Irina F Sevrioukova
Affiliation: University of California
Sevrioukova I, Poulos T. Pyridine-substituted desoxyritonavir is a more potent inhibitor of cytochrome P450 3A4 than ritonavir. J Med Chem. 2013;56:3733-41 pubmed publisher
..Additionally, Ser119 was identified as a key residue assisting binding of ritonavir-like inhibitors, which emphasizes the importance of polar interactions in the CYP3A4-ligand association. ..
Sevrioukova I, Poulos T, Churbanova I. Crystal structure of the putidaredoxin reductase x putidaredoxin electron transfer complex. J Biol Chem. 2010;285:13616-20 pubmed publisher
Sevrioukova I, Poulos T. Ritonavir analogues as a probe for deciphering the cytochrome P450 3A4 inhibitory mechanism. Curr Top Med Chem. 2014;14:1348-55 pubmed
Sevrioukova I, Poulos T. Structure and mechanism of the complex between cytochrome P4503A4 and ritonavir. Proc Natl Acad Sci U S A. 2010;107:18422-7 pubmed publisher
Sevrioukova I, Poulos T. Current Approaches for Investigating and Predicting Cytochrome P450 3A4-Ligand Interactions. Adv Exp Med Biol. 2015;851:83-105 pubmed publisher
Sevrioukova I, Hazzard J, Tollin G, Poulos T. Laser flash induced electron transfer in P450cam monooxygenase: putidaredoxin reductase-putidaredoxin interaction. Biochemistry. 2001;40:10592-600 pubmed
..Transient kinetics as a function of ionic strength suggest that, in contrast to the Pdx-P450cam redox couple where complex formation is predominantly electrostatic, the Pdx-Pdr association is driven by nonelectrostatic interactions. ..
Sevrioukova I, Garcia C, Li H, Bhaskar B, Poulos T. Crystal structure of putidaredoxin, the [2Fe-2S] component of the P450cam monooxygenase system from Pseudomonas putida. J Mol Biol. 2003;333:377-92 pubmed
..Therefore, Trp106, previously shown to be important in the Pdr-to-Pdx and Pdx-to-P450cam electron transfer reactions is in a position to regulate and/or mediate electron transfer to or from the [2Fe-2S] center of Pdx. ..
Sevrioukova I. Apoptosis-inducing factor: structure, function, and redox regulation. Antioxid Redox Signal. 2011;14:2545-79 pubmed publisher
Sevrioukova I, Poulos T. Interaction of human cytochrome P4503A4 with ritonavir analogs. Arch Biochem Biophys. 2012;520:108-16 pubmed publisher