MICHAEL SHADLEN

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint Neural basis of a perceptual decision in the parietal cortex (area LIP) of the rhesus monkey
    M N Shadlen
    Howard Hughes Medical Institute, Department of Physiology and Biophysics, and Regional Primate Research Center, University of Washington, Seattle, Washington 98195 7290, USA
    J Neurophysiol 86:1916-36. 2001
  2. ncbi request reprint Response of neurons in the lateral intraparietal area during a combined visual discrimination reaction time task
    Jamie D Roitman
    Program in Neurobiology and Behavior, Department of Physiology and Biophysics, and Regional Primate Research Center, University of Washington, Seattle, Washington 98195 7290, USA
    J Neurosci 22:9475-89. 2002
  3. ncbi request reprint A representation of the hazard rate of elapsed time in macaque area LIP
    Peter Janssen
    Howard Hughes Medical Institute, National Primate Research Center and Department of Physiology and Biophysics, University of Washington, Box 357290, Seattle, Washington 98195, USA
    Nat Neurosci 8:234-41. 2005
  4. pmc Microstimulation of macaque area LIP affects decision-making in a motion discrimination task
    Timothy D Hanks
    Howard Hughes Medical Institute, National Primate Research Center, and Department of Physiology and Biophysics, University of Washington, Seattle, Washington 98195, USA
    Nat Neurosci 9:682-9. 2006
  5. ncbi request reprint Representation of time by neurons in the posterior parietal cortex of the macaque
    Matthew I Leon
    Howard Hughes Medical Institute, Department of Physiology and Biophysics and Regional Primate Research Center, University of Washington, Seattle, WA 98195, USA
    Neuron 38:317-27. 2003
  6. doi request reprint Bounded integration in parietal cortex underlies decisions even when viewing duration is dictated by the environment
    Roozbeh Kiani
    Howard Hughes Medical Institute, National Primate Research Center, and Department of Physiology and Biophysics, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 28:3017-29. 2008
  7. ncbi request reprint Probabilistic reasoning by neurons
    Tianming Yang
    Howard Hughes Medical Institute, Department of Physiology and Biophysics, National Primate Research Center, University of Washington, Box 357290, Seattle, Washington 98195 7290, USA
    Nature 447:1075-80. 2007
  8. pmc Decision-making with multiple alternatives
    Anne K Churchland
    Howard Hughes Medical Institute, Department of Physiology and Biophysics, National Primate Research Center, University of Washington Medical School, Seattle, Washington 98195, USA
    Nat Neurosci 11:693-702. 2008
  9. pmc Representation of confidence associated with a decision by neurons in the parietal cortex
    Roozbeh Kiani
    Howard Hughes Medical Institute, National Primate Research Center and Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195, USA
    Science 324:759-64. 2009
  10. pmc Temporal context calibrates interval timing
    Mehrdad Jazayeri
    Helen Hay Whitney Foundation, New York, New York, USA
    Nat Neurosci 13:1020-6. 2010

Research Grants

  1. NEURAL MECHANISMS OF VISUAL PERCEPTION
    MICHAEL SHADLEN; Fiscal Year: 2007
  2. NEURAL MECHANISMS OF VISUAL PERCEPTION
    MICHAEL SHADLEN; Fiscal Year: 2005
  3. NEURAL MECHANISMS OF VISUAL PERCEPTION
    MICHAEL SHADLEN; Fiscal Year: 2000
  4. NEURAL MECHANISMS OF VISUAL PERCEPTION
    MICHAEL NEIL SHADLEN; Fiscal Year: 2010

