Research Topics
Species | William N SetzerSummaryAffiliation: University of Alabama in Huntsville Country: USA Publications
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Publications
Essential oils and anxiolytic aromatherapyWilliam N Setzer
Department of Chemistry, University of Alabama in Huntsville, Huntsville, Alabama 35899, USA
Nat Prod Commun 4:1305-16. 2009..This review discusses the chemical constituents and CNS effects of these aromatherapeutic essential oils, as well as recent studies on additional essential oils with anxiolytic activities...
In-silico investigation of antitrypanosomal phytochemicals from Nigerian medicinal plantsWilliam N Setzer
Department of Chemistry, University of Alabama in Huntsville, Huntsville, Alabama, USA
PLoS Negl Trop Dis 6:e1727. 2012..Many affected people live in remote areas with limited access to health services and, therefore, rely on traditional herbal medicines for treatment...- HPLC-NMR/HPLC-MS analysis of the bark extract of Stauranthus perforatusWilliam N Setzer
Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
Phytochem Anal 14:54-9. 2003.... 
A theoretical investigation of cytotoxic activity of celastroid triterpenoidsWilliam N Setzer
Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
J Mol Model 15:197-201. 2009....- A DFT analysis of thermal decomposition reactions important to natural productsWilliam N Setzer
Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
Nat Prod Commun 5:993-8. 2010..g., boiling aqueous solutions, gas-chromatograph injection ports). Activation enthalpies for pyrolytic eliminations are around 40 kcal/mol and are unlikely to occur during extraction or GC analysis... - A computational investigation of sulfur-containing heterocyclic components from the anal sac secretions of Mustela speciesWilliam N Setzer
Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
J Mol Model 14:967-73. 2008.... - Ab initio analysis of the Cope rearrangement of germacrane sesquiterpenoidsWilliam N Setzer
Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
J Mol Model 14:335-42. 2008..Apparently, the generally small energy differences between the two forms in these sesquiterpenoids cannot be adequately reproduced at these levels of calculation... - Lignin-derived oak phenolics: a theoretical examination of additional potential health benefits of red wineWilliam N Setzer
Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
J Mol Model 17:1841-5. 2011..Thus, lignin-derived oak phenolics, although found in small concentrations, may contribute to the beneficial antioxidant, chemopreventive, and cardioprotective effects of red wine... - Bioactive principles in the bark of Pilidiostigma tropicumWilliam N Setzer
Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
J Mol Model 12:703-11. 2006..A favorable pi-pi interaction between rhodomyrtoxin B and the cytosine-guanine base pair is predicted, but the orientation of the interaction cannot be predicted based on frontier molecular orbitals... - Isolation of cupanioside, a novel cytotoxic and antibacterial long-chain fatty alcohol glycoside from the bark of Cupania glabraWilliam N Setzer
Department of Chemistry, University of Alabama in Huntsville, Huntsville, Alabama, USA
Planta Med 71:686-8. 2005..The structure was elucidated by analysis of 2D-NMR spectra... - Leaf essential oil composition of five Zanthoxylum species from Monteverde, Costa RicaWilliam N Setzer
Department of Chemistry, University of Alabama in Huntsville, Huntsville, Alabama 35899, USA
Mol Divers 9:3-13. 2005..monophyllum, Z. acuminatum, Z. fagara, and Zanthoxylum sp. nov. Linalool, 4-terpineol, alpha-terpineol, and trans-2-hexenol, are found in all of the Zanthoxylum species examined in this study... - Conformational analysis of thioether musks using density functional theoryWilliam N Setzer
Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA E Mail Tel 1 256 824 6519
Int J Mol Sci 10:3488-501. 2009..Unfortunately, there was little agreement between the computational methods at the levels of theory used in this study... - Antimicrobial activity of Artemisia douglasiana leaf essential oilWilliam N Setzer
Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
Fitoterapia 75:192-200. 2004..The essential oil shows limited antimicrobial activity in vitro, so it is unclear if the oil exerts a direct antimicrobial effect in vivo, or plays some role in stimulation of host defenses... - Drugs from the cloudforest: the search for new medicines from Monteverde, Costa RicaWilliam N Setzer
Department of Chemistry, University of Alabama in Huntsville, Huntsville, Alabama 35899, USA
Nat Prod Commun 6:1549-58. 2011..The group has focused primarily on anticancer agents, antimicrobial agents, and antiparasitic agents. This review presents an overview of some of our efforts in natural products drug discovery from Monteverde, Costa Rica... - Plant-derived triterpenoids as potential antineoplastic agentsW N Setzer
Department of Chemistry, The University of Alabama in Huntsville, Huntsville, AL 35899, USA
Mini Rev Med Chem 3:540-56. 2003..This review covers the recent developments regarding antineoplastic/cytotoxic triterpenoids, excluding saponins, from higher plants... - Prenylated isoflavonoids from Rhynchosia edulisIfedayo V Ogungbe
