Research Topics
| E ShaharSummaryAffiliation: University of Minnesota Country: USA Publications
Research Grants
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Detail Information
Publications
Docosahexaenoic acid and smoking-related chronic obstructive pulmonary disease. The Atherosclerosis Risk in Communities Study InvestigatorsE Shahar
Division of Epidemiology, School of Public Health, and Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA
Am J Respir Crit Care Med 159:1780-5. 1999..DHA may have a role in preventing or treating COPD and other chronic inflammatory conditions of the lung. Pilot testing of that hypothesis in experimental models seems warranted...- Plasma lipid profile and incident ischemic stroke: the Atherosclerosis Risk in Communities (ARIC) studyEyal Shahar
Division of Epidemiology, University of Minnesota, 1300 South Second St, Suite 300, Minneapolis, MN 55454, USA
Stroke 34:623-31. 2003..The role of circulating lipids and lipoproteins in the pathogenesis of ischemic stroke remains uncertain despite 3 decades of research. We examined this issue in a large population-based cohort... - Hormone replacement therapy and sleep-disordered breathingEyal Shahar
Division of Epidemiology, University of Minnesota, 1300 South Second Street, Suite 300, Minneapolis, MN 55454, USA
Am J Respir Crit Care Med 167:1186-92. 2003..36; 95% confidence interval, 0.21 to 0.60). If the observed associations are causal, hormone replacement therapy could have a role in preventing or alleviating sleep-disordered breathing... - Generalizability: beyond plausibility and handwavingEyal Shahar
Division of Epidemiology, University of Minnesota, Minneapolis, MN 55454, USA
J Eval Clin Pract 9:151-9. 2003.... - Trends in acute coronary heart disease mortality, morbidity, and medical care from 1985 through 1997: the Minnesota heart surveyP G McGovern
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, USA
Circulation 104:19-24. 2001..Coronary heart disease (CHD) mortality continued to decline from 1985 to 1997... - Stroke rates during the 1980s. The Minnesota Stroke SurveyE Shahar
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis 55454 1015, USA
Stroke 28:275-9. 1997..In the present study, we examined trends in the rate of hospitalized stroke in Minneapolis/ St Paul between 1980 and 1990... - Sleep-disordered breathing and cardiovascular disease: cross-sectional results of the Sleep Heart Health StudyE Shahar
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA
Am J Respir Crit Care Med 163:19-25. 2001..99-1.62), respectively. These findings are compatible with modest to moderate effects of sleep-disordered breathing on heterogeneous manifestations of CVD within a range of AHI values that are considered normal or only mildly elevated... - Familial history of stroke and stroke risk. The Family Heart StudyD Liao
Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill 27514, USA
Stroke 28:1908-12. 1997.... - White blood cell count and incidence of coronary heart disease and ischemic stroke and mortality from cardiovascular disease in African-American and White men and women: atherosclerosis risk in communities studyC D Lee
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, 55454-1015, USA
Am J Epidemiol 154:758-64. 2001..An elevated WBC count is directly associated with increased incidence of coronary heart disease and ischemic stroke and mortality from cardiovascular disease in African-American and White men and women... 
Asthma and incident cardiovascular disease: the Atherosclerosis Risk in Communities StudyJ G Schanen
University of Minnesota, School of Public Health, Division of Epidemiology and Community Health, 1300 South 2nd Street, Suite 300, Minneapolis, MN 55454, USA
Thorax 60:633-8. 2005..This finding warrants replication and may motivate a search for possible mechanisms that link asthma and stroke...- Ethnic differences in coronary calcification: the Multi-Ethnic Study of Atherosclerosis (MESA)Diane E Bild
Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, MD, USA
Circulation 111:1313-20. 2005.... - Serum uric acid and risk of ischemic stroke: the ARIC StudyAtsushi Hozawa
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 1300 South 2nd Street, Suite 300, Minneapolis, MN 55454-1015, USA
Atherosclerosis 187:401-7. 2006..08). CONCLUSION: Our findings suggest that UA is an independent predictor of ischemic stroke among subjects not using diuretics, but that elevated UA itself may not cause ischemic stroke... - Polysomnographic predictors of blood pressure and hypertension: is one index best?Susan Redline
Case Western Reserve University, Cleveland, OH, USA
Sleep 28:1122-30. 2005..This study addresses the relative merits of using alternative polysomnography indexes by characterizing the consistency and strength of the association of each index with blood pressure and hypertension... 
