Affiliation: University of Miami
- Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cellsGiovanna Gallina
Istituto Oncologico Veneto, Padua, Italy
J Clin Invest 116:2777-90. 2006..Moreover, our data show how the inflammatory response elicited by tumors had detrimental effects on the adaptive immune system and suggest novel approaches for the treatment of tumor-induced immune dysfunctions...
- High-dose granulocyte-macrophage colony-stimulating factor-producing vaccines impair the immune response through the recruitment of myeloid suppressor cellsPaolo Serafini
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA
Cancer Res 64:6337-43. 2004....
- Myeloid-derived suppressor cells promote cross-tolerance in B-cell lymphoma by expanding regulatory T cellsPaolo Serafini
Department of Microbiology and Immunology, Dodson Interdisciplinary Immunotherapy Institute, University of Miami, School of Medicine, Miami, Florida 33136, USA
Cancer Res 68:5439-49. 2008....
- FOXP3 Subcellular Localization Predicts Recurrence in Oral Squamous Cell CarcinomaDonald T Weed
Department of Otolaryngology, University of Miami, Miller School of Medicine, Miami, Florida, United States of America Sylvester Comprehensive Cancer Center, University of Miami, Miami, Florida, United States of America
PLoS ONE 8:e71908. 2013..Thus, we propose elevated levels of the cFOXP3/nFOXP3 ratio within tumor infiltrating CD4(+) T cells as a predictor of OSCC recurrence. ..
- Aptamer-mediated blockade of IL4Rα triggers apoptosis of MDSCs and limits tumor progressionFelix Roth
Department of Microbiology and Immunology, Sylvester Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida, USA
Cancer Res 72:1373-83. 2012..More broadly, these findings suggest therapeutic strategies based on IL4Rα signaling blockades to arrest an important cellular mechanism of tumoral immune escape mediated by MDSCs and TAM in cancer...
- Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell functionPaolo Serafini
Sidney Kimmel Comprehensive Cancer Center, Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University, Baltimore, MD 21231, USA
J Exp Med 203:2691-702. 2006..In light of the recent data that enzymes mediating MDSC-dependent immunosuppression in mice are active also in humans, these findings demonstrate a potentially novel use of PDE5 inhibitors as adjuncts to tumor-specific immune therapy...
- Myeloid suppressor cells in cancer: recruitment, phenotype, properties, and mechanisms of immune suppressionPaolo Serafini
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA
Semin Cancer Biol 16:53-65. 2006..The present article summarizes recent findings on the interaction between developing cancers and these recently described "myeloid suppressor cells"...
- Activated marrow-infiltrating lymphocytes effectively target plasma cells and their clonogenic precursorsKimberly Noonan
Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University, Baltimore, Maryland 21231, USA
Cancer Res 65:2026-34. 2005..Taken together, these results highlight the intrinsic tumor specificity of MILs and describe a novel approach for the generation of tumor-specific T-cell populations suitable for adoptive immunotherapy of multiple myeloma...
- Nitroaspirin corrects immune dysfunction in tumor-bearing hosts and promotes tumor eradication by cancer vaccinationCarmela De Santo
Department of Oncology and Surgical Sciences, Oncology Section, Padua University, 35128 Padua, Italy
Proc Natl Acad Sci U S A 102:4185-90. 2005..Because cancer vaccines and NO aspirin are currently being investigated in independent phase I/II clinical trials, these findings offer a rationale to combine these treatments in subjects with advanced neoplastic diseases...
- Effective genetic vaccination with a widely shared endogenous retroviral tumor antigen requires CD40 stimulation during tumor rejection phaseVincenzo Bronte
Department of Oncology and Surgical Sciences, University of Padova, Padova, Italy
J Immunol 171:6396-405. 2003....
- Derangement of immune responses by myeloid suppressor cellsPaolo Serafini
Department of Oncology and Surgical Sciences, Oncology Section, Azienda Ospedaliera, Via Gattamelata 64, 35128, Padova, Italy
Cancer Immunol Immunother 53:64-72. 2004..This review examines recent findings on the nature, properties, and mechanisms of action of these myeloid suppressor cells (MSCs)...
- L-arginine metabolism in myeloid cells controls T-lymphocyte functionsVincenzo Bronte
Department of Oncology and Surgical Sciences, Via Gattamelata 64, 35128, Padua, Italy
Trends Immunol 24:302-6. 2003..This Opinion is the second in a series on the regulation of the immune system by metabolic pathways...
- IL-4-induced arginase 1 suppresses alloreactive T cells in tumor-bearing miceVincenzo Bronte
Department of Oncology and Surgical Sciences, University of Padua, Padua, Italy
J Immunol 170:270-8. 2003....
- Myeloid suppressor lines inhibit T cell responses by an NO-dependent mechanismAlessandra Mazzoni
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 Department of Oncology and Surgical Sciences, Oncology Section, Azienda Ospedaliera, Padova, Italy
J Immunol 168:689-95. 2002..The distinctive capacity of MSC to generate suppressive signals when encountering activated T cells defines a specialized subset of myeloid cells that most likely serve a regulatory function during times of heightened immune activity...