Detail Information

Publications20

  1. ncbi request reprint Neural basis of a perceptual decision in the parietal cortex (area LIP) of the rhesus monkey
    M N Shadlen
    Howard Hughes Medical Institute, Department of Physiology and Biophysics, and Regional Primate Research Center, University of Washington, Seattle, Washington 98195 7290, USA
    J Neurophysiol 86:1916-36. 2001
    ..The time course of the neural response suggests that LIP accumulates sensory signals relevant to the selection of a target for an eye movement...
  2. ncbi request reprint Response of neurons in the lateral intraparietal area during a combined visual discrimination reaction time task
    Jamie D Roitman
    Program in Neurobiology and Behavior, Department of Physiology and Biophysics, and Regional Primate Research Center, University of Washington, Seattle, Washington 98195 7290, USA
    J Neurosci 22:9475-89. 2002
    ..A threshold level of LIP activity appears to mark the completion of the decision process and to govern the tradeoff between accuracy and speed of perception...
  3. ncbi request reprint A representation of the hazard rate of elapsed time in macaque area LIP
    Peter Janssen
    Howard Hughes Medical Institute, National Primate Research Center and Department of Physiology and Biophysics, University of Washington, Box 357290, Seattle, Washington 98195, USA
    Nat Neurosci 8:234-41. 2005
    ..The results indicate that the parietal cortex contains circuitry for representing the time structure of environmental cues over a range of seconds...
  4. pmc Microstimulation of macaque area LIP affects decision-making in a motion discrimination task
    Timothy D Hanks
    Howard Hughes Medical Institute, National Primate Research Center, and Department of Physiology and Biophysics, University of Washington, Seattle, Washington 98195, USA
    Nat Neurosci 9:682-9. 2006
    ..Microstimulation never directly evoked saccades, nor did it change reaction times in a simple saccade task. These results demonstrate that the discharge of LIP neurons is causally related to decision formation in the discrimination task...
  5. ncbi request reprint Representation of time by neurons in the posterior parietal cortex of the macaque
    Matthew I Leon
    Howard Hughes Medical Institute, Department of Physiology and Biophysics and Regional Primate Research Center, University of Washington, Seattle, WA 98195, USA
    Neuron 38:317-27. 2003
    ..Thus, in addition to their role in spatial processing and sensorimotor integration, posterior parietal neurons encode signals related to the perception of time...
  6. doi request reprint Bounded integration in parietal cortex underlies decisions even when viewing duration is dictated by the environment
    Roozbeh Kiani
    Howard Hughes Medical Institute, National Primate Research Center, and Department of Physiology and Biophysics, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 28:3017-29. 2008
    ..Thus, the readout of visual cortex embraces a termination rule to limit processing even when potentially useful information is available...
  7. ncbi request reprint Probabilistic reasoning by neurons
    Tianming Yang
    Howard Hughes Medical Institute, Department of Physiology and Biophysics, National Primate Research Center, University of Washington, Box 357290, Seattle, Washington 98195 7290, USA
    Nature 447:1075-80. 2007
    ..Monkeys learned to combine probabilistic information from the shape combinations. Moreover, neurons in the parietal cortex reveal the addition and subtraction of probabilistic quantities that underlie decision-making on this task...
  8. pmc Decision-making with multiple alternatives
    Anne K Churchland
    Howard Hughes Medical Institute, Department of Physiology and Biophysics, National Primate Research Center, University of Washington Medical School, Seattle, Washington 98195, USA
    Nat Neurosci 11:693-702. 2008
    ..These physiological observations constitute an effective strategy for handling increased task difficulty. The differences appear to explain subjects' accuracy and reaction times...
  9. pmc Representation of confidence associated with a decision by neurons in the parietal cortex
    Roozbeh Kiani
    Howard Hughes Medical Institute, National Primate Research Center and Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195, USA
    Science 324:759-64. 2009
    ..Monkeys exercised this option in a manner that revealed their degree of certainty. Neurons in parietal cortex represented formation of the direction decision and the degree of certainty underlying the decision to opt out...
  10. pmc Temporal context calibrates interval timing
    Mehrdad Jazayeri
    Helen Hay Whitney Foundation, New York, New York, USA
