Irina Sevrioukova

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Ritonavir analogues as a probe for deciphering the cytochrome P450 3A4 inhibitory mechanism
    Irina F Sevrioukova
    University of California Irvine, Department of Molecular Biology and Biochemistry, 3205 McGaugh Hall, Irvine, California 92697 3900, USA
    Curr Top Med Chem 14:1348-55. 2014
  2. ncbi request reprint Dissecting cytochrome P450 3A4-ligand interactions using ritonavir analogues
    Irina F Sevrioukova
    Departments of Molecular Biology and Biochemistry, University of California, Irvine, California 92697, USA
    Biochemistry 52:4474-81. 2013
  3. ncbi request reprint Pyridine-substituted desoxyritonavir is a more potent inhibitor of cytochrome P450 3A4 than ritonavir
    Irina F Sevrioukova
    Departments of Molecular Biology and Biochemistry, University of California, Irvine, California 92697, United States
    J Med Chem 56:3733-41. 2013
  4. pmc Understanding the mechanism of cytochrome P450 3A4: recent advances and remaining problems
    Irina F Sevrioukova
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA
    Dalton Trans 42:3116-26. 2013
  5. pmc Interaction of human cytochrome P4503A4 with ritonavir analogs
    Irina F Sevrioukova
    Department of Molecular Biology and Biochemistry, University of California, Irvine, 92697, United States
    Arch Biochem Biophys 520:108-16. 2012
  6. pmc Crystal structure of the putidaredoxin reductase x putidaredoxin electron transfer complex
    Irina F Sevrioukova
    Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697 3900, USA
    J Biol Chem 285:13616-20. 2010
  7. doi request reprint Arginines 65 and 310 in putidaredoxin reductase are critical for interaction with putidaredoxin
    Irina F Sevrioukova
    Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697 3900, USA
    Biochemistry 49:5160-6. 2010
  8. pmc Apoptosis-inducing factor: structure, function, and redox regulation
    Irina F Sevrioukova
    Department of Molecular Biology and Biochemistry, University of California Irvine, CA 92697 3900, USA
    Antioxid Redox Signal 14:2545-79. 2011
  9. pmc Structure and mechanism of the complex between cytochrome P4503A4 and ritonavir
    Irina F Sevrioukova
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697 3900, USA
    Proc Natl Acad Sci U S A 107:18422-7. 2010
  10. pmc Redox-linked conformational dynamics in apoptosis-inducing factor
    Irina F Sevrioukova
    Department of Molecular Biology and Biochemistry, University of California, Irvine, 92697 3900, USA
    J Mol Biol 390:924-38. 2009

Research Grants

  1. Structure/Function Studies on Flavoproteins
    Irina Sevrioukova; Fiscal Year: 2007
  2. Structure/Function Studies on Flavoproteins
    Irina Sevrioukova; Fiscal Year: 2003
  3. Structure/Function Studies on Flavoproteins
    Irina Sevrioukova; Fiscal Year: 2004
  4. Structure/Function Studies on Flavoproteins
    Irina Sevrioukova; Fiscal Year: 2005
  5. Structure/Function Studies on Flavoproteins
    Irina Sevrioukova; Fiscal Year: 2006

