Xuesi M Shao

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Nicotine delivery to rats via lung alveolar region-targeted aerosol technology produces blood pharmacokinetics resembling human smoking
    Xuesi M Shao
    Department of Neurobiology, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Nicotine Tob Res 15:1248-58. 2013
  2. doi request reprint Central cholinergic regulation of respiration: nicotinic receptors
    Xuesi M Shao
    Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1763, USA
    Acta Pharmacol Sin 30:761-70. 2009
  3. pmc Alpha4* nicotinic receptors in preBotzinger complex mediate cholinergic/nicotinic modulation of respiratory rhythm
    Xuesi M Shao
    Department of Neurobiology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California 90095 1763, USA
    J Neurosci 28:519-28. 2008
  4. ncbi request reprint Micro-agar salt bridge in patch-clamp electrode holder stabilizes electrode potentials
    Xuesi M Shao
    Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1763, USA
    J Neurosci Methods 159:108-15. 2007
  5. pmc Efficient measurement of endogenous neurotransmitters in small localized regions of central nervous systems in vitro with HPLC
    Xuesi M Shao
    Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1763, USA
    J Neurosci Methods 160:256-63. 2007
  6. ncbi request reprint Cholinergic neurotransmission in the preBötzinger Complex modulates excitability of inspiratory neurons and regulates respiratory rhythm
    X M Shao
    Department of Neurobiology, David Geffen School of Medicine at UCLA, Box 951763, Los Angeles, CA 90095 1763, USA
    Neuroscience 130:1069-81. 2005
  7. pmc Modulation of AMPA receptors by cAMP-dependent protein kinase in preBötzinger complex inspiratory neurons regulates respiratory rhythm in the rat
    Xuesi M Shao
    Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1763, USA
    J Physiol 547:543-53. 2003
  8. ncbi request reprint Pharmacology of nicotinic receptors in preBötzinger complex that mediate modulation of respiratory pattern
    Xuesi M Shao
    Department of Neurobiology, UCLA School of Medicine, Los Angeles, California 90095 1763, USA
    J Neurophysiol 88:1851-8. 2002
  9. ncbi request reprint Mechanisms underlying regulation of respiratory pattern by nicotine in preBötzinger complex
    X M Shao
    Department of Neurobiology, UCLA School of Medicine, Los Angeles, California 90095 1763, USA
    J Neurophysiol 85:2461-7. 2001
  10. ncbi request reprint Parametric survival analysis for gating kinetics of single potassium channels
    X M Shao
    Department of Physiology, UCLA School of Medicine 90095, USA
    Brain Res 770:96-104. 1997

