Christine M Seroogy

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. pmc Inhaled corticosteroid use is associated with increased circulating T regulatory cells in children with asthma
    Anne Marie Singh
    Departments of Pediatrics, University of Wisconsin, 1111 Highland Avenue, 4139 WIMR, Madison, WI 53705 2275, USA
    Clin Mol Allergy 11:1. 2013
  2. ncbi request reprint The gene related to anergy in lymphocytes, an E3 ubiquitin ligase, is necessary for anergy induction in CD4 T cells
    Christine M Seroogy
    Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Immunol 173:79-85. 2004
  3. ncbi request reprint The role of T regulatory cells in asthma
    Christine M Seroogy
    Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Wisconsin Madison, USA
    J Allergy Clin Immunol 116:996-9. 2005
  4. pmc Cutting edge: The transmembrane E3 ligase GRAIL ubiquitinates the costimulatory molecule CD40 ligand during the induction of T cell anergy
    Neil B Lineberry
    Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Immunol 181:1622-6. 2008
  5. doi request reprint Sustained expression of GRAIL during hematopoiesis results in dysregulated differentiation
    Debra A MacKenzie
    Division of Allergy Immunology Rheumatology, Department of Pediatrics, University of Wisconsin, Madison, WI, USA
    Acta Haematol 122:230-7. 2009
  6. pmc Calpain 4 is not necessary for LFA-1-mediated function in CD4+ T cells
    Sarah A Wernimont
    University of Wisconsin, Madison, Wisconsin, United States of America
    PLoS ONE 5:e10513. 2010
  7. ncbi request reprint GRAIL is up-regulated in CD4+ CD25+ T regulatory cells and is sufficient for conversion of T cells to a regulatory phenotype
    Debra A MacKenzie
    Department of Pediatrics, Division of Allergy Immunology Rheumatology, University of Wisconsin, Madison, Wisconsin 53792, USA
    J Biol Chem 282:9696-702. 2007
  8. pmc Gene related to anergy in lymphocytes (GRAIL) expression in CD4+ T cells impairs actin cytoskeletal organization during T cell/antigen-presenting cell interactions
    Jill M Schartner
    Department of Cellular and Molecular Pathology, University of Wisconsin, Madison, Wisconsin 53792 4108, USA
    J Biol Chem 284:34674-81. 2009
  9. ncbi request reprint Dendritic cells amplify T cell-mediated immune responses in the central nervous system
    Jozsef Karman
    Cellular and Molecular Pathology Graduate Program, Department of Pathology, University of Wisconsin, 1300 University Avenue, Madison, WI 53706, USA
    J Immunol 177:7750-60. 2006
  10. doi request reprint Suppression of T-cell expansion by melanoma is exerted on resting cells
    Andrew J Russ
    Section of Surgical Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    Ann Surg Oncol 18:3848-57. 2011

Research Grants

  1. GENE THERAPY IN ANIMAL MODEL OF AUTOIMMUNE DISEASE
    Christine Seroogy; Fiscal Year: 2002
  2. Role of GRAIL in CD25+ T Regulatory Cells
    Christine Seroogy; Fiscal Year: 2006

