William N Setzer

Summary

Affiliation: University of Alabama in Huntsville
Country: USA

Publications

  1. ncbi request reprint Essential oils and anxiolytic aromatherapy
    William N Setzer
    Department of Chemistry, University of Alabama in Huntsville, Huntsville, Alabama 35899, USA
    Nat Prod Commun 4:1305-16. 2009
  2. pmc The chemical composition and antimicrobial activity of the leaf oil of Cupressus lusitanica from Monteverde, Costa Rica
    Sara L Hassanzadeh
    Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
    Pharmacognosy Res 2:19-21. 2010
  3. pmc Volatile constituents of Pinus roxburghii from Nepal
    Prabodh Satyal
    Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
    Pharmacognosy Res 5:43-8. 2013
  4. pmc Germacrene d cyclization: an ab initio investigation
    William N Setzer
    Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
    Int J Mol Sci 9:89-97. 2008
  5. pmc In-silico investigation of antitrypanosomal phytochemicals from Nigerian medicinal plants
    William N Setzer
    Department of Chemistry, University of Alabama in Huntsville, Huntsville, Alabama, USA
    PLoS Negl Trop Dis 6:e1727. 2012
  6. ncbi request reprint Drugs from the cloudforest: the search for new medicines from Monteverde, Costa Rica
    William N Setzer
    Department of Chemistry, University of Alabama in Huntsville, Huntsville, Alabama 35899, USA
    Nat Prod Commun 6:1549-58. 2011
  7. doi request reprint A theoretical investigation of cytotoxic activity of celastroid triterpenoids
    William N Setzer
    Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
    J Mol Model 15:197-201. 2009
  8. ncbi request reprint HPLC-NMR/HPLC-MS analysis of the bark extract of Stauranthus perforatus
    William N Setzer
    Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
    Phytochem Anal 14:54-9. 2003
  9. doi request reprint Lignin-derived oak phenolics: a theoretical examination of additional potential health benefits of red wine
    William N Setzer
    Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
    J Mol Model 17:1841-5. 2011
  10. ncbi request reprint A DFT analysis of thermal decomposition reactions important to natural products
    William N Setzer
    Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
    Nat Prod Commun 5:993-8. 2010

Research Grants

Collaborators

  • Joseph G Leahy
  • Chen Wang
  • Nongkran Lumjuan
  • Catherine Taylor
  • Liqing Chen
  • Janet Hemingway
  • Prabodh Satyal
  • Prajwal Paudel
  • William A Haber
  • Ifedayo V Ogungbe
  • Noura S Dosoky
  • Debra M Moriarity
  • Bernhard Vogler
  • Sarah L Miller
  • Hana McFeeters
  • Gabrielle M Hill
  • Maria C Palazzo
  • Samjhana Maharjan
  • Ambika Poudel
  • Robert L McFeeters
  • Luis R Cruz-Vera
  • Tameka M Walker
  • Sarah M Harris
  • Kimberli M Helms
  • Samson Sibanda
  • Rebecca A Crouch
  • Lauren C Eiter
  • Angela I Rea
  • Sara L Hassanzadeh
  • Caitlin E Cassidy
  • Ashley B Walden
  • Justin D Richmond
  • Brenda S Wright
  • Kendall G Byler
  • Amelia K Boehme
  • Ramona A Cole
  • Yujun Wang
  • Joseph A Noletto
  • Robert O Lawton
  • Ephraim T Gwebu
  • Jennifer M Schmidt
  • Mary C Setzer
  • Nawal Shrestha
  • Josna Raut
  • Kiran Kumar Pokharel
  • Akash Deo
  • Suraj K Pokharel
  • Bimala Lamichhane
  • Ananad Kafle
  • Rachel M Thompson
  • Brittany L Kincer
  • Morgan J Gilbert
  • Randall C Wilson
  • Meenakshi Nagarkoti
  • Pamela D Twigg
  • Betsy R Jackes
  • Henry Fadamiro
  • Jessika A Tuten
  • Heather E Villanueva
  • Brittany R Agius
  • Hilary Ranson
  • Li Qiu
  • Edward J Meehan
  • Melvin Poole
  • Grace Chigwada
  • Glenn A Gentry

