S Sethi

Summary

Affiliation: University at Buffalo
Country: USA

Publications

  1. doi request reprint Inflammation in COPD: implications for management
    Sanjay Sethi
    University at Buffalo, Buffalo, NY 14215, USA
    Am J Med 125:1162-70. 2012
  2. pmc Design and validation of a supragenome array for determination of the genomic content of Haemophilus influenzae isolates
    Rory A Eutsey
    Center for Genomic Sciences, Allegheny Singer Research Institute, Allegheny General Hospital, Pittsburgh, PA 15212, USA
    BMC Genomics 14:484. 2013
  3. pmc Moraxella catarrhalis acquisition, airway inflammation and protease-antiprotease balance in chronic obstructive pulmonary disease
    Ganapathi I Parameswaran
    Division of Infectious Diseases, University at Buffalo, State University of New York, 701 Ellicott Street, Buffalo, NY 14203, USA
    BMC Infect Dis 9:178. 2009
  4. pmc Airway inflammation and bronchial bacterial colonization in chronic obstructive pulmonary disease
    Sanjay Sethi
    Division of Pulmonary Critical Care and Sleep Medicine, and Division of Infectious Diseases, Department of Medicine, University at Buffalo, Buffalo, NY, USA
    Am J Respir Crit Care Med 173:991-8. 2006
  5. ncbi request reprint Bacteria in exacerbations of chronic obstructive pulmonary disease: phenomenon or epiphenomenon?
    Sanjay Sethi
    Department of Medicine, University of Buffalo SUNY, Buffalo, NY 14215, USA
    Proc Am Thorac Soc 1:109-14. 2004
  6. ncbi request reprint Strain-specific immune response to Haemophilus influenzae in chronic obstructive pulmonary disease
    Sanjay Sethi
    Department of Medicine, University of Buffalo SUNY and the Veterans Affairs Western New York Healthcare System, Buffalo, NY 14215, USA
    Am J Respir Crit Care Med 169:448-53. 2004
  7. ncbi request reprint New developments in the pathogenesis of acute exacerbations of chronic obstructive pulmonary disease
    Sanjay Sethi
    Division of Pulmonary, Critical Care and Sleep Medicine, University at Buffalo, State University of New York and the VA Western New York Healthcare System, Buffalo, New York 14215, USA
    Curr Opin Infect Dis 17:113-9. 2004
  8. ncbi request reprint A randomized, double-blind study comparing 5 days oral gemifloxacin with 7 days oral levofloxacin in patients with acute exacerbation of chronic bronchitis
    S Sethi
    Pulmonary and Critical Care Medicine, University at Buffalo, State University of New York, Buffalo, NY, USA
    Respir Med 98:697-707. 2004
  9. ncbi request reprint Managing patients with recurrent acute exacerbations of chronic bronchitis: a common clinical problem
    Sanjay Sethi
    Division of Pulmonary and Critical Care Medicine, State University of New York, VA Medical Research, Buffalo, NY, USA
    Curr Med Res Opin 20:1511-21. 2004
  10. ncbi request reprint Acute exacerbations of chronic bronchitis: new developments concerning microbiology and pathophysiology--impact on approaches to risk stratification and therapy
    Sanjay Sethi
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University at Buffalo SUNY, Buffalo, NY 14260, USA
    Infect Dis Clin North Am 18:861-82, ix. 2004

Research Grants

Collaborators

Detail Information

Publications68

  1. doi request reprint Inflammation in COPD: implications for management
    Sanjay Sethi
    University at Buffalo, Buffalo, NY 14215, USA
    Am J Med 125:1162-70. 2012
    ..The importance of inflammation in COPD needs to be better understood by clinicians, and the differences in inflammation in COPD versus asthma should be considered carefully to optimize the use of anti-inflammatory agents...
  2. pmc Design and validation of a supragenome array for determination of the genomic content of Haemophilus influenzae isolates
    Rory A Eutsey
    Center for Genomic Sciences, Allegheny Singer Research Institute, Allegheny General Hospital, Pittsburgh, PA 15212, USA
    BMC Genomics 14:484. 2013
    ..influenzae display extensive genomic diversity and plasticity. The development of strategies to successfully prevent, diagnose and treat H. influenzae infections depends on tools to ascertain the gene content of individual isolates...