Novel metabolic risk factors for incident heart failure and their relationship with obesity: the MESA (Multi-Ethnic Study of Atherosclerosis) studyHossein Bahrami
Cardiology Division, Department of Medicine, School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
J Am Coll Cardiol 51:1775-83. 2008....- Physical activity and breast cancer incidence in middle-aged women: a prospective cohort studyAmy J Mertens
Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55454, USA
Breast Cancer Res Treat 97:209-14. 2006..31 (95% CI=0.87-1.96) for the sport index and 0.87 (95% CI=0.61-1.24) for the work index. Our findings do not corroborate the majority of previous reports, which implicated physical inactivity as a risk factor for breast cancer... - Association of nocturnal arrhythmias with sleep-disordered breathing: The Sleep Heart Health StudyReena Mehra
Department of Medicine and Pediatrics, Case Western Reserve University, Cleveland, OH 44106, USA
Am J Respir Crit Care Med 173:910-6. 2006..Sleep-disordered breathing recurrent intermittent hypoxia and sympathetic nervous system activity surges provide the milieu for cardiac arrhythmia development... - Coronary risk factors and myocardial perfusion in asymptomatic adults: the Multi-Ethnic Study of Atherosclerosis (MESA)Lu Wang
Division of Epidemiology, School of Public Health, School of Medicine, University of Minnesota, Minneapolis, Minnesota, USA
J Am Coll Cardiol 47:565-72. 2006..Our study results imply that changes in coronary vascular reactivity, in response to risk factors, may be detected in adults without symptomatic CHD... - Prognostic value of a novel classification scheme for heart failure: the Minnesota Heart Failure CriteriaJoseph Kim
Medical Statistics Unit, London School of Hygiene and Tropical Medicine, University of London, UK
Am J Epidemiol 164:184-93. 2006..They closely approximate a nearly full version of the Framingham Criteria but require many fewer variables and can facilitate epidemiologic case-finding for heart failure... - Risk factors for ischemic stroke subtypes: the Atherosclerosis Risk in Communities studyTetsuya Ohira
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 1300 S 2nd St, Minneapolis, MN 55454-1015, USA
Stroke 37:2493-8. 2006..CONCLUSIONS: The impact of traditional and nontraditional risk factors other than hypertension on the incidence of ischemic stroke varied according to its subtype... - Association of restless legs syndrome and cardiovascular disease in the Sleep Heart Health StudyJohn W Winkelman
Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, 1505 Commonwealth Avenue, Brighton, MA 02135, USA
Neurology 70:35-42. 2008..We evaluated the cross-sectional association between restless legs syndrome (RLS) and prevalent cardiovascular disease (CVD) in a large community-based sample of middle-aged and elderly subjects... - Lung function and ischemic stroke incidence: the Atherosclerosis Risk in Communities studyAtsushi Hozawa
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 1300 South Second Street, Suite 300, Minneapolis, MN 55454-1015, USA
Chest 130:1642-9. 2006..CONCLUSIONS: Among white subjects, participants with impaired lung function have a modestly higher risk of ischemic stroke even if they have never smoked nor had respiratory symptoms... - Association of physical activity with sleep-disordered breathingStuart F Quan
Arizona Respiratory Center, University of Arizona Health Sciences Center, 1501 N Campbell, Tucson, AZ 85724, USA
Sleep Breath 11:149-57. 2007..A program of regular vigorous physical activity of at least 3 h per week may be a useful adjunctive treatment modality for SDB, but this association needs confirmation with a prospective clinical trial... - Hemostatic and inflammatory risk factors for intracerebral hemorrhage in a pooled cohortJared D Sturgeon
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 1300 S Second St, Minneapolis, MN 55454 1015, USA
Stroke 39:2268-73. 2008..The purpose of this study was to identify novel risk factors for intracerebral hemorrhagic stroke (ICH)... - Sleep-disordered breathing, glucose intolerance, and insulin resistance: the Sleep Heart Health StudyNaresh M Punjabi
Division of Pulmonary and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD21224, USA
Am J Epidemiol 160:521-30. 2004..The results of this study suggest that SDB is independently associated with glucose intolerance and insulin resistance and may lead to type 2 diabetes mellitus... - B-mode ultrasound-detected carotid artery lesions with and without acoustic shadowing and their association with markers of inflammation and endothelial activation: the atherosclerosis risk in communities studyKelly J Hunt
