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Genomes and Genes | Rajal B ShahSummaryAffiliation: University of Michigan Country: USA Publications
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Publications
Comparison of the basal cell-specific markers, 34betaE12 and p63, in the diagnosis of prostate cancerRajal B Shah
Deparment of Pathology and Urology, University of Michigan School of Medicine and Comprenhensive Cancer Center, Ann Arbor, Michigan 48109, USA
Am J Surg Pathol 26:1161-8. 2002..p63 may be used as an alternative to 34betaE12 stain for difficult prostate lesions...
The discovery of common recurrent transmembrane protease serine 2 (TMPRSS2)-erythroblastosis virus E26 transforming sequence (ETS) gene fusions in prostate cancer: significance and clinical implicationsRajal B Shah
Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Adv Anat Pathol 16:145-53. 2009....- Image-guided biopsy in the evaluation of renal mass lesions in contemporary urological practice: indications, adequacy, clinical impact, and limitations of the pathological diagnosisRajal B Shah
Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA
Hum Pathol 36:1309-15. 2005..Most biopsies can be classified into clinically relevant categories; however, caution is advised while interpreting oncocytic neoplasms because sampling and tumor heterogeneity may adversely affect interpretation... - Current perspectives on the Gleason grading of prostate cancerRajal B Shah
Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
Arch Pathol Lab Med 133:1810-6. 2009..In addition, better understanding of the morphologic spectrum of prostate cancer and its subsequent outcome have prompted the refinement of the grading criteria and reporting practices applicable to contemporary practice management... - Androgen-independent prostate cancer is a heterogeneous group of diseases: lessons from a rapid autopsy programRajal B Shah
Department of Pathology, University of Michigan School of Medicine, Ann Arbor, Michigan, USA
Cancer Res 64:9209-16. 2004..An appreciation of this heterogeneity is critical to evaluating diagnostic and prognostic biomarkers as well as to designing therapeutic targets for advanced disease... 
The role of SPINK1 in ETS rearrangement-negative prostate cancersScott A Tomlins
Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Cancer Cell 13:519-28. 2008..We identified the aggressive 22RV1 cell line as a SPINK1 outlier expression model and demonstrate that SPINK1 knockdown in 22RV1 attenuates invasion, suggesting a functional role in ETS rearrangement-negative prostate cancers...- Characterization of TMPRSS2-ETS gene aberrations in androgen-independent metastatic prostate cancerRohit Mehra
Michigan Center for Translational Pathology, Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA
Cancer Res 68:3584-90. 2008..These findings suggest that TMPRSS2-ERG with Edel is an aggressive and, in this study, uniformly lethal molecular subtype of prostate cancer associated with androgen-independent disease... - Characterization of ETS gene aberrations in select histologic variants of prostate carcinomaBo Han
Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Mod Pathol 22:1176-85. 2009..Overall, our data provide insight into the origin, molecular mechanism, and phenotypic association of ETS fusions in histologic variants of prostate carcinoma... - Noninvasive detection of TMPRSS2:ERG fusion transcripts in the urine of men with prostate cancerBharathi Laxman
Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Neoplasia 8:885-8. 2006..These results demonstrate that TMPRSS2:ERG gene fusions can be detected in the urine of patients with prostate cancer and support larger studies on prospective cohorts for noninvasive detection of prostate cancer... - Fluorescence in situ hybridization study shows association of PTEN deletion with ERG rearrangement during prostate cancer progressionBo Han
Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI, USA
Mod Pathol 22:1083-93. 2009..PTEN deletion and ERG rearrangement may cooperate, but contribute at different stages, in prostate cancer progression... - Prevalence of TMPRSS2-ERG fusion prostate cancer among men undergoing prostate biopsy in the United StatesJuan Miguel Mosquera
Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Clin Cancer Res 15:4706-11. 2009..We sought to determine the prevalence of TMPRSS2-ERG gene fusion among prostate-specific antigen-screened men undergoing prostate biopsy in the United States... - Role of the TMPRSS2-ERG gene fusion in prostate cancerScott A Tomlins
Michigan Center for Translational Pathology, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Neoplasia 10:177-88. 2008..Our results support previous work suggesting that TMPRSS2-ERG fusions mediate invasion, consistent with the defining histologic distinction between PIN and prostate cancer... - ETS gene aberrations in atypical cribriform lesions of the prostate: Implications for the distinction between intraductal carcinoma of the prostate and cribriform high-grade prostatic intraepithelial neoplasiaBo Han
Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, USA
Am J Surg Pathol 34:478-85. 2010..However, there are lesions that do not fully satisfy the criteria for IDC-P yet are worse than typical HGPIN and are difficult to distinguish based on morphologic criteria alone... - Multiple adverse histological features increase the odds of under staging T1 bladder cancerAlon Z Weizer
Department of Urology, University of Michigan, Ann Arbor, Michigan, USA
J Urol 182:59-65; discussion 65. 2009..In this study we evaluated clinicopathological features to aid in the identification of patients with clinical T1 bladder cancer at risk for under staging... - Usefulness of basal cell cocktail (34betaE12 + p63) in the diagnosis of atypical prostate glandular proliferationsRajal B Shah
Department of Pathology, University of Michigan School of Medicine, Ann Arbor 48109, USA
Am J Clin Pathol 122:517-23. 2004..The cocktail provides a simple, cost-effective improvement in basal cell immunohistochemical analysis of difficult prostate lesions... - A fluorescence in situ hybridization screen for E26 transformation-specific aberrations: identification of DDX5-ETV4 fusion protein in prostate cancerBo Han
Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
Cancer Res 68:7629-37. 2008..Fourth, we identified a ubiquitously expressed, androgen-insensitive gene, DDX5, fused in frame with ETV4, leading to the expression of a DDX5-ETV4 fusion protein... - Heterogeneity of TMPRSS2 gene rearrangements in multifocal prostate adenocarcinoma: molecular evidence for an independent group of diseasesRohit Mehra
Michigan Center for Translational Pathology, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Cancer Res 67:7991-5. 2007..Understanding this molecular heterogeneity is critical to the future development and utility of diagnostic and prognostic PCA biomarkers... - A polycomb repression signature in metastatic prostate cancer predicts cancer outcomeJindan Yu
Michigan Center for Translational Pathology, Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA
Cancer Res 67:10657-63. 2007..Therefore, PcG proteins play a central role in the epigenetic silencing of target genes and functionally link stem cells, metastasis, and cancer survival... - Integrative analysis of genomic aberrations associated with prostate cancer progressionJung H Kim
Michigan Center for Translational Pathology, Department of Pathology, Department of Urology, Program of Bioinformatics, and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109 0940, USA
Cancer Res 67:8229-39. 2007..Integrative analysis with matched mRNA profiles identified genetic alterations in several proposed candidate genes implicated in prostate cancer progression... - Integrative genomic and proteomic analysis of prostate cancer reveals signatures of metastatic progressionSooryanarayana Varambally
Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
Cancer Cell 8:393-406. 2005.... - Integrating biomedical knowledge to model pathways of prostate cancer progressionDavid S Morris
Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
Cell Cycle 6:1177-87. 2007..Analyzing complex gene expression signatures in the context of molecular concepts improves integrative models and may improve detection, prognostication, or targeted therapy... - Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancerScott A Tomlins
Department of Pathology, University of Michigan Medical School, 1301 Catherine Street, Ann Arbor, MI 48109-0602, USA
Science 310:644-8. 2005..These results have implications in the development of carcinomas and the molecular diagnosis and treatment of prostate cancer... - Comprehensive assessment of TMPRSS2 and ETS family gene aberrations in clinically localized prostate cancerRohit Mehra
Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Mod Pathol 20:538-44. 2007.... - Distinct classes of chromosomal rearrangements create oncogenic ETS gene fusions in prostate cancerScott A Tomlins
Michigan Center for Translational Pathology, Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
Nature 448:595-9. 2007..Furthermore, the identification of androgen-repressed and insensitive 5' fusion partners may have implications for the anti-androgen treatment of advanced prostate cancer... - Integrative molecular concept modeling of prostate cancer progressionScott A Tomlins
Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
Nat Genet 39:41-51. 2007..Taken together, these data show that analyzing gene expression signatures in the context of a compendium of molecular concepts is useful in understanding cancer biology... - Integrative genomics analysis reveals silencing of beta-adrenergic signaling by polycomb in prostate cancerJindan Yu
