Sharmila Shankar

Summary

Affiliation: University of Kansas Medical Center
Country: USA

Publications

  1. pmc Hedgehog signaling antagonist GDC-0449 (Vismodegib) inhibits pancreatic cancer stem cell characteristics: molecular mechanisms
    Brahma N Singh
    Department of Pharmacology, Toxicology and Therapeutics, and Medicine, The University of Kansas Medical Center, Kansas City, Kansas, United States of America
    PLoS ONE 6:e27306. 2011
  2. pmc Targeting epigenetic regulation of miR-34a for treatment of pancreatic cancer by inhibition of pancreatic cancer stem cells
    Dara Nalls
    Departments of Pathology and Laboratory Medicine, The University of Kansas Medical Center, Kansas City, Kansas, United States of America
    PLoS ONE 6:e24099. 2011
  3. pmc Sonic hedgehog signaling inhibition provides opportunities for targeted therapy by sulforaphane in regulating pancreatic cancer stem cell self-renewal
    Mariana Rodova
    Department of Pathology and Laboratory Medicine, The University of Kansas Cancer Center, Kansas City, United States of America
    PLoS ONE 7:e46083. 2012
  4. pmc EGCG inhibits growth of human pancreatic tumors orthotopically implanted in Balb C nude mice through modulation of FKHRL1/FOXO3a and neuropilin
    Sharmila Shankar
    Department of Pathology and Laboratory Medicine, The University of Kansas Cancer Center, The University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Mol Cell Biochem 372:83-94. 2013
  5. pmc Inhibition of PI3K/AKT and MAPK/ERK pathways causes activation of FOXO transcription factor, leading to cell cycle arrest and apoptosis in pancreatic cancer
    Sanjit K Roy
    Department of Pathology and Laboratory Medicine, The University of Kansas Cancer Center, The University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS, 66160, USA
    J Mol Signal 5:10. 2010
  6. doi request reprint Sulforaphane regulates self-renewal of pancreatic cancer stem cells through the modulation of Sonic hedgehog-GLI pathway
    Shih Hui Li
    Department of Pathology and Laboratory Medicine, The University of Kansas Cancer Center, The University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Mol Cell Biochem 373:217-27. 2013
  7. pmc Inhibition of sonic hedgehog pathway and pluripotency maintaining factors regulate human pancreatic cancer stem cell characteristics
    Su Ni Tang
    Department of Pharmacology, Toxicology and Therapeutics, and Medicine, University of Kansas Cancer Center, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Int J Cancer 131:30-40. 2012
  8. ncbi request reprint GANT-61 inhibits pancreatic cancer stem cell growth in vitro and in NOD/SCID/IL2R gamma null mice xenograft
    Junsheng Fu
    Department of Pathology and Laboratory Medicine, The University of Kansas Cancer Center, The University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Cancer Lett 330:22-32. 2013
  9. pmc NPV-LDE-225 (Erismodegib) inhibits epithelial mesenchymal transition and self-renewal of glioblastoma initiating cells by regulating miR-21, miR-128, and miR-200
    Junsheng Fu
    Department of Pathology and Laboratory Medicine, The University of Kansas Cancer Center, The University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Neuro Oncol 15:691-706. 2013
  10. pmc Resveratrol inhibits pancreatic cancer stem cell characteristics in human and KrasG12D transgenic mice by inhibiting pluripotency maintaining factors and epithelial-mesenchymal transition
    Sharmila Shankar
    Department of Pathology and Laboratory Medicine, The University of Kansas Cancer Center, The University of Kansas Medical Center, Kansas City, Kansas, United States of America
    PLoS ONE 6:e16530. 2011

