Homayoun Shams

Summary

Affiliation: University of Texas Health Center
Country: USA

Publications

  1. ncbi request reprint Characterization of a Mycobacterium tuberculosis peptide that is recognized by human CD4+ and CD8+ T cells in the context of multiple HLA alleles
    Homayoun Shams
    Center for Pulmonary and Infectious Disease Control, and Department of Microbiology, University of Texas Health Center, Tyler, TX 75708, USA
    J Immunol 173:1966-77. 2004
  2. ncbi request reprint Human CD8+ T cells recognize epitopes of the 28-kDa hemolysin and the 38-kDa antigen of Mycobacterium tuberculosis
    Homayoun Shams
    Center for Pulmonary and Infectious Disease Control, University of Texas Health Center, 11937 U S Hwy 271, Tyler, TX 75708 3154, USA
    J Leukoc Biol 74:1008-14. 2003
  3. ncbi request reprint NK cells regulate CD8+ T cell effector function in response to an intracellular pathogen
    Ramakrishna Vankayalapati
    Center for Pulmonary and Infectious Disease Control, University of Texas Health Center, 11937 US Highway 271, Tyler, TX 75708, USA
    J Immunol 172:130-7. 2004
  4. ncbi request reprint IS6110 functions as a mobile, monocyte-activated promoter in Mycobacterium tuberculosis
    Hassan Safi
    Department of Microbiology, Center for Pulmonary and Infectious Disease Control, University of Texas Health Center at Tyler, 11937 US Highway 271, Tyler, TX 75708 3154, USA
    Mol Microbiol 52:999-1012. 2004
  5. pmc Vaccination strategies to enhance local immunity and protection against Mycobacteriun tuberculosis
    Peter Klucar
    Center for Pulmonary and Infectious Disease Control, University of Texas Health Science Center at Tyler, Tyler, TX 75708, United States
    Vaccine 27:1816-24. 2009
  6. ncbi request reprint Cyclic AMP response element-binding protein positively regulates production of IFN-gamma by T cells in response to a microbial pathogen
    Buka Samten
    Center for Pulmonary and Infectious Disease Control, Department of Microbiology and Immunology, University of Texas Health Center, Tyler, TX 75708, USA
    J Immunol 174:6357-63. 2005
  7. pmc CREB, ATF, and AP-1 transcription factors regulate IFN-gamma secretion by human T cells in response to mycobacterial antigen
    Buka Samten
    Center for Pulmonary and Infectious Disease Control, University of Texas Health Center, Tyler, TX 75708, USA
    J Immunol 181:2056-64. 2008
  8. doi request reprint Characterization of effector functions of human peptide-specific CD4+ T-cell clones for an intracellular pathogen
    Peter Klucar
    Department of Microbiology and Immunology, University of Texas Health Center at Tyler, Tyler, TX, USA
    Hum Immunol 69:475-83. 2008
  9. doi request reprint ESAT-6 inhibits production of IFN-gamma by Mycobacterium tuberculosis-responsive human T cells
    Xisheng Wang
    Department of Microbiologyand Immunology, Center for Pulmonary and Infectious Disease Control, University of Texas Health Science Center, Tyler, TX 75708, USA
    J Immunol 182:3668-77. 2009
  10. ncbi request reprint CD40 ligand trimer enhances the response of CD8+ T cells to Mycobacterium tuberculosis
    Buka Samten
    Department of Microbiology and Immunology and Center for Pulmonary and Infectious Disease Control, University of Texas Health Center, Tyler, TX 75708, USA
    J Immunol 170:3180-6. 2003

