Rajal B Shah

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi request reprint Comparison of the basal cell-specific markers, 34betaE12 and p63, in the diagnosis of prostate cancer
    Rajal B Shah
    Deparment of Pathology and Urology, University of Michigan School of Medicine and Comprenhensive Cancer Center, Ann Arbor, Michigan 48109, USA
    Am J Surg Pathol 26:1161-8. 2002
  2. ncbi request reprint Androgen-independent prostate cancer is a heterogeneous group of diseases: lessons from a rapid autopsy program
    Rajal B Shah
    Department of Pathology, University of Michigan School of Medicine, Ann Arbor, Michigan, USA
    Cancer Res 64:9209-16. 2004
  3. doi request reprint Current perspectives on the Gleason grading of prostate cancer
    Rajal B Shah
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
    Arch Pathol Lab Med 133:1810-6. 2009
  4. ncbi request reprint Image-guided biopsy in the evaluation of renal mass lesions in contemporary urological practice: indications, adequacy, clinical impact, and limitations of the pathological diagnosis
    Rajal B Shah
    Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA
    Hum Pathol 36:1309-15. 2005
  5. doi request reprint The discovery of common recurrent transmembrane protease serine 2 (TMPRSS2)-erythroblastosis virus E26 transforming sequence (ETS) gene fusions in prostate cancer: significance and clinical implications
    Rajal B Shah
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Adv Anat Pathol 16:145-53. 2009
  6. pmc The role of SPINK1 in ETS rearrangement-negative prostate cancers
    Scott A Tomlins
    Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Cancer Cell 13:519-28. 2008
  7. pmc Characterization of TMPRSS2-ETS gene aberrations in androgen-independent metastatic prostate cancer
    Rohit Mehra
    Michigan Center for Translational Pathology, Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Cancer Res 68:3584-90. 2008
  8. pmc Noninvasive detection of TMPRSS2:ERG fusion transcripts in the urine of men with prostate cancer
    Bharathi Laxman
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Neoplasia 8:885-8. 2006
  9. pmc Characterization of ETS gene aberrations in select histologic variants of prostate carcinoma
    Bo Han
    Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Mod Pathol 22:1176-85. 2009
  10. pmc Fluorescence in situ hybridization study shows association of PTEN deletion with ERG rearrangement during prostate cancer progression
    Bo Han
    Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI, USA
    Mod Pathol 22:1083-93. 2009

Collaborators

Detail Information

Publications75

  1. ncbi request reprint Comparison of the basal cell-specific markers, 34betaE12 and p63, in the diagnosis of prostate cancer
    Rajal B Shah
    Deparment of Pathology and Urology, University of Michigan School of Medicine and Comprenhensive Cancer Center, Ann Arbor, Michigan 48109, USA
    Am J Surg Pathol 26:1161-8. 2002
    ..p63 may be used as an alternative to 34betaE12 stain for difficult prostate lesions...
  2. ncbi request reprint Androgen-independent prostate cancer is a heterogeneous group of diseases: lessons from a rapid autopsy program
    Rajal B Shah
    Department of Pathology, University of Michigan School of Medicine, Ann Arbor, Michigan, USA
    Cancer Res 64:9209-16. 2004
    ..An appreciation of this heterogeneity is critical to evaluating diagnostic and prognostic biomarkers as well as to designing therapeutic targets for advanced disease...
  3. doi request reprint Current perspectives on the Gleason grading of prostate cancer
    Rajal B Shah
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
    Arch Pathol Lab Med 133:1810-6. 2009
    ..In addition, better understanding of the morphologic spectrum of prostate cancer and its subsequent outcome have prompted the refinement of the grading criteria and reporting practices applicable to contemporary practice management...
  4. ncbi request reprint Image-guided biopsy in the evaluation of renal mass lesions in contemporary urological practice: indications, adequacy, clinical impact, and limitations of the pathological diagnosis
    Rajal B Shah
    Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA
    Hum Pathol 36:1309-15. 2005
    ..Most biopsies can be classified into clinically relevant categories; however, caution is advised while interpreting oncocytic neoplasms because sampling and tumor heterogeneity may adversely affect interpretation...
