Genomes and Genes
Christine M Seroogy
Affiliation: University of Wisconsin
- Inhaled corticosteroid use is associated with increased circulating T regulatory cells in children with asthmaAnne Marie Singh
Departments of Pediatrics, University of Wisconsin, 1111 Highland Avenue, 4139 WIMR, Madison, WI 53705 2275, USA
Clin Mol Allergy 11:1. 2013..The secondary aim was to explore the association between Treg cell frequency with allergen sensitization, disease severity and medication use...
- The gene related to anergy in lymphocytes, an E3 ubiquitin ligase, is necessary for anergy induction in CD4 T cellsChristine M Seroogy
Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA 94305, USA
J Immunol 173:79-85. 2004..These data provide direct evidence that a biochemical pathway composed of GRAIL and/or GRAIL-interacting proteins is important in the development of the CD4 T cell anergic phenotype in vivo...
- The role of T regulatory cells in asthmaChristine M Seroogy
Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Wisconsin Madison, USA
J Allergy Clin Immunol 116:996-9. 2005..Collectively, this new information suggests that a greater understanding of these pathways might lead to new therapeutic targets for asthma and other diseases of chronic airway inflammation...
- Cutting edge: The transmembrane E3 ligase GRAIL ubiquitinates the costimulatory molecule CD40 ligand during the induction of T cell anergyNeil B Lineberry
Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
J Immunol 181:1622-6. 2008..These data provide a model for intrinsic T cell regulation of costimulatory molecules and a molecular framework for the initiation of clonal T cell anergy...
- Sustained expression of GRAIL during hematopoiesis results in dysregulated differentiationDebra A MacKenzie
Division of Allergy Immunology Rheumatology, Department of Pediatrics, University of Wisconsin, Madison, WI, USA
Acta Haematol 122:230-7. 2009..The E3 ubiquitin ligase, GRAIL (RNF128), is expressed in the bone marrow, but its role is as yet undefined. In this study, we evaluate the effect of GRAIL expression during hematopoietic differentiation in vitro and in vivo...
- Calpain 4 is not necessary for LFA-1-mediated function in CD4+ T cellsSarah A Wernimont
University of Wisconsin, Madison, Wisconsin, United States of America
PLoS ONE 5:e10513. 2010..However, these studies have been limited by the use of calpain inhibitors, which have known off-target effects...
- GRAIL is up-regulated in CD4+ CD25+ T regulatory cells and is sufficient for conversion of T cells to a regulatory phenotypeDebra A MacKenzie
Department of Pediatrics, Division of Allergy Immunology Rheumatology, University of Wisconsin, Madison, Wisconsin 53792, USA
J Biol Chem 282:9696-702. 2007..These data demonstrate that GRAIL is differentially expressed in naturally occurring and peripherally induced CD25(+) T regulatory cells and that the expression of GRAIL is linked to their functional regulatory activity...
- Gene related to anergy in lymphocytes (GRAIL) expression in CD4+ T cells impairs actin cytoskeletal organization during T cell/antigen-presenting cell interactionsJill M Schartner
Department of Cellular and Molecular Pathology, University of Wisconsin, Madison, Wisconsin 53792 4108, USA
J Biol Chem 284:34674-81. 2009..These data demonstrate a novel role for GRAIL in modulating T/APC interactions and provide further insight into the cell biology of anergic T cells...
- Dendritic cells amplify T cell-mediated immune responses in the central nervous systemJozsef Karman
Cellular and Molecular Pathology Graduate Program, Department of Pathology, University of Wisconsin, 1300 University Avenue, Madison, WI 53706, USA
J Immunol 177:7750-60. 2006..Therefore, these data justify more attention to Ag-specific therapeutic approaches for neuroinflammation...
- Suppression of T-cell expansion by melanoma is exerted on resting cellsAndrew J Russ
Section of Surgical Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
Ann Surg Oncol 18:3848-57. 2011..Immunotherapeutic cancer protocols often rely on the ability to promote proliferative expansion of tumor-specific T-cell, but the influence of cancer on in vivo T-cell expansion remains largely undefined...
- T-cell anergy: from phenotype to genotype and backChristine M Seroogy
Department of Pediatrics, University of Wisconsin, Madison, WI, USA
Immunol Res 28:255-64. 2003....
- Retroviral gene therapy of collagen-induced arthritis by local delivery of IL-4Ingo H Tarner
Department of Medicine, Division of Immunology and Rheumatology, Stanford University, School of Medicine, Stanford, California 94305, USA
Clin Immunol 105:304-14. 2002....
- CD4 T-helper cells engineered to produce IL-10 prevent allergen-induced airway hyperreactivity and inflammationJae Won Oh
Division of Immunology and Allergy, Department of Pediatrics, Stanford University, CA 94305, USA
J Allergy Clin Immunol 110:460-8. 2002..T(H)2 cells play a critical role in the pathogenesis of asthma, but the precise immunologic mechanisms that inhibit T(H)2 cell function in vivo are not well understood...
- Association between CD4(+)CD25(high) T cells and atopy in childrenTuomas Jartti
Department of Pediatrics, University of Wisconsin, Madison, WI 53792 4108, USA
J Allergy Clin Immunol 120:177-83. 2007..There is evidence that CD4(+)CD25(high) T-regulatory cells are important for establishing tolerance to allergens, but information in children is limited...