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Characterization of a Mycobacterium tuberculosis peptide that is recognized by human CD4+ and CD8+ T cells in the context of multiple HLA alleles
    Homayoun Shams
    Center for Pulmonary and Infectious Disease Control, and Department of Microbiology, University of Texas Health Center, Tyler, TX 75708, USA
    J Immunol 173:1966-77. 2004
    ....
  2. ncbi request reprint Human CD8+ T cells recognize epitopes of the 28-kDa hemolysin and the 38-kDa antigen of Mycobacterium tuberculosis
    Homayoun Shams
    Center for Pulmonary and Infectious Disease Control, University of Texas Health Center, 11937 U S Hwy 271, Tyler, TX 75708 3154, USA
    J Leukoc Biol 74:1008-14. 2003
    ..We speculate that hemolysins may alter the phagosomal membrane surrounding intracellular M. tuberculosis, allowing themselves and other antigens to gain access to the major histocompatibility complex class I processing pathway...
  3. ncbi request reprint NK cells regulate CD8+ T cell effector function in response to an intracellular pathogen
    Ramakrishna Vankayalapati
    Center for Pulmonary and Infectious Disease Control, University of Texas Health Center, 11937 US Highway 271, Tyler, TX 75708, USA
    J Immunol 172:130-7. 2004
    ..tuberculosis and other intracellular pathogens...
  4. ncbi request reprint IS6110 functions as a mobile, monocyte-activated promoter in Mycobacterium tuberculosis
    Hassan Safi
    Department of Microbiology, Center for Pulmonary and Infectious Disease Control, University of Texas Health Center at Tyler, 11937 US Highway 271, Tyler, TX 75708 3154, USA
    Mol Microbiol 52:999-1012. 2004
    ..The ability to activate genes during infection suggests that IS6110 has the potential to influence growth characteristics of different strains, and indicates another mechanism by which IS6110 can impact M. tuberculosis evolution...
  5. pmc Vaccination strategies to enhance local immunity and protection against Mycobacteriun tuberculosis
    Peter Klucar
    Center for Pulmonary and Infectious Disease Control, University of Texas Health Science Center at Tyler, Tyler, TX 75708, United States
    Vaccine 27:1816-24. 2009
    ..We conclude that CFP10 is a potential vaccine candidate and that coating vaccines with PEI enhances local protective immunity to tuberculosis..
  6. ncbi request reprint Cyclic AMP response element-binding protein positively regulates production of IFN-gamma by T cells in response to a microbial pathogen
    Buka Samten
    Center for Pulmonary and Infectious Disease Control, Department of Microbiology and Immunology, University of Texas Health Center, Tyler, TX 75708, USA
    J Immunol 174:6357-63. 2005
    ..These findings demonstrate that CREB positively regulates IFN-gamma production by human T cells that respond to M. tuberculosis...
  7. pmc CREB, ATF, and AP-1 transcription factors regulate IFN-gamma secretion by human T cells in response to mycobacterial antigen
    Buka Samten
    Center for Pulmonary and Infectious Disease Control, University of Texas Health Center, Tyler, TX 75708, USA
    J Immunol 181:2056-64. 2008
    ..Additionally, ATF-2 controls expression of CREB and c-Jun during T cell activation...
  8. doi request reprint Characterization of effector functions of human peptide-specific CD4+ T-cell clones for an intracellular pathogen
    Peter Klucar
    Department of Microbiology and Immunology, University of Texas Health Center at Tyler, Tyler, TX, USA
    Hum Immunol 69:475-83. 2008
    ....
  9. doi request reprint ESAT-6 inhibits production of IFN-gamma by Mycobacterium tuberculosis-responsive human T cells
    Xisheng Wang
    Department of Microbiologyand Immunology, Center for Pulmonary and Infectious Disease Control, University of Texas Health Science Center, Tyler, TX 75708, USA
    J Immunol 182:3668-77. 2009
    ..We conclude that ESAT-6 directly inhibits human T cell responses to mycobacterial Ags by affecting TCR signaling pathways downstream of ZAP70...
  10. ncbi request reprint CD40 ligand trimer enhances the response of CD8+ T cells to Mycobacterium tuberculosis
    Buka Samten
