Cheikh I Seye

Summary

Affiliation: University of Missouri
Country: USA

Publications

  1. ncbi request reprint Functional P2Y2 nucleotide receptors mediate uridine 5'-triphosphate-induced intimal hyperplasia in collared rabbit carotid arteries
    Cheikh I Seye
    Department of Biochemistry, University of Missouri Columbia, Columbia, MO 65212, USA
    Circulation 106:2720-6. 2002
  2. ncbi request reprint The P2Y2 nucleotide receptor mediates UTP-induced vascular cell adhesion molecule-1 expression in coronary artery endothelial cells
    Cheikh I Seye
    Department of Biochemistry, University of Missouri, Columbia 65212, USA
    J Biol Chem 278:24960-5. 2003
  3. pmc P2 receptors in atherosclerosis and postangioplasty restenosis
    Cheikh I Seye
    Department of Biochemistry, 540C Life Sciences Center, University of Missouri Columbia, 1201 Rollins Road, Columbia, MO, 65211 7310, USA
    Purinergic Signal 2:471-80. 2006
  4. pmc P2 receptors in atherosclerosis and postangioplasty restenosis
    Cheikh I Seye
    Department of Biochemistry, University of Missouri Columbia, 540C Life Sciences Center, 1201 Rollins Road, Columbia, MO, 65211 7310, USA
    Purinergic Signal 3:153-62. 2007
  5. ncbi request reprint The P2Y2 nucleotide receptor mediates vascular cell adhesion molecule-1 expression through interaction with VEGF receptor-2 (KDR/Flk-1)
    Cheikh I Seye
    Department of Biochemistry, University of Missouri Columbia, Columbia, Missouri 65212, USA
    J Biol Chem 279:35679-86. 2004
  6. pmc P2Y2 nucleotide receptors mediate metalloprotease-dependent phosphorylation of epidermal growth factor receptor and ErbB3 in human salivary gland cells
    Ann M Ratchford
    Department of Biochemistry, University of Missouri, Christopher S Bond Life Sciences Center, Columbia, Missouri 65211, USA
    J Biol Chem 285:7545-55. 2010
  7. pmc The P2Y2 nucleotide receptor requires interaction with alpha v integrins to access and activate G12
    Zhongji Liao
    Department of Biochemistry, Life Sciences Center, University of Missouri Columbia, Columbia, MO 65211, USA
    J Cell Sci 120:1654-62. 2007
  8. pmc Interleukin-1beta enhances nucleotide-induced and alpha-secretase-dependent amyloid precursor protein processing in rat primary cortical neurons via up-regulation of the P2Y(2) receptor
    Qiongman Kong
    Interdisciplinary Neuroscience Program, University of Missouri, Columbia, Missouri, USA
    J Neurochem 109:1300-10. 2009
  9. pmc P2Y2 nucleotide receptor activation up-regulates vascular cell adhesion molecule-1 [corrected] expression and enhances lymphocyte adherence to a human submandibular gland cell line
    Olga J Baker
    Department of Biochemistry, University of Missouri Columbia, 540E Christopher S Bond Life Sciences Center, 1201 Rollins Road, Columbia, MO 65211 0001, USA
    Mol Immunol 45:65-75. 2008
  10. pmc Binding of the P2Y2 nucleotide receptor to filamin A regulates migration of vascular smooth muscle cells
    Ningpu Yu
    Department of Biochemistry, University of Missouri, Columbia, MO 65211 7310, USA
    Circ Res 102:581-8. 2008