  5. doi request reprint The discovery of common recurrent transmembrane protease serine 2 (TMPRSS2)-erythroblastosis virus E26 transforming sequence (ETS) gene fusions in prostate cancer: significance and clinical implications
    Rajal B Shah
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Adv Anat Pathol 16:145-53. 2009
    ....
  6. pmc The role of SPINK1 in ETS rearrangement-negative prostate cancers
    Scott A Tomlins
    Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Cancer Cell 13:519-28. 2008
    ..We identified the aggressive 22RV1 cell line as a SPINK1 outlier expression model and demonstrate that SPINK1 knockdown in 22RV1 attenuates invasion, suggesting a functional role in ETS rearrangement-negative prostate cancers...
  7. pmc Characterization of TMPRSS2-ETS gene aberrations in androgen-independent metastatic prostate cancer
    Rohit Mehra
    Michigan Center for Translational Pathology, Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Cancer Res 68:3584-90. 2008
    ..These findings suggest that TMPRSS2-ERG with Edel is an aggressive and, in this study, uniformly lethal molecular subtype of prostate cancer associated with androgen-independent disease...
  8. pmc Noninvasive detection of TMPRSS2:ERG fusion transcripts in the urine of men with prostate cancer
    Bharathi Laxman
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Neoplasia 8:885-8. 2006
    ..These results demonstrate that TMPRSS2:ERG gene fusions can be detected in the urine of patients with prostate cancer and support larger studies on prospective cohorts for noninvasive detection of prostate cancer...
  9. pmc Characterization of ETS gene aberrations in select histologic variants of prostate carcinoma
    Bo Han
    Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Mod Pathol 22:1176-85. 2009
    ..Overall, our data provide insight into the origin, molecular mechanism, and phenotypic association of ETS fusions in histologic variants of prostate carcinoma...
  10. pmc Fluorescence in situ hybridization study shows association of PTEN deletion with ERG rearrangement during prostate cancer progression
    Bo Han
    Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI, USA
    Mod Pathol 22:1083-93. 2009
    ..PTEN deletion and ERG rearrangement may cooperate, but contribute at different stages, in prostate cancer progression...
  11. pmc Prevalence of TMPRSS2-ERG fusion prostate cancer among men undergoing prostate biopsy in the United States
    Juan Miguel Mosquera
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Clin Cancer Res 15:4706-11. 2009
    ..We sought to determine the prevalence of TMPRSS2-ERG gene fusion among prostate-specific antigen-screened men undergoing prostate biopsy in the United States...
  12. pmc Role of the TMPRSS2-ERG gene fusion in prostate cancer
    Scott A Tomlins
    Michigan Center for Translational Pathology, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Neoplasia 10:177-88. 2008
    ..Our results support previous work suggesting that TMPRSS2-ERG fusions mediate invasion, consistent with the defining histologic distinction between PIN and prostate cancer...
  13. ncbi request reprint Usefulness of basal cell cocktail (34betaE12 + p63) in the diagnosis of atypical prostate glandular proliferations
    Rajal B Shah
    Department of Pathology, University of Michigan School of Medicine, Ann Arbor 48109, USA
    Am J Clin Pathol 122:517-23. 2004
    ..The cocktail provides a simple, cost-effective improvement in basal cell immunohistochemical analysis of difficult prostate lesions...
  14. doi request reprint ETS gene aberrations in atypical cribriform lesions of the prostate: Implications for the distinction between intraductal carcinoma of the prostate and cribriform high-grade prostatic intraepithelial neoplasia
    Bo Han
    Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, USA
    Am J Surg Pathol 34:478-85. 2010
    ..However, there are lesions that do not fully satisfy the criteria for IDC-P yet are worse than typical HGPIN and are difficult to distinguish based on morphologic criteria alone...