Department of Pathology, Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Cancer Cell 12:419-31. 2007..Taken together, we demonstrate the power of integrating multiple diverse genomic data to decipher targets of disease-related genes... - Characterization of bone metastases from rapid autopsies of prostate cancer patientsRohit Mehra
Department of Internal Medicine and Urology, University of Michigan Medical School, 7303 Cancer Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA
Clin Cancer Res 17:3924-32. 2011..No intensive studies, however, have been conducted on osseous metastatic tissues from patients with metastatic prostate cancer due to lack of access to such tissues for profiling and other research... - TMPRSS2:ETV4 gene fusions define a third molecular subtype of prostate cancerScott A Tomlins
Department of Pathology, University of Michigan Medical School, 1301 Catherine Street, Ann Arbor, MI 48109, USA
Cancer Res 66:3396-400. 2006..This result defines a third molecular subtype of prostate cancer and supports the hypothesis that dysregulation of ETS family members through fusions with TMRPSS2 may be an initiating event in prostate cancer development... - Prostate-specific antigen, high-molecular-weight cytokeratin (clone 34betaE12), and/or p63: an optimal immunohistochemical panel to distinguish poorly differentiated prostate adenocarcinoma from urothelial carcinomaLakshmi P Kunju
Department of Pathology, University of Michigan School of Medicine, 1500 E. Medical Center Drive, Ann Arbor, MI 48109, USA
Am J Clin Pathol 125:675-81. 2006..This panel was used on 26 diagnostically challenging cases and resolved 81% of cases as UCa vs PCa. The majority of PCa cases retain PSA. Negative PSA with positive HMWCK and/or p63 establishes a diagnosis of UCa... - Utility of extended pattern prostate biopsies for tumor localization: pathologic correlations after radical prostatectomyRyan T Schulte
Department of Urology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0330, USA
Cancer 113:1559-65. 2008..In the current study, we sought to examine the ability of contemporary extended pattern prostate biopsy to predict the location of tumors... - Evaluation of the prostate peripheral zone/capsule in patients undergoing radical cystoprostatectomy: defining risk with prostate capsule sparing cystectomyAlon Z Weizer
Department of Urology, University of Michigan, Ann Arbor, MI 48109 0330, USA
Urol Oncol 25:460-4. 2007..Because concerns remain regarding incomplete surgical resection, we evaluated the risk of urothelial and prostate cancer in a series of patients undergoing radical cystoprostatectomy... - p63, CK7, PAX8 and INI-1: an optimal immunohistochemical panel to distinguish poorly differentiated urothelial cell carcinoma from high-grade tumours of the renal collecting systemJason C Carvalho
Department of Pathology, University of Michigan Medical Center, 1500 E Medical Center Drive, Ann Arbor, MI 48109 0602, USA
Histopathology 60:597-608. 2012..Accurate classification, especially the distinction of UC from RCC, is critical, as therapeutic approaches differ... - Introducing parametric fusion PET/MRI of primary prostate cancerHyunjin Park
Department of Radiology, University of Michigan, Ann Arbor, MI, USA
J Nucl Med 53:546-51. 2012..We assessed the performance of parametric fusion PET/MRI based on (11)C-choline PET/CT and apparent diffusion coefficient (ADC) maps derived from diffusion-weighted MRI for the identification of primary prostate cancer... - Epidermal growth factor receptor (ErbB1) expression in prostate cancer progression: correlation with androgen independenceRajal B Shah
Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0932, USA
Prostate 66:1437-44. 2006..The role of the epidermal growth factor receptor (ErbB1) in the progression of prostate cancer is incompletely understood... - Atypical cribriform lesions of the prostate: relationship to prostatic carcinoma and implication for diagnosis in prostate biopsiesRajal B Shah
Department of Pathology, University of Michigan, Ann Arbor, USA
Am J Surg Pathol 34:470-7. 2010.... - Perineural invasion is a marker for pathologically advanced disease in localized prostate cancerIrwin H Lee
Department of Radiation Oncology, University of Michigan, 1500 E Medical Center Drive, Ann Arbor, MI 48109, USA
Int J Radiat Oncol Biol Phys 68:1059-64. 2007..To determine if perineural invasion (PNI) should be included in addition to prostate-specific antigen (PSA), biopsy Gleason score, and clinical T-stage for risk-stratification of patients with localized prostate cancer... - Nested variant of urothelial carcinoma: a clinicopathologic and immunohistochemical study of 30 pure and mixed casesMatthew J Wasco
Department of Pathology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