Detail Information

Publications47

  1. ncbi request reprint Essential oils and anxiolytic aromatherapy
    William N Setzer
    Department of Chemistry, University of Alabama in Huntsville, Huntsville, Alabama 35899, USA
    Nat Prod Commun 4:1305-16. 2009
    ..This review discusses the chemical constituents and CNS effects of these aromatherapeutic essential oils, as well as recent studies on additional essential oils with anxiolytic activities...
  2. pmc The chemical composition and antimicrobial activity of the leaf oil of Cupressus lusitanica from Monteverde, Costa Rica
    Sara L Hassanzadeh
    Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
    Pharmacognosy Res 2:19-21. 2010
    ..The essential oil was screened for antimicrobial activity, and it showed antibacterial activity against Bacillus cereus and antifungal activity against Aspergillus niger...
  3. pmc Volatile constituents of Pinus roxburghii from Nepal
    Prabodh Satyal
    Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
    Pharmacognosy Res 5:43-8. 2013
    ..Pinus roxburghii Sarg. Is one of 3 species of pine found in Nepal, the oil of which is traditionally used to treat cuts, wounds, boils, and blisters...
  4. pmc Germacrene d cyclization: an ab initio investigation
    William N Setzer
    Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
    Int J Mol Sci 9:89-97. 2008
    ..The calculated energies are in general agreement with experimentally observed product distributions, both from acid-catalyzed cyclizations as well as distribution of the compounds in essential oils...
  5. pmc In-silico investigation of antitrypanosomal phytochemicals from Nigerian medicinal plants
    William N Setzer
    Department of Chemistry, University of Alabama in Huntsville, Huntsville, Alabama, USA
    PLoS Negl Trop Dis 6:e1727. 2012
    ..Many affected people live in remote areas with limited access to health services and, therefore, rely on traditional herbal medicines for treatment...
  6. ncbi request reprint Drugs from the cloudforest: the search for new medicines from Monteverde, Costa Rica
    William N Setzer
    Department of Chemistry, University of Alabama in Huntsville, Huntsville, Alabama 35899, USA
    Nat Prod Commun 6:1549-58. 2011
    ..The group has focused primarily on anticancer agents, antimicrobial agents, and antiparasitic agents. This review presents an overview of some of our efforts in natural products drug discovery from Monteverde, Costa Rica...
  7. doi request reprint A theoretical investigation of cytotoxic activity of celastroid triterpenoids
    William N Setzer
    Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
    J Mol Model 15:197-201. 2009
    ....
  8. ncbi request reprint HPLC-NMR/HPLC-MS analysis of the bark extract of Stauranthus perforatus
    William N Setzer
    Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
    Phytochem Anal 14:54-9. 2003
    ....
  9. doi request reprint Lignin-derived oak phenolics: a theoretical examination of additional potential health benefits of red wine
    William N Setzer
    Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
    J Mol Model 17:1841-5. 2011
    ..Thus, lignin-derived oak phenolics, although found in small concentrations, may contribute to the beneficial antioxidant, chemopreventive, and cardioprotective effects of red wine...
  10. ncbi request reprint A DFT analysis of thermal decomposition reactions important to natural products
    William N Setzer
    Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
    Nat Prod Commun 5:993-8. 2010
    ..g., boiling aqueous solutions, gas-chromatograph injection ports). Activation enthalpies for pyrolytic eliminations are around 40 kcal/mol and are unlikely to occur during extraction or GC analysis...
  11. pmc Conformational analysis of thioether musks using density functional theory
    William N Setzer
    Department of Chemistry, University of Alabama in Huntsville, 35899, USA
