D W Severson

Summary

Affiliation: University of Notre Dame
Country: USA

Publications

  1. doi request reprint Mosquito genomics: progress and challenges
    David W Severson
    Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556, USA
    Annu Rev Entomol 57:143-66. 2012
  2. pmc Influence of urban landscapes on population dynamics in a short-distance migrant mosquito: evidence for the dengue vector Aedes aegypti
    Ryan R Hemme
    Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana, United States of America
    PLoS Negl Trop Dis 4:e634. 2010
  3. pmc Global cross-talk of genes of the mosquito Aedes aegypti in response to dengue virus infection
    Susanta K Behura
    Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, USA
    PLoS Negl Trop Dis 5:e1385. 2011
  4. pmc Comparative expression profiles of midgut genes in dengue virus refractory and susceptible Aedes aegypti across critical period for virus infection
    Chitra Chauhan
    Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, United States of America
    PLoS ONE 7:e47350. 2012
  5. pmc Stage-specific transcription during development of Aedes aegypti
    Brent W Harker
    Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN 46556, USA
    BMC Dev Biol 13:29. 2013
  6. pmc Overlapping genes of Aedes aegypti: evolutionary implications from comparison with orthologs of Anopheles gambiae and other insects
    Susanta K Behura
    Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA
    BMC Evol Biol 13:124. 2013
  7. pmc Nucleotide substitutions in dengue virus serotypes from Asian and American countries: insights into intracodon recombination and purifying selection
    Susanta K Behura
    Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame, 46556, Notre Dame, IN, USA
    BMC Microbiol 13:37. 2013
  8. pmc Analysis of 14 BAC sequences from the Aedes aegypti genome: a benchmark for genome annotation and assembly
    Neil F Lobo
    Center for Global Health and Infectious Diseases, Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556 0369, USA
    Genome Biol 8:R88. 2007
  9. pmc Genome-based polymorphic microsatellite development and validation in the mosquito Aedes aegypti and application to population genetics in Haiti
    Diane D Lovin
    Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556 5645 USA
    BMC Genomics 10:590. 2009
  10. ncbi request reprint Genetic and physical mapping in mosquitoes: molecular approaches
    D W Severson
    Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556, USA
    Annu Rev Entomol 46:183-219. 2001