Hum Pathol 41:163-71. 2010..78). Increased awareness and familiarity with the clinicopathologic spectrum is critical for confident recognition and adequate management of this very aggressive variant of UC... - Partial atrophy in prostate needle biopsies: a detailed analysis of its morphology, immunophenotype, and cellular kineticsChristopher G Przybycin
Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
Am J Surg Pathol 32:58-64. 2008..PA foci do not represent a spectrum of proliferative inflammatory atrophy, justifying its term... - Dickkopf-1 expression increases early in prostate cancer development and decreases during progression from primary tumor to metastasisChristopher L Hall
Department of Urology, The University of Michigan, Ann Arbor, Michigan, USA
Prostate 68:1396-404. 2008..We previously demonstrated through over-expression of the Wnt inhibitor dickkopf-1 (DKK-1) that Wnts contribute to the osteoblastic component of PCa osseous lesions in vivo... - Investigation on tumor hypoxia in resectable primary prostate cancer as demonstrated by 18F-FAZA PET/CT utilizing multimodality fusion techniquesRita Garcia-Parra
Department of Radiology, Division of Nuclear Medicine, University of Michigan, 1500 E Medical Center Drive, Ann Arbor, MI 48109, USA
Eur J Nucl Med Mol Imaging 38:1816-23. 2011.... - Characterization of TMPRSS2-ERG fusion high-grade prostatic intraepithelial neoplasia and potential clinical implicationsJuan Miguel Mosquera
Department of Pathology, Brigham and Women s Hospital, Boston, MA, USA
Clin Cancer Res 14:3380-5. 2008..This may have significant clinical implications given that TMPRSS2-ERG fusion prostate cancer is associated with a more aggressive clinical course... - Papillary renal cell carcinoma with oncocytic cells and nonoverlapping low grade nuclei: expanding the morphologic spectrum with emphasis on clinicopathologic, immunohistochemical and molecular featuresLakshmi P Kunju
Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA
Hum Pathol 39:96-101. 2008..Morphologic spectrum of these PRCCs emphasizes that the future prognostic model of PRCC may need to be based primarily on the nuclear characteristics, irrespective of the cytoplasmic features... - Elevated alpha-methylacyl-CoA racemase enzymatic activity in prostate cancerChandan Kumar-Sinha
Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109-0602, USA
Am J Pathol 164:787-93. 2004..Taken together, our studies suggest that AMACR activity is increased in prostate cancer relative to benign epithelia and suggests that monitoring AMACR activity levels in prostate needle biopsies may have clinical applications... 
Perlecan, a candidate gene for the CAPB locus, regulates prostate cancer cell growth via the Sonic Hedgehog pathwayMilton W Datta
Department of Pathology, Emory University, Atlanta, GA 30322, USA
Mol Cancer 5:9. 2006..Previously we have linked Perlecan to Hedgehog signaling in Drosophila. More recently, we have demonstrated the importance of Hedgehog signaling in humans for advanced prostate cancer...- Adoption of new technology and healthcare quality: surgical margins after robotic prostatectomyAlon Z Weizer
Department of Urology, University of Michigan, Ann Arbor, Michigan 48109, USA
Urology 70:96-100. 2007..To study the evolution of surgical margins in robotic prostatectomy (DVP), to ascertain the surgical volume necessary to provide quality cancer care... - Expression of renal cell carcinoma antigen (RCC) in renal epithelial and nonrenal tumors: diagnostic ImplicationsNasir Bakshi
Department of Pathology, Oklahoma University Health Sciences Center, Oklahoma City, Oklahoma, USA
Appl Immunohistochem Mol Morphol 15:310-5. 2007..RCC also does not reliably differentiate subtypes of renal epithelial neoplasms... - Whole transcriptome amplification for gene expression profiling and development of molecular archivesScott A Tomlins
Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109-0602, USA
Neoplasia 8:153-62. 2006..Taken together, WTA represents a versatile approach to profile and archive cDNA from minute tumor samples and is compatible with partially degraded RNA... - Multiple prostate cancer cores with different Gleason grades submitted in the same specimen container without specific site designation: should each core be assigned an individual Gleason score?Lakshmi P Kunju
Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA
Hum Pathol 40:558-64. 2009..When multiple intact cores are submitted in the same container without specific identifiers, individual cores with cancer should be graded and/or the Worst Gleason score should be recorded... - E-cadherin protein expression predicts prostate cancer salvage radiotherapy outcomesMichael E Ray
Department of Radiation Oncology, Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan 48109 0010, USA
J Urol 176:1409-14; discussion 1414. 2006..Altered expression of the adhesion molecule E-cadherin may be associated with the invasive and metastatic phenotype. We examined the relationship between E-cadherin expression and outcomes after salvage radiotherapy... - Detection of aggressive primary prostate cancer with 11C-choline PET/CT using multimodality fusion techniquesMorand Piert