    Int J Mol Sci 10:3488-501. 2009
    ..Unfortunately, there was little agreement between the computational methods at the levels of theory used in this study...
  12. doi request reprint A computational investigation of sulfur-containing heterocyclic components from the anal sac secretions of Mustela species
    William N Setzer
    Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
    J Mol Model 14:967-73. 2008
    ....
  13. doi request reprint Ab initio analysis of the Cope rearrangement of germacrane sesquiterpenoids
    William N Setzer
    Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
    J Mol Model 14:335-42. 2008
    ..Apparently, the generally small energy differences between the two forms in these sesquiterpenoids cannot be adequately reproduced at these levels of calculation...
  14. ncbi request reprint Bioactive principles in the bark of Pilidiostigma tropicum
    William N Setzer
    Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
    J Mol Model 12:703-11. 2006
    ..A favorable pi-pi interaction between rhodomyrtoxin B and the cytosine-guanine base pair is predicted, but the orientation of the interaction cannot be predicted based on frontier molecular orbitals...
  15. ncbi request reprint Isolation of cupanioside, a novel cytotoxic and antibacterial long-chain fatty alcohol glycoside from the bark of Cupania glabra
    William N Setzer
    Department of Chemistry, University of Alabama in Huntsville, Huntsville, Alabama, USA
    Planta Med 71:686-8. 2005
    ..The structure was elucidated by analysis of 2D-NMR spectra...
  16. ncbi request reprint Leaf essential oil composition of five Zanthoxylum species from Monteverde, Costa Rica
    William N Setzer
    Department of Chemistry, University of Alabama in Huntsville, Huntsville, Alabama 35899, USA
    Mol Divers 9:3-13. 2005
    ..monophyllum, Z. acuminatum, Z. fagara, and Zanthoxylum sp. nov. Linalool, 4-terpineol, alpha-terpineol, and trans-2-hexenol, are found in all of the Zanthoxylum species examined in this study...
  17. ncbi request reprint Plant-derived triterpenoids as potential antineoplastic agents
    W N Setzer
    Department of Chemistry, The University of Alabama in Huntsville, Huntsville, AL 35899, USA
    Mini Rev Med Chem 3:540-56. 2003
    ..This review covers the recent developments regarding antineoplastic/cytotoxic triterpenoids, excluding saponins, from higher plants...
  18. ncbi request reprint Antimicrobial activity of Artemisia douglasiana leaf essential oil
    William N Setzer
    Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
    Fitoterapia 75:192-200. 2004
    ..The essential oil shows limited antimicrobial activity in vitro, so it is unclear if the oil exerts a direct antimicrobial effect in vivo, or plays some role in stimulation of host defenses...
  19. ncbi request reprint Prenylated isoflavonoids from Rhynchosia edulis
    Ifedayo V Ogungbe
    Department of Chemistry, University of Alabama in Huntsville, Huntsville, Alabama 35899, USA
    Nat Prod Commun 6:1637-44. 2011
    ..These isoflavonoids showed weak inhibitory activity towards rhodesain, the major cathepsin-L like protease in Trypanosoma brucei. They also have weak antiproliferative activity towards MCF-7 cells...
  20. ncbi request reprint Bioactivity and chemical composition of the leaf essential oils of Zanthoxylum rhoifolium and Zanthoxylum setulosum from Monteverde, Costa Rica
    Amelia K Boehme
    Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
    Nat Prod Res 22:31-6. 2008
    ..Neither Z. rhoifolium nor Z. setulosum leaf oils exhibited cytotoxicity or antibacterial activity. Both oils showed activity against A. salina...
  21. ncbi request reprint Bioactivities and compositional analyses of Cinnamomum essential oils from Nepal: C. camphora, C. tamala, and C. glaucescens
    Prabodh Satyal
    Department ofChemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
    Nat Prod Commun 8:1777-84. 2013