  15. doi request reprint Multiple adverse histological features increase the odds of under staging T1 bladder cancer
    Alon Z Weizer
    Department of Urology, University of Michigan, Ann Arbor, Michigan, USA
    J Urol 182:59-65; discussion 65. 2009
    ..In this study we evaluated clinicopathological features to aid in the identification of patients with clinical T1 bladder cancer at risk for under staging...
  16. ncbi request reprint Integrative analysis of genomic aberrations associated with prostate cancer progression
    Jung H Kim
    Michigan Center for Translational Pathology, Department of Pathology, Department of Urology, Program of Bioinformatics, and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109 0940, USA
    Cancer Res 67:8229-39. 2007
    ..Integrative analysis with matched mRNA profiles identified genetic alterations in several proposed candidate genes implicated in prostate cancer progression...
  17. ncbi request reprint Heterogeneity of TMPRSS2 gene rearrangements in multifocal prostate adenocarcinoma: molecular evidence for an independent group of diseases
    Rohit Mehra
    Michigan Center for Translational Pathology, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Cancer Res 67:7991-5. 2007
    ..Understanding this molecular heterogeneity is critical to the future development and utility of diagnostic and prognostic PCA biomarkers...
  18. pmc A fluorescence in situ hybridization screen for E26 transformation-specific aberrations: identification of DDX5-ETV4 fusion protein in prostate cancer
    Bo Han
    Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Cancer Res 68:7629-37. 2008
    ..Fourth, we identified a ubiquitously expressed, androgen-insensitive gene, DDX5, fused in frame with ETV4, leading to the expression of a DDX5-ETV4 fusion protein...
  19. ncbi request reprint A polycomb repression signature in metastatic prostate cancer predicts cancer outcome
    Jindan Yu
    Michigan Center for Translational Pathology, Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Cancer Res 67:10657-63. 2007
    ..Therefore, PcG proteins play a central role in the epigenetic silencing of target genes and functionally link stem cells, metastasis, and cancer survival...
  20. ncbi request reprint Integrative molecular concept modeling of prostate cancer progression
    Scott A Tomlins
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Nat Genet 39:41-51. 2007
    ..Taken together, these data show that analyzing gene expression signatures in the context of a compendium of molecular concepts is useful in understanding cancer biology...
  21. ncbi request reprint Integrating biomedical knowledge to model pathways of prostate cancer progression
    David S Morris
    Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Cell Cycle 6:1177-87. 2007
    ..Analyzing complex gene expression signatures in the context of molecular concepts improves integrative models and may improve detection, prognostication, or targeted therapy...
  22. ncbi request reprint Comprehensive assessment of TMPRSS2 and ETS family gene aberrations in clinically localized prostate cancer
    Rohit Mehra
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Mod Pathol 20:538-44. 2007
    ....
  23. ncbi request reprint Integrative genomic and proteomic analysis of prostate cancer reveals signatures of metastatic progression
    Sooryanarayana Varambally
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Cancer Cell 8:393-406. 2005
    ....
  24. ncbi request reprint Distinct classes of chromosomal rearrangements create oncogenic ETS gene fusions in prostate cancer
    Scott A Tomlins
    Michigan Center for Translational Pathology, Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Nature 448:595-9. 2007
    ..Furthermore, the identification of androgen-repressed and insensitive 5' fusion partners may have implications for the anti-androgen treatment of advanced prostate cancer...
  25. ncbi request reprint TMPRSS2:ETV4 gene fusions define a third molecular subtype of prostate cancer
    Scott A Tomlins
    Department of Pathology, University of Michigan Medical School, 1301 Catherine Street, Ann Arbor, MI 48109, USA
    Cancer Res 66:3396-400. 2006
    ..This result defines a third molecular subtype of prostate cancer and supports the hypothesis that dysregulation of ETS family members through fusions with TMRPSS2 may be an initiating event in prostate cancer development...