Department of Radiology, University of Michigan, Ann Arbor, Michigan 48109 0028, USA
J Nucl Med 50:1585-93. 2009..The aim of the study was to assess whether (11)C-choline PET/CT could identify high-risk primary adenocarcinoma of the prostate... - Percent positive biopsy cores as a prognostic factor for prostate cancer treated with external beam radiationAaron C Spalding
Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
Urology 69:936-40. 2007..To examine the prognostic value of percent positive cores (PPC) in prostate cancer patients treated with external beam radiotherapy (RT)... - Lymphoepithelioma-like carcinoma of the urinary bladder: clinicopathologic, immunohistochemical, and molecular featuresSean R Williamson
Department of Pathology, Indiana University School of Medicine, Indianapolis, IN, USA
Am J Surg Pathol 35:474-83. 2011..Investigation of immunohistochemical and molecular characteristics of bladder LELC is limited. The pathogenesis and biological behavior of these tumors are controversial... - Diagnostic usefulness of monoclonal antibody P504S in the workup of atypical prostatic glandular proliferationsLakshmi P Kunju
Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI, USA
Am J Clin Pathol 120:737-45. 2003..Most HGPINs show diffuse moderate P504S staining. AAH may show focal P504S staining. We recommend using P504S along with morphologic examination and conventional basal cell markers... - Cluster analysis of immunohistochemical profiles delineates CK7, vimentin, S100A1 and C-kit (CD117) as an optimal panel in the differential diagnosis of renal oncocytoma from its mimicsJason C Carvalho
Department of Pathology, University of Michigan Medical Center, Ann Arbor, MI, USA
Histopathology 58:169-79. 2011.... - Use of extended pattern technique for initial prostate biopsyWendy Siu
Departments of Urology and Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA
J Urol 174:505-9. 2005..A significant association between more needle cores at initial prostate biopsy and finding smaller and clinically insignificant cancer was not apparent... - Neoadjuvant docetaxel and capecitabine in patients with high risk prostate cancerJudah Friedman
Division of Hematology and Oncology, Department of Medicine, University of Michigan School of Medicine and University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48109 0946, USA
J Urol 179:911-5; discussion 915-6. 2008..We assessed activity and safety of neoadjuvant docetaxel and capecitabine in patients with high risk prostate cancer... - In vivo visualization of metastatic prostate cancer and quantitation of disease progression in immunocompromised miceLinda M Kalikin
Department of Urology, Division of Hematology and Oncology, The University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48109-0946, USA
Cancer Biol Ther 2:656-60. 2003..This model provides a controllable biological system for further investigation into the pathogenesis of metastatic prostate cancer and evaluation of new therapies... - Nephron-sparing diagnosis and management of renal keratinizing desquamative squamous metaplasiaMichael Borofsky
Department of Urology, University of Michigan Health System, Ann Arbor, Michigan 48109, USA
J Endourol 23:51-5. 2009..We report the favorable clinical course of two cases of renal KDSM diagnosed and managed with a nephron-sparing approach, relying on ureteroscopy and serial imaging... - CXCL12 overexpression and secretion by aging fibroblasts enhance human prostate epithelial proliferation in vitroLesa Begley
Department of Urology, The University of Michigan, Ann Arbor, 48109, USA
Aging Cell 4:291-8. 2005..These studies represent an important first step towards a mechanistic elucidation of the role of aging in the etiology of benign and malignant prostatic diseases... - Urothelial carcinoma with divergent histologic differentiation (mixed histologic features) predicts the presence of locally advanced bladder cancer when detected at transurethral resectionMatthew J Wasco
Department of Pathology, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
Urology 70:69-74. 2007..This study examined the incidence, pathologic spectrum, and clinical significance of this phenomenon... - Localized amyloidosis of the upper urinary tract: a case series of three patients managed with reconstructive surgery or surveillanceTudor Borza
Department of Urology, University of Michigan Health System, Ann Arbor, Michigan 48109 5330, USA
J Endourol 24:641-4. 2010..To evaluate the clinical presentation, diagnosis, treatment, and prognosis of primary localized amyloidosis of the upper urinary tract... - Variable penetrance of a consensus classification scheme for renal cell carcinomaJohn M Hollingsworth
Department of Urology, Michigan Urology Center, University of Michigan Health System, Ann Arbor, Michigan 48109 0330, USA