Research Grants

Collaborators

Detail Information

Publications47

  1. doi request reprint Mosquito genomics: progress and challenges
    David W Severson
    Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556, USA
    Annu Rev Entomol 57:143-66. 2012
    ..Here we review the current status of genome research in mosquitoes and identify potential areas for further investigations...
  2. pmc Influence of urban landscapes on population dynamics in a short-distance migrant mosquito: evidence for the dengue vector Aedes aegypti
    Ryan R Hemme
    Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana, United States of America
    PLoS Negl Trop Dis 4:e634. 2010
    ..Population replacement and genetic control strategies currently under consideration are also dependent upon a thorough understanding of mosquito dispersal in urban settings...
  3. pmc Global cross-talk of genes of the mosquito Aedes aegypti in response to dengue virus infection
    Susanta K Behura
    Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, USA
    PLoS Negl Trop Dis 5:e1385. 2011
    ..The early time periods after infection with DENV define critical cellular processes that determine ultimate success or failure of the virus to establish infection in the mosquito...
  4. pmc Comparative expression profiles of midgut genes in dengue virus refractory and susceptible Aedes aegypti across critical period for virus infection
    Chitra Chauhan
    Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, United States of America
    PLoS ONE 7:e47350. 2012
    ..How A. aegypti responds to DENV infection relative to which genes and associated pathways contribute to its differential susceptibility as a vector is not well defined...
  5. pmc Stage-specific transcription during development of Aedes aegypti
    Brent W Harker
    Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN 46556, USA
    BMC Dev Biol 13:29. 2013
    ..However, detailed knowledge of gene expression patterns pertaining to developmental stages of A. aegypti is largely lacking...
  6. pmc Overlapping genes of Aedes aegypti: evolutionary implications from comparison with orthologs of Anopheles gambiae and other insects
    Susanta K Behura
    Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA
    BMC Evol Biol 13:124. 2013
    ..The overlapping gene pairs of A. aegypti were further compared with orthologs of other selected insects to conduct several hypothesis driven investigations relating to the evolution and rearrangement of overlapping genes...
  7. pmc Nucleotide substitutions in dengue virus serotypes from Asian and American countries: insights into intracodon recombination and purifying selection
    Susanta K Behura
    Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame, 46556, Notre Dame, IN, USA
    BMC Microbiol 13:37. 2013
    ..Numerous studies have been performed that investigated genetic diversity of DENV, but the precise mechanism(s) of dengue virus evolution are not well understood...
  8. pmc Analysis of 14 BAC sequences from the Aedes aegypti genome: a benchmark for genome annotation and assembly
    Neil F Lobo
    Center for Global Health and Infectious Diseases, Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556 0369, USA
    Genome Biol 8:R88. 2007
    ..PCR and sequencing were used to experimentally confirm expression and sequence of a subset of these transcripts...
  9. pmc Genome-based polymorphic microsatellite development and validation in the mosquito Aedes aegypti and application to population genetics in Haiti
    Diane D Lovin
    Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556 5645 USA
    BMC Genomics 10:590. 2009
    ....
  10. ncbi request reprint Genetic and physical mapping in mosquitoes: molecular approaches
    D W Severson
    Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556, USA
    Annu Rev Entomol 46:183-219. 2001
    ..This review focuses on advances in genome-based analysis and their specific applications to mosquitoes...
  11. pmc Enhancing genome investigations in the mosquito Culex quinquefasciatus via BAC library construction and characterization
    Paul V Hickner
    Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA
    BMC Res Notes 4:358. 2011
    ..abstract:..
  12. ncbi request reprint Investigations of dengue-2 susceptibility and body size among Aedes aegypti populations
    J R Schneider
    Department of Biological Sciences, Center for Global Health and Infectious Diseases, University of Notre Dame, Notre Dame, Indiana, U S A
    Med Vet Entomol 21:370-6. 2007
    ..We suggest that either the two traits are genetically independent or that our ability to detect interactions between them was limited by their respective inheritances as quantitative traits...
  13. ncbi request reprint Comparative genome analysis of the yellow fever mosquito Aedes aegypti with Drosophila melanogaster and the malaria vector mosquito Anopheles gambiae
    D W Severson
    Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA David W
    J Hered 95:103-13. 2004
    ....
  14. ncbi request reprint A targeted approach to the identification of candidate genes determining susceptibility to Plasmodium gallinaceum in Aedes aegypti
    I Morlais
    Center for Tropical Disease Research and Training, Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA
    Mol Genet Genomics 269:753-64. 2003
    ..Here we describe their isolation and discuss their putative roles in parasite-mosquito interactions and their use as potential targets in strategies designed to block transmission of malaria...
  15. pmc Identification of a polymorphic mucin-like gene expressed in the midgut of the mosquito, Aedes aegypti, using an integrated bulked segregant and differential display analysis
    I Morlais
    Center for Tropical Disease Research and Training, Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556, USA
    Genetics 158:1125-36. 2001
    ..The AeIMUC1 gene chromosome location and allelic polymorphisms raise the possibility that the protein might be involved in parasite-mosquito interactions...
  16. ncbi request reprint Characterization of an Aedes aegypti bacterial artificial chromosome (BAC) library and chromosomal assignment of BAC clones for physical mapping quantitative trait loci that influence Plasmodium susceptibility