  3. pmc Moraxella catarrhalis acquisition, airway inflammation and protease-antiprotease balance in chronic obstructive pulmonary disease
    Ganapathi I Parameswaran
    Division of Infectious Diseases, University at Buffalo, State University of New York, 701 Ellicott Street, Buffalo, NY 14203, USA
    BMC Infect Dis 9:178. 2009
    ..catarrhalis as compared to colonization...
  4. pmc Airway inflammation and bronchial bacterial colonization in chronic obstructive pulmonary disease
    Sanjay Sethi
    Division of Pulmonary Critical Care and Sleep Medicine, and Division of Infectious Diseases, Department of Medicine, University at Buffalo, Buffalo, NY, USA
    Am J Respir Crit Care Med 173:991-8. 2006
    ..Objective: To test the hypothesis that bacterial colonization is associated with airway inflammation in stable COPD...
  5. ncbi request reprint Bacteria in exacerbations of chronic obstructive pulmonary disease: phenomenon or epiphenomenon?
    Sanjay Sethi
    Department of Medicine, University of Buffalo SUNY, Buffalo, NY 14215, USA
    Proc Am Thorac Soc 1:109-14. 2004
    ..Future work should strive to understand better the host-pathogen interaction that leads to an exacerbation and to develop novel therapeutic and preventive measures...
  6. ncbi request reprint Strain-specific immune response to Haemophilus influenzae in chronic obstructive pulmonary disease
    Sanjay Sethi
    Department of Medicine, University of Buffalo SUNY and the Veterans Affairs Western New York Healthcare System, Buffalo, NY 14215, USA
    Am J Respir Crit Care Med 169:448-53. 2004
    ..2%) heterologous strains. Development of an immune response to H. influenzae supports its role in causing exacerbations. The strain specificity of the immune response likely represents a mechanism of recurrent exacerbations...
  7. ncbi request reprint New developments in the pathogenesis of acute exacerbations of chronic obstructive pulmonary disease
    Sanjay Sethi
    Division of Pulmonary, Critical Care and Sleep Medicine, University at Buffalo, State University of New York and the VA Western New York Healthcare System, Buffalo, New York 14215, USA
    Curr Opin Infect Dis 17:113-9. 2004
    ..The application of better study designs and new research methodologies has shed considerable light on the pathogenesis of this common clinical syndrome...
  8. ncbi request reprint A randomized, double-blind study comparing 5 days oral gemifloxacin with 7 days oral levofloxacin in patients with acute exacerbation of chronic bronchitis
    S Sethi
    Pulmonary and Critical Care Medicine, University at Buffalo, State University of New York, Buffalo, NY, USA
    Respir Med 98:697-707. 2004
    ..To demonstrate that 5 days of treatment with a new fluoroquinolone, gemifloxacin, is at least as effective as 7 days of treatment with levofloxacin in adult patients with acute exacerbation of chronic bronchitis (AECB)...
  9. ncbi request reprint Managing patients with recurrent acute exacerbations of chronic bronchitis: a common clinical problem
    Sanjay Sethi
    Division of Pulmonary and Critical Care Medicine, State University of New York, VA Medical Research, Buffalo, NY, USA
    Curr Med Res Opin 20:1511-21. 2004
    ..There is a substantial need for more research to understand the etiology and identify efficacious interventions to reduce the frequency of exacerbations of COPD...
  10. ncbi request reprint Acute exacerbations of chronic bronchitis: new developments concerning microbiology and pathophysiology--impact on approaches to risk stratification and therapy
    Sanjay Sethi
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University at Buffalo SUNY, Buffalo, NY 14260, USA
    Infect Dis Clin North Am 18:861-82, ix. 2004
    ..This article discusses a rational, stratified approach to the use of antibiotics for this condition based on these recent studies...
  11. ncbi request reprint Moxifloxacin for the treatment of acute exacerbations of chronic obstructive pulmonary disease
    Sanjay Sethi
    Division of Pulmonary, Critical Care and Sleep Medicine, State University of New York, and Department of Veterans Affairs, Western New York Healthcare System, Buffalo, New York, USA
    Clin Infect Dis 41:S177-85. 2005
    ..A discussion of patient stratification that permits identification of those who require initial aggressive antibiotic therapy is presented...
