Nicholas Shaheen

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi request reprint Barrett's esophagus and the costs of "doing something"
    Evan S Dellon
    Gastrointest Endosc 65:31-5. 2007
  2. doi request reprint Efficacy and safety of lesogaberan in gastro-oesophageal reflux disease: a randomised controlled trial
    Nicholas J Shaheen
    Center for Esophageal Diseases and Swallowing, Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Gut 62:1248-55. 2013
  3. doi request reprint Esophageal mucosal breaks in gastroesophageal reflux disease partially responsive to proton pump inhibitor therapy
    Nicholas J Shaheen
    Center for Esophageal Diseases and Swallowing, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7080, USA
    Am J Gastroenterol 108:529-34. 2013
  4. pmc Multilayered epithelium in a rat model and human Barrett's esophagus: similar expression patterns of transcription factors and differentiation markers
    Xiaoxin Chen
    Cancer Research Program, Julius L, Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, 700 George Street, Durham, NC 27707, USA
    BMC Gastroenterol 8:1. 2008
  5. pmc What is the best management strategy for high grade dysplasia in Barrett's oesophagus? A cost effectiveness analysis
    N J Shaheen
    CB 7080, UNC CH, Chapel Hill, NC 27599 7080, USA
    Gut 53:1736-44. 2004
  6. pmc Quality of life following radiofrequency ablation of dysplastic Barrett's esophagus
    N J Shaheen
    University of North Carolina School of Medicine and School of Public Health, Chapel Hill, NC 27599, USA
    Endoscopy 42:790-9. 2010
  7. doi request reprint When to consider endoscopic ablation therapy for Barrett's esophagus
    Nicholas J Shaheen
    Division of Gastroenterology and Hepatology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7080, USA
    Curr Opin Gastroenterol 26:361-6. 2010
  8. ncbi request reprint Advances in Barrett's esophagus and esophageal adenocarcinoma
    Nicholas J Shaheen
    Center for Esophageal Diseases and Swallowing, Department of Medicine, University of North Carolina Schools of Medicine and Public Health, Chapel Hill 27599 7080, USA
    Gastroenterology 128:1554-66. 2005
  9. ncbi request reprint Does screening for Barrett's esophagus and adenocarcinoma of the esophagus prolong survival?
    Evan S Dellon
    Center for Esophageal Diseases and Swallowing, Division of Gastroenterology and Hepatology, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7080, USA
    J Clin Oncol 23:4478-82. 2005
  10. ncbi request reprint The perception of cancer risk in patients with prevalent Barrett's esophagus enrolled in an endoscopic surveillance program
    Nicholas J Shaheen
    Center for Esophageal Diseases and Swallowing, Division of Gastroenterology and Hepatology, University of North Carolina Schools of Medicine and Public Health, Chapel Hill, 27599, USA
    Gastroenterology 129:429-36. 2005

Research Grants

Detail Information

Publications68

  1. ncbi request reprint Barrett's esophagus and the costs of "doing something"
    Evan S Dellon
    Gastrointest Endosc 65:31-5. 2007
  2. doi request reprint Efficacy and safety of lesogaberan in gastro-oesophageal reflux disease: a randomised controlled trial
    Nicholas J Shaheen
    Center for Esophageal Diseases and Swallowing, Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Gut 62:1248-55. 2013
    ..gov reference: NCT01005251)...
  3. doi request reprint Esophageal mucosal breaks in gastroesophageal reflux disease partially responsive to proton pump inhibitor therapy
    Nicholas J Shaheen
    Center for Esophageal Diseases and Swallowing, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7080, USA
    Am J Gastroenterol 108:529-34. 2013
    ..The aim of this study was to determine the prevalence of esophageal mucosal breaks among patients who have a partial response to PPI therapy...