  26. ncbi request reprint Integrative genomics analysis reveals silencing of beta-adrenergic signaling by polycomb in prostate cancer
    Jindan Yu
    Department of Pathology, Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Cancer Cell 12:419-31. 2007
    ..Taken together, we demonstrate the power of integrating multiple diverse genomic data to decipher targets of disease-related genes...
  27. pmc Characterization of bone metastases from rapid autopsies of prostate cancer patients
    Rohit Mehra
    Department of Internal Medicine and Urology, University of Michigan Medical School, 7303 Cancer Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA
    Clin Cancer Res 17:3924-32. 2011
    ..No intensive studies, however, have been conducted on osseous metastatic tissues from patients with metastatic prostate cancer due to lack of access to such tissues for profiling and other research...
  28. ncbi request reprint Prostate-specific antigen, high-molecular-weight cytokeratin (clone 34betaE12), and/or p63: an optimal immunohistochemical panel to distinguish poorly differentiated prostate adenocarcinoma from urothelial carcinoma
    Lakshmi P Kunju
    Department of Pathology, University of Michigan School of Medicine, 1500 E Medical Center Drive, Ann Arbor, MI 48109, USA
    Am J Clin Pathol 125:675-81. 2006
    ..This panel was used on 26 diagnostically challenging cases and resolved 81% of cases as UCa vs PCa. The majority of PCa cases retain PSA. Negative PSA with positive HMWCK and/or p63 establishes a diagnosis of UCa...
  29. pmc Utility of extended pattern prostate biopsies for tumor localization: pathologic correlations after radical prostatectomy
    Ryan T Schulte
    Department of Urology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0330, USA
    Cancer 113:1559-65. 2008
    ..In the current study, we sought to examine the ability of contemporary extended pattern prostate biopsy to predict the location of tumors...
  30. ncbi request reprint Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer
    Scott A Tomlins
    Department of Pathology, University of Michigan Medical School, 1301 Catherine Street, Ann Arbor, MI 48109 0602, USA
    Science 310:644-8. 2005
    ..These results have implications in the development of carcinomas and the molecular diagnosis and treatment of prostate cancer...
  31. ncbi request reprint Evaluation of the prostate peripheral zone/capsule in patients undergoing radical cystoprostatectomy: defining risk with prostate capsule sparing cystectomy
    Alon Z Weizer
    Department of Urology, University of Michigan, Ann Arbor, MI 48109 0330, USA
    Urol Oncol 25:460-4. 2007
    ..Because concerns remain regarding incomplete surgical resection, we evaluated the risk of urothelial and prostate cancer in a series of patients undergoing radical cystoprostatectomy...
  32. pmc Characterization of TMPRSS2-ERG fusion high-grade prostatic intraepithelial neoplasia and potential clinical implications
    Juan Miguel Mosquera
    Department of Pathology, Brigham and Women s Hospital, Boston, MA, USA
    Clin Cancer Res 14:3380-5. 2008
    ..This may have significant clinical implications given that TMPRSS2-ERG fusion prostate cancer is associated with a more aggressive clinical course...
  33. doi request reprint p63, CK7, PAX8 and INI-1: an optimal immunohistochemical panel to distinguish poorly differentiated urothelial cell carcinoma from high-grade tumours of the renal collecting system
    Jason C Carvalho
    Department of Pathology, University of Michigan Medical Center, 1500 E Medical Center Drive, Ann Arbor, MI 48109 0602, USA
    Histopathology 60:597-608. 2012
    ..Accurate classification, especially the distinction of UC from RCC, is critical, as therapeutic approaches differ...
  34. doi request reprint Introducing parametric fusion PET/MRI of primary prostate cancer
    Hyunjin Park
    Department of Radiology, University of Michigan, Ann Arbor, MI, USA
    J Nucl Med 53:546-51. 2012
    ..We assessed the performance of parametric fusion PET/MRI based on (11)C-choline PET/CT and apparent diffusion coefficient (ADC) maps derived from diffusion-weighted MRI for the identification of primary prostate cancer...