Department of Chemistry, University of Alabama in Huntsville, Huntsville, Alabama 35899, USA
Nat Prod Commun 6:1637-44. 2011..These isoflavonoids showed weak inhibitory activity towards rhodesain, the major cathepsin-L like protease in Trypanosoma brucei. They also have weak antiproliferative activity towards MCF-7 cells... - Bioactivity and chemical composition of the leaf essential oils of Zanthoxylum rhoifolium and Zanthoxylum setulosum from Monteverde, Costa RicaAmelia K Boehme
Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
Nat Prod Res 22:31-6. 2008..Neither Z. rhoifolium nor Z. setulosum leaf oils exhibited cytotoxicity or antibacterial activity. Both oils showed activity against A. salina... - Essential oil compositions and cytotoxic activities of Dendropanax capillaris, Oreopanax nubigenus, and Schefflera rodrigueziana from Monteverde, Costa RicaJustin D Richmond
Department of Chemistry, University of Alabama in Huntsville, Huntsville, Alabama 35899, USA
Nat Prod Commun 4:271-4. 2009..8%). Both O. nubigenus and S. rodrigueziana leaf oils showed notable in-vitro cytotoxicity on MDA-MB-231 cells, which may be attributable to the relatively high concentrations of germacrene D and beta-caryophyllene in those oils... - Phytomedicinal potential of tropical cloudforest plants from Monteverde, Costa RicaMary C Setzer
Department of Biological Sciences, University of Alabama, Huntsville, Alabama 35899, USA
Rev Biol Trop 51:647-73. 2003..Thus, 101 of the plant species examined in this work, or 62%, showed marked bioactivity in one or more bioassays. These results underscore the phytomedicinal potential of Neotropical cloud forests... - Inhibition of essential bacterial peptidyl-tRNA hydrolase activity by tropical plant extractsHana McFeeters
Department of Chemistry, University of Alabama in Huntsville, 301 Sparkman Drive, Huntsville, AL 35899, USA
Nat Prod Commun 7:1107-10. 2012..IC50 values ranged from 0.02 to > 53.8 microg of extract per 1 unit of Pth, holding promise for in vivo screening. The inhibitory components in these extracts may serve as lead compounds for development of novel antibacterials... - A phytochemical investigation of Zanthoxylum setulosumTameka M Walker
Department of Chemistry, University of Alabama in Huntsville, Huntsville, Alabama 35899, USA
Nat Prod Commun 6:1807-8. 2011..setulosum. All structures were determined using NMR spectroscopic techniques (1H NMR and 13 degrees C NMR) and GC-MS and by comparison with literature data. Lupeol proved to be the cytotoxic component of Z. setulosum bark... - Vitexin inhibits polyubiquitin synthesis by the ubiquitin-conjugating enzyme E2-25KKimberli M Helms
Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
Nat Prod Commun 6:1411-6. 2011..An IC50 for vitexin was calculated to be approximately 0.5 mM. Molecular modeling simulations were used to predict the mode of inhibition and NMR spectra were used to confirm the binding site of vitexin to E2-25K... - Chemical composition of the leaf essential oil of Casimiroa edulis La Llave & Lex. (Rutaceae) from Monteverde, Costa RicaSarah L Miller
Department of Chemistry, University of Alabama in Huntsville, Huntsville, Alabama 35899, USA
Nat Prod Commun 4:425-6. 2009..The leaf oil was dominated by sesquiterpene hydrocarbons, predominately germacrene D (16-22%) and (E)-caryophyllene (16-17%), consistent with the traditional use of this plant as a sedative, sleep inducer and hypotensive... - Phytochemical investigation of Verbesina turbacensis Kunth: trypanosome cysteine protease inhibition by (-)-bornyl estersIfedayo V Ogungbe
Department of Chemistry, University of Alabama in Huntsville, Huntsville, Alabama 35899, USA
Nat Prod Commun 5:1161-6. 2010..1%). Three bornyl hydroxycinnamic esters isolated from the acetone bark extract were found to inhibit the cysteine protease, rhodesain. Molecular docking analysis to probe the inhibitory interactions of the esters was also carried out... - Cytotoxic activity of Ozoroa insignis from ZimbabweAngela I Rea
Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
Fitoterapia 74:732-5. 2003..Bioactivity-directed chromatographic separation led to isolation of anacardic acid and ginkgoic acid as the cytotoxic components... - Leaf essential oil composition of three species of Myrcianthes from Monteverde, Costa RicaRamona A Cole
Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
Chem Biodivers 5:1327-34. 2008..A cluster analysis reveals large chemical variation not only between members of the genus, but also between samples of the same species... - Quinoline alkaloids as intercalative topoisomerase inhibitorsKendall G Byler
Department of Chemistry, University of Alabama in Huntsville, 35899, USA
J Mol Model 15:1417-26. 2009..Thus, not only can quinoline alkaloids dock intercalatively into DNA, but the docked orientations are also electronically favorable... - Seasonal variation in the leaf essential oil composition of Zanthoxylum clava-herculis growing in Huntsville, AlabamaLauren C Eiter
Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