  4. pmc Multilayered epithelium in a rat model and human Barrett's esophagus: similar expression patterns of transcription factors and differentiation markers
    Xiaoxin Chen
    Cancer Research Program, Julius L, Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, 700 George Street, Durham, NC 27707, USA
    BMC Gastroenterol 8:1. 2008
    ..Invest. 2004;84:753-765). The purpose of this study was to compare the phenotype of rat MLE with human MLE, in order to gain insight into the nature of MLE and its potential role in the development of BE...
  5. pmc What is the best management strategy for high grade dysplasia in Barrett's oesophagus? A cost effectiveness analysis
    N J Shaheen
    CB 7080, UNC CH, Chapel Hill, NC 27599 7080, USA
    Gut 53:1736-44. 2004
    ..However, it is unclear which of these strategies provides the greatest life expectancy, and the costs associated with the management strategies are unknown...
  6. pmc Quality of life following radiofrequency ablation of dysplastic Barrett's esophagus
    N J Shaheen
    University of North Carolina School of Medicine and School of Public Health, Chapel Hill, NC 27599, USA
    Endoscopy 42:790-9. 2010
    ..This study assessed the influence of dysplastic Barrett's esophagus on QoL and evaluated whether endoscopic treatment of dysplastic Barrett's esophagus with radiofrequency ablation (RFA) improves QoL...
  7. doi request reprint When to consider endoscopic ablation therapy for Barrett's esophagus
    Nicholas J Shaheen
    Division of Gastroenterology and Hepatology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7080, USA
    Curr Opin Gastroenterol 26:361-6. 2010
    ..To evaluate timing and patient selection for endoscopic ablative therapy in Barrett's esophagus...
  8. ncbi request reprint Advances in Barrett's esophagus and esophageal adenocarcinoma
    Nicholas J Shaheen
    Center for Esophageal Diseases and Swallowing, Department of Medicine, University of North Carolina Schools of Medicine and Public Health, Chapel Hill 27599 7080, USA
    Gastroenterology 128:1554-66. 2005
    ..Similarly, although endoscopic screening is widely practiced, its value in patients with chronic gastroesophageal reflux disease symptoms is of unproven value, and recommending bodies are divided as to its practice...
  9. ncbi request reprint Does screening for Barrett's esophagus and adenocarcinoma of the esophagus prolong survival?
    Evan S Dellon
    Center for Esophageal Diseases and Swallowing, Division of Gastroenterology and Hepatology, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7080, USA
    J Clin Oncol 23:4478-82. 2005
    ....
  10. ncbi request reprint The perception of cancer risk in patients with prevalent Barrett's esophagus enrolled in an endoscopic surveillance program
    Nicholas J Shaheen
    Center for Esophageal Diseases and Swallowing, Division of Gastroenterology and Hepatology, University of North Carolina Schools of Medicine and Public Health, Chapel Hill, 27599, USA
    Gastroenterology 129:429-36. 2005
    ..5% per year. Patients may have difficulty understanding this risk. This study assessed the perceived risk of cancer in patients with BE, and correlated their risk estimates with their health care use behaviors...
  11. ncbi request reprint Endoscopic anti-reflux devices: a year of challenges and change
    Joseph E Cassara
    Center for Esophageal Diseases and Swallowing, Division of Gastroenterology and Hepatology, University of North Carolina Schools of Medicine and Public Health, Chapel Hill, North Carolina, USA
    Curr Opin Gastroenterol 22:423-8. 2006
    ..These devices utilize a variety of methods in an attempt to decrease reflux of gastric contents. This work reviews the most notable results of endoscopic antireflux procedure studies published in 2005...
  12. doi request reprint Radiofrequency ablation in Barrett's esophagus with dysplasia
    Nicholas J Shaheen
    Center for Esophageal Diseases and Swallowing, University of North Carolina School of Medicine, CB 7080, Chapel Hill, NC 27599 7080, USA
    N Engl J Med 360:2277-88. 2009
    ..We assessed whether endoscopic radiofrequency ablation could eradicate dysplastic Barrett's esophagus and decrease the rate of neoplastic progression...