    L V Jiménez
    Center for Tropical Disease Research and Training, Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556 5645, USA
    Insect Mol Biol 13:37-44. 2004
    ....
  17. ncbi request reprint Comparative linkage map development and identification of an autosomal locus for insensitive acetylcholinesterase-mediated insecticide resistance in Culex tritaeniorhynchus
    A Mori
    Department of Biological Sciences, University of Notre Dame, IN 46556 5645, USA
    Insect Mol Biol 10:197-203. 2001
    ..No evidence for a second Ace gene was observed, even under very low stringency hybridization conditions...
  18. pmc RNAi knock-downs support roles for the mucin-like (AeIMUC1) gene and short-chain dehydrogenase/reductase (SDR) gene in Aedes aegypti susceptibility to Plasmodium gallinaceum
    M Berois
    Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN 46556, U S A
    Med Vet Entomol 26:112-5. 2012
    ..Overall, these results suggest that both AeIMUC1 and SDR play a role in Ae. aegypti vector competence to P. gallinaceum...
  19. pmc Quantitative trait loci determining autogeny and body size in the Asian tiger mosquito (Aedes albopictus)
    A Mori
    Department of Biological Sciences, Center for Global Health and Infectious Diseases, University of Notre Dame, Notre Dame, IN 46556 5645, USA
    Heredity (Edinb) 101:75-82. 2008
    ..Correlation between autogeny and body size may reflect an increased ability for larger females to accumulate sufficient nutrient reserves to support oogenesis without the requirement for a blood meal...
  20. ncbi request reprint Complete mitochondrial DNA sequence and amino acid analysis of the cytochrome C oxidase subunit I (COI) from Aedes aegypti
    I Morlais
    Department of Biological Sciences, Center for Tropical Disease Research and Training, University of Notre Dame, Notre Dame, IN 46556, USA
    DNA Seq 13:123-7. 2002
    ..All SNPs occurred as synonymous transitions such that the peptide sequence is conserved among A. aegypti strains. RT-PCR analysis showed that COI is expressed at similar levels in all developmental stages and tissues...
  21. pmc Coadaptation of isoacceptor tRNA genes and codon usage bias for translation efficiency in Aedes aegypti and Anopheles gambiae
    S K Behura
    Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA
    Insect Mol Biol 20:177-87. 2011
    ..Our results suggest that these genes and the related pathways may be under translational selection in these mosquitoes...
  22. ncbi request reprint Natural skip oviposition of the mosquito Aedes aegypti indicated by codominant genetic markers
    Y M Colton
    Center for Tropical Disease Research and Training, Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, U S A
    Med Vet Entomol 17:195-204. 2003
    ..Members of 19 predicted families clustered as groups across multiple containers, providing molecular evidence for skip-oviposition behaviour in Ae. aegypti females, whereby individual females oviposit in more than one container...
  23. ncbi request reprint Intraspecific DNA variation in nuclear genes of the mosquito Aedes aegypti
    I Morlais
    Center for Tropical Disease Research and Training, Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA
    Insect Mol Biol 12:631-9. 2003
    ....
  24. ncbi request reprint DNA barcoding of parasites and invertebrate disease vectors: what you don't know can hurt you
    Nora J Besansky
    Center for Tropical Disease Research and Training, Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA
    Trends Parasitol 19:545-6. 2003
  25. ncbi request reprint Aedes aegypti genomics
    David W Severson
    Department of Biological Sciences, Center for Tropical Disease Research and Training, University of Notre Dame, Notre Dame, IN 46556, USA
    Insect Biochem Mol Biol 34:715-21. 2004
    ..This information will be invaluable to the global effort to develop novel strategies for preventing arthropod-borne disease transmission...
  26. ncbi request reprint Linkage map organization of expressed sequence tags and sequence tagged sites in the mosquito, Aedes aegypti
    D W Severson
    Center for Tropical Disease Research and Training, Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA
    Insect Mol Biol 11:371-8. 2002
    ..Access to sequence data for all markers will facilitate their continued development for use in high-throughput SNP marker analyses and also provides additional physical anchor points for an anticipated genome sequencing effort...
  27. ncbi request reprint Genetic basis for reproductive diapause is correlated with life history traits within the Culex pipiens complex
    A Mori
    Center for Global Health and Infectious Diseases, Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556 5645, USA
    Insect Mol Biol 16:515-24. 2007
    ....
  28. pmc Comparative analysis of nuclear tRNA genes of Nasonia vitripennis and other arthropods, and relationships to codon usage bias
    S K Behura
    Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA
    Insect Mol Biol 19:49-58. 2010
    ..Furthermore, we also present evidence that the copy number of isoacceptor tRNAs (those having a different anticodon but charge the same amino acid) is correlated with codon usage patterns of highly expressed genes in Nasonia...
  29. ncbi request reprint Microsatellite isolation and linkage group identification in the yellow fever mosquito Aedes aegypti
    Eric W Chambers
    Center for Global Health and Infectious Diseases, Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA
    J Hered 98:202-10. 2007
    ..Additionally, most A. aegypti microsatellites are closely associated with repetitive elements that likely accounts for the limited success in developing an extensive panel of microsatellite marker loci...
  30. ncbi request reprint Cage trials using an endogenous meiotic drive gene in the mosquito Aedes aegypti to promote population replacement
    Sung Jae Cha
    Center for Tropical Disease Research and Training, Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, USA
    Am J Trop Med Hyg 74:62-8. 2006
    ....
  31. ncbi request reprint Population dynamics of an endogenous meiotic drive system in Aedes aegypti in Trinidad