    Nat Neurosci 13:1020-6. 2010
    ..This finding suggests that the CNS incorporates knowledge about temporal uncertainty to adapt internal timing mechanisms to the temporal statistics of the environment...
  11. ncbi request reprint The effect of stimulus strength on the speed and accuracy of a perceptual decision
    John Palmer
    Department of Psychology, University of Washington, Seattle, WA, USA
    J Vis 5:376-404. 2005
    ..The theory's analytic chronometric function allows one to extend theories of accuracy to response time...
  12. ncbi request reprint A role for neural integrators in perceptual decision making
    Mark E Mazurek
    Howard Hughes Medical Institute, Department of Physiology and Biophysics, and National Primate Research Center, University of Washington, Seattle, WA 98195 7290, USA
    Cereb Cortex 13:1257-69. 2003
    ..The model explains a variety of behavioral and physiological measurements obtained from monkeys...
  13. ncbi request reprint Microstimulation of visual cortex affects the speed of perceptual decisions
    Jochen Ditterich
    Howard Hughes Medical Institute, National Primate Research Center, and Department of Physiology and Biophysics, University of Washington, 1959 NE Pacific Street, Seattle, Washington 98195, USA
    Nat Neurosci 6:891-8. 2003
    ..Our findings suggest that during the formation of a decision, sensory evidence for competing propositions is compared and accumulates to a decision-making threshold...
  14. ncbi request reprint Banburismus and the brain: decoding the relationship between sensory stimuli, decisions, and reward
    Joshua I Gold
    Department of Neuroscience, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuron 36:299-308. 2002
    ..In the codebreaking scheme, the threshold determined the speed and accuracy of the decision process. Here we propose that in the brain, the threshold may be controlled by neural circuits that calculate the rate of reward...
  15. ncbi request reprint The influence of behavioral context on the representation of a perceptual decision in developing oculomotor commands
    Joshua I Gold
    Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6074, USA
    J Neurosci 23:632-51. 2003
    ..The results suggest that formation of the decision and formation of the behavioral response share a common level of neural organization, but only when the decision is associated with a specific, predictable movement...
  16. ncbi request reprint The neural basis of decision making
    Joshua I Gold
    Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6074, USA
    Annu Rev Neurosci 30:535-74. 2007
    ..We focus on simple decisions that can be studied in the laboratory but emphasize general principles likely to extend to other settings...
  17. ncbi request reprint When is enough enough?
    Roozbeh Kiani
    Nat Neurosci 9:861-3. 2006
  18. ncbi request reprint Neural activity in macaque parietal cortex reflects temporal integration of visual motion signals during perceptual decision making
    Alexander C Huk
    Center for Perceptual Systems, Department of Psychology, University of Texas, Austin, Texas 78712, USA
    J Neurosci 25:10420-36. 2005
    ..Temporal integration may be a fundamental computation underlying higher cognitive functions that are dissociated from immediate sensory inputs or motor outputs...
  19. doi request reprint One-dimensional dynamics of attention and decision making in LIP
    Surya Ganguli
    Sloan Swartz Center for Theoretical Neurobiology, University of California, San Francisco, San Francisco, CA 94143, USA
    Neuron 58:15-25. 2008
    ....
  20. ncbi request reprint Pursuing commitments
    Michael N Shadlen
    Nat Neurosci 5:819-21. 2002

Research Grants14

  1. NEURAL MECHANISMS OF VISUAL PERCEPTION
    MICHAEL SHADLEN; Fiscal Year: 2007
    ..Such understanding promises to provide the means to promote recovery of both sensory and intellectual function in the face of neurological disease. ..
  2. NEURAL MECHANISMS OF VISUAL PERCEPTION
    MICHAEL SHADLEN; Fiscal Year: 2005
    ..Such understanding promises to provide the means to promote recovery of both sensory and intellectual function in the face of neurological disease. ..
  3. NEURAL MECHANISMS OF VISUAL PERCEPTION
    MICHAEL SHADLEN; Fiscal Year: 2000
    ..By elucidating its neurobiological basis these studies are likely to found new approaches for intervening in diseases affecting visual cognition and intellectual function. ..
  4. NEURAL MECHANISMS OF VISUAL PERCEPTION
    MICHAEL NEIL SHADLEN; Fiscal Year: 2010
    ..Such understanding promises to provide the means to promote recovery of both sensory and intellectual function in the face of neurological disease. ..