  13. ncbi request reprint Gastroesophageal reflux disease as an etiology of sleep disturbance in subjects with insomnia and minimal reflux symptoms: a pilot study of prevalence and response to therapy
    Nicholas J Shaheen
    Center for Esophageal Diseases and Swallowing, Division of Gastroenterology and Hepatology, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7080, USA
    Dig Dis Sci 53:1493-9. 2008
    ..GERD's role in sleep disturbance of minimally symptomatic patients with poor sleep quality is less clear...
  14. doi request reprint Improving screening practices for Barrett's esophagus
    Nicholas J Shaheen
    Departments of Medicine and Epidemiology, Schools of Medicine and Public Health, CB 7080, UNC CH, Chapel Hill, NC 27599 7080, USA
    Surg Oncol Clin N Am 18:423-37. 2009
    ..We suggest modifications to BE screening practices that may have the potential to improve outcomes for patients with BE...
  15. pmc Randomised clinical trial: high-dose acid suppression for chronic cough - a double-blind, placebo-controlled study
    N J Shaheen
    Center for Esophageal Diseases and Swallowing, University of North Carolina School of Medicine, Chapel Hill, 27599 7080, USA
    Aliment Pharmacol Ther 33:225-34. 2011
    ..Cough may be a manifestation of gastro-oesophageal reflux disease (GERD). The utility of acid suppression in GERD-related cough is uncertain...
  16. ncbi request reprint Association between hemochromatosis (HFE) gene mutation carrier status and the risk of colon cancer
    Nicholas J Shaheen
    Center for Gastrointestinal Biology and Disease and Division of Digestive Diseases and Nutrition, University of North Carolina, Chapel Hill 27599 7080, USA
    J Natl Cancer Inst 95:154-9. 2003
    ..Mutations in the hemochromatosis (HFE) gene are associated with increased total body iron stores in some individuals. We assessed the risk of colon cancer among individuals with and without HFE gene mutations...
  17. ncbi request reprint Is there publication bias in the reporting of cancer risk in Barrett's esophagus?
    N J Shaheen
    Division of Digestive Diseases and Nutrition, Department of Medicine, and Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7080, USA
    Gastroenterology 119:333-8. 2000
    ..The aim of this study was to assess those publications reporting a cancer risk in BE for evidence of publication bias...
  18. ncbi request reprint Chemoprevention of gastrointestinal malignancies with nonsteroidal antiinflammatory drugs
    Nicholas J Shaheen
    Division of Digestive Diseases and Nutrition and the Center for Gastrointestinal Biology and Disease, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7080, USA
    Cancer 94:950-63. 2002
    ..The newer COX-2 specific agents may provide a less GI-toxic alternative to nonselective NSAIDs as chemoprotective agents...
  19. pmc Durability of radiofrequency ablation in Barrett's esophagus with dysplasia
    Nicholas J Shaheen
    Center for Esophageal Diseases and Swallowing, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7080, USA
    Gastroenterology 141:460-8. 2011
    ..We assessed long-term rates of eradication, durability of neosquamous epithelium, disease progression, and safety of RFA in patients with dysplastic BE...
  20. ncbi request reprint Gastroesophageal reflux, Barrett esophagus, and esophageal cancer: clinical applications
    Nicholas Shaheen
    Division of Digestive Diseases and Nutrition, Center for Esophageal Disease and Swallowing, CB 7080, University of North Carolina Chapel Hill, Chapel Hill, NC 27599 7080, USA
    JAMA 287:1982-6. 2002
    ..Applying data reviewed in the companion article, we propose practical answers to common clinical situations regarding care of patients with reflux. We also present an algorithm for treatment of patients with chronic GERD symptoms...