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Functional P2Y2 nucleotide receptors mediate uridine 5'-triphosphate-induced intimal hyperplasia in collared rabbit carotid arteries
    Cheikh I Seye
    Department of Biochemistry, University of Missouri Columbia, Columbia, MO 65212, USA
    Circulation 106:2720-6. 2002
    ..P2Y2 receptor mRNA is upregulated in intimal lesions of rat aorta, but it is unclear how this G-protein-coupled receptor contributes to development of intimal hyperplasia...
  2. ncbi request reprint The P2Y2 nucleotide receptor mediates UTP-induced vascular cell adhesion molecule-1 expression in coronary artery endothelial cells
    Cheikh I Seye
    Department of Biochemistry, University of Missouri, Columbia 65212, USA
    J Biol Chem 278:24960-5. 2003
    ..These findings suggest a novel role for the P2Y2 receptor in the p38- and Rho kinase-dependent expression of VCAM-1 that mediates the recruitment of monocytes by vascular endothelium associated with the development of atherosclerosis...
  3. pmc P2 receptors in atherosclerosis and postangioplasty restenosis
    Cheikh I Seye
    Department of Biochemistry, 540C Life Sciences Center, University of Missouri Columbia, 1201 Rollins Road, Columbia, MO, 65211 7310, USA
    Purinergic Signal 2:471-80. 2006
    ....
  4. pmc P2 receptors in atherosclerosis and postangioplasty restenosis
    Cheikh I Seye
    Department of Biochemistry, University of Missouri Columbia, 540C Life Sciences Center, 1201 Rollins Road, Columbia, MO, 65211 7310, USA
    Purinergic Signal 3:153-62. 2007
    ....
  5. ncbi request reprint The P2Y2 nucleotide receptor mediates vascular cell adhesion molecule-1 expression through interaction with VEGF receptor-2 (KDR/Flk-1)
    Cheikh I Seye
    Department of Biochemistry, University of Missouri Columbia, Columbia, Missouri 65212, USA
    J Biol Chem 279:35679-86. 2004
    ..These data indicate a novel mechanism whereby a nucleotide receptor transactivates a receptor tyrosine kinase to generate an inflammatory response associated with atherosclerosis...
  6. pmc P2Y2 nucleotide receptors mediate metalloprotease-dependent phosphorylation of epidermal growth factor receptor and ErbB3 in human salivary gland cells
    Ann M Ratchford
    Department of Biochemistry, University of Missouri, Christopher S Bond Life Sciences Center, Columbia, Missouri 65211, USA
    J Biol Chem 285:7545-55. 2010
    ..These results suggest that P2Y(2)R activation in salivary gland cells promotes the formation of EGFR/ErbB3 heterodimers and metalloprotease-dependent neuregulin 1 release, resulting in the activation of both EGFR and ErbB3...
  7. pmc The P2Y2 nucleotide receptor requires interaction with alpha v integrins to access and activate G12
    Zhongji Liao
    Department of Biochemistry, Life Sciences Center, University of Missouri Columbia, Columbia, MO 65211, USA
    J Cell Sci 120:1654-62. 2007
    ....
  8. pmc Interleukin-1beta enhances nucleotide-induced and alpha-secretase-dependent amyloid precursor protein processing in rat primary cortical neurons via up-regulation of the P2Y(2) receptor
    Qiongman Kong
    Interdisciplinary Neuroscience Program, University of Missouri, Columbia, Missouri, USA
    J Neurochem 109:1300-10. 2009
    ..These results demonstrate that elevated levels of pro-inflammatory cytokines associated with neurodegenerative diseases, such as IL-1beta, can enhance non-amyloidogenic APP processing through up-regulation of the P2Y(2)R in neurons...
  9. pmc P2Y2 nucleotide receptor activation up-regulates vascular cell adhesion molecule-1 [corrected] expression and enhances lymphocyte adherence to a human submandibular gland cell line
    Olga J Baker
    Department of Biochemistry, University of Missouri Columbia, 540E Christopher S Bond Life Sciences Center, 1201 Rollins Road, Columbia, MO 65211 0001, USA
    Mol Immunol 45:65-75. 2008
    ..These results suggest that P2Y2R activation in salivary gland cells increases the EGFR-dependent expression of VCAM-1 and the binding of lymphocytes, a pathway relevant to inflammation associated with SS...
  10. pmc Binding of the P2Y2 nucleotide receptor to filamin A regulates migration of vascular smooth muscle cells
    Ningpu Yu
    Department of Biochemistry, University of Missouri, Columbia, MO 65211 7310, USA
    Circ Res 102:581-8. 2008
    ..Thus, this study demonstrates that P2Y(2)R/FLNa interaction selectively regulates spreading and migration of vascular SMCs...
  11. pmc P2Y2 nucleotide receptor-mediated responses in brain cells
    Troy S Peterson
    Department of Biochemistry, Bond Life Sciences Center, University of Missouri, Columbia, MO 65211, USA
    Mol Neurobiol 41:356-66. 2010
    ..Thus, activation of pro-inflammatory P2Y(2)Rs in glial cells can promote neuroprotective responses, suggesting that P2Y(2)Rs represent a novel pharmacological target in neurodegenerative and other pro-inflammatory diseases...
  12. ncbi request reprint Src homology 3 binding sites in the P2Y2 nucleotide receptor interact with Src and regulate activities of Src, proline-rich tyrosine kinase 2, and growth factor receptors
    Jun Liu
    Department of Biochemistry, University of Missouri Columbia, Columbia, Missouri 65212, USA
    J Biol Chem 279:8212-8. 2004
    ....