CVD Program, Department of Epidemiology, School of Public Health, University of North Carolina, 137 E. Franklin St, Bank of America, Suite 306, Chapel Hill, NC, USA
Atherosclerosis 162:145-55. 2002..38 (95% CI: 1.10, 1.74)], a marker of endothelial activation. Associations with endothelial adhesion molecules were inconsistent. Further studies aimed at elucidating the mechanisms of arterial mineralization are warranted... - Predictors of sleep-disordered breathing in community-dwelling adults: the Sleep Heart Health StudyTerry Young
Department of Population Health Sciences, University of Wisconsin, Madison, WI, USA
Arch Intern Med 162:893-900. 2002..Breathing pauses and obesity may be particularly insensitive for identifying SDB in older people. A better understanding of predictive factors for SDB, particularly in older adults, is needed... - Serum insulin and glucose levels and breast cancer incidence: the atherosclerosis risk in communities studyPamela J Mink
Division of Cancer Prevention and Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA
Am J Epidemiol 156:349-52. 2002..39, 95% confidence interval: 0.86, 2.23). Circulating insulin levels were not predictive of future breast cancer incidence, but there may be a weak association with type 2 diabetes, perhaps modulated via increased adiposity... - Measures of cognitive function in persons with varying degrees of sleep-disordered breathing: the Sleep Heart Health StudyLori L Boland
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, MN 55454, USA
J Sleep Res 11:265-72. 2002..In this sample of free-living individuals with mostly mild to moderate levels of SDB, the degree of SDB appeared to be unrelated to three measures of cognitive performance... - Fifteen-year trends in cardiovascular risk factors (1980-1982 through 1995-1997): the Minnesota Heart SurveyDonna K Arnett
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, MN 55454 1015, USA
Am J Epidemiol 156:929-35. 2002..Paul from 1980-1982 to 1995-1997 were paralleled by less favorable recent trends in total cholesterol, hypercholesterolemia, adiposity, and physical activity... - Risk factors for intracerebral hemorrhage in a pooled prospective studyJared D Sturgeon
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 1300 S Second Street, Suite 300, Minneapolis, MN 55454 1015, USA
Stroke 38:2718-25. 2007..We studied risk factors for ICH in a pooled cohort of the Atherosclerosis Risk in Communities Study (ARIC) and the Cardiovascular Health Study (CHS)... - Diabetes and sleep disturbances: findings from the Sleep Heart Health StudyHelaine E Resnick
MedStar Research Institute, Hyattsville, Maryland 20783, USA
Diabetes Care 26:702-9. 2003..To test the hypothesis that diabetes is independently associated with sleep-disordered breathing (SDB), and in particular that diabetes is associated with sleep abnormalities of a central, rather than obstructive, nature... - On morality and logic in medical practice: commentary on 'A critical appraisal of evidence-based medicine: some ethical considerations' (Gupta 2003; Journal of Evaluation in Clinical Practice 9, 111-121)Eyal Shahar
School of Public Health, University of Minnesota, Minneapolis, USA
J Eval Clin Pract 9:133-5. 2003 - Associations of whole-grain, refined-grain, and fruit and vegetable consumption with risks of all-cause mortality and incident coronary artery disease and ischemic stroke: the Atherosclerosis Risk in Communities (ARIC) StudyLyn M Steffen
Division of Epidemiology, University of Minnesota School of Public Health, Minneapolis, 55454, USA
Am J Clin Nutr 78:383-90. 2003..However, the findings were inconsistent for fruit and vegetable intake... - Glycaemia (haemoglobin A1c) and incident ischaemic stroke: the Atherosclerosis Risk in Communities (ARIC) StudyElizabeth Selvin
Department of Epidemiology, Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205 2223, USA
Lancet Neurol 4:821-6. 2005..Haemoglobin A1c (HbA(1c)), a measure of long-term glycaemia, is strongly related to retinopathy, nephropathy, and neuropathy in diabetes. We sought to assess the association between HbA(1c) and stroke in people with and without diabetes... - Sleep and reported daytime sleepiness in normal subjects: the Sleep Heart Health StudyJoyce A Walsleben
Department of Pulmonary and Critical Care, New York University School of Medicine, USA