  21. ncbi request reprint Gastroesophageal reflux, barrett esophagus, and esophageal cancer: scientific review
    Nicholas Shaheen
    Division of Digestive Diseases and Nutrition, Center for Esophageal Disease and Swallowing, CB 7080, University of North Carolina Chapel Hill, Chapel Hill, NC 27599 7080, USA
    JAMA 287:1972-81. 2002
    ..Some have recommended that patients with chronic reflux symptoms undergo upper endoscopy to assess for Barrett esophagus and to screen for cancer...
  22. pmc Safety and efficacy of endoscopic spray cryotherapy for Barrett's esophagus with high-grade dysplasia
    Nicholas J Shaheen
    Center for Esophageal Diseases and Swallowing, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7080, USA
    Gastrointest Endosc 71:680-5. 2010
    ..Endoscopic ablation to treat Barrett's esophagus (BE) with high-grade dysplasia (HGD) is associated with a decreased incidence of esophageal adenocarcinoma. Endoscopic spray cryotherapy (CRYO) demonstrates promising preliminary data...
  23. ncbi request reprint Does a surgical antireflux procedure decrease the incidence of esophageal adenocarcinoma in Barrett's esophagus? A meta-analysis
    Kathleen E Corey
    Center for Esophageal Diseases and Swallowing, The Division of Digestive Diseases, and the School of Public Health, University of North Carolina at, North Carolina, Chapel Hill 27599 7080, USA
    Am J Gastroenterol 98:2390-4. 2003
    ..This study compared the reported incidence of esophageal adenocarcinoma in subjects with BE who underwent SARP with those with BE who had medical management...
  24. pmc Quality of life in GERD and Barrett's esophagus is related to gender and manifestation of disease
    Quinn K Lippmann
    School of Public Health, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina 27599 7080, USA
    Am J Gastroenterol 104:2695-703. 2009
    ..We sought to compare BE and GERD (stratified by erosive reflux disease (ERD) and non-erosive reflux disease (NERD)) with regard to HRQoL and psychological impact...
  25. doi request reprint Esophageal dilation in eosinophilic esophagitis: safety and predictors of clinical response and complications
    Evan S Dellon
    Center for Esophageal Diseases and Swallowing, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
    Gastrointest Endosc 71:706-12. 2010
    ..Esophageal strictures resulting from eosinophilic esophagitis present management challenges, and high rates of rents and perforation have been reported...
  26. doi request reprint Should patients with Barrett's oesophagus be kept under surveillance? The case against
    A Sidney Barritt
    University of North Carolina, Department of Medicine, Division of Gastroenterology and Hepatology, Campus Box 7080, Chapel Hill, NC 27599 7080, United States
    Best Pract Res Clin Gastroenterol 22:741-50. 2008
    ..Taken individually or together, these limitations make a strong case against surveillance endoscopy in Barrett's oesophagus...
  27. pmc Clinical, endoscopic, and histologic findings distinguish eosinophilic esophagitis from gastroesophageal reflux disease
    Evan S Dellon
    Center for Esophageal Diseases and Swallowing, Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
    Clin Gastroenterol Hepatol 7:1305-13; quiz 1261. 2009
    ..We aimed to characterize the clinical, endoscopic, and histologic features of EoE and GERD and to identify factors that might be used to differentiate them...
  28. ncbi request reprint Variability in diagnostic criteria for eosinophilic esophagitis: a systematic review
    Evan S Dellon
    Center for Esophageal Diseases and Swallowing, and Center for Gastrointestinal Biology and Disease, Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
    Am J Gastroenterol 102:2300-13. 2007
    ..Our understanding of this disease is hampered by the lack of a uniform diagnostic standard. The aim of this systematic review was to determine the range of diagnostic strategies and histologic criteria in the EoE literature...
  29. pmc Inter- and intraobserver reliability and validation of a new method for determination of eosinophil counts in patients with esophageal eosinophilia
    Evan S Dellon
    Center for Esophageal Diseases and Swallowing, Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7080, USA
    Dig Dis Sci 55:1940-9. 2010
    ..Diagnosis of eosinophilic esophagitis (EoE) requires quantification of esophageal eosinophilia...