  12. pmc Efficacy and safety of pharmacokinetically enhanced amoxicillin-clavulanate at 2,000/125 milligrams twice daily for 5 days versus amoxicillin-clavulanate at 875/125 milligrams twice daily for 7 days in the treatment of acute exacerbations of chronic bronc
    Sanjay Sethi
    University of Buffalo, 3495 Bailey Ave, Medical Research 151, Buffalo, NY 14215, USA
    Antimicrob Agents Chemother 49:153-60. 2005
    ....
  13. pmc Antibiotic activity of telithromycin and comparators against bacterial pathogens isolated from 3,043 patients with acute exacerbation of chronic bronchitis
    Sanjay Sethi
    University at Buffalo SUNY, USA
    Ann Clin Microbiol Antimicrob 4:5. 2005
    ..Antibacterial resistance is increasing worldwide and little surveillance data exist concerning pathogens isolated from patients with AECB...
  14. ncbi request reprint Airway bacterial concentrations and exacerbations of chronic obstructive pulmonary disease
    Sanjay Sethi
    Veterans Affairs Western New York Healthcare System 151, 3495 Bailey Avenue, Buffalo, NY 14215, USA
    Am J Respir Crit Care Med 176:356-61. 2007
    ..Bacterial concentrations are higher during exacerbation than during stable disease; however, these studies are cross sectional and devoid of strain typing...
  15. ncbi request reprint Gatifloxacin in community-acquired respiratory tract infection
    Sanjay Sethi
    Department of Medicine, Division of Pulmonary Critical Care Sleep Medicine, University at Buffalo SUNY, Buffalo, NY 14215, USA
    Expert Opin Pharmacother 4:1847-55. 2003
    ....
  16. doi request reprint Molecular diagnosis of respiratory tract infection in acute exacerbations of chronic obstructive pulmonary disease
    Sanjay Sethi
    Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University at Buffalo, State University of New York, Veterans Affairs Western New York Health Care System, Buffalo, New York 14215, USA
    Clin Infect Dis 52:S290-5. 2011
    ....
  17. ncbi request reprint Bronchodilator combination therapy for the treatment of chronic obstructive pulmonary disease
    Sanjay Sethi
    University at Buffalo, State University of New York, V A Western New York Health Care System, Buffalo, NY 14215, USA
    Curr Clin Pharmacol 6:48-61. 2011
    ..The objective of this article is to review clinical data on combined bronchodilator therapy with β2-adrenergic receptor agonists and anticholinergics in patients with COPD...
  18. doi request reprint Infection as a comorbidity of COPD
    S Sethi
    Division of Pulmonary, Critical Care and Sleep Medicine, Dept of Medicine, University at Buffalo, State University of New York, VA Western New York Health Care System, 3495 Bailey Avenue, Buffalo, NY 14215 USA
    Eur Respir J 35:1209-15. 2010
    ..Enhanced understanding of the host-pathogen interaction is needed to better prevent and treat respiratory tract infection in COPD...
  19. doi request reprint Antibiotics in acute exacerbations of chronic bronchitis
    Sanjay Sethi
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University at Buffalo SUNY Buffalo, NY, USA
    Expert Rev Anti Infect Ther 8:405-17. 2010
    ..Factors to be considered in antimicrobial agent selection include local tissue penetration, effects on bacteriological eradication, duration of therapy, speed of resolution and prevention or delay of recurrences...
  20. pmc Pulsed moxifloxacin for the prevention of exacerbations of chronic obstructive pulmonary disease: a randomized controlled trial
    Sanjay Sethi
    Division of Pulmonary, Critical Care and Sleep Medicine, University of Buffalo, State University of New York, Buffalo, NY, USA
    Respir Res 11:10. 2010
    ..This proof-of-concept study evaluates whether intermittent pulsed moxifloxacin treatment could reduce the frequency of these exacerbations...