Sleep 27:293-8. 2004..To describe the distribution of nocturnal sleep characteristics and reports of daytime sleepiness in a large well-defined group of healthy adults... - Sleep-disordered breathing is not associated with the presence of retinal microvascular abnormalities: the Sleep Heart Health StudyLori L Boland
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, MN 55454-1015, USA
Sleep 27:467-73. 2004..However, since this is the first investigation of a link between retinopathy and SDB, similar studies should be conducted in other population samples to demonstrate either consistency or inconsistency of our findings across studies... - Prediction of ischemic stroke risk in the Atherosclerosis Risk in Communities StudyLloyd E Chambless
Department of Biostatistics, School of Public Health, University of North Carolina, Chapel Hill, NC 27514 4145, USA
Am J Epidemiol 160:259-69. 2004..79 to 0.83 to 0.84; for men, it went from 0.76 to 0.78 to 0.80. These modest improvements are not enough to influence clinical and public health efforts to reduce the community burden of IS... - Baldness and myocardial infarction in men: the atherosclerosis risk in communities studyEyal Shahar
Division of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ 85724, USA
Am J Epidemiol 167:676-83. 2008..The results of this study suggest that male pattern baldness is not a surrogate measure of an important risk factor for myocardial infarction or asymptomatic atherosclerosis... - Estimating causal parameters without target populationsEyal Shahar
Division of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ 85724, USA
J Eval Clin Pract 13:814-6. 2007..Some methods to adjust for confounders heavily draw upon this idea... - HDL-cholesterol and incidence of breast cancer in the ARIC cohort studyAnna M Kucharska-Newton
Department of Epidemiology, University of North Carolina at Chapel Hill, NC, USA
Ann Epidemiol 18:671-7. 2008..S. communities... - Relation of sleep-disordered breathing to carotid plaque and intima-media thicknessKeattiyoat Wattanakit
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Suite 300, 1300 South 2nd Street, Minneapolis, MN 55454, United States
Atherosclerosis 197:125-31. 2008..Sleep-disordered breathing (SDB) is associated with clinical cardiovascular disease (CVD), but its relation to subclinical atherosclerosis remains to be determined... - Coronary artery calcification and myocardial perfusion in asymptomatic adults: the MESA (Multi-Ethnic Study of Atherosclerosis)Lu Wang
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA
J Am Coll Cardiol 48:1018-26. 2006..Myocardial perfusion could be impaired by or manifest the progression to subclinical coronary atherosclerosis in the absence of clinical CHD... - Retinal vascular caliber, cardiovascular risk factors, and inflammation: the multi-ethnic study of atherosclerosis (MESA)Tien Yin Wong
Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia
Invest Ophthalmol Vis Sci 47:2341-50. 2006..To describe the relationship of retinal arteriolar and venular caliber with cardiovascular risk factors, including inflammatory biomarkers, in a multiethnic population of whites, blacks, Hispanics, and Chinese... - Case definitions for acute coronary heart disease in epidemiology and clinical research studies: a statement from the AHA Council on Epidemiology and Prevention; AHA Statistics Committee; World Heart Federation Council on Epidemiology and Prevention; the Russell V Luepker
Circulation 108:2543-9. 2003 - Hospitalized heart failure: rates and long-term mortalityEyal Shahar
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis 55454, USA
J Card Fail 10:374-9. 2004..LVEF, when measured in the context of heart failure-related hospitalization, is not a strong predictor of death... - Sleep and sleep-disordered breathing in adults with predominantly mild obstructive airway diseaseMark H Sanders
Division of Pulmonary, Allergy, and Critical Care Medicine, Montefiore University Hospital, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Am J Respir Crit Care Med 167:7-14. 2003....
Research Grants
- COMMUNITY SURVEILLANCE OF CONGESTIVE HEART FAILUREEyal Shahar; Fiscal Year: 2002..The investigators point out that the results of the proposed surveillance will provide guidance to public health decisions, broader surveillance projects of CHF, and a sensitive gauge of the success of medical efforts. ..
- Sleep Heart Health Study (SHHS)Eyal Shahar; Fiscal Year: 2007..Accomplishing these goals will provide important information concerning the public health impact of SDB. ..