  30. pmc Gastrointestinal endoscopy nurse experience and polyp detection during screening colonoscopy
    Evan S Dellon
    Center for Gastrointestinal Biology and Disease, Division of Gastroenterology and Hepatology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7080, USA
    Clin Gastroenterol Hepatol 6:1342-7. 2008
    ..The effect of gastrointestinal endoscopy nursing experience on polyp detection is unknown. The aim of this study was to determine whether nurse experience is associated with odds of polyp detection...
  31. pmc Health-related quality of life in patients with Barrett's esophagus: a systematic review
    Seth D Crockett
    Center for Esophageal Diseases and Swallowing, Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina 27599 7080, USA
    Clin Gastroenterol Hepatol 7:613-23. 2009
    ..We sought to systematically review the published literature on HRQoL of patients with BE...
  32. doi request reprint Diagnosis of eosinophilic esophagitis after fundoplication for 'refractory reflux': implications for preoperative evaluation
    Evan S Dellon
    Center for Esophageal Diseases and Swallowing, Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
    Dis Esophagus 23:191-5. 2010
    ..Given the rising prevalence of EoE, we recommend obtaining proximal and distal esophageal biopsies in such patients prior to performing anti-reflux surgery...
  33. ncbi request reprint Claudin-18: a dominant tight junction protein in Barrett's esophagus and likely contributor to its acid resistance
    Biljana Jovov
    Dept of Medicine, Univ of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Am J Physiol Gastrointest Liver Physiol 293:G1106-13. 2007
    ..We conclude that Cldn-18 is the dominant claudin in the TJ of SCE and propose that the change from a Cldn-18-deficient TJ in SqE to a Cldn-18-rich TJ in SCE contributes to the greater acid resistance of BE...
  34. ncbi request reprint A very low-carbohydrate diet improves gastroesophageal reflux and its symptoms
    Gregory L Austin
    Division of Gastroenterology and Hepatology and the Center for Esophageal Diseases and Swallowing, University of North Carolina, Chapel Hill, North Carolina, USA
    Dig Dis Sci 51:1307-12. 2006
    ..5% (P=0.022). Mean GSAS-ds score decreased from 1.28 to 0.72 (P=0.0004). These data suggest that a very low-carbohydrate diet in obese individuals with GERD significantly reduces distal esophageal acid exposure and improves symptoms...
  35. doi request reprint Tryptase staining of mast cells may differentiate eosinophilic esophagitis from gastroesophageal reflux disease
    Evan S Dellon
    Division of Gastroenterology and Hepatology, Department of Medicine, Center for Esophageal Diseases and Swallowing, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7080, USA
    Am J Gastroenterol 106:264-71. 2011
    ..Our aim was to determine whether tryptase staining of esophageal mast cells differentiates EoE from gastroesophageal reflux disease (GERD) and has utility for diagnosis of EoE...
  36. ncbi request reprint Factors influencing the shift of patients from one proton pump inhibitor to another: the effect of direct-to-consumer advertising
    Richard A Hansen
    Division of Pharmaceutical Policy and Evaluative Sciences, University of North Carolina, Chapel Hill, NC 27599, USA
    Clin Ther 27:1478-87. 2005
    ..Switching from one proton pump inhibitor (PPI) to another is common, and may be related to factors other than efficacy and tolerability...
  37. ncbi request reprint Fundoplication improves disordered esophageal motility
    T Ryan Heider
    Division of Gastrointestinal Surgery and Digestive Diseases, Department of Surgery, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7210, USA
    J Gastrointest Surg 7:159-63. 2003
    ..These data, along with prior data showing that postoperative dysphagia is not common, imply that surgeons should apply complete fundoplication liberally in patients with disordered preoperative esophageal motility...