Collaborators

Detail Information

Publications14

  1. pmc Inhaled corticosteroid use is associated with increased circulating T regulatory cells in children with asthma
    Anne Marie Singh
    Departments of Pediatrics, University of Wisconsin, 1111 Highland Avenue, 4139 WIMR, Madison, WI 53705 2275, USA
    Clin Mol Allergy 11:1. 2013
    ..The secondary aim was to explore the association between Treg cell frequency with allergen sensitization, disease severity and medication use...
  2. ncbi request reprint The gene related to anergy in lymphocytes, an E3 ubiquitin ligase, is necessary for anergy induction in CD4 T cells
    Christine M Seroogy
    Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Immunol 173:79-85. 2004
    ..These data provide direct evidence that a biochemical pathway composed of GRAIL and/or GRAIL-interacting proteins is important in the development of the CD4 T cell anergic phenotype in vivo...
  3. ncbi request reprint The role of T regulatory cells in asthma
    Christine M Seroogy
    Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Wisconsin Madison, USA
    J Allergy Clin Immunol 116:996-9. 2005
    ..Collectively, this new information suggests that a greater understanding of these pathways might lead to new therapeutic targets for asthma and other diseases of chronic airway inflammation...
  4. pmc Cutting edge: The transmembrane E3 ligase GRAIL ubiquitinates the costimulatory molecule CD40 ligand during the induction of T cell anergy
    Neil B Lineberry
    Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Immunol 181:1622-6. 2008
    ..These data provide a model for intrinsic T cell regulation of costimulatory molecules and a molecular framework for the initiation of clonal T cell anergy...
  5. doi request reprint Sustained expression of GRAIL during hematopoiesis results in dysregulated differentiation
    Debra A MacKenzie
    Division of Allergy Immunology Rheumatology, Department of Pediatrics, University of Wisconsin, Madison, WI, USA
    Acta Haematol 122:230-7. 2009
    ..The E3 ubiquitin ligase, GRAIL (RNF128), is expressed in the bone marrow, but its role is as yet undefined. In this study, we evaluate the effect of GRAIL expression during hematopoietic differentiation in vitro and in vivo...
  6. pmc Calpain 4 is not necessary for LFA-1-mediated function in CD4+ T cells
    Sarah A Wernimont
    University of Wisconsin, Madison, Wisconsin, United States of America
    PLoS ONE 5:e10513. 2010
    ..However, these studies have been limited by the use of calpain inhibitors, which have known off-target effects...
  7. ncbi request reprint GRAIL is up-regulated in CD4+ CD25+ T regulatory cells and is sufficient for conversion of T cells to a regulatory phenotype
    Debra A MacKenzie
    Department of Pediatrics, Division of Allergy Immunology Rheumatology, University of Wisconsin, Madison, Wisconsin 53792, USA
    J Biol Chem 282:9696-702. 2007
    ..These data demonstrate that GRAIL is differentially expressed in naturally occurring and peripherally induced CD25(+) T regulatory cells and that the expression of GRAIL is linked to their functional regulatory activity...
  8. pmc Gene related to anergy in lymphocytes (GRAIL) expression in CD4+ T cells impairs actin cytoskeletal organization during T cell/antigen-presenting cell interactions
    Jill M Schartner
    Department of Cellular and Molecular Pathology, University of Wisconsin, Madison, Wisconsin 53792 4108, USA
    J Biol Chem 284:34674-81. 2009
    ..These data demonstrate a novel role for GRAIL in modulating T/APC interactions and provide further insight into the cell biology of anergic T cells...
  9. ncbi request reprint Dendritic cells amplify T cell-mediated immune responses in the central nervous system
    Jozsef Karman
    Cellular and Molecular Pathology Graduate Program, Department of Pathology, University of Wisconsin, 1300 University Avenue, Madison, WI 53706, USA
    J Immunol 177:7750-60. 2006
    ..Therefore, these data justify more attention to Ag-specific therapeutic approaches for neuroinflammation...
  10. doi request reprint Suppression of T-cell expansion by melanoma is exerted on resting cells
    Andrew J Russ
    Section of Surgical Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    Ann Surg Oncol 18:3848-57. 2011
    ..Immunotherapeutic cancer protocols often rely on the ability to promote proliferative expansion of tumor-specific T-cell, but the influence of cancer on in vivo T-cell expansion remains largely undefined...
  11. ncbi request reprint T-cell anergy: from phenotype to genotype and back
    Christine M Seroogy
    Department of Pediatrics, University of Wisconsin, Madison, WI, USA
    Immunol Res 28:255-64. 2003
    ....
  12. ncbi request reprint Retroviral gene therapy of collagen-induced arthritis by local delivery of IL-4
    Ingo H Tarner
    Department of Medicine, Division of Immunology and Rheumatology, Stanford University, School of Medicine, Stanford, California 94305, USA
    Clin Immunol 105:304-14. 2002
    ....
  13. ncbi request reprint CD4 T-helper cells engineered to produce IL-10 prevent allergen-induced airway hyperreactivity and inflammation
    Jae Won Oh
    Division of Immunology and Allergy, Department of Pediatrics, Stanford University, CA 94305, USA
    J Allergy Clin Immunol 110:460-8. 2002
    ..T(H)2 cells play a critical role in the pathogenesis of asthma, but the precise immunologic mechanisms that inhibit T(H)2 cell function in vivo are not well understood...
  14. ncbi request reprint Association between CD4(+)CD25(high) T cells and atopy in children
    Tuomas Jartti
    Department of Pediatrics, University of Wisconsin, Madison, WI 53792 4108, USA
    J Allergy Clin Immunol 120:177-83. 2007
    ..There is evidence that CD4(+)CD25(high) T-regulatory cells are important for establishing tolerance to allergens, but information in children is limited...

Research Grants2

  1. GENE THERAPY IN ANIMAL MODEL OF AUTOIMMUNE DISEASE
    Christine Seroogy; Fiscal Year: 2002
    ..5 years ago. Since that time she has acquired new skills in cellular immunology and gene therapy. Additional years of training, provided by the MCSDA, will allow her to develop into an independent investigator. ..
  2. Role of GRAIL in CD25+ T Regulatory Cells
    Christine Seroogy; Fiscal Year: 2006
    ....