Ying Shan

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. ncbi request reprint Mapping of the chick heme oxygenase-1 proximal promoter for responsiveness to metalloporphyrins
    Ying Shan
    Department of Medicine, and the The Liver Biliary Pancreatic Center, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655, USA
    Arch Biochem Biophys 399:159-66. 2002
  2. ncbi request reprint Identification of key elements that are responsible for heme-mediated induction of the avian heme oxygenase-1 gene
    Ying Shan
    Department of Medicine, University of Connecticut Health Center, Farmington 06030, USA
    Biochim Biophys Acta 1679:87-94. 2004
  3. pmc Reciprocal effects of micro-RNA-122 on expression of heme oxygenase-1 and hepatitis C virus genes in human hepatocytes
    Ying Shan
    Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut, USA
    Gastroenterology 133:1166-74. 2007
  4. ncbi request reprint Role of Bach1 and Nrf2 in up-regulation of the heme oxygenase-1 gene by cobalt protoporphyrin
    Ying Shan
    Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut, USA
    FASEB J 20:2651-3. 2006
  5. ncbi request reprint Role of Bach-1 in regulation of heme oxygenase-1 in human liver cells: insights from studies with small interfering RNAS
    Ying Shan
    Department of Medicine and Pharmacology, the General Clinical Research Center of the University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    J Biol Chem 279:51769-74. 2004
  6. ncbi request reprint HCV proteins increase expression of heme oxygenase-1 (HO-1) and decrease expression of Bach1 in human hepatoma cells
    Tahereh Ghaziani
    Department of Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 1111, USA
    J Hepatol 45:5-12. 2006
  7. pmc Effects of silymarin on hepatitis C virus and haem oxygenase-1 gene expression in human hepatoma cells
    Vania Bonifaz
    Department of Microbial Biology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Liver Int 29:366-73. 2009
  8. ncbi request reprint Association of hepatitis C virus infection with serum iron status: analysis of data from the third National Health and Nutrition Examination Survey
    Ying Shan
    Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
    Clin Infect Dis 40:834-41. 2005
  9. ncbi request reprint Iron as a co-morbid factor in nonhemochromatotic liver disease
    Herbert L Bonkovsky
    University of Connecticut Health Center, MC 1111, 263 Farmington Avenue, Farmington, CT 06030 1111, USA
    Alcohol 30:137-44. 2003
  10. pmc Zinc mesoporphyrin induces rapid and marked degradation of the transcription factor Bach1 and up-regulates HO-1
    Weihong Hou
    The Liver Biliary Pancreatic Center, Carolinas Medical Center, Charlotte, NC 28232 2861, USA
    Biochim Biophys Acta 1779:195-203. 2008

Collaborators

Detail Information

Publications11

  1. ncbi request reprint Mapping of the chick heme oxygenase-1 proximal promoter for responsiveness to metalloporphyrins
    Ying Shan
    Department of Medicine, and the The Liver Biliary Pancreatic Center, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655, USA
    Arch Biochem Biophys 399:159-66. 2002
    ..We conclude that the chick HO-1 promoter region contains a unique sequence that subserves up-regulation of the gene by metalloporphyrins and propose the name "metalloporphyrin-responsive element" for this sequence...
  2. ncbi request reprint Identification of key elements that are responsible for heme-mediated induction of the avian heme oxygenase-1 gene
    Ying Shan
    Department of Medicine, University of Connecticut Health Center, Farmington 06030, USA
    Biochim Biophys Acta 1679:87-94. 2004
    ..1Luc or pcHO7.1-4.6Luc as templates. Single and multiple mutations of HeREs and MPRE significantly abrogated the heme- and CoPP-dependent up-regulation of reporter gene expression in transient or stable transfection experiments...
  3. pmc Reciprocal effects of micro-RNA-122 on expression of heme oxygenase-1 and hepatitis C virus genes in human hepatocytes
    Ying Shan
    Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut, USA
    Gastroenterology 133:1166-74. 2007
    ..This study was to assess whether a specific miR-122 antagomir down-regulates HCV protein replication and up-regulates HO-1...
  4. ncbi request reprint Role of Bach1 and Nrf2 in up-regulation of the heme oxygenase-1 gene by cobalt protoporphyrin
    Ying Shan
    Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut, USA
    FASEB J 20:2651-3. 2006
    ..Because CoPP, unlike heme, is neither a prooxidant nor a substrate for HO-1, it might be considered as a potential therapeutic agent in situations where up-regulation of HO-1 is desired...
  5. ncbi request reprint Role of Bach-1 in regulation of heme oxygenase-1 in human liver cells: insights from studies with small interfering RNAS
    Ying Shan
    Department of Medicine and Pharmacology, the General Clinical Research Center of the University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    J Biol Chem 279:51769-74. 2004
    ..Exogenous heme produces additional up-regulation, beyond that produced by Bach-1 siRNAs, suggesting that heme does not act solely through its effects on Bach-1...
  6. ncbi request reprint HCV proteins increase expression of heme oxygenase-1 (HO-1) and decrease expression of Bach1 in human hepatoma cells
    Tahereh Ghaziani
    Department of Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 1111, USA
    J Hepatol 45:5-12. 2006
    ..Other recent work has implicated Bach1, a heme binding protein that represses gene expression, in the regulation of HO-1 gene expression...
  7. pmc Effects of silymarin on hepatitis C virus and haem oxygenase-1 gene expression in human hepatoma cells
    Vania Bonifaz
    Department of Microbial Biology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Liver Int 29:366-73. 2009
    ..HCV infection is associated with increased hepatic oxidative stress, and one of the antioxidant enzymes that protect cells against this stress is haem oxygenase-1 (HO-1)...
  8. ncbi request reprint Association of hepatitis C virus infection with serum iron status: analysis of data from the third National Health and Nutrition Examination Survey
    Ying Shan
    Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
    Clin Infect Dis 40:834-41. 2005
    ..In the present study, the association of hepatitis C virus (HCV) infection with serum measurements of iron status was assessed in the US population...
  9. ncbi request reprint Iron as a co-morbid factor in nonhemochromatotic liver disease
    Herbert L Bonkovsky
    University of Connecticut Health Center, MC 1111, 263 Farmington Avenue, Farmington, CT 06030 1111, USA
    Alcohol 30:137-44. 2003
    ..Iron loading has also been described after portosystemic shunts and in end-stage liver disease...
  10. pmc Zinc mesoporphyrin induces rapid and marked degradation of the transcription factor Bach1 and up-regulates HO-1
    Weihong Hou
    The Liver Biliary Pancreatic Center, Carolinas Medical Center, Charlotte, NC 28232 2861, USA
    Biochim Biophys Acta 1779:195-203. 2008
    ..Our results indicate that ZnMP up-regulates HO-1 gene expression by markedly increasing Bach1 protein degradation in a proteasome-dependent manner...
  11. ncbi request reprint Cell cycle-controlled interaction of nucleolin with the retinoblastoma protein and cancerous cell transformation
    Edgar Grinstein
    Institute of Transplantation Diagnostics and Cellular Therapeutics, Heinrich Heine University Medical Center, 40225 Dusseldorf, Germany
    J Biol Chem 281:22223-35. 2006
    ..Our findings suggest that deregulated nucleolin activity due to a loss of Rb contributes to tumor development in malignant diseases, thus providing further insights into the molecular network for the Rb-mediated tumor suppression...