  38. pmc Endoscopic spray cryotherapy for esophageal cancer: safety and efficacy
    Bruce D Greenwald
    Division of Gastroenterology and Hepatology, University of Maryland School of Medicine and Greenebaum Cancer Center, Baltimore, Maryland 21201 1595, USA
    Gastrointest Endosc 71:686-93. 2010
    ..Few options exist for patients with localized esophageal cancer ineligible for conventional therapies. Endoscopic spray cryotherapy with low-pressure liquid nitrogen has demonstrated efficacy in this setting in early studies...
  39. doi request reprint Outcomes of a combined antegrade and retrograde approach for dilatation of radiation-induced esophageal strictures (with video)
    Evan S Dellon
    Center for Esophageal Diseases and Swallowing, Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
    Gastrointest Endosc 71:1122-9. 2010
    ..Treatment of head, neck, and esophageal cancers with radiation therapy can lead to esophageal strictures. In some cases, these can progress to complete esophageal obstruction, precluding typical antegrade endoscopic dilation...
  40. doi request reprint Reduced polyp detection as endoscopy shift progresses: experience with screening colonoscopy at a tertiary-care hospital
    Millie D Long
    Department of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7080, USA
    J Clin Gastroenterol 45:253-8. 2011
    ..To determine whether polyp detection rates are reduced as time progresses through half and full-day endoscopy shifts...
  41. ncbi request reprint Upper endoscopy as a screening and surveillance tool in esophageal adenocarcinoma: a review of the evidence
    Nicholas J Shaheen
    Center for Gastrointestinal Biology and Disease, University of North Carolina School of Medicine, Chapel Hill 27599 7080, USA
    Am J Gastroenterol 97:1319-27. 2002
    ..Based on the currently available data, consideration should be given to expanding the intervals between endoscopic surveillance sessions...
  42. doi request reprint Barrett's oesophagus
    Nicholas J Shaheen
    Center for Esophageal Diseases and Swallowing, Division of Gastroenterology and Hepatology, University of North Carolina School of Medicine, NC, USA
    Lancet 373:850-61. 2009
    ..We conclude with a discussion of future directions for research, focusing on treatment of early neoplasia, and modifications of current practices to show our evolving understanding of this condition...
  43. doi request reprint Esophageal adenocarcinoma in Barrett's esophagus after endoscopic ablative therapy: a meta-analysis and systematic review
    Sachin Wani
    Division of Gastroenterology and Hepatology, Veterans Affairs Medical Center, University of Kansas School of Medicine, Kansas City, Missouri, USA
    Am J Gastroenterol 104:502-13. 2009
    ..The objective of this study was to determine the cancer incidence in BE patients after ablative therapy and compare these rates to cohort studies of BE patients not undergoing ablation...
  44. pmc Effect of GI endoscopy nurse experience on screening colonoscopy outcomes
    Evan S Dellon
    Department of Medicine, Division of Gastroenterology and Hepatology, Center for Gastrointestinal Biology and Disease, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7080, USA
    Gastrointest Endosc 70:331-43. 2009
    ..The effect of the GI endoscopy nurse experience on colonoscopy outcomes is unknown...
  45. ncbi request reprint Screening for upper gastrointestinal tract malignancies
    Alphonso Brown
    Center for Gastrointestinal Biology and Disease, University of North Carolina School of Medicine, Chapel Hill 27599 7080, USA
    Semin Oncol 31:487-97. 2004
    ..In this review we will detail the evidence supporting our current screening methods and provide a concise overview of current screening recommendations for select upper GI malignancies...
  46. ncbi request reprint Insurance, employment, and psychosocial consequences of a diagnosis of hereditary hemochromatosis in subjects without end organ damage
    Nicholas J Shaheen
    Center for Gastrointestinal Biology and Disease, and the Division of Digestive Diseases and Nutrition, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Am J Gastroenterol 98:1175-80. 2003
    ..The extent to which these difficulties occur is unclear. The aim of this study was to assess the insurance, employment, and psychosocial consequences of a diagnosis of HH in subjects with no end organ damage...