    Sung Jae Cha
    Center for Tropical Disease Research and Training, Department of Biological Sciences University of Notre Dame, Notre Dame, Indiana 46556, USA
    Am J Trop Med Hyg 75:70-7. 2006
    ..Continued studies of the dynamics of the M(D) system in natural populations are critical to considerations of its use in population replacement...
  32. pmc Molecular cloning and characterization of the complete acetylcholinesterase gene (Ace1) from the mosquito Aedes aegypti with implications for comparative genome analysis
    Akio Mori
    Center for Global Health and Infectious Diseases, Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556 5645, USA
    Insect Biochem Mol Biol 37:667-74. 2007
    ..The Ace1 locus maps to the p-arm of chromosome 3, which corresponds to the orthologous genome regions in Culex spp. and An. gambiae...
  33. ncbi request reprint Reinvestigation of an endogenous meiotic drive system in the mosquito, Aedes aegypti (Diptera: Culicidae)
    Akio Mori
    Center for Tropical Disease Research and Training, Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556 5645, USA
    J Med Entomol 41:1027-33. 2004
    ..aegypti into natural populations where M(D) and insensitive m3 alleles are likely segregating...
  34. pmc Environmental conditions in water storage drums and influences on Aedes aegypti in Trinidad, West Indies
    Ryan R Hemme
    Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, IN 46556, USA
    Acta Trop 112:59-66. 2009
    ..aegypti development. Exposing water storage drums to direct sunlight or increased heat may be used in conjunction with sealing containers to reduce production of A. aegypti when draining and chemical treatment are impractical...
  35. ncbi request reprint Utility of comparative anchor-tagged sequences as physical anchors for comparative genome analysis among the Culicidae
    Eric W Chambers
    Center for Tropical Disease Research and Training, Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556, USA
    Am J Trop Med Hyg 69:98-104. 2003
    ..aegypti, and more importantly demonstrate an efficient strategy for developing comparative anchor marker loci for any species of Culicidae...
  36. ncbi request reprint The Anopheles genome and comparative insect genomics
    Thomas C Kaufman
    Department of Biology, Indiana University, Bloomington, IN 47405, USA
    Science 298:97-8. 2002
    ..The Anopheles gambiae genome sequence, coupled with the Drosophila melanogaster genome sequence, provides a better understanding of the insects, a group that contains our friends, foes, and competitors...
  37. pmc Genome sequence of Aedes aegypti, a major arbovirus vector
    Vishvanath Nene
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Science 316:1718-23. 2007
    ..An increase in genes encoding odorant binding, cytochrome P450, and cuticle domains relative to An. gambiae suggests that members of these protein families underpin some of the biological differences between the two mosquito species...
  38. pmc Michelob_x is the missing inhibitor of apoptosis protein antagonist in mosquito genomes
    Lei Zhou
    Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, 32610, USA
    EMBO Rep 6:769-74. 2005
    ..Its proapoptotic activity is totally dependent on the IAP-binding motif. Like reaper in Drosophila, mx is transcriptionally induced by ultraviolet irradiation to mediate cell death...
  39. pmc VectorBase: a home for invertebrate vectors of human pathogens
    Daniel Lawson
    European Bioinformatics Institute EMBL EBI, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK
    Nucleic Acids Res 35:D503-5. 2007
    ....
  40. ncbi request reprint Surveillance of dengue fever cases using a novel Aedes aegypti population sampling method in Trinidad, West Indies: the cardinal points approach
    Dave D Chadee
    Department of Life Sciences, University of the West Indies, St Augustine, Trinidad and Tobago
    Acta Trop 104:1-7. 2007
    ....
  41. pmc Evolutionary dynamics of immune-related genes and pathways in disease-vector mosquitoes
    Robert M Waterhouse
    Division of Cell and Molecular Biology, Faculty of Natural Sciences, Imperial College London, London SW7 2AZ, UK
    Science 316:1738-43. 2007
    ..These dynamics reflect in part continuous readjustment between accommodation and rejection of pathogens and suggest how innate immunity may have evolved...
  42. pmc Dynamics of molecular markers linked to the resistance loci in a mosquito-Plasmodium system
    Guiyun Yan
    Department of Animal Health and Biomedical Sciences, University of Wisconsin, Madison 53706, USA
    Genetics 164:511-9. 2003
    ..The results are discussed in relation to the proposed malaria control strategy through genetic disruption of vector competence...
  43. ncbi request reprint Culicine genomics
    Dennis L Knudson
    Department of Bioagricultural Sciences and Pest Management, Colorado State University, Fort Collins, CO 80523, USA
    Insect Biochem Mol Biol 32:1193-7. 2002
  44. ncbi request reprint Isolation and characterization of the RanGAP gene in the mosquito Aedes aegypti
    Sung Jae Cha
    Department of Molecular Microbiology and Immunology, Johns Hopkins School of Public Health, Malaria Research Institute, Baltimore, MD, USA
    DNA Seq 17:223-30. 2006
    ..The RanGAP locus was mapped to the q-arm of chromosome 2. Because the meiotic drive gene (M(D)) in A. aegypti was previously shown to be tightly linked with the sex determining locus on chromosome 1, RanGAP is likely not the M(D) gene...
  45. ncbi request reprint An amino acid substitution attributable to insecticide-insensitivity of acetylcholinesterase in a Japanese encephalitis vector mosquito, Culex tritaeniorhynchus
    Takeshi Nabeshima
    Institute of Agriculture and Forestry, University of Tsukuba, Tsukuba, Ibaraki 305 8572, Japan
    Biochem Biophys Res Commun 313:794-801. 2004
    ..The F455W replacement in the Ace2 gene is solely responsible for the insecticide-insensitivity of AChE in TYM mosquitoes...
  46. ncbi request reprint The Aedes aegypti glutathione transferase family
    Nongkran Lumjuan
    Vector Group, Liverpool School of Tropical Medicine, Pembroke Palace, Liverpool L3 5QA, UK
    Insect Biochem Mol Biol 37:1026-35. 2007
    ....