Nat Prod Commun 5:457-60. 2010..The ratio of oxygenated monoterpenoids to monoterpene hydrocarbons generally increased during the season, largely reflected in the 1,8-cineole/limonene ratio... - Comparative molecular docking of antitrypanosomal natural products into multiple Trypanosoma brucei drug targetsIfedayo V Ogungbe
Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
Molecules 14:1513-36. 2009..Compounds like cissampeloflavone, 3-geranylemodin and ningpogenin thus offer profound promise... - Essential oil compositions of three Lantana species from Monteverde, Costa RicaAshley B Walden
Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
Nat Prod Commun 4:105-8. 2009..The very different compositions for L. camara are consistent with the wide diversity of chemical compositions observed in previous reports for this species... - Cancer-relevant biochemical targets of cytotoxic Lonchocarpus flavonoids: a molecular docking analysisCaitlin E Cassidy
Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
J Mol Model 16:311-26. 2010..We conclude, therefore, that the Lonchocarpus flavonoids possibly owe their cytotoxic activity by inhibition of one or more of these enzymes... - Peptidyl-tRNA hydrolase screening combined with molecular docking reveals the antibiotic potential of Syzygium johnsonii bark extractSarah M Harris
Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
Nat Prod Commun 6:1421-4. 2011..This work is the forerunner of activity-directed isolation, purification, and structure elucidation of the inhibitory components from Syzygium johnsonii extracts and studies of compound interaction with Pth... - Bioactivities of volatile components from Nepalese Artemisia speciesPrabodh Satyal
Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
Nat Prod Commun 7:1651-8. 2012..If decomposition does occur, it likely proceeds by way of homolytic peroxide bond cleavage rather than retro-Diels-Alder elimination of molecular oxygen... - Monoterpene hydrocarbons may serve as antipredation defensive compounds in Boisea trivittata, the boxelder bugMaria C Palazzo
Department of Chemistry, University of Alabama in Huntsville, Huntsville, Alabama 35899, USA
Nat Prod Commun 4:457-9. 2009..9%), limonene (14.7%), myrcene (0.8%), and (E)-beta-ocimene (0.6%). The presence of these antifeedant volatile chemicals may serve to provide some protection of boxelder bugs from predation... - Attenuation of cytotoxic natural product DNA intercalating agents by caffeineGabrielle M Hill
Department of Chemistry, University of Alabama in Huntsville, Huntsville, Alabama 35899, USA
Sci Pharm 79:729-47. 2011..Relatively strong π-π interaction energies between caffeine and the intercalators were found, suggesting an "interceptor" role of caffeine protecting the DNA from intercalation... - Structure of an insect epsilon class glutathione S-transferase from the malaria vector Anopheles gambiae provides an explanation for the high DDT-detoxifying activityYujun Wang
Laboratory for Structural Biology, Department of Chemistry, Graduate Program of Biotechnology, University of Alabama in Huntsville, Huntsville, AL 35899, USA
J Struct Biol 164:228-35. 2008.... - Seasonal variation and bioactivity in the leaf oil of Liriodendron tulipifera growing in Huntsville, AlabamaSarah L Miller
Department of Chemistry, University of Alabama in Huntsville, Huntsville, Alabama 35899, USA
Nat Prod Commun 4:839-43. 2009..The leaf oils exhibited in-vitro antibacterial activity against Bacillus cereus and Staphylococcus aureus as well as cytotoxic activity on MDA-MB-231 and Hs 578T human breast tumor cells... - Chemical compositions and biological activities of Amomum subulatum essential oils from NepalPrabodh Satyal
Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
Nat Prod Commun 7:1233-6. 2012..The seed oil was only marginally toxic to the fire ant (LC50 = 1500 microg/mL), but moderately toxic to the nematode and the fruit fly (LC50 = 341 and 441 microg/mL, respectively)... - Isolation and characterization of a stilbene-degrading strain of Pseudomonas fluorescens, and production of antioxidant compounds by stilbene metabolismJoseph G Leahy
Department of Biological Sciences, University of Alabama in Huntsville, Huntsville, AL 35899, USA
Biosci Biotechnol Biochem 67:2286-7. 2003..Degradation of trans-stilbene by this strain yielded two metabolites that had significant antioxidant activity... - The chemical composition and antimicrobial activity of the leaf oil of Cupressus lusitanica from Monteverde, Costa RicaSara L Hassanzadeh
Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
Pharmacognosy Res 2:19-21. 2010..The essential oil was screened for antimicrobial activity, and it showed antibacterial activity against Bacillus cereus and antifungal activity against Aspergillus niger... - Composition and bioactivity of the leaf essential oil of Heteropyxis dehniae from ZimbabweSamson Sibanda
Department of Chemistry, University of Zimbabwe, Box MP 167, Harare, Zimbabwe
J Ethnopharmacol 92:107-11. 2004..Caryophyllene oxide shows notable cytotoxic activity with LC50 values of 147-351 microM...
Research Grants
- Anti-Trypanosomal Agents from a Neotropical CloudforestWILLIAM SETZER; Fiscal Year: 2004..The long-term benefit of this research project is the development of new medicines to treat patients with Chagas disease. ..