    Department of Microbiology and Immunology and Center for Pulmonary and Infectious Disease Control, University of Texas Health Center, Tyler, TX 75708, USA
    J Immunol 170:3180-6. 2003
    ..We conclude that CD40LT can enhance CD8(+) T cell effector function in response to M. tuberculosis...
  11. ncbi request reprint The principal sigma factor sigA mediates enhanced growth of Mycobacterium tuberculosis in vivo
    Shiping Wu
    Department of Microbiology and Immunology, Center for Pulmonary and Infectious Disease Control, University of Texas Health Center, 11937 US Highway 271, Tyler, TX, USA
    Mol Microbiol 51:1551-62. 2004
    ..This effect may be mediated in part by increased resistance to reactive oxygen intermediates...
  12. pmc Exposure to cigarette smoke inhibits the pulmonary T-cell response to influenza virus and Mycobacterium tuberculosis
    Yan Feng
    Center for Pulmonary and Infectious Disease Control, The University of Texas Health Science Center at Tyler, Tyler, TX 75708, USA
    Infect Immun 79:229-37. 2011
    ..tuberculosis and influenza virus in a physiologically relevant animal model, increasing susceptibility to both pathogens...
  13. pmc Enzyme-linked immunospot and tuberculin skin testing to detect latent tuberculosis infection
    Homayoun Shams
    CPIDC, University of Texas Health Center, 11937 U S Highway 271, Tyler, TX 75708 3154
    Am J Respir Crit Care Med 172:1161-8. 2005
    ..Diagnosis of latent tuberculosis infection (LTBI) is currently based on the tuberculin skin test. The enzyme-linked immunospot assay (ELISPOT) is a new blood test to diagnose LTBI...
  14. doi request reprint Progress in understanding the human immune responses to Mycobacterium tuberculosis
    Peter F Barnes
    Department of Medicine, The University of Texas Health Science Center at Tyler, Tyler, TX, USA
    Tuberculosis (Edinb) 89:S5-9. 2009
    ....
  15. doi request reprint GM-CSF in the lung protects against lethal influenza infection
    Fang fang Huang
    Center for Pulmonary and Infectious Disease Control, University of Texas Health Science Center at Tyler, Texas, USA
    Am J Respir Crit Care Med 184:259-68. 2011
    ..Alveolar macrophages contribute to host defenses against influenza in animal models. Enhancing alveolar macrophage function may contribute to protection against influenza...
  16. ncbi request reprint The CD14 receptor does not mediate entry of Mycobacterium tuberculosis into human mononuclear phagocytes
    Homayoun Shams
    Center for Pulmonary and Infectious Disease Control, University of Texas Health Center, 11937 U S Highway 271, Tyler, TX 75708 3154, USA
    FEMS Immunol Med Microbiol 36:63-9. 2003
    ..tuberculosis; (2) M. tuberculosis infection upregulates CD14 expression on mononuclear phagocytes, and this may facilitate the pathogen's capacity to modulate the immune response...
  17. ncbi request reprint Serum cytokine concentrations do not parallel Mycobacterium tuberculosis-induced cytokine production in patients with tuberculosis
    Ramakrishna Vankayalapati
    Center for Pulmonary and Infectious Disease Control, and Department of Microbiology and Immunology, University of Texas Health Center, Tyler, TX 75708 3154, USA
    Clin Infect Dis 36:24-8. 2003
    ..tuberculosis-induced cytokine levels, and increased IL-10 serum levels in patients with tuberculosis inhibit IFN-gamma production in response to mycobacterial antigens...
  18. ncbi request reprint Recent developments in veterinary vaccinology
    Homayoun Shams
    Center for Pulmonary and Infectious Diseases Control, University of Texas Health Center at Tyler, 11937 US Highway 271, Tyler, TX 75708 3154, USA
    Vet J 170:289-99. 2005
    ..The present review focuses on recent advances in veterinary vaccinology and addresses the effects and impact of modern microbiology, immunology, and molecular biology...
  19. pmc Evasion of peptide, but not lipid antigen presentation, through pathogen-induced dendritic cell maturation
    David L Hava
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, 1 Jimmy Fund Way, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:11281-6. 2008
    ....