  13. pmc Proinflammatory cytokines tumor necrosis factor-alpha and interferon-gamma alter tight junction structure and function in the rat parotid gland Par-C10 cell line
    Olga J Baker
    Dept of Biochemistry, Univ of Missouri Columbia, 540A Christopher S Bond Life Sciences Center, Columbia, MO 65211, USA
    Am J Physiol Cell Physiol 295:C1191-201. 2008
    ..Our results suggest that cytokine production is an important contributor to secretory dysfunction in SS by disrupting TJ integrity of salivary epithelium...
  14. ncbi request reprint The P2Y2 nucleotide receptor interacts with alphav integrins to activate Go and induce cell migration
    Sriparna Bagchi
    Department of Biochemistry, University of Missouri, Columbia, Missouri 65211, USA
    J Biol Chem 280:39050-7. 2005
    ..Thus, the RGD-dependent interaction between the P2Y(2)R and alpha(v) integrins is necessary for the P2Y(2)R to activate G(o) and to initiate G(o)-mediated signaling events leading to chemotaxis...
  15. ncbi request reprint Cloning, up-regulation, and mitogenic role of porcine P2Y2 receptor in coronary artery smooth muscle cells
    Jianzhong Shen
    Department of Medical Pharmacology and Physiology, Center for Diabetes and Cardiovascular Health, University of Missouri Columbia, School of Medicine, USA
    Mol Pharmacol 66:1265-74. 2004
    ....
  16. ncbi request reprint P2Y2 nucleotide receptors enhance alpha-secretase-dependent amyloid precursor protein processing
    Jean M Camden
    Department of Biochemistry, University of Missouri Columbia, Columbia, Missouri 65211 7310, USA
    J Biol Chem 280:18696-702. 2005
    ..These results may contribute to an understanding of the non-amyloidogenic processing of APP...
  17. pmc P2X(7) nucleotide receptors mediate caspase-8/9/3-dependent apoptosis in rat primary cortical neurons
    Qiongman Kong
    Interdisciplinary Neuroscience Program, University of Missouri Columbia, Columbia, Missouri, USA
    Purinergic Signal 1:337-47. 2005
    ..Taken together, these data indicate that extracellular nucleotides mediate neuronal apoptosis through activation of P2X(7)Rs and their downstream signaling pathways involving JNK1, ERK and caspases 8/9/3...
  18. ncbi request reprint P2 receptors: intracellular signaling
    Laurie Erb
    Department of Biochemistry, University of Missouri Columbia, Life Sciences Center, 1201 Rollins Rd, Columbia, MO 65211, USA
    Pflugers Arch 452:552-62. 2006
    ..These intracellular signaling pathways and their regulation by P2 receptors are discussed in this review...
  19. ncbi request reprint Differential coupling of the P2Y1 receptor to Galpha14 and Galphaq/11 proteins during the development of the rat salivary gland
    Olga J Baker
    Department of Biochemistry, University of Missouri Columbia, 540E Life Sciences Center, 1201 Rollins Road, Columbia, MO 65211 7310, USA
    Arch Oral Biol 51:359-70. 2006
    ..However, P2Y1R mRNA levels do not change with age, suggesting that the age-dependent decrease in the [Ca2+]i response to P2Y1R agonists may be due to alterations in the activity of a component of the P2Y1R signalling pathway...
  20. ncbi request reprint P2 receptors in health and disease
    Gary A Weisman
    Department of Biochemistry, 540 Life Sciences Center, University of Missouri Columbia, Columbia, MO 65211, USA
    Biotechnol Genet Eng Rev 22:171-95. 2006
    ....
  21. ncbi request reprint P2Y receptors in the mammalian nervous system: pharmacology, ligands and therapeutic potential
    Gary A Weisman
    Department of Biochemistry, 540E Life Sciences Center, 1201 Rollins Road, University of Missouri, Columbia, MO 65211 7310, USA
    CNS Neurol Disord Drug Targets 11:722-38. 2012
    ....
  22. ncbi request reprint P2Y receptors activate neuroprotective mechanisms in astrocytic cells
    Nataliya E Chorna
    Department of Chemistry, Rio Piedras Campus, University of Puerto Rico, San Juan, Puerto Rico
    J Neurochem 91:119-32. 2004
    ..Taken together, our results suggest an important novel role for the P2Y2 receptor in survival and neuroprotective mechanisms under pathological conditions...
  23. ncbi request reprint Upregulation and formation of SDS-resistant oligomers of the proapoptotic factor Bax in experimental atherosclerosis
    Cheikh I Seye
    Division of Pharmacology, University of Antwerp, Wilrijk, Belgium
    Ann N Y Acad Sci 1010:738-41. 2003
  24. ncbi request reprint Mechanisms for inhibition of P2 receptors signaling in neural cells
    Fernando A Gonzalez
    Department of Chemistry, University of Puerto Rico, Rio Piedras Campus, Puerto Rico
    Mol Neurobiol 31:65-79. 2005
    ..Understanding selective mechanisms for regulating P2Y2 receptor signaling could provide novel targets for therapeutic strategies in the management of brain injury, synaptogenesis, and neurological disorders...
  25. ncbi request reprint 7-Ketocholesterol induces reversible cytochrome c release in smooth muscle cells in absence of mitochondrial swelling
    Cheikh I Seye
    Laboratory of Pharmacology, University of Antwerp, Campus Drie Eiken, Wilrijk, B 2610 Antwerp, Belgium
    Cardiovasc Res 64:144-53. 2004
    ..We investigated whether cytochrome c release participated in SMC death induced by 7-ketocholesterol and whether the processes were reversible...