Affiliation: University of Arizona
Mandal A, Shahidullah M, Delamere N. TRPV1-dependent ERK1/2 activation in porcine lens epithelium. Exp Eye Res. 2018;172:128-136 pubmed publisher
..Further studies are ongoing to determine what functional changes are triggered by the TRPV1-linked signaling pathways and how they might relate to lens volume homeostasis. ..
Matagne V, Wondolowski J, Frerking M, Shahidullah M, Delamere N, Sandau U, et al
. Correcting deregulated Fxyd1 expression rescues deficits in neuronal arborization and potassium homeostasis in MeCP2 deficient male mice. Brain Res. 2018;1697:45-52 pubmed publisher
..These results indicate that excess of Fxyd1 in the absence of MeCP2 results in deregulation of endogenous K+ conductances functionally associated with NKA and leads to stunted neuronal growth. ..
Shahidullah M, Mandal A, Delamere N. Responses of sodium-hydrogen exchange to nitric oxide in porcine cultured nonpigmented ciliary epithelium. Invest Ophthalmol Vis Sci. 2009;50:5851-8 pubmed publisher
..Although NHE inhibitors are known to lower intraocular pressure (IOP), further studies are needed to understand whether changes in NHE activity contribute to the IOP-lowering effect of NO donors. ..
Shahidullah M, Mandal A, Delamere N. Damage to lens fiber cells causes TRPV4-dependent Src family kinase activation in the epithelium. Exp Eye Res. 2015;140:85-93 pubmed publisher
..Increased Na,K-ATPase activity gives the lens greater capacity to control ion concentrations in the fiber mass and the Na,K-ATPase response may reflect the critical contribution of the epithelium to lens ion homeostasis. ..
Shahidullah M, Mandal A, Beimgraben C, Delamere N. Hyposmotic stress causes ATP release and stimulates Na,K-ATPase activity in porcine lens. J Cell Physiol. 2012;227:1428-37 pubmed publisher
..The responses might signify an autoregulatory loop initiated by mechanical stress or osmotic swelling. ..
Mandal A, Shahidullah M, Delamere N. Calcium entry via connexin hemichannels in lens epithelium. Exp Eye Res. 2015;132:52-8 pubmed publisher
..Even though connexins form channels with a large carrying capacity, calcium entry does not increase the cytoplasmic calcium concentration beyond a tolerable physiological range. ..
Shahidullah M, To C, Pelis R, Delamere N. Studies on bicarbonate transporters and carbonic anhydrase in porcine nonpigmented ciliary epithelium. Invest Ophthalmol Vis Sci. 2009;50:1791-800 pubmed publisher
..Bicarbonate transport plays a role in aqueous humor (AH) secretion. The authors examined bicarbonate transport mechanisms and carbonic anhydrase (CA) in porcine nonpigmented ciliary epithelium (NPE)...
Shahidullah M, Mandal A, Delamere N. TRPV4 in porcine lens epithelium regulates hemichannel-mediated ATP release and Na-K-ATPase activity. Am J Physiol Cell Physiol. 2012;302:C1751-61 pubmed publisher
..The results point to TRPV4-mediated calcium entry that causes a cytoplasmic calcium increase which is an essential early step in the mechanism used by the lens to sense and respond to hyposmotic stress. ..