J J Shacka

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. doi request reprint Mouse models of neuronal ceroid lipofuscinoses: useful pre-clinical tools to delineate disease pathophysiology and validate therapeutics
    John J Shacka
    Neuropathology Division, Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Brain Res Bull 88:43-57. 2012
  2. pmc Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity
    Liyan Qiao
    Department of Pathology, University of Alabama at Birmingham, USA
    Mol Brain 1:17. 2008
  3. ncbi request reprint Cathepsin D deficiency and NCL/Batten disease: there's more to death than apoptosis
    John J Shacka
    Department of Pathology, Neuropathology Division, University of Alabama at Birmingham, Birmingham, Alabama 35294 0017, USA
    Autophagy 3:474-6. 2007
  4. ncbi request reprint Autophagy, bafilomycin and cell death: the "a-B-cs" of plecomacrolide-induced neuroprotection
    John J Shacka
    Department of Pathology, Neuropathology Division, University of Alabama at Birmingham, Birmingham, Alabama 35294 0017, USA
    Autophagy 2:228-30. 2006
  5. ncbi request reprint Bcl-2 family and the central nervous system: from rheostat to real complex
    J J Shacka
    Division of Neuropathology, Department of Pathology, Birmingham, AL 35233 0017, USA
    Cell Death Differ 13:1299-304. 2006
  6. ncbi request reprint The autophagy-lysosomal degradation pathway: role in neurodegenerative disease and therapy
    John J Shacka
    Division of Neuropathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Front Biosci 13:718-36. 2008
  7. ncbi request reprint p53 transcription-dependent and -independent regulation of cerebellar neural precursor cell apoptosis
    Ying Geng
    Division of Neuropathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Neuropathol Exp Neurol 66:66-74. 2007
  8. ncbi request reprint Cathepsin D deficiency induces persistent neurodegeneration in the absence of Bax-dependent apoptosis
    John J Shacka
    Department of Pathology, Neuropathology Division, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Neurosci 27:2081-90. 2007
  9. pmc Lysosome dysfunction triggers Atg7-dependent neural apoptosis
    Ken C Walls
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0017, USA
    J Biol Chem 285:10497-507. 2010
  10. ncbi request reprint Bafilomycin A1 inhibits chloroquine-induced death of cerebellar granule neurons
    John J Shacka
    Department of Pathology, Division of Neuropathology, University of Alabama at Birmingham, SC961, 1530 3rd Ave South, Birmingham, AL 35294 0017, USA
    Mol Pharmacol 69:1125-36. 2006