Collaborators

Detail Information

Publications23

  1. pmc Hedgehog signaling antagonist GDC-0449 (Vismodegib) inhibits pancreatic cancer stem cell characteristics: molecular mechanisms
    Brahma N Singh
    Department of Pharmacology, Toxicology and Therapeutics, and Medicine, The University of Kansas Medical Center, Kansas City, Kansas, United States of America
    PLoS ONE 6:e27306. 2011
    ..The objectives of this study were to examine the molecular mechanisms by which GDC-0449 regulates human pancreatic CSC characteristics in vitro...
  2. pmc Targeting epigenetic regulation of miR-34a for treatment of pancreatic cancer by inhibition of pancreatic cancer stem cells
    Dara Nalls
    Departments of Pathology and Laboratory Medicine, The University of Kansas Medical Center, Kansas City, Kansas, United States of America
    PLoS ONE 6:e24099. 2011
    ....
  3. pmc Sonic hedgehog signaling inhibition provides opportunities for targeted therapy by sulforaphane in regulating pancreatic cancer stem cell self-renewal
    Mariana Rodova
    Department of Pathology and Laboratory Medicine, The University of Kansas Cancer Center, Kansas City, United States of America
    PLoS ONE 7:e46083. 2012
    ..We propose that pancreatic cancer preventative effects of SFN may result from inhibition of the Shh pathway. Thus Sulforaphane potentially represents an inexpensive, safe and effective alternative for the management of pancreatic cancer...
  4. pmc EGCG inhibits growth of human pancreatic tumors orthotopically implanted in Balb C nude mice through modulation of FKHRL1/FOXO3a and neuropilin
    Sharmila Shankar
    Department of Pathology and Laboratory Medicine, The University of Kansas Cancer Center, The University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Mol Cell Biochem 372:83-94. 2013
    ..As a conclusion, EGCG can be used for the prevention and/or treatment of pancreatic cancer...
  5. pmc Inhibition of PI3K/AKT and MAPK/ERK pathways causes activation of FOXO transcription factor, leading to cell cycle arrest and apoptosis in pancreatic cancer
    Sanjit K Roy
    Department of Pathology and Laboratory Medicine, The University of Kansas Cancer Center, The University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS, 66160, USA
    J Mol Signal 5:10. 2010
    ....
  6. doi request reprint Sulforaphane regulates self-renewal of pancreatic cancer stem cells through the modulation of Sonic hedgehog-GLI pathway
    Shih Hui Li
    Department of Pathology and Laboratory Medicine, The University of Kansas Cancer Center, The University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Mol Cell Biochem 373:217-27. 2013
    ....
  7. pmc Inhibition of sonic hedgehog pathway and pluripotency maintaining factors regulate human pancreatic cancer stem cell characteristics
    Su Ni Tang
    Department of Pharmacology, Toxicology and Therapeutics, and Medicine, University of Kansas Cancer Center, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Int J Cancer 131:30-40. 2012
    ..Since aberrant SHh signaling occurs in pancreatic tumorigenesis, therapeutics that target SHh pathway may improve the outcomes of patients with pancreatic cancer by targeting CSCs...
  8. ncbi request reprint GANT-61 inhibits pancreatic cancer stem cell growth in vitro and in NOD/SCID/IL2R gamma null mice xenograft
    Junsheng Fu
    Department of Pathology and Laboratory Medicine, The University of Kansas Cancer Center, The University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Cancer Lett 330:22-32. 2013
    ..Our data highlight the importance of Shh pathway for self-renewal and metastasis of pancreatic CSCs, and also suggest Gli as a therapeutic target for pancreatic cancer in eliminating CSCs...
  9. pmc NPV-LDE-225 (Erismodegib) inhibits epithelial mesenchymal transition and self-renewal of glioblastoma initiating cells by regulating miR-21, miR-128, and miR-200
    Junsheng Fu
    Department of Pathology and Laboratory Medicine, The University of Kansas Cancer Center, The University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Neuro Oncol 15:691-706. 2013
    ....
  10. pmc Resveratrol inhibits pancreatic cancer stem cell characteristics in human and KrasG12D transgenic mice by inhibiting pluripotency maintaining factors and epithelial-mesenchymal transition
    Sharmila Shankar
    Department of Pathology and Laboratory Medicine, The University of Kansas Cancer Center, The University of Kansas Medical Center, Kansas City, Kansas, United States of America
    PLoS ONE 6:e16530. 2011
    ..The objectives of this study were to examine the molecular mechanisms by which resveratrol inhibits stem cell characteristics of pancreatic CSCs derived from human primary tumors and Kras(G12D) transgenic mice...
  11. pmc Sulforaphane synergizes with quercetin to inhibit self-renewal capacity of pancreatic cancer stem cells
    Rakesh K Srivastava
    Department of Pharmacology, Toxicology and Therapeutics, and Medicine, The University of Kansas Cancer Center, The University of Kansas Medical Center, Kansas City, KS 66160, USA
    Front Biosci (Elite Ed) 3:515-28. 2011
    ..These data suggest that SFN either alone or in combination with quercetin can eliminate cancer stem cell-characteristics...
  12. pmc EGCG enhances the therapeutic potential of gemcitabine and CP690550 by inhibiting STAT3 signaling pathway in human pancreatic cancer
    Su Ni Tang
    Department of Pharmacology, Toxicology and Therapeutics, and Medicine, The University of Kansas Cancer Center, The University of Kansas Medical Center, Kansas City, Kansas, United States of America
    PLoS ONE 7:e31067. 2012
    ....
  13. pmc Rottlerin-induced autophagy leads to the apoptosis in breast cancer stem cells: molecular mechanisms
