Affiliation: University of North Carolina
Country: USA


  1. request reprint
    Serody J, Cook D, Kirby S, Reap E, Shea T, Frelinger J. Murine T lymphocytes incapable of producing macrophage inhibitory protein-1 are impaired in causing graft-versus-host disease across a class I but not class II major histocompatibility complex barrier. Blood. 1999;93:43-50 pubmed
    ..This data show that blockade of chemokine production or function may provide a new approach to the prevention or treatment of GVHD but that chemokines that recruit both CD4(+) and CD8(+) lymphocytes may need to be targeted. ..
  2. request reprint
    Serody J, Burkett S, Panoskaltsis Mortari A, Ng Cashin J, McMahon E, Matsushima G, et al. T-lymphocyte production of macrophage inflammatory protein-1alpha is critical to the recruitment of CD8(+) T cells to the liver, lung, and spleen during graft-versus-host disease. Blood. 2000;96:2973-80 pubmed
    ..However, the increased expression only led to enhanced recruitment of CD8(+), but not CD4(+), donor T cells. Production of MIP-1alpha by donor T cells is important in the occurrence of GVHD and functions in a tissue-dependent fashion. ..