Paolo Serafini

Summary

Affiliation: University of Miami
Country: USA

Publications

  1. pmc Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells
    Giovanna Gallina
    Istituto Oncologico Veneto, Padua, Italy
    J Clin Invest 116:2777-90. 2006
  2. ncbi request reprint High-dose granulocyte-macrophage colony-stimulating factor-producing vaccines impair the immune response through the recruitment of myeloid suppressor cells
    Paolo Serafini
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA
    Cancer Res 64:6337-43. 2004
  3. pmc Myeloid-derived suppressor cells promote cross-tolerance in B-cell lymphoma by expanding regulatory T cells
    Paolo Serafini
    Department of Microbiology and Immunology, Dodson Interdisciplinary Immunotherapy Institute, University of Miami, School of Medicine, Miami, Florida 33136, USA
    Cancer Res 68:5439-49. 2008
  4. pmc FOXP3 Subcellular Localization Predicts Recurrence in Oral Squamous Cell Carcinoma
    Donald T Weed
    Department of Otolaryngology, University of Miami, Miller School of Medicine, Miami, Florida, United States of America Sylvester Comprehensive Cancer Center, University of Miami, Miami, Florida, United States of America
    PLoS ONE 8:e71908. 2013
  5. doi request reprint Aptamer-mediated blockade of IL4Rα triggers apoptosis of MDSCs and limits tumor progression
    Felix Roth
    Department of Microbiology and Immunology, Sylvester Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida, USA
    Cancer Res 72:1373-83. 2012
  6. pmc Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function
    Paolo Serafini
    Sidney Kimmel Comprehensive Cancer Center, Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University, Baltimore, MD 21231, USA
    J Exp Med 203:2691-702. 2006
  7. ncbi request reprint Myeloid suppressor cells in cancer: recruitment, phenotype, properties, and mechanisms of immune suppression
    Paolo Serafini
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA
    Semin Cancer Biol 16:53-65. 2006
  8. ncbi request reprint Activated marrow-infiltrating lymphocytes effectively target plasma cells and their clonogenic precursors
    Kimberly Noonan
    Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University, Baltimore, Maryland 21231, USA
    Cancer Res 65:2026-34. 2005
  9. pmc Nitroaspirin corrects immune dysfunction in tumor-bearing hosts and promotes tumor eradication by cancer vaccination
    Carmela De Santo
    Department of Oncology and Surgical Sciences, Oncology Section, Padua University, 35128 Padua, Italy
    Proc Natl Acad Sci U S A 102:4185-90. 2005
  10. ncbi request reprint Effective genetic vaccination with a widely shared endogenous retroviral tumor antigen requires CD40 stimulation during tumor rejection phase
    Vincenzo Bronte
    Department of Oncology and Surgical Sciences, University of Padova, Padova, Italy
    J Immunol 171:6396-405. 2003

Collaborators

  • Cecilia Melani
  • Vincenzo Bronte
  • Carmela De Santo
  • Donald T Weed
  • Adriana C De La Fuente
  • Jennifer L Vella
  • Felix Roth
  • Paola Zanovello
  • Giovanna Gallina
  • Ivan Borrello
  • Luigi Dolcetti
  • Mario P Colombo
  • Ilaria Marigo
  • Kimberly Noonan
  • Alessandra Mazzoni
  • Gail Walker
  • Ronen Nazarian
  • Carmen R Gomez-Fernandez
  • Alessia Zoso
  • Luca Inverardi
  • Giuseppe Basso
  • Frank Brombacher
  • Silvio Bicciato
  • Piero Musiani
  • Katie Whartenby
  • William Matsui
  • Manlio Bolla
  • Gladys Tan
  • Rebecca Carbley
  • Mark Bonyhadi
  • Piero Del Soldato
  • Manuela Iezzi
  • Jahan Khalili
  • Cristiana Guiducci
  • Hyam Levitsky
  • Alberto Visintin
  • David M Segal
  • Jessica H Spitzer
  • Elisa Apolloni