  47. ncbi request reprint Extra-esophageal GERD: clinical dilemma of epidemiology versus clinical practice
    Millie D Long
    Center for Esophageal Diseases and Swallowing, University of North Carolina Chapel Hill, Campus Box 7080, Chapel Hill, NC 27599 7080, USA
    Curr Gastroenterol Rep 9:195-202. 2007
    ..We offer potential explanations for the discrepancy between the epidemiologic associations and the lack of response to therapy in clinical trials...
  48. ncbi request reprint Impact of comorbidity on colorectal cancer screening in the veterans healthcare system
    Deborah A Fisher
    Center for Health Services Research in Primary Care, Durham Veterans Affairs Medical Center, Durham, North Carolina, USA
    Clin Gastroenterol Hepatol 5:991-6. 2007
    ..Our aim was to determine the relationship between patient comorbidity and screening by fecal occult blood test in a national sample of veterans...
  49. ncbi request reprint The burden of gastrointestinal and liver diseases, 2006
    Nicholas J Shaheen
    Division of Gastroenterology and Hepatology, University of North Carolina School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Am J Gastroenterol 101:2128-38. 2006
    ..Digestive and liver diseases are a source of significant morbidity, mortality, and health-care costs for the U.S. population. An annual report of the toll of these diseases could be helpful to clinicians, policymakers, and researchers...
  50. ncbi request reprint Effect of a new diagnosis of Barrett's esophagus on insurance status
    Nicholas J Shaheen
    Center for Esophageal Diseases and Swallowing, University of North Carolina Schools of Medicine and Public Health, Chapel Hill, North Carolina, USA
    Am J Gastroenterol 100:577-80. 2005
    ..Despite this increased risk, most cohort studies demonstrate that the mean life expectancy of subjects with BE is no different than age-matched controls. The indirect costs associated with a diagnosis of BE are unclear...
  51. ncbi request reprint The epidemiology of gastroesophageal reflux disease
    Nicholas Shaheen
    Division of Digestive Diseases and Nutrition and the Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, USA
    Am J Med Sci 326:264-73. 2003
    ..Next, we briefly touch on the epidemiology of GERD complications, including erosive esophagitis, strictures, and Barrett esophagus. We will end with a brief discussion of population screening of those with GERD for Barrett esophagus...
  52. doi request reprint The use of carbon dioxide for insufflation during GI endoscopy: a systematic review
    Evan S Dellon
    Department of Medicine, Division of Gastroenterology and Hepatology, Center for Esophageal Diseases and Swallowing, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7080, USA
    Gastrointest Endosc 69:843-9. 2009
    ..Insufflation of the lumen is required for visualization during GI endoscopy. Carbon dioxide (CO(2)) has been proposed as an alternative to room air for insufflation...
  53. doi request reprint American Gastroenterological Association Institute technical review on the management of gastroesophageal reflux disease
    Peter J Kahrilas
    Department of Medicine, Gastroenterology Division, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Gastroenterology 135:1392-1413, 1413.e1-5. 2008
  54. ncbi request reprint Resection of benign esophageal stricture through a minimally invasive endoscopic and transgastric approach
    T A Lucktong
    Department of Surgery, University of North Carolina at Chapel Hill, 27599, USA
    Am Surg 68:720-3. 2002
    ..After this procedure the patient maintained esophageal patency with a diminished need for dilation. Details of our technique are described and the literature is reviewed...
  55. ncbi request reprint Digestive and liver diseases statistics, 2004
    Mark W Russo
    Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina, Chapel Hill, NC 27599 7555, USA
    Gastroenterology 126:1448-53. 2004
    ..These data may be useful for policy makers, grant applicants, and authors...
  56. doi request reprint American Gastroenterological Association Medical Position Statement on the management of gastroesophageal reflux disease
    Peter J Kahrilas
    Department of Medicine, Gastroenterology Division, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Gastroenterology 135:1383-1391, 1391.e1-5. 2008
  57. ncbi request reprint Pantoprazole reduces the size of postbanding ulcers after variceal band ligation: a randomized, controlled trial
    Nicholas J Shaheen
    Division of Gastroenterology and Hepatology, University of North Carolina School of Medicine, Chapel Hill, NC, USA
    Hepatology 41:588-94. 2005
    ..However, the total ulcer number and patient symptoms were not different between the groups...
