Manish B Shah

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc A structural snapshot of CYP2B4 in complex with paroxetine provides insights into ligand binding and clusters of conformational states
    Manish B Shah
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Drive, Mail Code 0703, La Jolla, CA 92093 0703, USA
    J Pharmacol Exp Ther 346:113-20. 2013
  2. pmc Conformational adaptation of human cytochrome P450 2B6 and rabbit cytochrome P450 2B4 revealed upon binding multiple amlodipine molecules
    Manish B Shah
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California 92093, United States
    Biochemistry 51:7225-38. 2012
  3. pmc Structures of cytochrome P450 2B6 bound to 4-benzylpyridine and 4-(4-nitrobenzyl)pyridine: insight into inhibitor binding and rearrangement of active site side chains
    Manish B Shah
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093 0703, USA
    Mol Pharmacol 80:1047-55. 2011
  4. pmc Comparison of in vitro metabolism of ticlopidine by human cytochrome P450 2B6 and rabbit cytochrome P450 2B4
    Jyothi C Talakad
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California, USA
    Drug Metab Dispos 39:539-50. 2011
  5. pmc Structural and thermodynamic basis of (+)-α-pinene binding to human cytochrome P450 2B6
    P Ross Wilderman
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California 92093, United States
    J Am Chem Soc 135:10433-40. 2013
  6. pmc X-ray crystal structure of the cytochrome P450 2B4 active site mutant F297A in complex with clopidogrel: insights into compensatory rearrangements of the binding pocket
    Manish B Shah
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, United States
    Arch Biochem Biophys 530:64-72. 2013
  7. pmc Plasticity of cytochrome P450 2B4 as investigated by hydrogen-deuterium exchange mass spectrometry and X-ray crystallography
    P Ross Wilderman
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093, USA
    J Biol Chem 285:38602-11. 2010
  8. pmc Crystal structure of a cytochrome P450 2B6 genetic variant in complex with the inhibitor 4-(4-chlorophenyl)imidazole at 2.0-A resolution
    Sean C Gay
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Dr 0703, La Jolla, CA 92093, USA
    Mol Pharmacol 77:529-38. 2010

Detail Information

Publications8

  1. pmc A structural snapshot of CYP2B4 in complex with paroxetine provides insights into ligand binding and clusters of conformational states
    Manish B Shah
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Drive, Mail Code 0703, La Jolla, CA 92093 0703, USA
    J Pharmacol Exp Ther 346:113-20. 2013
    ..Overall, the results from the comparison of all 16 structures of CYP2B4 demonstrate a cluster of protein conformations that were observed in the presence or absence of various ligands...
  2. pmc Conformational adaptation of human cytochrome P450 2B6 and rabbit cytochrome P450 2B4 revealed upon binding multiple amlodipine molecules
    Manish B Shah
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California 92093, United States
    Biochemistry 51:7225-38. 2012
    ..In addition, the structures exhibit the versatility that can be exploited via in silico studies with other P450 2B6 ligands as large as raloxifene and itraconazole...
  3. pmc Structures of cytochrome P450 2B6 bound to 4-benzylpyridine and 4-(4-nitrobenzyl)pyridine: insight into inhibitor binding and rearrangement of active site side chains
    Manish B Shah
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093 0703, USA
    Mol Pharmacol 80:1047-55. 2011
    ....
  4. pmc Comparison of in vitro metabolism of ticlopidine by human cytochrome P450 2B6 and rabbit cytochrome P450 2B4
    Jyothi C Talakad
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California, USA
    Drug Metab Dispos 39:539-50. 2011
    ....
  5. pmc Structural and thermodynamic basis of (+)-α-pinene binding to human cytochrome P450 2B6
    P Ross Wilderman
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California 92093, United States
    J Am Chem Soc 135:10433-40. 2013
    ..The results indicate that the specific components of enthalpic contribution to ligand binding are closely tied to the degree of enzyme flexibility. ..
  6. pmc X-ray crystal structure of the cytochrome P450 2B4 active site mutant F297A in complex with clopidogrel: insights into compensatory rearrangements of the binding pocket
    Manish B Shah
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, United States
    Arch Biochem Biophys 530:64-72. 2013
    ..The study provides insight into how the altered active site adapts to accommodate and interact with the substrate in a distinct orientation while maintaining the overall closed protein conformation...
  7. pmc Plasticity of cytochrome P450 2B4 as investigated by hydrogen-deuterium exchange mass spectrometry and X-ray crystallography
    P Ross Wilderman
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093, USA
    J Biol Chem 285:38602-11. 2010
    ..The results indicate that conformational changes observed in available crystal structures of the promiscuous xenobiotic metabolizing cytochrome P450 2B4 are consistent with its solution structural behavior...
  8. pmc Crystal structure of a cytochrome P450 2B6 genetic variant in complex with the inhibitor 4-(4-chlorophenyl)imidazole at 2.0-A resolution
    Sean C Gay
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Dr 0703, La Jolla, CA 92093, USA
    Mol Pharmacol 77:529-38. 2010
    ..However, it is unknown whether 2B6 undergoes structural reorganization to accommodate bulkier molecules, as previously inferred from multiple P450 2B4 crystal structures...