  35. doi request reprint Atypical cribriform lesions of the prostate: relationship to prostatic carcinoma and implication for diagnosis in prostate biopsies
    Rajal B Shah
    Department of Pathology, University of Michigan, Ann Arbor, USA
    Am J Surg Pathol 34:470-7. 2010
    ....
  36. pmc Perineural invasion is a marker for pathologically advanced disease in localized prostate cancer
    Irwin H Lee
    Department of Radiation Oncology, University of Michigan, 1500 E Medical Center Drive, Ann Arbor, MI 48109, USA
    Int J Radiat Oncol Biol Phys 68:1059-64. 2007
    ..To determine if perineural invasion (PNI) should be included in addition to prostate-specific antigen (PSA), biopsy Gleason score, and clinical T-stage for risk-stratification of patients with localized prostate cancer...
  37. ncbi request reprint Epidermal growth factor receptor (ErbB1) expression in prostate cancer progression: correlation with androgen independence
    Rajal B Shah
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0932, USA
    Prostate 66:1437-44. 2006
    ..The role of the epidermal growth factor receptor (ErbB1) in the progression of prostate cancer is incompletely understood...
  38. ncbi request reprint Partial atrophy in prostate needle biopsies: a detailed analysis of its morphology, immunophenotype, and cellular kinetics
    Christopher G Przybycin
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
    Am J Surg Pathol 32:58-64. 2008
    ..PA foci do not represent a spectrum of proliferative inflammatory atrophy, justifying its term...
  39. doi request reprint Nested variant of urothelial carcinoma: a clinicopathologic and immunohistochemical study of 30 pure and mixed cases
    Matthew J Wasco
    Department of Pathology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    Hum Pathol 41:163-71. 2010
    ..78). Increased awareness and familiarity with the clinicopathologic spectrum is critical for confident recognition and adequate management of this very aggressive variant of UC...
  40. pmc Investigation on tumor hypoxia in resectable primary prostate cancer as demonstrated by 18F-FAZA PET/CT utilizing multimodality fusion techniques
    Rita Garcia-Parra
    Department of Radiology, Division of Nuclear Medicine, University of Michigan, 1500 E Medical Center Drive, Ann Arbor, MI 48109, USA
    Eur J Nucl Med Mol Imaging 38:1816-23. 2011
    ....
  41. pmc Dickkopf-1 expression increases early in prostate cancer development and decreases during progression from primary tumor to metastasis
    Christopher L Hall
    Department of Urology, The University of Michigan, Ann Arbor, Michigan, USA
    Prostate 68:1396-404. 2008
    ..We previously demonstrated through over-expression of the Wnt inhibitor dickkopf-1 (DKK-1) that Wnts contribute to the osteoblastic component of PCa osseous lesions in vivo...
  42. ncbi request reprint Papillary renal cell carcinoma with oncocytic cells and nonoverlapping low grade nuclei: expanding the morphologic spectrum with emphasis on clinicopathologic, immunohistochemical and molecular features
    Lakshmi P Kunju
    Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA
    Hum Pathol 39:96-101. 2008
    ..Morphologic spectrum of these PRCCs emphasizes that the future prognostic model of PRCC may need to be based primarily on the nuclear characteristics, irrespective of the cytoplasmic features...
  43. pmc Perlecan, a candidate gene for the CAPB locus, regulates prostate cancer cell growth via the Sonic Hedgehog pathway
    Milton W Datta
    Department of Pathology, Emory University, Atlanta, GA 30322, USA
    Mol Cancer 5:9. 2006
    ..Previously we have linked Perlecan to Hedgehog signaling in Drosophila. More recently, we have demonstrated the importance of Hedgehog signaling in humans for advanced prostate cancer...
  44. ncbi request reprint Adoption of new technology and healthcare quality: surgical margins after robotic prostatectomy
    Alon Z Weizer
    Department of Urology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Urology 70:96-100. 2007
    ..To study the evolution of surgical margins in robotic prostatectomy (DVP), to ascertain the surgical volume necessary to provide quality cancer care...