    ..C. glaucescens fruit essential oil showed notable nematicidal activity, as well as termiticidal and mosquito larvicidal activity. The root essential oil of C. tamala was toxic to mosquito larvae and fire ants...
  22. ncbi request reprint Bioactivities of volatile components from Nepalese Artemisia species
    Prabodh Satyal
    Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
    Nat Prod Commun 7:1651-8. 2012
    ..If decomposition does occur, it likely proceeds by way of homolytic peroxide bond cleavage rather than retro-Diels-Alder elimination of molecular oxygen...
  23. ncbi request reprint Phytomedicinal potential of tropical cloudforest plants from Monteverde, Costa Rica
    Mary C Setzer
    Department of Biological Sciences, University of Alabama, Huntsville, Alabama 35899, USA
    Rev Biol Trop 51:647-73. 2003
    ..Thus, 101 of the plant species examined in this work, or 62%, showed marked bioactivity in one or more bioassays. These results underscore the phytomedicinal potential of Neotropical cloud forests...
  24. ncbi request reprint Essential oil compositions and cytotoxic activities of Dendropanax capillaris, Oreopanax nubigenus, and Schefflera rodrigueziana from Monteverde, Costa Rica
    Justin D Richmond
    Department of Chemistry, University of Alabama in Huntsville, Huntsville, Alabama 35899, USA
    Nat Prod Commun 4:271-4. 2009
    ..8%). Both O. nubigenus and S. rodrigueziana leaf oils showed notable in-vitro cytotoxicity on MDA-MB-231 cells, which may be attributable to the relatively high concentrations of germacrene D and beta-caryophyllene in those oils...
  25. ncbi request reprint Vitexin inhibits polyubiquitin synthesis by the ubiquitin-conjugating enzyme E2-25K
    Kimberli M Helms
    Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
    Nat Prod Commun 6:1411-6. 2011
    ..An IC50 for vitexin was calculated to be approximately 0.5 mM. Molecular modeling simulations were used to predict the mode of inhibition and NMR spectra were used to confirm the binding site of vitexin to E2-25K...
  26. ncbi request reprint Chemical compositions, phytotoxicity, and biological activities of Acorus calamus essential oils from Nepal
    Prabodh Satyal
    Department of Chemistry, University of Alabama in Huntsville, Huntsville, Alabama 35899, USA
    Nat Prod Commun 8:1179-81. 2013
    ..The rhizome oil also showed notable brine shrimp lethality (LC50 = 9.48 microg/mL), cytotoxic activity (92.2% kill on MCF-7 cells at 100 microg/mL), and antifungal activity against Aspergillus niger (MIC = 19.5 microg/mL)...
  27. ncbi request reprint Inhibition of essential bacterial peptidyl-tRNA hydrolase activity by tropical plant extracts
    Hana McFeeters
    Department of Chemistry, University of Alabama in Huntsville, 301 Sparkman Drive, Huntsville, AL 35899, USA
    Nat Prod Commun 7:1107-10. 2012
    ..IC50 values ranged from 0.02 to > 53.8 microg of extract per 1 unit of Pth, holding promise for in vivo screening. The inhibitory components in these extracts may serve as lead compounds for development of novel antibacterials...
  28. ncbi request reprint A phytochemical investigation of Zanthoxylum setulosum
    Tameka M Walker
    Department of Chemistry, University of Alabama in Huntsville, Huntsville, Alabama 35899, USA
    Nat Prod Commun 6:1807-8. 2011
    ..setulosum. All structures were determined using NMR spectroscopic techniques (1H NMR and 13 degrees C NMR) and GC-MS and by comparison with literature data. Lupeol proved to be the cytotoxic component of Z. setulosum bark...
  29. ncbi request reprint Phytochemical investigation of Verbesina turbacensis Kunth: trypanosome cysteine protease inhibition by (-)-bornyl esters
    Ifedayo V Ogungbe
    Department of Chemistry, University of Alabama in Huntsville, Huntsville, Alabama 35899, USA
    Nat Prod Commun 5:1161-6. 2010