  21. doi request reprint New paradigms in the pathogenesis of chronic obstructive pulmonary disease II
    Sanjay Sethi
    Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University at Buffalo, SUNY, Buffalo, New York, USA
    Proc Am Thorac Soc 6:532-4. 2009
    ..COPD is heterogeneous; therefore it is likely infections have a varying degree of importance among patients with this disease...
  22. pmc The problems of meta-analysis for antibiotic treatment of chronic obstructive pulmonary disease, a heterogeneous disease: a commentary on Puhan et al
    Sanjay Sethi
    Division of Pulmonary, Critical Care and Sleep Medicine, University at Buffalo, State University of New York and VA Western New York Healthcare System, Buffalo, New York, USA
    BMC Med 6:29. 2008
    ..Future trials need to take into account this heterogeneity as well as incorporate novel end-points to address this important issue...
  23. ncbi request reprint Inflammatory profile of new bacterial strain exacerbations of chronic obstructive pulmonary disease
    Sanjay Sethi
    Division of Pulmonary and Critical Care and Sleep Medicine, Department of Medicine, University at Buffalo, State University of New York, USA
    Am J Respir Crit Care Med 177:491-7. 2008
    ..The relationship between clinical severity and course of exacerbation and inflammation is also not fully understood...
  24. ncbi request reprint New strains of bacteria and exacerbations of chronic obstructive pulmonary disease
    Sanjay Sethi
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, State University of New York, Buffalo, NY, USA
    N Engl J Med 347:465-71. 2002
    ..We hypothesized that the acquisition of a new strain of a pathogenic bacterial species is associated with exacerbation of chronic obstructive pulmonary disease...
  25. ncbi request reprint Pathogenesis and treatment of acute exacerbations of chronic obstructive pulmonary disease
    Sanjay Sethi
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University at Buffalo SUNY, Buffalo, New York, USA
    Semin Respir Crit Care Med 26:192-203. 2005
    ..Improved treatment based on enhanced understanding and good clinical evidence should lead to better outcomes in this common clinical entity...
  26. ncbi request reprint Infectious etiology of acute exacerbations of chronic bronchitis
    S Sethi
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, State University of New York at Buffalo and Department of Veterans Affairs Western New York Healthcare System, Buffalo, NY 14215, USA
    Chest 117:380S-5S. 2000
    ..Emerging evidence from molecular epidemiology and measurement of airway inflammation further support the role of bacteria in AECB. When properly defined, 80% of AECB are likely to be infectious in origin...
  27. ncbi request reprint Eradication of H. influenzae in AECB: A pooled analysis of moxifloxacin phase III trials compared with macrolide agents
    M S Niederman
    Department of Medicine, Winthrop University Hospital, 222 Station Plaza North, Suite 509, Mineola, NY 11501, USA
    Respir Med 100:1781-90. 2006
    ..278); similar results were found when moxifloxacin was compared individually with each macrolide. For patients with AECB due to H. influenzae, moxifloxacin provided superior bacterial eradication rates than macrolide therapy...
  28. ncbi request reprint Human serum and mucosal antibody responses to outer membrane protein G1b of Moraxella catarrhalis in chronic obstructive pulmonary disease
    Diana G Adlowitz
    Department of Microbiology, University of Buffalo, State University of New York, USA
    FEMS Immunol Med Microbiol 46:139-46. 2006
    ..These observations indicate that outer membrane protein G1b should be evaluated further as a vaccine antigen...
  29. pmc Human antibody response to outer membrane protein G1a, a lipoprotein of Moraxella catarrhalis
    Diana G Adlowitz
    Department of Microbiology and Immunology, University at Buffalo, State University of New York, 14215, USA
    Infect Immun 73:6601-7. 2005
    ..These observations indicate that OMP G1a, a highly conserved surface protein, should be evaluated further as a vaccine candidate...
  30. ncbi request reprint Acute exacerbations of chronic bronchitis: what role for the new fluoroquinolones?
    A Obaji
    Division of Pulmonary and Critical Care Medicine, State University of New York at Buffalo, USA
    Drugs Aging 18:1-11. 2001
    ..Such selected use of the new fluoroquinolones balances individual benefit with societal concerns of the use of these agents for AECB...