  45. ncbi request reprint Expression of renal cell carcinoma antigen (RCC) in renal epithelial and nonrenal tumors: diagnostic Implications
    Nasir Bakshi
    Department of Pathology, Oklahoma University Health Sciences Center, Oklahoma City, Oklahoma, USA
    Appl Immunohistochem Mol Morphol 15:310-5. 2007
    ..RCC also does not reliably differentiate subtypes of renal epithelial neoplasms...
  46. pmc Whole transcriptome amplification for gene expression profiling and development of molecular archives
    Scott A Tomlins
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109 0602, USA
    Neoplasia 8:153-62. 2006
    ..Taken together, WTA represents a versatile approach to profile and archive cDNA from minute tumor samples and is compatible with partially degraded RNA...
  47. pmc Elevated alpha-methylacyl-CoA racemase enzymatic activity in prostate cancer
    Chandan Kumar-Sinha
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0602, USA
    Am J Pathol 164:787-93. 2004
    ..Taken together, our studies suggest that AMACR activity is increased in prostate cancer relative to benign epithelia and suggests that monitoring AMACR activity levels in prostate needle biopsies may have clinical applications...
  48. ncbi request reprint E-cadherin protein expression predicts prostate cancer salvage radiotherapy outcomes
    Michael E Ray
    Department of Radiation Oncology, Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan 48109 0010, USA
    J Urol 176:1409-14; discussion 1414. 2006
    ..Altered expression of the adhesion molecule E-cadherin may be associated with the invasive and metastatic phenotype. We examined the relationship between E-cadherin expression and outcomes after salvage radiotherapy...
  49. pmc Detection of aggressive primary prostate cancer with 11C-choline PET/CT using multimodality fusion techniques
    Morand Piert
    Department of Radiology, University of Michigan, Ann Arbor, Michigan 48109 0028, USA
    J Nucl Med 50:1585-93. 2009
    ..The aim of the study was to assess whether (11)C-choline PET/CT could identify high-risk primary adenocarcinoma of the prostate...
  50. ncbi request reprint Percent positive biopsy cores as a prognostic factor for prostate cancer treated with external beam radiation
    Aaron C Spalding
    Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Urology 69:936-40. 2007
    ..To examine the prognostic value of percent positive cores (PPC) in prostate cancer patients treated with external beam radiotherapy (RT)...
  51. doi request reprint Lymphoepithelioma-like carcinoma of the urinary bladder: clinicopathologic, immunohistochemical, and molecular features
    Sean R Williamson
    Department of Pathology, Indiana University School of Medicine, Indianapolis, IN, USA
    Am J Surg Pathol 35:474-83. 2011
    ..Investigation of immunohistochemical and molecular characteristics of bladder LELC is limited. The pathogenesis and biological behavior of these tumors are controversial...
  52. ncbi request reprint Diagnostic usefulness of monoclonal antibody P504S in the workup of atypical prostatic glandular proliferations
    Lakshmi P Kunju
    Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI, USA
    Am J Clin Pathol 120:737-45. 2003
    ..Most HGPINs show diffuse moderate P504S staining. AAH may show focal P504S staining. We recommend using P504S along with morphologic examination and conventional basal cell markers...
  53. doi request reprint Multiple prostate cancer cores with different Gleason grades submitted in the same specimen container without specific site designation: should each core be assigned an individual Gleason score?
    Lakshmi P Kunju
    Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA
    Hum Pathol 40:558-64. 2009
    ..When multiple intact cores are submitted in the same container without specific identifiers, individual cores with cancer should be graded and/or the Worst Gleason score should be recorded...
  54. doi request reprint Cluster analysis of immunohistochemical profiles delineates CK7, vimentin, S100A1 and C-kit (CD117) as an optimal panel in the differential diagnosis of renal oncocytoma from its mimics
    Jason C Carvalho
    Department of Pathology, University of Michigan Medical Center, Ann Arbor, MI, USA
    Histopathology 58:169-79. 2011
    ....