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Ritonavir analogues as a probe for deciphering the cytochrome P450 3A4 inhibitory mechanism
    Irina F Sevrioukova
    University of California Irvine, Department of Molecular Biology and Biochemistry, 3205 McGaugh Hall, Irvine, California 92697 3900, USA
    Curr Top Med Chem 14:1348-55. 2014
    ....
  2. ncbi request reprint Dissecting cytochrome P450 3A4-ligand interactions using ritonavir analogues
    Irina F Sevrioukova
    Departments of Molecular Biology and Biochemistry, University of California, Irvine, California 92697, USA
    Biochemistry 52:4474-81. 2013
    ..Overall, however, the end group contributes less to the ligand association process, which, in contrast, is greatly facilitated by the polar interactions mediated by the active site Ser119. ..
  3. ncbi request reprint Pyridine-substituted desoxyritonavir is a more potent inhibitor of cytochrome P450 3A4 than ritonavir
    Irina F Sevrioukova
    Departments of Molecular Biology and Biochemistry, University of California, Irvine, California 92697, United States
    J Med Chem 56:3733-41. 2013
    ..Additionally, Ser119 was identified as a key residue assisting binding of ritonavir-like inhibitors, which emphasizes the importance of polar interactions in the CYP3A4-ligand association...
  4. pmc Understanding the mechanism of cytochrome P450 3A4: recent advances and remaining problems
    Irina F Sevrioukova
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA
    Dalton Trans 42:3116-26. 2013
    ..Owing to its importance in drug development and therapy, CYP3A4 has been the most extensively studied mammalian P450. In this review we provide an overview on recent progress and remaining problems in the CYP3A4 research...
  5. pmc Interaction of human cytochrome P4503A4 with ritonavir analogs
    Irina F Sevrioukova
    Department of Molecular Biology and Biochemistry, University of California, Irvine, 92697, United States
    Arch Biochem Biophys 520:108-16. 2012
    ....
  6. pmc Crystal structure of the putidaredoxin reductase x putidaredoxin electron transfer complex
    Irina F Sevrioukova
    Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697 3900, USA
    J Biol Chem 285:13616-20. 2010
    ....
  7. doi request reprint Arginines 65 and 310 in putidaredoxin reductase are critical for interaction with putidaredoxin
    Irina F Sevrioukova
    Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697 3900, USA
    Biochemistry 49:5160-6. 2010
    ....
  8. pmc Apoptosis-inducing factor: structure, function, and redox regulation
    Irina F Sevrioukova
    Department of Molecular Biology and Biochemistry, University of California Irvine, CA 92697 3900, USA
    Antioxid Redox Signal 14:2545-79. 2011
    ....
  9. pmc Structure and mechanism of the complex between cytochrome P4503A4 and ritonavir
    Irina F Sevrioukova
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697 3900, USA
    Proc Natl Acad Sci U S A 107:18422-7. 2010
    ....
  10. pmc Redox-linked conformational dynamics in apoptosis-inducing factor
    Irina F Sevrioukova
    Department of Molecular Biology and Biochemistry, University of California, Irvine, 92697 3900, USA
    J Mol Biol 390:924-38. 2009
    ..Structural findings agree with biochemical data and support the hypothesis that both normal and apoptogenic functions of AIF are controlled by NADH...
  11. ncbi request reprint Laser flash induced electron transfer in P450cam monooxygenase: putidaredoxin reductase-putidaredoxin interaction
    I F Sevrioukova
    Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92612 3900, USA
    Biochemistry 40:10592-600. 2001
    ..Transient kinetics as a function of ionic strength suggest that, in contrast to the Pdx-P450cam redox couple where complex formation is predominantly electrostatic, the Pdx-Pdr association is driven by nonelectrostatic interactions...
  12. ncbi request reprint Putidaredoxin reductase, a new function for an old protein
    Irina F Sevrioukova
    Department of Molecular Biology and the Program in Macromolecular Structure, University of California, Irvine 92612 3900, USA
    J Biol Chem 277:25831-9. 2002
    ..This function of the flavoprotein can be dissociated from electron transfer to putidaredoxin. Similarity of Pdr to the enzymes of the glutathione reductase family is discussed...
  13. ncbi request reprint Crystal structure of putidaredoxin, the [2Fe-2S] component of the P450cam monooxygenase system from Pseudomonas putida
    Irina F Sevrioukova
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92612 3900, USA
    J Mol Biol 333:377-92. 2003
    ..Therefore, Trp106, previously shown to be important in the Pdr-to-Pdx and Pdx-to-P450cam electron transfer reactions is in a position to regulate and/or mediate electron transfer to or from the [2Fe-2S] center of Pdx...
  14. ncbi request reprint Crystal structure of putidaredoxin reductase from Pseudomonas putida, the final structural component of the cytochrome P450cam monooxygenase
    Irina F Sevrioukova
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92612 3900, USA
    J Mol Biol 336:889-902. 2004
    ..The crystallographic model of Pdr explains differences in the electron transfer mechanism in the Pdr-putidaredoxin redox couple and their mammalian counterparts, adrenodoxin reductase and adrenodoxin...
  15. ncbi request reprint Redox-dependent structural reorganization in putidaredoxin, a vertebrate-type [2Fe-2S] ferredoxin from Pseudomonas putida
    Irina F Sevrioukova
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92612 3900, USA
    J Mol Biol 347:607-21. 2005
    ..This redox-linked change in surface properties is likely to be responsible for different binding affinity of oxidized and reduced Pdx to the hemoprotein...
  16. doi request reprint Production and characterization of a functional putidaredoxin reductase-putidaredoxin covalent complex
    Inna Y Churbanova
    Department of Molecular Biology, University of California, Irvine, California 92697 3900, USA
    Biochemistry 49:58-67. 2010
    ....
  17. pmc Putidaredoxin-to-cytochrome P450cam electron transfer: differences between the two reductive steps required for catalysis
    Vadim Yu Kuznetsov
    Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697 3900, USA
    Biochemistry 45:11934-44. 2006
    ....
  18. ncbi request reprint The putidaredoxin reductase-putidaredoxin electron transfer complex: theoretical and experimental studies
    Vadim Yu Kuznetsov
    Department of Molecular Biology, University of California, Irvine, California 92612 3900, USA
    J Biol Chem 280:16135-42. 2005
    ....
  19. ncbi request reprint Electron transfer between cytochrome P450cin and its FMN-containing redox partner, cindoxin
    Novelle Kimmich
    Departments of Molecular Biology and Biochemistry, Chemistry and Physiology, and Biophysics, University of California, Irvine, CA 92612, USA
    J Biol Chem 282:27006-11. 2007
    ..Here we characterize the kinetics and specificity of electron transfer between cindoxin and P450cin as well as discuss the influence of possible binding surface interactions using homology models...
  20. ncbi request reprint Redox-dependent changes in molecular properties of mitochondrial apoptosis-inducing factor
    Inna Y Churbanova
    Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697 3900, USA
    J Biol Chem 283:5622-31. 2008
    ....
  21. ncbi request reprint Photoreduction of the active site of the metalloprotein putidaredoxin by synchrotron radiation
    Mary C Corbett
    Department of Chemistry, Stanford University, Stanford, CA 94305 5080, USA
    Acta Crystallogr D Biol Crystallogr 63:951-60. 2007
    ..The study also illustrates the need for direct measurement of the redox states of the metals, through X-ray absorption spectroscopy, simultaneously with the crystallographic measurements...