  31. ncbi request reprint Sequence stability of the gene encoding outer membrane protein P2 of nontypeable Haemophilus influenzae in the human respiratory tract
    Thomas J Hiltke
    Division of Infectious Diseases, Department of Medicine, University at Buffalo, State University of New York, Buffalo, NY, USA
    J Infect Dis 185:627-31. 2002
    ..Most of these changes occurred within areas of repetitive DNA, suggesting that this type of DNA has a role in antigenic variation of P2. The sequence of ompP2 is relatively stable during persistence of NTHI in the human host...
  32. ncbi request reprint Systemic and mucosal antibody response to Moraxella catarrhalis after exacerbations of chronic obstructive pulmonary disease
    Faris Bakri
    Division of Infectious Diseases, Department of Medicine, University at Buffalo, State University of New York, Buffalo, NY, USA
    J Infect Dis 185:632-40. 2002
    ..Therefore, adults with COPD develop variable humoral immune responses to M. catarrhalis after exacerbations, including new serum IgG and new mucosal IgA to epitopes on the bacterial surface...
  33. pmc Use of Moraxella catarrhalis lipooligosaccharide mutants to identify specific oligosaccharide epitopes recognized by human serum antibodies
    Johanna M Schwingel
    Department of Microbiology and Immunology, University at Buffalo, Buffalo, NY 14214, USA
    Infect Immun 77:4548-58. 2009
    ..catarrhalis LOS epitopes developed during natural infection...
  34. pmc Optimizing antibiotic selection in treating COPD exacerbations
    Attiya Siddiqi
    Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Veterans Affairs Western New York Health Care System, Buffalo, NY 14125, USA
    Int J Chron Obstruct Pulmon Dis 3:31-44. 2008
    ....
  35. ncbi request reprint Bacterial infection and the pathogenesis of COPD
    S Sethi
    VA Western New York Healthcare System and Department of Medicine, Division of Pulmonary and Critical Care, State University of New York at Buffalo, Buffalo, NY 14215, USA
    Chest 117:286S-91S. 2000
    ..Application of newer molecular and immunologic research techniques is helping us define precisely the role of bacterial infection in COPD...
  36. pmc Bacterial infection in chronic obstructive pulmonary disease in 2000: a state-of-the-art review
    S Sethi
    Division of Pulmonary and Critical Medicine, State University of New York at Buffalo, Buffalo, New York, USA
    Clin Microbiol Rev 14:336-63. 2001
    ....
  37. ncbi request reprint Simultaneous respiratory tract colonization by multiple strains of nontypeable haemophilus influenzae in chronic obstructive pulmonary disease: implications for antibiotic therapy
    T F Murphy
    Division of Infectious Diseases, Department of Microbiology, State University of New York at Buffalo, USA
    J Infect Dis 180:404-9. 1999
    ..Therefore, multiple strains of H. influenzae are frequently present simultaneously in the sputum of adults with COPD, and the antimicrobial susceptibility of different strains in the same sputum sometimes differs...
  38. ncbi request reprint Chronic obstructive pulmonary disease: role of bacteria and guide to antibacterial selection in the older patient
    Timothy F Murphy
    Division of Infectious Diseases, University at Buffalo, State University of New York and Department of Veterans Affairs Western New York Health System, Buffalo, USA
    Drugs Aging 19:761-75. 2002
    ..The major goals of antibacterial therapy for exacerbations of COPD are acceleration of symptom resolution and prevention of the complications of exacerbation...
  39. doi request reprint Pseudomonas aeruginosa in chronic obstructive pulmonary disease
    Timothy F Murphy
    Medical Research 151, Buffalo Veterans Affairs Medical Center, 3495 Bailey Avenue, Buffalo, NY 14215, USA
    Am J Respir Crit Care Med 177:853-60. 2008
    ..Pseudomonas aeruginosa is isolated from adults with chronic obstructive pulmonary disease (COPD) in cross-sectional studies. However, patterns of carriage and the role of P. aeruginosa in COPD are unknown...
  40. ncbi request reprint Serum antipneumococcal antibodies and pneumococcal colonization in adults with chronic obstructive pulmonary disease
    Richard Malley
    Division of Infectious Diseases, Department of Medicine, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Infect Dis 196:928-35. 2007
    ..We thus conclude that, in adult patients with COPD, resistance to pneumococcal colonization is unlikely to be determined by higher serum antibody concentrations to pneumococcal antigens...