Research Grants16

  1. Diapause in Culex Mosquitoes
    David Severson; Fiscal Year: 2009
    ..The proposed research will provide valuable new information on the biology of the mosquito relating to the ability of adult females to survive temperate climate winter in a diapause state. ..
  2. Molecular Genetics of Dengue Resistance in Mosquitoes
    David Severson; Fiscal Year: 2007
    ..abstract_text> ..
  3. Molecular Genetics of Dengue Resistance in Mosquitoes
    David Severson; Fiscal Year: 2006
    ..abstract_text> ..
  4. Molecular Genetics of Dengue Resistance in Mosquitoes
    David Severson; Fiscal Year: 2005
    ..abstract_text> ..
  5. Molecular Genetics of Dengue Resistance in Mosquitoes
    David Severson; Fiscal Year: 2004
    ..abstract_text> ..
  6. RFLP MAPPING OF PLASMODIUM REFACTORY GENES IN MOSQUITOES
    David Severson; Fiscal Year: 2004
    ..abstract_text> ..
  7. The Aedes aegypti Genome Project
    David Severson; Fiscal Year: 2003
    ..The long range goal is to promote and foster collaboration between funding agencies to support an effort to sequence the entire A. aegypti genome. ..
  8. RFLP MAPPING OF PLASMODIUM REFACTORY GENES IN MOSQUITOES
    David Severson; Fiscal Year: 2003
    ..abstract_text> ..
  9. RFLP MAPPING OF PLASMODIUM REFACTORY GENES IN MOSQUITOES
    David Severson; Fiscal Year: 2002
    ..abstract_text> ..
  10. RFLP MAPPING OF PLASMODIUM REFACTORY GENES IN MOSQUITOES
    David Severson; Fiscal Year: 2001
    ..abstract_text> ..
  11. RFLP MAPPING OF PLASMODIUM REFACTORY GENES IN MOSQUITOES
    David Severson; Fiscal Year: 2000
    ..abstract_text> ..
  12. RFLP MAPPING OF PLASMODIUM REFRACTORY GENES IN MOSQUITOS
    David Severson; Fiscal Year: 1999
    ..gambiae using markers developed for Ae. aegypti in cooperation with The Johns Hopkins University. ..
  13. Diapause in Culex Mosquitoes
    David W Severson; Fiscal Year: 2010
    ..The proposed research will provide valuable new information on the biology of the mosquito relating to the ability of adult females to survive temperate climate winter in a diapause state. ..