Collaborators

Detail Information

Publications21

  1. pmc Nicotine delivery to rats via lung alveolar region-targeted aerosol technology produces blood pharmacokinetics resembling human smoking
    Xuesi M Shao
    Department of Neurobiology, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Nicotine Tob Res 15:1248-58. 2013
    ..Nicotine in cigarette smoke is deposited and absorbed in the lungs, which results in a rapidly peaked slowly declining arterial concentration. This pattern plays an important role in initiation of nicotine addiction...
  2. doi request reprint Central cholinergic regulation of respiration: nicotinic receptors
    Xuesi M Shao
    Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1763, USA
    Acta Pharmacol Sin 30:761-70. 2009
    ....
  3. pmc Alpha4* nicotinic receptors in preBotzinger complex mediate cholinergic/nicotinic modulation of respiratory rhythm
    Xuesi M Shao
    Department of Neurobiology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California 90095 1763, USA
    J Neurosci 28:519-28. 2008
    ..Furthermore, functional alpha4* nAChRs are present in XII nucleus and mediate cholinergic/nicotinic modulation of tonic activity in XIIn...
  4. ncbi request reprint Micro-agar salt bridge in patch-clamp electrode holder stabilizes electrode potentials
    Xuesi M Shao
    Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1763, USA
    J Neurosci Methods 159:108-15. 2007
    ..This method is easy to implement and provides long-term recording stability. The micro-agar salt bridge can fit in most commercial patch electrode holders and can be conveniently maintained...
  5. pmc Efficient measurement of endogenous neurotransmitters in small localized regions of central nervous systems in vitro with HPLC
    Xuesi M Shao
    Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1763, USA
    J Neurosci Methods 160:256-63. 2007
    ..Our data also suggest that there is endogenous ACh release in spinal ventral motor columns at fourth cervical (C4) level that regulates the respiratory-related motor activity...
  6. ncbi request reprint Cholinergic neurotransmission in the preBötzinger Complex modulates excitability of inspiratory neurons and regulates respiratory rhythm
    X M Shao
    Department of Neurobiology, David Geffen School of Medicine at UCLA, Box 951763, Los Angeles, CA 90095 1763, USA
    Neuroscience 130:1069-81. 2005
    ....
  7. pmc Modulation of AMPA receptors by cAMP-dependent protein kinase in preBötzinger complex inspiratory neurons regulates respiratory rhythm in the rat
    Xuesi M Shao
    Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1763, USA
    J Physiol 547:543-53. 2003
    ..Moreover, the basal level of endogenous PKA activity appears to be a determinant of resting respiratory frequency...
  8. ncbi request reprint Pharmacology of nicotinic receptors in preBötzinger complex that mediate modulation of respiratory pattern
    Xuesi M Shao
    Department of Neurobiology, UCLA School of Medicine, Los Angeles, California 90095 1763, USA
    J Neurophysiol 88:1851-8. 2002
    ..This study provides a useful model system for evaluating potential therapeutic cholinergic agents for their respiratory effects and side effects...
  9. ncbi request reprint Mechanisms underlying regulation of respiratory pattern by nicotine in preBötzinger complex
    X M Shao
    Department of Neurobiology, UCLA School of Medicine, Los Angeles, California 90095 1763, USA
    J Neurophysiol 85:2461-7. 2001
    ..These mechanisms may account for the cholinergic regulation of respiratory frequency and pattern...
  10. ncbi request reprint Parametric survival analysis for gating kinetics of single potassium channels
    X M Shao
    Department of Physiology, UCLA School of Medicine 90095, USA
    Brain Res 770:96-104. 1997
    ..This work demonstrates that the survival analysis procedures can be useful tools for analyzing neurophysiological signals...
  11. ncbi request reprint Measure and statistical test for cross-correlation between paired neuronal spike trains with small sample size
    X M Shao
    Department of Physiological Science, University of California at Los Angeles 90095 1527, USA
    J Neurosci Methods 70:141-52. 1996
    ..These methods are especially useful when thousands of cross-correlograms need to be screened quickly and automatically...
  12. doi request reprint Missense mutation T485S alters NBCe1-A electrogenicity causing proximal renal tubular acidosis
    Quansheng Zhu
    Division of Nephrology, Department of Medicine, University of California, Los Angeles, CA 90095 1689, USA
    Am J Physiol Cell Physiol 305:C392-405. 2013
    ....
  13. pmc Reelin demarcates a subset of pre-Bötzinger complex neurons in adult rat
    Wenbin Tan
    Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    J Comp Neurol 520:606-19. 2012
    ..We suggest that reelin is a useful molecular marker for pre-BötC neurons in adult rodents and may play a functional role in pre-BötC microcircuits...
  14. pmc Silencing preBötzinger complex somatostatin-expressing neurons induces persistent apnea in awake rat
    Wenbin Tan
    Department of Neurobiology, Box 951763, David Geffen School of Medicine at University of California Los Angeles, 650 Charles E Young Dr South, Los Angeles, California 90095, USA
    Nat Neurosci 11:538-40. 2008
    ..We hypothesize that breathing requires preBötC Sst neurons and that their sudden depression can lead to serious, even fatal, respiratory failure...
  15. ncbi request reprint Golli protein negatively regulates store depletion-induced calcium influx in T cells
    Ji Ming Feng
    Semel Institute of Neuroscience and Human Behavior, UCLA Geffen School of Medicine, 635 Charles Young Drive, Los Angeles, California 90095, USA
    Immunity 24:717-27. 2006
    ..These results indicate that golli functions in a unique way to regulate T cell activation through a mechanism involving the modulation of the calcium homeostasis...
  16. ncbi request reprint RT-PCR reveals muscarinic acetylcholine receptor mRNA in the pre-Bötzinger complex
    J Lai
    Department of Neurobiology, University of California, Los Angeles, California 90095-1763, USA
    Am J Physiol Lung Cell Mol Physiol 281:L1420-4. 2001
    ..All five subtypes, M(1)-M(5), were observed in the second round of amplification. Our results suggest that the majority of muscarinic receptor subtypes in the pre-BötC are M(2) and M(3), with minor expression of M(1), M(4), and M(5)...
  17. ncbi request reprint Dihydromyricetin prevents fetal alcohol exposure-induced behavioral and physiological deficits: the roles of GABAA receptors in adolescence
    Jing Liang
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA
    Neurochem Res 39:1147-61. 2014
    ..The absence of adverse side effects and the ability of DHM to prevent FAE consequences suggest that DHM is an attractive candidate for development as a treatment for prevention of fetal alcohol spectrum disorders. ..
  18. ncbi request reprint Dihydromyricetin ameliorates behavioral deficits and reverses neuropathology of transgenic mouse models of Alzheimer's disease
    Jing Liang
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA
    Neurochem Res 39:1171-81. 2014
    ..Therefore DHM is a promising candidate medication for AD. We propose a novel target, gephyrin, for treatment of AD. ..
  19. ncbi request reprint Electrostatic interactions of S4 voltage sensor in Shaker K+ channel
    D M Papazian
    Department of Physiology, School of Medicine, University of California, Los Angeles 90024, USA
    Neuron 14:1293-301. 1995
    ..A simple structural hypothesis is proposed to account for the effects of the rescued double mutant combinations on the relative stabilities of open and closed channel conformations...
  20. doi request reprint A new technique for multiple re-use of planar patch clamp chips
    Liyo Kao
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, United States
    J Neurosci Methods 208:205-10. 2012
    ....
  21. pmc Dihydromyricetin as a novel anti-alcohol intoxication medication
    Yi Shen
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    J Neurosci 32:390-401. 2012
    ..We demonstrated pharmacological properties of DHM consistent with those expected to underlie successful medical treatment of AUDs; therefore DHM is a therapeutic candidate...