  55. ncbi request reprint Use of extended pattern technique for initial prostate biopsy
    Wendy Siu
    Departments of Urology and Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Urol 174:505-9. 2005
    ..We examined the impact of using an extended pattern schema on cancer detection and also on the finding of smaller and clinically insignificant cancer...
  56. pmc Neoadjuvant docetaxel and capecitabine in patients with high risk prostate cancer
    Judah Friedman
    Division of Hematology and Oncology, Department of Medicine, University of Michigan School of Medicine and University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48109 0946, USA
    J Urol 179:911-5; discussion 915-6. 2008
    ..We assessed activity and safety of neoadjuvant docetaxel and capecitabine in patients with high risk prostate cancer...
  57. ncbi request reprint In vivo visualization of metastatic prostate cancer and quantitation of disease progression in immunocompromised mice
    Linda M Kalikin
    Department of Urology, Division of Hematology and Oncology, The University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48109 0946, USA
    Cancer Biol Ther 2:656-60. 2003
    ..This model provides a controllable biological system for further investigation into the pathogenesis of metastatic prostate cancer and evaluation of new therapies...
  58. doi request reprint Nephron-sparing diagnosis and management of renal keratinizing desquamative squamous metaplasia
    Michael Borofsky
    Department of Urology, University of Michigan Health System, Ann Arbor, Michigan 48109, USA
    J Endourol 23:51-5. 2009
    ..We report the favorable clinical course of two cases of renal KDSM diagnosed and managed with a nephron-sparing approach, relying on ureteroscopy and serial imaging...
  59. ncbi request reprint CXCL12 overexpression and secretion by aging fibroblasts enhance human prostate epithelial proliferation in vitro
    Lesa Begley
    Department of Urology, The University of Michigan, Ann Arbor, 48109, USA
    Aging Cell 4:291-8. 2005
    ..These studies represent an important first step towards a mechanistic elucidation of the role of aging in the etiology of benign and malignant prostatic diseases...
  60. ncbi request reprint Urothelial carcinoma with divergent histologic differentiation (mixed histologic features) predicts the presence of locally advanced bladder cancer when detected at transurethral resection
    Matthew J Wasco
    Department of Pathology, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    Urology 70:69-74. 2007
    ..This study examined the incidence, pathologic spectrum, and clinical significance of this phenomenon...
  61. doi request reprint Localized amyloidosis of the upper urinary tract: a case series of three patients managed with reconstructive surgery or surveillance
    Tudor Borza
    Department of Urology, University of Michigan Health System, Ann Arbor, Michigan 48109 5330, USA
    J Endourol 24:641-4. 2010
    ..To evaluate the clinical presentation, diagnosis, treatment, and prognosis of primary localized amyloidosis of the upper urinary tract...
  62. ncbi request reprint Variable penetrance of a consensus classification scheme for renal cell carcinoma
    John M Hollingsworth
    Department of Urology, Michigan Urology Center, University of Michigan Health System, Ann Arbor, Michigan 48109 0330, USA
    Urology 69:452-6. 2007
    ..The histologic classification of kidney cancer has been revised to reflect this new paradigm...
  63. ncbi request reprint Utility of cytokeratin 20 and Ki-67 as markers of urothelial dysplasia
    Lakshmi P Kunju
    Department of Pathology, University of Michigan School of Medicine, Ann Arbor, Michigan 48109, USA
    Pathol Int 55:248-54. 2005
    ..In summary, abnormal CK20 is a useful adjunct to morphology for confirming dysplasia. Ki-67 by itself is a less reliable marker of dysplasia. E-Cad is not a useful marker in this setting...
  64. ncbi request reprint Clonality of sarcomatous and carcinomatous elements in sarcomatoid carcinoma of the prostate
    Michael E Ray
    Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, USA
    Urology 67:423.e5-423.e8. 2006
    ....