    ..1%). Three bornyl hydroxycinnamic esters isolated from the acetone bark extract were found to inhibit the cysteine protease, rhodesain. Molecular docking analysis to probe the inhibitory interactions of the esters was also carried out...
  30. ncbi request reprint Chemical composition of the leaf essential oil of Casimiroa edulis La Llave & Lex. (Rutaceae) from Monteverde, Costa Rica
    Sarah L Miller
    Department of Chemistry, University of Alabama in Huntsville, Huntsville, Alabama 35899, USA
    Nat Prod Commun 4:425-6. 2009
    ..The leaf oil was dominated by sesquiterpene hydrocarbons, predominately germacrene D (16-22%) and (E)-caryophyllene (16-17%), consistent with the traditional use of this plant as a sedative, sleep inducer and hypotensive...
  31. ncbi request reprint Juglans regia and J. nigra, two trees important in traditional medicine: A comparison of leaf essential oil compositions and biological activities
    Prajwal Paudel
    Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
    Nat Prod Commun 8:1481-6. 2013
    ..nigra leaf oil was less phytotoxic. The presence of eugenol and methyl salicylate in the leaves of J. regia are consistent with the traditional uses of this plant to treat toothache, rheumatism, and fungal infections...
  32. ncbi request reprint Cytotoxic activity of Ozoroa insignis from Zimbabwe
    Angela I Rea
    Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
    Fitoterapia 74:732-5. 2003
    ..Bioactivity-directed chromatographic separation led to isolation of anacardic acid and ginkgoic acid as the cytotoxic components...
  33. ncbi request reprint Seasonal variation in the leaf essential oil composition of Zanthoxylum clava-herculis growing in Huntsville, Alabama
    Lauren C Eiter
    Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
    Nat Prod Commun 5:457-60. 2010
    ..The ratio of oxygenated monoterpenoids to monoterpene hydrocarbons generally increased during the season, largely reflected in the 1,8-cineole/limonene ratio...
  34. doi request reprint Quinoline alkaloids as intercalative topoisomerase inhibitors
    Kendall G Byler
    Department of Chemistry, University of Alabama in Huntsville, 35899, USA
    J Mol Model 15:1417-26. 2009
    ..Thus, not only can quinoline alkaloids dock intercalatively into DNA, but the docked orientations are also electronically favorable...
  35. doi request reprint Leaf essential oil composition of three species of Myrcianthes from Monteverde, Costa Rica
    Ramona A Cole
    Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
    Chem Biodivers 5:1327-34. 2008
    ..A cluster analysis reveals large chemical variation not only between members of the genus, but also between samples of the same species...
  36. doi request reprint Comparative molecular docking of antitrypanosomal natural products into multiple Trypanosoma brucei drug targets
    Ifedayo V Ogungbe
    Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
    Molecules 14:1513-36. 2009
    ..Compounds like cissampeloflavone, 3-geranylemodin and ningpogenin thus offer profound promise...
  37. ncbi request reprint Essential oil compositions of three Lantana species from Monteverde, Costa Rica
    Ashley B Walden
    Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
    Nat Prod Commun 4:105-8. 2009
    ..The very different compositions for L. camara are consistent with the wide diversity of chemical compositions observed in previous reports for this species...
  38. doi request reprint Cancer-relevant biochemical targets of cytotoxic Lonchocarpus flavonoids: a molecular docking analysis
    Caitlin E Cassidy
    Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
    J Mol Model 16:311-26. 2010
    ..We conclude, therefore, that the Lonchocarpus flavonoids possibly owe their cytotoxic activity by inhibition of one or more of these enzymes...
  39. ncbi request reprint Peptidyl-tRNA hydrolase screening combined with molecular docking reveals the antibiotic potential of Syzygium johnsonii bark extract