Research Grants5

  1. Structure/Function Studies on Flavoproteins
    Irina Sevrioukova; Fiscal Year: 2007
    ..The study will explain the mechanisms of electron transfer and dithiol/disulfide oxidoreduction catalyzed by putidaredoxin reductase and will provide an insight into the mechanism and function of apoptosis inducing factor. ..
  2. Structure/Function Studies on Flavoproteins
    Irina Sevrioukova; Fiscal Year: 2003
    ..The study will explain the mechanisms of electron transfer and dithiol/disulfide oxidoreduction catalyzed by putidaredoxin reductase and will provide an insight into the mechanism and function of apoptosis inducing factor. ..
  3. Structure/Function Studies on Flavoproteins
    Irina Sevrioukova; Fiscal Year: 2004
    ..The study will explain the mechanisms of electron transfer and dithiol/disulfide oxidoreduction catalyzed by putidaredoxin reductase and will provide an insight into the mechanism and function of apoptosis inducing factor. ..
  4. Structure/Function Studies on Flavoproteins
    Irina Sevrioukova; Fiscal Year: 2005
    ..The study will explain the mechanisms of electron transfer and dithiol/disulfide oxidoreduction catalyzed by putidaredoxin reductase and will provide an insight into the mechanism and function of apoptosis inducing factor. ..
  5. Structure/Function Studies on Flavoproteins
    Irina Sevrioukova; Fiscal Year: 2006
    ..The study will explain the mechanisms of electron transfer and dithiol/disulfide oxidoreduction catalyzed by putidaredoxin reductase and will provide an insight into the mechanism and function of apoptosis inducing factor. ..