  58. ncbi request reprint Positive and negative predictive values: use of inflammatory bowel disease serologic markers
    Gregory L Austin
    Division of Gastroenterology and Hepatology, CB 7080, University of North Carolina, Chapel Hill, NC 27599 7080, USA
    Am J Gastroenterol 101:413-6. 2006
  59. ncbi request reprint A critical review of the diagnosis and management of Barrett's esophagus: the AGA Chicago Workshop
    Prateek Sharma
    University of Kansas School of Medicine and VA Medical Center, Kansas City, Missouri 64128 2295, USA
    Gastroenterology 127:310-30. 2004
    ..The diagnosis and management of Barrett's esophagus (BE) are controversial. We conducted a critical review of the literature in BE to provide guidance on clinically relevant issues...
  60. ncbi request reprint Does fundoplication change the risk of esophageal cancer in the setting of GERD?
    Nicholas J Shaheen
    Am J Gastroenterol 100:1009-11. 2005
    ..Until more data are available, patients should not be advised to undergo surgical fundoplication as an antineoplastic measure...
  61. ncbi request reprint The rise and fall (and rise?) of endoscopic anti-reflux procedures
    Nicholas J Shaheen
    Gastroenterology 131:952-4. 2006
  62. doi request reprint Circumferential ablation of Barrett's esophagus that contains high-grade dysplasia: a U.S. Multicenter Registry
    Robert A Ganz
    Minnesota Gastroenterology, Plymouth, Minnesota 55446, USA
    Gastrointest Endosc 68:35-40. 2008
    ..The management strategies for Barrett's esophagus (BE) that contains high-grade dysplasia (HGD) include intensive endoscopic surveillance, photodynamic therapy, thermal ablation, EMR, and esophagectomy...
  63. ncbi request reprint Should we worry about the length of Barrett's esophagus?
    Nicholas J Shaheen
    Gastrointest Endosc 62:682-5. 2005
  64. ncbi request reprint Raising the bar in studies of endoscopic anti-reflux procedures
    Nicholas J Shaheen
    Gastroenterology 128:779-82. 2005
  65. ncbi request reprint What is the right age cutoff for immediate endoscopic investigation of dyspepsia?
    Nicholas J Shaheen
    Gastroenterology 123:2149-50; discussion 2150. 2002
  66. ncbi request reprint The risk of end stage liver disease and hepatocellular carcinoma among persons infected with hepatitis C virus: publication bias?
    Boone Goodgame
    Section of Gastroenterology, Houston Veterans Affairs Medical Center, Baylor College of Medicine, Houston, Texas 77030, USA
    Am J Gastroenterol 98:2535-42. 2003
    ..We performed a systematic review of the literature to identify and to analyze studies that examine such cohorts...
  67. ncbi request reprint Is Stretta ready for primetime?
    Michelle T Thiny
    Gastroenterology 123:643-4; discussion 644-5. 2002
  68. ncbi request reprint Functional chest pain of presumed esophageal origin
    Yehuda Ringel
    Arch Intern Med 162:365-6. 2002

Research Grants2

  1. Epidemiologic Case-control Study of Barrett's Esophagus
    Nicholas Shaheen; Fiscal Year: 2005
    ..Finally, by comparing subjects with Barrett's to controls with reflux, and controlling for severs of reflux, the impact of a Barrett's diagnosis on quality of life and psychological stress may be seen. ..
  2. The Perception of Cancer Risk in Patients with Barrett's Esophagus
    Nicholas Shaheen; Fiscal Year: 2007
    ..The resultant study application will assess health-related quality of life, health-related anxiety and healthcare utilization as outcomes. ..