cell death is not a sufficient cause of failed pattern formation in the PrV of the DRG11(-/-). A signaling pathway involving DRG11 may, therefore, be the elusive PrV pattern maker... - Expression levels of cytoskeletal proteins indicate pathological aging of S100B transgenic mice: an immunohistochemical study of MAP-2, drebrin and GAP-43Lee A Shapiro
Program in Biopsychology, Department of Psychology, State University of New York, Stony Brook, NY 11794 2500, USA
Brain Res 1019:39-46. 2004..Overall, the data suggest that S100B overexpression leads to changes in cytoskeletal markers. The longitudinal effects of S100B overexpression are discussed with relevance to aging and pathology... - Increased clusterin expression in old but not young adult S100B transgenic mice: evidence of neuropathological aging in a model of Down SyndromeLee A Shapiro
Department of Psychology, State University of New York at Stony Brook, Stony Brook, NY 11794 2500, USA
Brain Res 1010:17-21. 2004..Our findings show increased clusterin expression in the aged S100B mice compared to their CD-1 controls, a finding we have interpreted as further evidence of pathological brain aging...