  65. ncbi request reprint MDCT urography of upper tract urothelial neoplasms
    Elaine M Caoili
    Department of Radiology, University of Michigan Health System, B1 132 Taubman Center 0302, 1500 E Medical Center Dr, Ann Arbor, MI 48109 0302, USA
    AJR Am J Roentgenol 184:1873-81. 2005
    ..The purpose of our study was to review the MDCT urography appearance of pathologically proven transitional cell carcinomas of the renal collecting system and ureter and to correlate the MDCT urography findings with pathology findings...
  66. doi request reprint Interobserver reproducibility in the diagnosis of invasive micropapillary carcinoma of the urinary tract among urologic pathologists
    Ankur R Sangoi
    Department of Pathology, Stanford University, Stanford, CA, USA
    Am J Surg Pathol 34:1367-76. 2010
    ..These findings suggest that more study of IMPC is needed to identify the individual pathologic features that might potentially correlate with an aggressive outcome and response to intravesical therapy...
  67. ncbi request reprint Sclerosing mucoepidermoid carcinoma of the parotid gland
    S Brett Heavner
    Department of Otolaryngology Head and Neck Surgery, The University of Michigan Medical Center, 1904 Taubman Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA
    Eur Arch Otorhinolaryngol 263:955-9. 2006
    ..Patients should be followed closely with serial MRI imaging studies of the tumor bed with complete clinical evaluation of the regional lymphatics and chest to evaluate for evidence of recurrence or metastasis...
  68. ncbi request reprint Detection and expression of human BK virus sequences in neoplastic prostate tissues
    Dweepanita Das
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109 0942, USA
    Oncogene 23:7031-46. 2004
    ..Although BKV DNA was found in benign and atrophic lesions, TAg and p53 coexpression was observed only in atrophic lesions...
  69. ncbi request reprint The quality of surgical pathology care for men undergoing radical prostatectomy in the U.S
    David C Miller
    Department of Urology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095 1738, USA
    Cancer 109:2445-53. 2007
    ..The authors assessed adherence with the College of American Pathologists (CAP) radical prostatectomy (RP) practice protocol in a national sample of men who underwent RP for early-stage prostate cancer...
  70. doi request reprint Tubulocystic carcinoma of the kidney: clinicopathologic and molecular characterization
    Ximing J Yang
    Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, New York, NY 10021, USA
    Am J Surg Pathol 32:177-87. 2008
    ....
  71. ncbi request reprint Prostate-specific membrane antigen expression as a predictor of prostate cancer progression
    Sven Perner
    Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Hum Pathol 38:696-701. 2007
    ..6-9.7, P < .001, respectively). In summary, PSMA is independently associated with PSA recurrence in a high-risk cohort and thus might provide insight into the additional use of adjuvant therapy. Validation on other cohorts is required...
  72. ncbi request reprint A working group classification of focal prostate atrophy lesions
    Angelo M De Marzo
    Johns Hopkins University School of Medicine, USA
    Am J Surg Pathol 30:1281-91. 2006
    ..In conclusion, these criteria for variants of focal prostate atrophy may facilitate studies to examine the relation between various patterns of prostate atrophy and prostate cancer...
  73. doi request reprint Clear cell papillary renal cell carcinoma: a distinct histopathologic and molecular genetic entity
    Stefano Gobbo
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Am J Surg Pathol 32:1239-45. 2008
    ..This tumor has immunophenotypic and genetic profiles distinct from those of either classic papillary or clear cell renal cell carcinoma, and should be considered a distinct entity in the spectrum of renal cell neoplasia...
  74. ncbi request reprint Trends in the use of gross and frozen section pathological consultations during partial or radical nephrectomy for renal cell carcinoma
    David C Miller
    Department of Urology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
    J Urol 179:461-7; discussion 467. 2008
    ..We explored this hypothesis by evaluating national trends in the use of intraoperative pathological consultation during radical or partial nephrectomy with time, across regions, and by patient and provider characteristics...
  75. pmc Isolated recurrent renal cell carcinoma metastatic to the bladder
    Daya P Joshi
    Department of Urology, University of Michigan Hospitals, Ann Arbor 48109, USA
    J Natl Med Assoc 94:912-4. 2002