Detail Information

Publications14

  1. pmc Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells
    Giovanna Gallina
    Istituto Oncologico Veneto, Padua, Italy
    J Clin Invest 116:2777-90. 2006
    ..Moreover, our data show how the inflammatory response elicited by tumors had detrimental effects on the adaptive immune system and suggest novel approaches for the treatment of tumor-induced immune dysfunctions...
  2. ncbi request reprint High-dose granulocyte-macrophage colony-stimulating factor-producing vaccines impair the immune response through the recruitment of myeloid suppressor cells
    Paolo Serafini
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA
    Cancer Res 64:6337-43. 2004
    ....
  3. pmc Myeloid-derived suppressor cells promote cross-tolerance in B-cell lymphoma by expanding regulatory T cells
    Paolo Serafini
    Department of Microbiology and Immunology, Dodson Interdisciplinary Immunotherapy Institute, University of Miami, School of Medicine, Miami, Florida 33136, USA
    Cancer Res 68:5439-49. 2008
    ....
  4. pmc FOXP3 Subcellular Localization Predicts Recurrence in Oral Squamous Cell Carcinoma
    Donald T Weed
    Department of Otolaryngology, University of Miami, Miller School of Medicine, Miami, Florida, United States of America Sylvester Comprehensive Cancer Center, University of Miami, Miami, Florida, United States of America
    PLoS ONE 8:e71908. 2013
    ..Thus, we propose elevated levels of the cFOXP3/nFOXP3 ratio within tumor infiltrating CD4(+) T cells as a predictor of OSCC recurrence. ..
  5. doi request reprint Aptamer-mediated blockade of IL4Rα triggers apoptosis of MDSCs and limits tumor progression
    Felix Roth
    Department of Microbiology and Immunology, Sylvester Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida, USA
    Cancer Res 72:1373-83. 2012
    ..More broadly, these findings suggest therapeutic strategies based on IL4Rα signaling blockades to arrest an important cellular mechanism of tumoral immune escape mediated by MDSCs and TAM in cancer...
  6. pmc Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function
    Paolo Serafini
    Sidney Kimmel Comprehensive Cancer Center, Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University, Baltimore, MD 21231, USA
    J Exp Med 203:2691-702. 2006
    ..In light of the recent data that enzymes mediating MDSC-dependent immunosuppression in mice are active also in humans, these findings demonstrate a potentially novel use of PDE5 inhibitors as adjuncts to tumor-specific immune therapy...
  7. ncbi request reprint Myeloid suppressor cells in cancer: recruitment, phenotype, properties, and mechanisms of immune suppression
    Paolo Serafini
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA
    Semin Cancer Biol 16:53-65. 2006
    ..The present article summarizes recent findings on the interaction between developing cancers and these recently described "myeloid suppressor cells"...
  8. ncbi request reprint Activated marrow-infiltrating lymphocytes effectively target plasma cells and their clonogenic precursors
    Kimberly Noonan
    Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University, Baltimore, Maryland 21231, USA
    Cancer Res 65:2026-34. 2005
    ..Taken together, these results highlight the intrinsic tumor specificity of MILs and describe a novel approach for the generation of tumor-specific T-cell populations suitable for adoptive immunotherapy of multiple myeloma...
  9. pmc Nitroaspirin corrects immune dysfunction in tumor-bearing hosts and promotes tumor eradication by cancer vaccination
    Carmela De Santo
    Department of Oncology and Surgical Sciences, Oncology Section, Padua University, 35128 Padua, Italy
    Proc Natl Acad Sci U S A 102:4185-90. 2005
    ..Because cancer vaccines and NO aspirin are currently being investigated in independent phase I/II clinical trials, these findings offer a rationale to combine these treatments in subjects with advanced neoplastic diseases...
  10. ncbi request reprint Effective genetic vaccination with a widely shared endogenous retroviral tumor antigen requires CD40 stimulation during tumor rejection phase
    Vincenzo Bronte
    Department of Oncology and Surgical Sciences, University of Padova, Padova, Italy
    J Immunol 171:6396-405. 2003
    ....
  11. ncbi request reprint Derangement of immune responses by myeloid suppressor cells
    Paolo Serafini
    Department of Oncology and Surgical Sciences, Oncology Section, Azienda Ospedaliera, Via Gattamelata 64, 35128, Padova, Italy
    Cancer Immunol Immunother 53:64-72. 2004
    ..This review examines recent findings on the nature, properties, and mechanisms of action of these myeloid suppressor cells (MSCs)...
  12. ncbi request reprint L-arginine metabolism in myeloid cells controls T-lymphocyte functions
    Vincenzo Bronte
    Department of Oncology and Surgical Sciences, Via Gattamelata 64, 35128, Padua, Italy
    Trends Immunol 24:302-6. 2003
    ..This Opinion is the second in a series on the regulation of the immune system by metabolic pathways...
  13. ncbi request reprint IL-4-induced arginase 1 suppresses alloreactive T cells in tumor-bearing mice
    Vincenzo Bronte
    Department of Oncology and Surgical Sciences, University of Padua, Padua, Italy
    J Immunol 170:270-8. 2003
    ....
  14. ncbi request reprint Myeloid suppressor lines inhibit T cell responses by an NO-dependent mechanism
    Alessandra Mazzoni
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 Department of Oncology and Surgical Sciences, Oncology Section, Azienda Ospedaliera, Padova, Italy
    J Immunol 168:689-95. 2002
    ..The distinctive capacity of MSC to generate suppressive signals when encountering activated T cells defines a specialized subset of myeloid cells that most likely serve a regulatory function during times of heightened immune activity...