S R Sesack

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi Ultrastructural associations between dopamine terminals and local circuit neurons in the monkey prefrontal cortex: a study of calretinin-immunoreactive cells
    S R Sesack
    Department of Neuroscience, University of Pittsburgh, PA 15260, USA
    Neurosci Lett 200:9-12. 1995
  2. ncbi GABA-containing neurons in the rat ventral tegmental area project to the prefrontal cortex
    D B Carr
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    Synapse 38:114-23. 2000
  3. ncbi Selective prefrontal cortex inputs to dopamine cells: implications for schizophrenia
    Susan R Sesack
    Departments of Neuroscience and Psychiatry, 446 Crawford Hall, University of Pittsburgh, 15260, Pittsburgh, PA, USA
    Physiol Behav 77:513-7. 2002
  4. ncbi Anatomical substrates for glutamate-dopamine interactions: evidence for specificity of connections and extrasynaptic actions
    Susan R Sesack
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    Ann N Y Acad Sci 1003:36-52. 2003
  5. ncbi Dopamine innervation of a subclass of local circuit neurons in monkey prefrontal cortex: ultrastructural analysis of tyrosine hydroxylase and parvalbumin immunoreactive structures
    S R Sesack
    Department of Neuroscience, University of Pittsburgh, PA 15260, USA
    Cereb Cortex 8:614-22. 1998
  6. ncbi Glutamate synaptic inputs to ventral tegmental area neurons in the rat derive primarily from subcortical sources
    N Omelchenko
    Department of Neuroscience, 210 Langley Hall, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Neuroscience 146:1259-74. 2007
  7. ncbi Dopamine transporter immunoreactivity in monkey cerebral cortex: regional, laminar, and ultrastructural localization
    D A Lewis
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Comp Neurol 432:119-36. 2001
  8. ncbi Relationship of cannabinoid CB1 receptor and cholecystokinin immunoreactivity in monkey dorsolateral prefrontal cortex
    S M Eggan
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Neuroscience 169:1651-61. 2010
  9. ncbi Ultrastructural localization of serotonin2A receptors in the middle layers of the rat prelimbic prefrontal cortex
    L A H Miner
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Neuroscience 116:107-17. 2003
  10. ncbi Ultrastructural localization of the norepinephrine transporter in superficial and deep layers of the rat prelimbic prefrontal cortex and its spatial relationship to probable dopamine terminals
    LeeAnn H Miner
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Comp Neurol 466:478-94. 2003

Research Grants

  1. CELLULAR BASIS FOR DOPAMINE ACTIONS IN PREFRONTAL CORTEX
    SUSAN SESACK; Fiscal Year: 2004
  2. Factors Regulating NE Transporter Localization in PFC
    SUSAN SESACK; Fiscal Year: 2007
  3. Persistent Impact of Developmental Nicotine on Cholinergic Input to DA Cells
    SUSAN SESACK; Fiscal Year: 2007