    Dhruv Kumar
    Department of Pharmacology, Toxicology and Therapeutics, and Internal Medicine, The University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Mol Cancer 12:171. 2013
    ..Recent studies have demonstrated the antitumor activities of plant-derived chemopreventive agent rottlerin (Rott). However, the molecular mechanism by which Rott induces autophagy in breast CSCs has not been investigated...
  14. pmc Resveratrol inhibits growth of orthotopic pancreatic tumors through activation of FOXO transcription factors
    Sanjit K Roy
    Department of Pharmacology, Toxicology and Therapeutics, and Medicine, The University of Kansas Cancer Center, The University of Kansas Medical Center, Kansas City, Kansas, United States of America
    PLoS ONE 6:e25166. 2011
    ..The objectives of this study were to examine whether FOXOs regulate antitumor activities of resveratrol in pancreatic cancer cells in vitro and in vivo...
  15. doi request reprint Ellagic acid inhibits human pancreatic cancer growth in Balb c nude mice
    Min Zhao
    Department of Pharmacology, Toxicology and Therapeutics, and Medicine, The University of Kansas Medical Center, Kansas City, KS 66160, USA
    Cancer Lett 337:210-7. 2013
    ..In view of the fact that EA could effectively inhibit human pancreatic cancer growth by suppressing Akt, Shh and Notch pathways, our findings suggest that the use of EA would be beneficial for the management of pancreatic cancer. ..
  16. doi request reprint Rottlerin induces autophagy which leads to apoptotic cell death through inhibition of PI3K/Akt/mTOR pathway in human pancreatic cancer stem cells
    Brahma N Singh
    Department of Pharmacology, Toxicology and Therapeutics, and Medicine, The University of Kansas Cancer Center, The University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Biochem Pharmacol 84:1154-63. 2012
    ..In summary, our data demonstrate that ROT can induce autophagy which leads to cell death in pancreatic CSCs...
  17. doi request reprint Rottlerin induces autophagy and apoptosis in prostate cancer stem cells via PI3K/Akt/mTOR signaling pathway
    Dhruv Kumar
    Department of Pharmacology, Toxicology and Therapeutics, and Medicine, The University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, 66160, USA Electronic address
    Cancer Lett 343:179-89. 2014
    ..In conclusion, a better understanding of the biology of autophagy and the pharmacology of autophagy modulators has the potential for facilitating the development of autophagy-based therapeutic interventions for prostate cancer. ..
  18. pmc Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications
    Brahma N Singh
    Department of Pharmacology, Toxicology and Therapeutics, and Medicine, The University of Kansas Cancer Center, The University of Kansas Medical Center, Kansas City, KS 66160, United States
    Biochem Pharmacol 82:1807-21. 2011
    ..Therefore, non-toxic natural agent could be useful either alone or in combination with conventional therapeutics for the prevention of tumor progression and/or treatment of human malignancies...
  19. doi request reprint MS-275 sensitizes TRAIL-resistant breast cancer cells, inhibits angiogenesis and metastasis, and reverses epithelial-mesenchymal transition in vivo
    Rakesh K Srivastava
    Department of Pharmacology, Toxicology and Therapeutics, and Medicine, The University of Kansas Cancer Center, The University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Mol Cancer Ther 9:3254-66. 2010
    ....
  20. pmc Embelin Suppresses Growth of Human Pancreatic Cancer Xenografts, and Pancreatic Cancer Cells Isolated from KrasG12D Mice by Inhibiting Akt and Sonic Hedgehog Pathways
    Minzhao Huang
    Department of Pharmacology, Toxicology and Therapeutics, and Medicine, The University of Kansas Cancer Center, The University of Kansas Medical Center, Kansas City, Kansas, United States of America
    PLoS ONE 9:e92161. 2014
    ..These data suggest that embelin can inhibit pancreatic cancer growth, angiogenesis and metastasis by suppressing Akt and Shh pathways, and can be developed for the treatment and/or prevention of pancreatic cancer. ..
  21. ncbi request reprint Epigenetic modifications by dietary phytochemicals: implications for personalized nutrition
    Sharmila Shankar
    Department of Pathology and Laboratory Medicine, The University of Kansas Medical Center, The University of Kansas Cancer Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Pharmacol Ther 138:1-17. 2013
    ..In this review, we will discuss the effect of dietary phytochemicals on genetic and epigenetic modifications and how these modifications help to prevent various types of cancers and improve health outcomes...
  22. pmc The dietary bioflavonoid quercetin synergizes with epigallocathechin gallate (EGCG) to inhibit prostate cancer stem cell characteristics, invasion, migration and epithelial-mesenchymal transition
    Su Ni Tang
    Department of Pharmacology, Toxicology and Therapeutics, and Medicine, The University of Kansas Cancer Center, The University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS, 66160, USA
    J Mol Signal 5:14. 2010
    ....
  23. ncbi request reprint FOXO transcription factors and VEGF neutralizing antibody enhance antiangiogenic effects of resveratrol
    Rakesh K Srivastava
    Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, KS 66160 7410, USA
    Mol Cell Biochem 337:201-12. 2010
    ..In conclusion, regulation of FOXO transcription factors by resveratrol may play an important role in angiogenesis which is critical for cancer, diabetic retinopathy, rheumatoid arthritis, psoriasis, and cardiovascular disorders...