  41. pmc Human immune response to outer membrane protein CD of Moraxella catarrhalis in adults with chronic obstructive pulmonary disease
    Timothy F Murphy
    Division of Infectious Diseases, University at Buffalo, The State University of New York, New York, USA
    Infect Immun 71:1288-94. 2003
    ..Three of 28 patients developed new mucosal IgA to OMP CD in sputum supernatants. This study establishes that OMP CD is a target of a systemic and mucosal immune response following infection and colonization in some patients with COPD...
  42. ncbi request reprint Haemophilus haemolyticus: a human respiratory tract commensal to be distinguished from Haemophilus influenzae
    Timothy F Murphy
    Department of Medicine, University at Buffalo, State University of New York, Buffalo, NY, USA
    J Infect Dis 195:81-9. 2007
    ..In a prospective study, selected isolates of apparent H. influenzae had an altered phenotype. We tested the hypothesis that these variant strains were genetically different from typical H. influenzae...
  43. ncbi request reprint Impaired phagocytosis of nontypeable Haemophilus influenzae by human alveolar macrophages in chronic obstructive pulmonary disease
    Charles S Berenson
    Division of Infectious Diseases, Department of Veterans Affairs Western New York Healthcare System, State University of New York at Buffalo School of Medicine, Buffalo, NY 14215, USA
    J Infect Dis 194:1375-84. 2006
    ..However, the immunologic mechanisms that mediate NTHI-induced macrophage responses are poorly understood. We hypothesized that immunologic responses of alveolar macrophages to NTHI are impaired in COPD...
  44. pmc Impaired alveolar macrophage response to Haemophilus antigens in chronic obstructive lung disease
    Charles S Berenson
    Infectious Disease Division, Department of Veterans Affairs Western New York Healthcare System, State University of New York at Buffalo School of Medicine, Buffalo, NY 14215, USA
    Am J Respir Crit Care Med 174:31-40. 2006
    ..Outer membrane protein (OMP) P6 and lipooligosaccharide (LOS) of NTHI are potent immunomodulators. We theorized that alveolar macrophages in COPD possess fundamental immune defects that permit NTHI to evade host responses...
  45. pmc Antigenic specificity of the mucosal antibody response to Moraxella catarrhalis in chronic obstructive pulmonary disease
    Timothy F Murphy
    VA Western New York Healthcare System, Medical Research 151, 3495 Bailey Avenue, Buffalo, NY 14215, USA
    Infect Immun 73:8161-6. 2005
    ..These results have important implications in understanding the mucosal immune response to M. catarrhalis in the setting of COPD and in elucidating the elements of a protective immune response...
  46. ncbi request reprint Persistent colonization by Haemophilus influenzae in chronic obstructive pulmonary disease
    Timothy F Murphy
    Division of Infectious Diseases, Department of Medicine, University at Buffalo, State University of New York and the Veterans Affairs Western New York Healthcare System, Buffalo, New York 14215, USA
    Am J Respir Crit Care Med 170:266-72. 2004
    ..influenzae and that sputum cultures underestimate the frequency of colonization of the respiratory tract by H. influenzae in COPD. This observation has a significant impact on understanding bacterial colonization in COPD...
  47. pmc Identification of surface antigens of Moraxella catarrhalis as targets of human serum antibody responses in chronic obstructive pulmonary disease
    Timothy F Murphy
    VA Western New York Healthcare System, Medical Research 151, 3495 Bailey Avenue, Buffalo, NY 14215, USA
    Infect Immun 73:3471-8. 2005
    ..These results have important implications in understanding human immune responses to M. catarrhalis and in elucidating the elements of a protective immune response...
  48. ncbi request reprint Role of nontypeable Haemophilus influenzae in exacerbations and progression of chronic obstructive pulmonary disease
    Nader Eldika
    Department of Medicine, Division of Pulmonary Critical Care and Sleep Medicine, University at Buffalo SUNY, New York, USA
    Curr Opin Pulm Med 12:118-24. 2006
    ..Application of modern understanding of bacterial pathogenesis and of innovative research methodologies, however, has considerably clarified its role...