    Sarah M Harris
    Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
    Nat Prod Commun 6:1421-4. 2011
    ..This work is the forerunner of activity-directed isolation, purification, and structure elucidation of the inhibitory components from Syzygium johnsonii extracts and studies of compound interaction with Pth...
  40. doi request reprint Volatile analysis and antimicrobial screening of the parasitic plant Cuscuta reflexa Roxb. from Nepal
    Prajwal Paudel
    a Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
    Nat Prod Res 28:106-10. 2014
    ..However, marginal activity against Aspergillus niger was observed (minimum inhibitory concentration = 313 μg/mL)...
  41. ncbi request reprint Chemical compositions and biological activities of Amomum subulatum essential oils from Nepal
    Prabodh Satyal
    Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
    Nat Prod Commun 7:1233-6. 2012
    ..The seed oil was only marginally toxic to the fire ant (LC50 = 1500 microg/mL), but moderately toxic to the nematode and the fruit fly (LC50 = 341 and 441 microg/mL, respectively)...
  42. ncbi request reprint Monoterpene hydrocarbons may serve as antipredation defensive compounds in Boisea trivittata, the boxelder bug
    Maria C Palazzo
    Department of Chemistry, University of Alabama in Huntsville, Huntsville, Alabama 35899, USA
    Nat Prod Commun 4:457-9. 2009
    ..9%), limonene (14.7%), myrcene (0.8%), and (E)-beta-ocimene (0.6%). The presence of these antifeedant volatile chemicals may serve to provide some protection of boxelder bugs from predation...
  43. pmc Attenuation of cytotoxic natural product DNA intercalating agents by caffeine
    Gabrielle M Hill
    Department of Chemistry, University of Alabama in Huntsville, Huntsville, Alabama 35899, USA
    Sci Pharm 79:729-47. 2011
    ..Relatively strong π-π interaction energies between caffeine and the intercalators were found, suggesting an "interceptor" role of caffeine protecting the DNA from intercalation...
  44. doi request reprint Structure of an insect epsilon class glutathione S-transferase from the malaria vector Anopheles gambiae provides an explanation for the high DDT-detoxifying activity
    Yujun Wang
    Laboratory for Structural Biology, Department of Chemistry, Graduate Program of Biotechnology, University of Alabama in Huntsville, Huntsville, AL 35899, USA
    J Struct Biol 164:228-35. 2008
    ....
  45. ncbi request reprint Seasonal variation and bioactivity in the leaf oil of Liriodendron tulipifera growing in Huntsville, Alabama
    Sarah L Miller
    Department of Chemistry, University of Alabama in Huntsville, Huntsville, Alabama 35899, USA
    Nat Prod Commun 4:839-43. 2009
    ..The leaf oils exhibited in-vitro antibacterial activity against Bacillus cereus and Staphylococcus aureus as well as cytotoxic activity on MDA-MB-231 and Hs 578T human breast tumor cells...
  46. ncbi request reprint Isolation and characterization of a stilbene-degrading strain of Pseudomonas fluorescens, and production of antioxidant compounds by stilbene metabolism
    Joseph G Leahy
    Department of Biological Sciences, University of Alabama in Huntsville, Huntsville, AL 35899, USA
    Biosci Biotechnol Biochem 67:2286-7. 2003
    ..Degradation of trans-stilbene by this strain yielded two metabolites that had significant antioxidant activity...
  47. ncbi request reprint Composition and bioactivity of the leaf essential oil of Heteropyxis dehniae from Zimbabwe
    Samson Sibanda
    Department of Chemistry, University of Zimbabwe, Box MP 167, Harare, Zimbabwe
    J Ethnopharmacol 92:107-11. 2004
    ..Caryophyllene oxide shows notable cytotoxic activity with LC50 values of 147-351 microM...

Research Grants1

  1. Anti-Trypanosomal Agents from a Neotropical Cloudforest
    WILLIAM SETZER; Fiscal Year: 2004
    ..The long-term benefit of this research project is the development of new medicines to treat patients with Chagas disease. ..