Affiliation: University of Texas at San Antonio
Smith T, Helm S, Chen Y, Lin Y, Karna S, Seshu J. Borrelia host adaptation Protein (BadP) is required for the colonization of a mammalian host by the agent of Lyme disease. Infect Immun. 2018;: pubmed publisher
..These findings have opened a novel regulatory mechanism, which impacts the virulence potential of Bb. ..
Lin Y, Chen Y, Smith T, Karna S, Seshu J. Short-Chain Fatty Acids Alter Metabolic and Virulence Attributes of Borrelia burgdorferi. Infect Immun. 2018;86: pubmed publisher
..burgdorferi during the mammalian phase of infection. ..
Lin Y, Romo J, Smith T, Reyes A, Karna S, Miller C, et al
. Spermine and Spermidine Alter Gene Expression and Antigenic Profile of Borrelia burgdorferi. Infect Immun. 2017;85: pubmed publisher
..These studies suggest that multiple host-derived signals/nutrients and their transport systems contribute to B. burgdorferi adaptation during the vector and vertebrate host phases of infection. ..
Van Laar T, Hole C, Rajasekhar Karna S, Miller C, Reddick R, Wormley F, et al
. Statins reduce spirochetal burden and modulate immune responses in the C3H/HeN mouse model of Lyme disease. Microbes Infect. 2016;18:430-435 pubmed publisher
..Statins have been shown to inhibit B. burgdorferi in vitro. Using a mouse model of Lyme disease, we found that statins contribute to reducing bacterial burden and altering the murine immune response to favor clearance of spirochetes...
Seshu J, Smith T, Lin Y, Karna S, Miller C, Van Laar T. Analysis of DNA and RNA Binding Properties of Borrelia burgdorferi Regulatory Proteins. Methods Mol Biol. 2018;1690:155-175 pubmed publisher
Stevenson B, Seshu J. Regulation of Gene and Protein Expression in the Lyme Disease Spirochete. Curr Top Microbiol Immunol. 2018;415:83-112 pubmed publisher
..We also highlight areas that are in need of substantially more research. ..