  49. pmc Outer membrane protein P6 of nontypeable Haemophilus influenzae is a potent and selective inducer of human macrophage proinflammatory cytokines
    Charles S Berenson
    Division of Infectious Diseases 151, VA Western NY Healthcare System, 3495 Bailey Avenue, Buffalo, New York 14215, USA
    Infect Immun 73:2728-35. 2005
    ..OMP P6 of NTHI is a specific trigger of bacteria-induced human macrophage inflammatory events, with IL-8 and TNF-alpha as key effectors of P6-induced macrophage responses...
  50. pmc Moraxella catarrhalis in chronic obstructive pulmonary disease: burden of disease and immune response
    Timothy F Murphy
    Buffalo Veterans Affairs Medical Center 151, 3495 Bailey Avenue, Buffalo, NY 14215, USA
    Am J Respir Crit Care Med 172:195-9. 2005
    ..Moraxella catarrhalis is frequently present in the sputum of adults with chronic obstructive pulmonary disease (COPD). Little is known about the role of M. catarrhalis in this common disease...
  51. ncbi request reprint Expression of a peroxiredoxin-glutaredoxin by Haemophilus influenzae in biofilms and during human respiratory tract infection
    Timothy F Murphy
    Division of Infectious Diseases, University at Buffalo, State University of New York, Buffalo, NY, USA
    FEMS Immunol Med Microbiol 44:81-9. 2005
    ..influenzae and the degree of involvement varies among strains; and (3) peroxiredoxin-glutaredoxin is expressed by H. influenzae during infection of the human respiratory tract and is recognized by the human immune system...
  52. pmc Analysis of antigenic structure and human immune response to outer membrane protein CD of Moraxella catarrhalis
    T F Murphy
    Divisions of Infectious Diseases, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York 14215, USA
    Infect Immun 67:4578-85. 1999
    ..While individual adults with COPD show variability in the immune response to OMP CD, a specific region of the OMP CD molecule (amino acids 203 to 260) is important as a target of the human immune response...
  53. ncbi request reprint Pathogenesis of bacterial exacerbations of COPD
    Sateesh B Veeramachaneni
    Division of Pulmonary, Critical Care, and Sleep Medicine, University at Buffalo SUNY, USA
    COPD 3:109-15. 2006
    ..Improved understanding of the host-pathogen interaction in the airways in COPD will lead to novel approaches to prevention and treatment of exacerbations...
  54. ncbi request reprint Lymphocyte proliferative response to P6 of Haemophilus influenzae is associated with relative protection from exacerbations of chronic obstructive pulmonary disease
    Yusuke Abe
    Department of Immunology, Roswell Park Cancer Institute, Buffalo, New York, USA
    Am J Respir Crit Care Med 165:967-71. 2002
    ..These results indicate that decreased proliferation of T cells to P6 is associated with exacerbations of COPD and suggest that the ability of T cells to recognize P6 is associated with relative protection from exacerbations due to NTHI...
  55. ncbi request reprint Horizontal transfer of the gene encoding outer membrane protein P2 of nontypeable Haemophilus influenzae, in a patient with chronic obstructive pulmonary disease
    Thomas J Hiltke
    Division of Infectious Diseases, Department of Medicine, University at Buffalo, Buffalo, New York 14215, USA
    J Infect Dis 188:114-7. 2003
    ..Observation of ompP2 horizontal transfer in the human respiratory tract has important implications for both the understanding of ompP2 diversity among strains and the future design of OMP P2-based vaccines...
  56. pmc Differential genome contents of nontypeable Haemophilus influenzae strains from adults with chronic obstructive pulmonary disease
    Matthew M Fernaays
    Department of Microbiology, VA Western New York Healthcare System, Medical Research 151, 3495 Bailey Avenue, Buffalo, NY 14215, USA
    Infect Immun 74:3366-74. 2006
    ..influenzae to cause exacerbations of COPD, supporting the concept that differences in pathogenic potential are based in part on genomic differences among infecting strains, not merely host factors...