Collaborators

Detail Information

Publications19

  1. doi request reprint Mouse models of neuronal ceroid lipofuscinoses: useful pre-clinical tools to delineate disease pathophysiology and validate therapeutics
    John J Shacka
    Neuropathology Division, Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Brain Res Bull 88:43-57. 2012
    ..In this review we will assess the current state of mouse models of NCL with regards to their unique pathophysiology and how these mice have helped investigators achieve a better understanding of human NCL disease and therapy...
  2. pmc Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity
    Liyan Qiao
    Department of Pathology, University of Alabama at Birmingham, USA
    Mol Brain 1:17. 2008
    ..Our data identify a conserved CD function in α-syn degradation and identify CD as a novel target for LB disease therapeutics...
  3. ncbi request reprint Cathepsin D deficiency and NCL/Batten disease: there's more to death than apoptosis
    John J Shacka
    Department of Pathology, Neuropathology Division, University of Alabama at Birmingham, Birmingham, Alabama 35294 0017, USA
    Autophagy 3:474-6. 2007
    ..Herein, we review CD deficiency in the broader context of NCL and offer potential mechanisms for neuron death and neurodegeneration induced by CD deficiency...
  4. ncbi request reprint Autophagy, bafilomycin and cell death: the "a-B-cs" of plecomacrolide-induced neuroprotection
    John J Shacka
    Department of Pathology, Neuropathology Division, University of Alabama at Birmingham, Birmingham, Alabama 35294 0017, USA
    Autophagy 2:228-30. 2006
    ....
  5. ncbi request reprint Bcl-2 family and the central nervous system: from rheostat to real complex
    J J Shacka
    Division of Neuropathology, Department of Pathology, Birmingham, AL 35233 0017, USA
    Cell Death Differ 13:1299-304. 2006
  6. ncbi request reprint The autophagy-lysosomal degradation pathway: role in neurodegenerative disease and therapy
    John J Shacka
    Division of Neuropathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Front Biosci 13:718-36. 2008
    ..Potential therapies for AD and PD are also discussed that may promote survival by regulating the autophagy and lysosomal degradation pathway...
  7. ncbi request reprint p53 transcription-dependent and -independent regulation of cerebellar neural precursor cell apoptosis
    Ying Geng
    Division of Neuropathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Neuropathol Exp Neurol 66:66-74. 2007
    ..Thus, p53 has multiple death promoting mechanisms in cerebellar NPCs...
  8. ncbi request reprint Cathepsin D deficiency induces persistent neurodegeneration in the absence of Bax-dependent apoptosis
    John J Shacka
    Department of Pathology, Neuropathology Division, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Neurosci 27:2081-90. 2007
    ....
  9. pmc Lysosome dysfunction triggers Atg7-dependent neural apoptosis
    Ken C Walls
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0017, USA
    J Biol Chem 285:10497-507. 2010
    ..These findings indicate that Atg7- and Beclin1-induced autophagy plays a cytoprotective role during starvation but that Atg7 has a unique pro-apoptotic function in response to lysosome dysfunction...
  10. ncbi request reprint Bafilomycin A1 inhibits chloroquine-induced death of cerebellar granule neurons
    John J Shacka
    Department of Pathology, Division of Neuropathology, University of Alabama at Birmingham, SC961, 1530 3rd Ave South, Birmingham, AL 35294 0017, USA
    Mol Pharmacol 69:1125-36. 2006
    ....
  11. ncbi request reprint Regulation of neuronal cell death and neurodegeneration by members of the Bcl-2 family: therapeutic implications
    John J Shacka
    Division of Neuropathology, Dept of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Curr Drug Targets CNS Neurol Disord 4:25-39. 2005
    ....
  12. pmc Low-dose bafilomycin attenuates neuronal cell death associated with autophagy-lysosome pathway dysfunction
    Violetta N Pivtoraiko
    Department of Pathology, Neuropathology Division, University of Alabama, Birmingham, AL, USA
    J Neurochem 114:1193-204. 2010
    ....
  13. pmc Oxidative stress and autophagy in the regulation of lysosome-dependent neuron death
    Violetta N Pivtoraiko
    Department of Pathology, Neuropathology Division, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Antioxid Redox Signal 11:481-96. 2009
    ....
  14. ncbi request reprint Altered regulation of phosphatidylinositol 3-kinase signaling in cathepsin D-deficient brain
    Ken C Walls
    Department of Cell Biology, Neuropathology Division, University of Alabama at Birmingham, Birmingham Alabama 35294 0017, USA
    Autophagy 3:222-9. 2007
    ..Together these observations indicate a pronounced decrease in pro-survival PI3-K signaling in CD-/- brain that may contribute to autophagic stress-induced and apoptotic neuropathology...
  15. pmc Kainic acid induces early and transient autophagic stress in mouse hippocampus
    John J Shacka
    Division of Neuropathology, Department of Pathology, University of Alabama at Birmingham, SC 961, 1530 3rd Ave S, Birmingham, AL 35294 0017, USA
    Neurosci Lett 414:57-60. 2007
    ..Together these data indicate the transient induction of autophagic stress by KA which may serve to regulate excitotoxic death in mouse hippocampus...
  16. pmc Localization of electrogenic Na/bicarbonate cotransporter NBCe1 variants in rat brain
    D Majumdar
    Department of Physiology and Biophysics, University of Alabama at Birmingham, 1918 University Boulevard, 812 MCLM, Birmingham, AL 35294, USA
    Neuroscience 155:818-32. 2008
    ..In summary, the B and C variants are the predominant NBCe1 variants in rat brain and exhibit different localization profiles...
  17. ncbi request reprint Two distinct signaling pathways regulate peroxynitrite-induced apoptosis in PC12 cells
    J J Shacka
    Department of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, AL, USA
    Cell Death Differ 13:1506-14. 2006
    ..Together, these results reveal that peroxynitrite-induced activation of the intrinsic apoptotic pathway involves interactions with the MLK/MAPK and Akt signaling pathways...
  18. pmc Cathepsin deficiency as a model for neuronal ceroid lipofuscinoses
    John J Shacka
    Department of Pathology, Neuropathology Division, University of Alabama at Birmingham, 35294 0017, USA
    Am J Pathol 167:1473-6. 2005
  19. ncbi request reprint Erythropoietin receptor signalling is required for normal brain development
    Xiaobing Yu
    Laboratory of Chemical Biology, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA
    Development 129:505-16. 2002
    ..5 in the developing brain, and that induction of erythropoietin and its receptor by hypoxia may contribute to selective cell survival in the brain...