Urology 69:452-6. 2007..The histologic classification of kidney cancer has been revised to reflect this new paradigm... - Utility of cytokeratin 20 and Ki-67 as markers of urothelial dysplasiaLakshmi P Kunju
Department of Pathology, University of Michigan School of Medicine, Ann Arbor, Michigan 48109, USA
Pathol Int 55:248-54. 2005..In summary, abnormal CK20 is a useful adjunct to morphology for confirming dysplasia. Ki-67 by itself is a less reliable marker of dysplasia. E-Cad is not a useful marker in this setting... - Clonality of sarcomatous and carcinomatous elements in sarcomatoid carcinoma of the prostateMichael E Ray
Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, USA
Urology 67:423.e5-423.e8. 2006.... - MDCT urography of upper tract urothelial neoplasmsElaine M Caoili
Department of Radiology, University of Michigan Health System, B1-132 Taubman Center 0302, 1500 E Medical Center Dr, Ann Arbor, MI 48109-0302, USA
AJR Am J Roentgenol 184:1873-81. 2005..The static 3D reconstructions used in this study are insufficient for visualization. Axial image review remains essential for tumor identification... - Interobserver reproducibility in the diagnosis of invasive micropapillary carcinoma of the urinary tract among urologic pathologistsAnkur R Sangoi
Department of Pathology, Stanford University, Stanford, CA, USA
Am J Surg Pathol 34:1367-76. 2010..These findings suggest that more study of IMPC is needed to identify the individual pathologic features that might potentially correlate with an aggressive outcome and response to intravesical therapy... - Sclerosing mucoepidermoid carcinoma of the parotid glandS Brett Heavner
Department of Otolaryngology-Head and Neck Surgery, The University of Michigan Medical Center, 1904 Taubman Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA
Eur Arch Otorhinolaryngol 263:955-9. 2006..Patients should be followed closely with serial MRI imaging studies of the tumor bed with complete clinical evaluation of the regional lymphatics and chest to evaluate for evidence of recurrence or metastasis... - Detection and expression of human BK virus sequences in neoplastic prostate tissuesDweepanita Das
Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109-0942, USA
Oncogene 23:7031-46. 2004..Although BKV DNA was found in benign and atrophic lesions, TAg and p53 coexpression was observed only in atrophic lesions... - Tubulocystic carcinoma of the kidney: clinicopathologic and molecular characterizationXiming J Yang
Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, New York, NY 10021, USA
Am J Surg Pathol 32:177-87. 2008.... - The quality of surgical pathology care for men undergoing radical prostatectomy in the U.SDavid C Miller
Department of Urology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095 1738, USA
Cancer 109:2445-53. 2007..The authors assessed adherence with the College of American Pathologists (CAP) radical prostatectomy (RP) practice protocol in a national sample of men who underwent RP for early-stage prostate cancer... - Prostate-specific membrane antigen expression as a predictor of prostate cancer progressionSven Perner
Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
Hum Pathol 38:696-701. 2007..6-9.7, P < .001, respectively). In summary, PSMA is independently associated with PSA recurrence in a high-risk cohort and thus might provide insight into the additional use of adjuvant therapy. Validation on other cohorts is required... - Trends in the use of gross and frozen section pathological consultations during partial or radical nephrectomy for renal cell carcinomaDavid C Miller
Department of Urology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
J Urol 179:461-7; discussion 467. 2008..We explored this hypothesis by evaluating national trends in the use of intraoperative pathological consultation during radical or partial nephrectomy with time, across regions, and by patient and provider characteristics... - A working group classification of focal prostate atrophy lesionsAngelo M De Marzo
Johns Hopkins University School of Medicine, USA
Am J Surg Pathol 30:1281-91. 2006..In conclusion, these criteria for variants of focal prostate atrophy may facilitate studies to examine the relation between various patterns of prostate atrophy and prostate cancer... - Isolated recurrent renal cell carcinoma metastatic to the bladderDaya P Joshi
Department of Urology, University of Michigan Hospitals, Ann Arbor 48109, USA
J Natl Med Assoc 94:912-4. 2002 - Clear cell papillary renal cell carcinoma: a distinct histopathologic and molecular genetic entityStefano Gobbo
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Am J Surg Pathol 32:1239-45. 2008..This tumor has immunophenotypic and genetic profiles distinct from those of either classic papillary or clear cell renal cell carcinoma, and should be considered a distinct entity in the spectrum of renal cell neoplasia...