  57. ncbi request reprint Inflammatory markers in bacterial exacerbations of COPD
    Timothy F Murphy
    Am J Respir Crit Care Med 165:132. 2002
  58. ncbi request reprint RSV infection--not for kids only
    Sanjay Sethi
    N Engl J Med 352:1810-2. 2005
  59. pmc Haemophilus influenzae from patients with chronic obstructive pulmonary disease exacerbation induce more inflammation than colonizers
    Cecilia L Chin
    Department of Internal Medicine, University of Iowa Carver College of Medicine, 200 Hawkins Drive, C33 GH, Iowa City, IA 52242, USA
    Am J Respir Crit Care Med 172:85-91. 2005
    ..Airway infection with Haemophilus influenzae causes airway inflammation, and isolation of new strains of this bacteria is associated with increased risk of exacerbations in patients with chronic obstructive pulmonary disease (COPD)...
  60. ncbi request reprint Acute exacerbations of chronic obstructive pulmonary disease
    Michael S Niederman
    Ann Intern Med 136:556-8; author reply 556-8. 2002
  61. pmc Serial isolates of persistent Haemophilus influenzae in patients with chronic obstructive pulmonary disease express diminishing quantities of the HMW1 and HMW2 adhesins
    Deborah M Cholon
    Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Infect Immun 76:4463-8. 2008
    ....
  62. doi request reprint COPD as a lung disease with systemic consequences--clinical impact, mechanisms, and potential for early intervention
    Marc Decramer
    Respiratory Division and Department of Rehabilitation Science, University Hospital, Katholieke Universiteit, Leuven, Belgium
    COPD 5:235-56. 2008
    ....
  63. ncbi request reprint Coinfection in exacerbations of COPD: a new frontier
    Sanjay Sethi
    Chest 129:223-4. 2006
  64. pmc Modulation of airway inflammation by Haemophilus influenzae isolates associated with chronic obstructive pulmonary disease exacerbation
    Dwight C Look
    Department of Internal Medicine, University of Iowa Carver College of Medicine, 200 Hawkins Drive, C33 GH, Iowa City, 52242, USA
    Proc Am Thorac Soc 3:482-3. 2006
  65. ncbi request reprint Exacerbations of chronic obstructive pulmonary disease
    Antonio Anzueto
    South Texas Veterans Health Care System, Audie L Murphy Division, University of Texas Health Science Center, 7400 Merton Minter Boulevard, San Antonio, TX 78229, USA
    Proc Am Thorac Soc 4:554-64. 2007
    ..We summarize the current literature, with special emphasis on the assessment of the long-term impact of this condition...
  66. ncbi request reprint Bacterial pneumonia. Managing a deadly complication of influenza in older adults with comorbid disease
    Sanjay Sethi
    School of Medicine and Biomedical Sciences, State University of New York at Buffalo, USA
    Geriatrics 57:56-61. 2002
    ..Protective rates are similar for residents of long-term care facilities...
  67. ncbi request reprint Musculoskeletal effects of chronic obstructive pulmonary disease: prevalent, linked, but ignored
    Sanjay Sethi
    Am J Respir Crit Care Med 170:1267-8. 2004
  68. ncbi request reprint Microbial contamination of hematopoietic progenitor cell grafts-incidence, clinical outcome, and cost-effectiveness: an analysis of 735 grafts
    Rammurti Kamble
    Section of Hematology Oncology and Bone Marrow Transplantation, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Transfusion 45:874-8. 2005
    ..Screening of progenitor cell grafts (marrow, peripheral blood, and cord blood) for microbial contamination is required by the standards of AABB. Clinical sequelae from infusion of these contaminated grafts, however, is uncommon...

Research Grants9

  1. HAEMOPHILUS ANTIGEN REGULATION OF INFLAMMATION IN COPD
    Sanjay Sethi; Fiscal Year: 2003
    ..Identification of the integral bacterial and host components that contribute to immune-mediated inflammation in COPD will ultimately lead to novel therapeutic strategies to alter disease progression and improve outcome in COPD. ..
  2. Innate Immunity and exacerbations of COPD
    Sanjay Sethi; Fiscal Year: 2009
    ..The overall goal of this research is to identify specific aspects of the innate defense of the lung that determine the frequency of exacerbations in COPD that will serve as potential therapeutic targets to reduce exacerbations. ..