Collaborators

Detail Information

Publications20

  1. ncbi Ultrastructural associations between dopamine terminals and local circuit neurons in the monkey prefrontal cortex: a study of calretinin-immunoreactive cells
    S R Sesack
    Department of Neuroscience, University of Pittsburgh, PA 15260, USA
    Neurosci Lett 200:9-12. 1995
    ..These findings suggest that dopamine afferents to the monkey PFC target the subclasses of GABA interneurons that do not contain CalR...
  2. ncbi GABA-containing neurons in the rat ventral tegmental area project to the prefrontal cortex
    D B Carr
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    Synapse 38:114-23. 2000
    ..This GABA-containing mesocortical pathway may provide substrates for both inhibitory and disinhibitory influences on PFC neuronal activity...
  3. ncbi Selective prefrontal cortex inputs to dopamine cells: implications for schizophrenia
    Susan R Sesack
    Departments of Neuroscience and Psychiatry, 446 Crawford Hall, University of Pittsburgh, 15260, Pittsburgh, PA, USA
    Physiol Behav 77:513-7. 2002
    ..These findings may explain some of the unique functional properties of mesoprefrontal DA neurons. Moreover, the results are important for understanding the pathophysiology of mental disorders such as schizophrenia...
  4. ncbi Anatomical substrates for glutamate-dopamine interactions: evidence for specificity of connections and extrasynaptic actions
    Susan R Sesack
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    Ann N Y Acad Sci 1003:36-52. 2003
    ....
  5. ncbi Dopamine innervation of a subclass of local circuit neurons in monkey prefrontal cortex: ultrastructural analysis of tyrosine hydroxylase and parvalbumin immunoreactive structures
    S R Sesack
    Department of Neuroscience, University of Pittsburgh, PA 15260, USA
    Cereb Cortex 8:614-22. 1998
    ....
  6. ncbi Glutamate synaptic inputs to ventral tegmental area neurons in the rat derive primarily from subcortical sources
    N Omelchenko
    Department of Neuroscience, 210 Langley Hall, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Neuroscience 146:1259-74. 2007
    ....
  7. ncbi Dopamine transporter immunoreactivity in monkey cerebral cortex: regional, laminar, and ultrastructural localization
    D A Lewis
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Comp Neurol 432:119-36. 2001
    ..Moreover, this distribution of DAT suggests that cortical DA fibers may permit greater neurotransmitter diffusion than subcortical DA axons...
  8. ncbi Relationship of cannabinoid CB1 receptor and cholecystokinin immunoreactivity in monkey dorsolateral prefrontal cortex
    S M Eggan
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Neuroscience 169:1651-61. 2010
    ..These axons target the perisomatic region of pyramidal neurons, providing a potential anatomical substrate for the impaired function of the DLPFC associated with cannabis use and schizophrenia...
  9. ncbi Ultrastructural localization of serotonin2A receptors in the middle layers of the rat prelimbic prefrontal cortex
    L A H Miner
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Neuroscience 116:107-17. 2003
    ..The results further suggest that serotonin acts presynaptically via this receptor subtype, most likely at receptors on monoamine fibers, and only rarely directly on glutamate axons...
  10. ncbi Ultrastructural localization of the norepinephrine transporter in superficial and deep layers of the rat prelimbic prefrontal cortex and its spatial relationship to probable dopamine terminals
    LeeAnn H Miner
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Comp Neurol 466:478-94. 2003
    ..These results suggest that, in the rat PFC, NE axons (1) contain predominantly cytoplasmic NET, (2) infrequently contain TH immunolabeling, and (3) may interact with probable DA afferents by means of extrasynaptic mechanisms...
  11. ncbi Prefrontal cortical projections to the rat dorsal raphe nucleus: ultrastructural features and associations with serotonin and gamma-aminobutyric acid neurons
    Michael P Jankowski
    Department of Neuroscience, University of Pittsburgh, Pennsylvania 15260, USA
    J Comp Neurol 468:518-29. 2004
    ..These results provide potential anatomical substrates whereby the PFC can both directly and indirectly regulate the activity of serotonin neurons in the DRN and possibly contribute to the pathophysiology of depression...
  12. ncbi Orexin axons in the rat ventral tegmental area synapse infrequently onto dopamine and gamma-aminobutyric acid neurons
    Judith Joyce Balcita-Pedicino
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Comp Neurol 503:668-84. 2007
    ..These studies have important implications for understanding the mechanisms whereby Orx can alter behavior through regulating VTA DA and GABA cell activity...
  13. ncbi Laterodorsal tegmental projections to identified cell populations in the rat ventral tegmental area
    Natalia Omelchenko
    Departments of Neuroscience and Psychiatry, University of Pittsburgh, Pittsburgh, PA 15260, USA
    J Comp Neurol 483:217-35. 2005
    ....
  14. ncbi Chronic stress increases the plasmalemmal distribution of the norepinephrine transporter and the coexpression of tyrosine hydroxylase in norepinephrine axons in the prefrontal cortex
    LeeAnn H Miner
    Department of Neuroscience and Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 26:1571-8. 2006
    ....
  15. ncbi Selective elimination of glutamatergic synapses on striatopallidal neurons in Parkinson disease models
    Michelle Day
    Department of Physiology, 303 East Chicago Avenue, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Nat Neurosci 9:251-9. 2006
    ..3 L-type Ca(2+) channels. The disconnection of striatopallidal neurons from motor command structures is likely to be a key step in the emergence of pathological activity that is responsible for symptoms in Parkinson disease...
  16. ncbi Cholinergic axons in the rat ventral tegmental area synapse preferentially onto mesoaccumbens dopamine neurons
    Natalia Omelchenko
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Comp Neurol 494:863-75. 2006
    ..As such, the results suggest that natural and drug rewards operating through cholinergic afferents to the VTA have a direct synaptic link to the mesoaccumbens DA neurons that modulate approach behaviors...
  17. ncbi Mediodorsal thalamic afferents to layer III of the rat prefrontal cortex: synaptic relationships to subclasses of interneurons
    Diana C Rotaru
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
    J Comp Neurol 490:220-38. 2005
    ..The apparent preferential input to ParV cells endows MD afferents with a strong indirect inhibitory influence on pyramidal neuron activity by virtue of ParV cell synapses onto soma, proximal dendrites, and axon initial segments...
  18. ncbi Ultrastructure at carbon fiber microelectrode implantation sites after acute voltammetric measurements in the striatum of anesthetized rats
    Jennifer L Peters
    Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA
    J Neurosci Methods 137:9-23. 2004
    ..Beyond this annular region, i.e. beyond 6.5 microm from the center of the spot of maximal damage, signs of microelectrode-associated damage were rare and consisted primarily of neurons with darkened cytoplasm...
  19. ncbi Projections from the paraventricular nucleus of the thalamus to the rat prefrontal cortex and nucleus accumbens shell: ultrastructural characteristics and spatial relationships with dopamine afferents
    Aline Pinto
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Comp Neurol 459:142-55. 2003
    ..These findings represent the first demonstration of postsynaptic convergence between DA and thalamic afferents to a striatal region and are consistent with direct synaptic modulation of PVT transmission by DA in the NAc but not the PFC...
  20. ncbi Ultrastructural interactions between terminals expressing the norepinephrine transporter and dopamine neurons in the rat and monkey ventral tegmental area
    Lindsay A Liprando
    Departments of Neuroscience and Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    Synapse 52:233-44. 2004
    ..The latter finding agrees with observations in cortical regions and represents the first report of its type in a subcortical structure...

Research Grants3

  1. CELLULAR BASIS FOR DOPAMINE ACTIONS IN PREFRONTAL CORTEX
    SUSAN SESACK; Fiscal Year: 2004
    ..Elucidating the synaptic organization of the mesocortical DA system will improve knowledge of the cellular mechanisms of DA modulation in cognition and the pathophysiology and treatment of major psychiatric disorders. ..
  2. Factors Regulating NE Transporter Localization in PFC
    SUSAN SESACK; Fiscal Year: 2007
    ..The findings from these studies will provide valuable information regarding the normal functions of the central NE system and its role in the pathophysiology and treatment of mental disorders. ..
  3. Persistent Impact of Developmental Nicotine on Cholinergic Input to DA Cells
    SUSAN SESACK; Fiscal Year: 2007
    ..The data obtained in these studies will facilitate the development of medical treatment strategies for the children of smokers by revealing the brain regions that are most fundamentally affected by early nicotine exposure. ..